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| | Oant_1882 | KEGG: bms:BR1301 precorrin-3B C17-methyltransferase, putative. (137 aa) |
| | Oant_0010 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: bms:BR0005 D-isomer specific 2-hydroxyacid dehydrogenase family protein. (318 aa) |
| | Oant_0018 | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: bmb:BruAb1_0037 PheA, prephenate dehydratase. (287 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (450 aa) |
| | Oant_0038 | Propionyl-CoA carboxylase; PFAM: carboxyl transferase; KEGG: bms:BR0019 carboxyl transferase family protein. (535 aa) |
| | Oant_0040 | Hydroxymethylglutaryl-CoA lyase; PFAM: pyruvate carboxyltransferase; KEGG: bmb:BruAb1_0017 3-hydroxy 3-methylglutarate-CoA lyase. (287 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: bmb:BruAb1_0074 ArgG, argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (412 aa) |
| | Oant_0094 | PFAM: transcriptional coactivator/pterin dehydratase; KEGG: bmb:BruAb1_0080 PhhB, pterin-4-alpha-carbinolamine dehydratase. (96 aa) |
| | ilvD | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: bmb:BruAb1_0096 IlvD, dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (611 aa) |
| | Oant_0177 | PFAM: protein of unknown function DUF540; KEGG: bmb:BruAb1_0163 hypothetical protein. (242 aa) |
| | Oant_0188 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (475 aa) |
| | Oant_0190 | PFAM: nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; KEGG: bms:BR0181 sulfite reductase (NADPH) hemoprotein beta-component. (556 aa) |
| | Oant_0197 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1263 aa) |
| | Oant_0199 | PFAM: aminotransferase class-III; KEGG: bmb:BruAb1_0186 hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (456 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (81 aa) |
| | Oant_0272 | PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: bmb:BruAb1_0198 alcohol dehydrogenase, zinc-containing. (344 aa) |
| | Oant_0279 | Transcriptional activator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (231 aa) |
| | Oant_0280 | PFAM: NMT1/THI5 like domain protein; KEGG: bmb:BruAb1_0208 ABC transporter, periplasmic substrate-binding protein. (322 aa) |
| | Oant_0281 | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). (209 aa) |
| | thiG | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa) |
| | Oant_0283 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: bmb:BruAb1_0211 thiamine biosynthesis ThiS. (65 aa) |
| | Oant_0284 | TIGRFAM: glycine oxidase ThiO; PFAM: FAD dependent oxidoreductase; KEGG: bmb:BruAb1_0212 D-amino acid oxidase family protein. (334 aa) |
| | Oant_0285 | TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: bme:BMEI1732 phosphomethylpyrimidine kinase / hydroxymethylpyrimidine kinase. (295 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa) |
| | Oant_0348 | TIGRFAM: amidase, hydantoinase/carbamoylase family; PFAM: peptidase M20; KEGG: bmf:BAB1_0310 peptidase M20/M25/M40. (415 aa) |
| | Oant_0359 | PFAM: dihydrodipicolinate synthetase; KEGG: atc:AGR_C_4548 hypothetical protein; Belongs to the DapA family. (300 aa) |
| | Oant_0366 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: bme:BMEI1638 glutamate synthase (NADPH) small chain. (500 aa) |
| | pgi | PFAM: phosphoglucose isomerase (PGI); KEGG: bms:BR0285 glucose-6-phosphate isomerase; Belongs to the GPI family. (549 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: bmb:BruAb1_0327 acetylornithine aminotransferase, hypothetical; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (403 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (397 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (289 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (284 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (323 aa) |
| | Oant_0495 | Transcriptional activator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP); Belongs to the TenA family. (220 aa) |
| | ubiA | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (342 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (216 aa) |
| | Oant_0535 | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: bmb:BruAb1_0443 FabI-1, enoyl-(acyl-carrier-protein) reductase. (272 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (364 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (371 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (638 aa) |
| | Oant_0570 | TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: bms:BR0457 malonyl CoA-acyl carrier protein transacylase. (314 aa) |
| | Oant_0571 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa) |
| | acpP-2 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | Oant_0573 | Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (419 aa) |
| | thrB | TIGRFAM: homoserine kinase; PFAM: aminoglycoside phosphotransferase; KEGG: bms:BR0476 homoserine kinase; Belongs to the pseudomonas-type ThrB family. (326 aa) |
| | Oant_0599 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: bmb:BruAb1_0506 ThrC, threonine synthase. (468 aa) |
| | Oant_0655 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: mlo:mlr9541 cysteine synthase. (335 aa) |
| | Oant_0665 | Threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: mlo:mll9542 threonine synthase homolog. (413 aa) |
| | fabA | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (172 aa) |
| | Oant_0740 | PFAM: Beta-ketoacyl synthase; KEGG: bms:BR2172 3-oxoacyl-(acyl-carrier-protein) synthase I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (407 aa) |
| | Oant_0741 | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: bmb:BruAb1_2144 FabI-2, enoyl-(acyl-carrier-protein) reductase. (272 aa) |
| | Oant_0784 | PFAM: SMP-30/Gluconolaconase/LRE domain protein; KEGG: bms:BR2130 Smp-30/Cgr1 family protein, putative. (302 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: bme:BMEI2017 N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (227 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (301 aa) |
| | Oant_0814 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: bmb:BruAb1_2081 FolC, FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (430 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (536 aa) |
| | hisE | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: bmb:BruAb1_2061 HisE, phosphoribosyl-ATP pyrophosphohydrolase. (107 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (261 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: bmb:BruAb1_2059 HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (243 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bmb:BruAb1_2056 HisB, imidazoleglycerol-phosphate dehydratase. (202 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (292 aa) |
| | Oant_0869 | PFAM: protein of unknown function DUF993; KEGG: bmb:BruAb1_2025 hypothetical protein. (389 aa) |
| | Oant_0903 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: bmb:BruAb1_2010 cobalamin synthesis protein/P47K family protein. (382 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (206 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (378 aa) |
| | Oant_0915 | KEGG: bme:BMEI0050 CobT protein; TIGRFAM: cobalt chelatase, pCobT subunit; PFAM: Cobalt chelatase CobT subunit; SMART: von Willebrand factor type A. (637 aa) |
| | Oant_0917 | Conserved hypothetical integral membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (216 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (300 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | Oant_0957 | TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase FAD-binding; FAD dependent oxidoreductase; KEGG: bms:BR1899 UbiH/COQ6 monooxygenase family. (414 aa) |
| | Oant_0976 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (244 aa) |
| | Oant_0992 | PFAM: oxidoreductase domain protein; Prephenate dehydrogenase; NADP oxidoreductase coenzyme F420-dependent; 6-phosphogluconate dehydrogenase NAD-binding; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: bms:BR1988 cyclohexadienyl dehydrogenase / prephenate dehydrogenase. (312 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: bme:BMEI0080 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (368 aa) |
| | Oant_0995 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: bmb:BruAb1_1961 Hpt, hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (421 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: bms:BR1981 argininosuccinate lyase. (466 aa) |
| | Oant_1007 | TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; KEGG: bms:BR1975 ATP:cob(I)alamin adenosyltransferase, putative; Belongs to the Cob(I)alamin adenosyltransferase family. (196 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (246 aa) |
| | Oant_1009 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: bmb:BruAb1_1949 hypothetical 6-pyruvoyl tetrahydrobiopterin synthase. (118 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (232 aa) |
| | Oant_1015 | TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: bme:BMEI0101 cysteine synthase A. (328 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa) |
| | ubiG | Ubiquinone biosynthesis O-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (248 aa) |
| | Oant_1034 | TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; KEGG: bmb:BruAb1_1850 aspartate kinase, monofunctional class; Belongs to the aspartokinase family. (423 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (378 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (427 aa) |
| | Oant_1072 | TIGRFAM: pyridoxal kinase; KEGG: bms:BR1830 pyridoxal kinase; Belongs to the pyridoxine kinase family. (298 aa) |
| | Oant_1093 | PFAM: Usg family protein; KEGG: bmb:BruAb1_1790 hypothetical usg protein. (95 aa) |
| | Oant_1119 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1169 aa) |
| | Oant_1129 | PFAM: protein of unknown function DUF336; KEGG: bmb:BruAb1_1757 hypothetical protein. (143 aa) |
| | Oant_1143 | TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase catalytic region; KEGG: bmb:BruAb1_1741 hypothetical protein. (218 aa) |
| | Oant_1174 | TIGRFAM: Quinone oxidoreductase putative PIG3; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: bme:BMEI0302 quinone oxidoreductase. (334 aa) |
| | Oant_1208 | PFAM: thiamine monophosphate synthase; KEGG: bmb:BruAb1_1692 hypothetical thiamine-phosphate pyrophosphorylase. (221 aa) |
| | Oant_1228 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (391 aa) |
| | Oant_1229 | TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: bms:BR1685 D-3-phosphoglycerate dehydrogenase. (533 aa) |
| | Oant_1313 | PFAM: GCN5-related N-acetyltransferase; KEGG: pfo:Pfl_3728 GCN5-related N-acetyltransferase. (153 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (263 aa) |
| | Oant_1318 | 2-polyprenylphenol 6-hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. (527 aa) |
| | Oant_1327 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: mlo:mlr2503 hypothetical protein. (228 aa) |
| | Oant_1328 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: bmb:BruAb2_0994 nitroreductase family protein. (207 aa) |
| | gpmA | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (206 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (277 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (125 aa) |
| | queG | Domain of unknown function DUF1730; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (393 aa) |
| | Oant_1340 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; NmrA family protein; Male sterility domain; KEGG: bmf:BAB2_1002 NADH-ubiquinone oxidoreductase 39 kd subunit. (328 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (395 aa) |
| | dapD | TIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; KEGG: bmb:BruAb2_0968 DapD, 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (284 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (296 aa) |
| | Oant_1373 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: bmb:BruAb2_0247 cobalamin synthesis protein/P47K family protein. (393 aa) |
| | Oant_1374 | PFAM: Creatininase; KEGG: bms:BRA0986 creatinine amidohydrolase, putative. (260 aa) |
| | Oant_1405 | Aminotransferase class-III; PFAM: aminoglycoside phosphotransferase; peptidase M23B; aminotransferase class-III; KEGG: bmb:BruAb2_0284 hypothetical protein. (1016 aa) |
| | Oant_1409 | PFAM: Asp/Glu racemase; KEGG: sme:SMc04361 putative hydantoin racemase protein. (228 aa) |
| | Oant_1442 | PFAM: aminotransferase class-III; KEGG: bms:BRA0926 omega-amino acid--pyruvate aminotransferase, putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (442 aa) |
| | Oant_1445 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (380 aa) |
| | Oant_1475 | KEGG: atc:AGR_C_4663 hypothetical protein. (302 aa) |
| | Oant_1477 | KEGG: atc:AGR_C_4658 acyl carrier protein. (83 aa) |
| | Oant_1597 | Anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; anthranilate synthase; PFAM: glutamine amidotransferase class-I; Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein; KEGG: bms:BR1570 anthranilate synthase. (731 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa) |
| | Oant_1640 | PFAM: protein of unknown function DUF526; KEGG: bmb:BruAb1_1516 hypothetical protein. (106 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (296 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; RimK domain protein ATP-grasp; KEGG: bms:BR1488 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1161 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: bms:BR1483 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (407 aa) |
| | Oant_1714 | PFAM: UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; KEGG: atc:AGR_L_1413 UDPglucose 6-dehydrogenase. (436 aa) |
| | Oant_1723 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: bmb:BruAb1_1445 MetF, 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (303 aa) |
| | Oant_1793 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (174 aa) |
| | Oant_1800 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: bme:BMEI0615 phosphoserine phosphatase. (299 aa) |
| | Oant_1804 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: bmb:BruAb1_1385 IlvB, acetolactate synthase large subunit. (607 aa) |
| | Oant_1805 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: bmb:BruAb1_1384 IlvN, acetolactate synthase, small subunit. (190 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (245 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (483 aa) |
| | Oant_1875 | Adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (173 aa) |
| | Oant_1876 | TIGRFAM: cobalamin biosynthesis protein CobW; PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: bms:BR1307 cobW protein, putative. (349 aa) |
| | Oant_1877 | TIGRFAM: cobaltochelatase, CobN subunit; PFAM: CobN/magnesium chelatase; KEGG: bms:BR1306 cobN protein. (1263 aa) |
| | Oant_1878 | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (212 aa) |
| | Oant_1885 | TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: bme:BMEI0701 precorrin-4 C11-methyltransferase. (261 aa) |
| | Oant_1886 | TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; KEGG: bms:BR1299 precorrin-6x reductase. (248 aa) |
| | cbiD | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (368 aa) |
| | cobB | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (436 aa) |
| | Oant_1890 | PFAM: aminotransferase class I and II; KEGG: bmb:BruAb1_1296 CobC, CobC protein. (331 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (327 aa) |
| | Oant_1896 | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: bme:BMEI0712 cbiG protein / precorrin-3B C17-methyltransferase. (572 aa) |
| | Oant_1897 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: bms:BR1288 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (244 aa) |
| | Oant_1898 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: bms:BR1287 precorrin-8X methylmutase. (208 aa) |
| | Oant_1899 | TIGRFAM: precorrin-3B synthase; PFAM: nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; KEGG: bms:BR1286 nitrite reductase family protein. (439 aa) |
| | Oant_1900 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: bmb:BruAb1_1286 CobL, precorrin-6Y C5,15-methyltransferase. (403 aa) |
| | Oant_1917 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: bme:BMEI0725 homoserine dehydrogenase. (439 aa) |
| | Oant_1919 | TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein; KEGG: bmb:BruAb1_1274 GlpX protein. (328 aa) |
| | Oant_1926 | TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat containing protein; serine acetyltransferase domain protein; KEGG: bmb:BruAb1_1265 CysE, serine acetyltransferase. (274 aa) |
| | Oant_2003 | PFAM: carboxyl transferase; KEGG: bmb:BruAb1_1193 propionlyl-CoA carboxylase. (510 aa) |
| | queF | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (155 aa) |
| | Oant_2016 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: bms:BR1175 L-serine dehydratase, iron-sulfur-dependent, single chain form. (467 aa) |
| | Oant_2033 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (255 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (157 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: bmb:BruAb1_1147 TrpC, indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (266 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa) |
| | kdsA | TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: bme:BMEI0850 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase). (277 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa) |
| | Oant_2066 | PFAM: cyclase/dehydrase; KEGG: bmb:BruAb1_1129 hypothetical protein. (151 aa) |
| | Oant_2087 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: bms:BR1004 glutamine synthetase, type I. (469 aa) |
| | gph | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (233 aa) |
| | Oant_2095 | TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase class II; KEGG: bme:BMEI0971 phospho-2-dehydro-3-deoxyheptonate aldolase. (459 aa) |
| | Oant_2115 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (282 aa) |
| | Oant_2116 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa) |
| | Oant_2117 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: bmb:BruAb1_1036 FolK, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (176 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (165 aa) |
| | Oant_2140 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: bms:BR1053 cysteine synthase. (342 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (141 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (383 aa) |
| | queA | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (363 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (321 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (176 aa) |
| | Oant_2273 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (154 aa) |
| | Oant_2274 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (459 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (442 aa) |
| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (339 aa) |
| | cobS | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (260 aa) |
| | Oant_2371 | PFAM: phosphopantetheine-binding; KEGG: bmb:BruAb1_0867 acyl carrier protein. (93 aa) |
| | Oant_2372 | PFAM: Beta-ketoacyl synthase; KEGG: bms:BR0854 3-oxoacyl-(acyl carrier protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (393 aa) |
| | Oant_2373 | PFAM: Beta-ketoacyl synthase; KEGG: bms:BR0853 beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (425 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: bms:BR0842 phosphoribosylaminoimidazole-succinocarboxamide synthase. (254 aa) |
| | argH-2 | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: atc:AGR_L_463 argininosuccinate lyase (arginosuccinase) (ASAL). (504 aa) |
| | Oant_2492 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: bme:BMEI1166 O-acetylhomoserine (thiol)-lyase / cysteine synthase. (428 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (311 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (323 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (352 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (153 aa) |
| | Oant_2527 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: bms:BR0768 riboflavin synthase, alpha subunit. (202 aa) |
| | Oant_2528 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (373 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (439 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (347 aa) |
| | Oant_2609 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: bmb:BruAb1_0698 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (537 aa) |
| | acpS | Holo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (158 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | ectC | Ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (128 aa) |
| | Oant_2819 | PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: bmb:BruAb2_0734 hypothetical 3-oxoacyl-(acyl-carrier-protein) synthase III. (317 aa) |
| | Oant_2820 | TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: bms:BRA0489 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (424 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (212 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (336 aa) |
| | Oant_2853 | PFAM: aminotransferase class-III; KEGG: mlo:mll0107 aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (455 aa) |
| | Oant_2857 | KEGG: pde:Pden_0476 thioesterase superfamily protein. (139 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (350 aa) |
| | fbp | PFAM: Inositol phosphatase/fructose-16-bisphosphatase; KEGG: bmb:BruAb2_0360 Fbp, fructose-1-6-bisphosphatase. (340 aa) |
| | Oant_2929 | PFAM: aldo/keto reductase; KEGG: mes:Meso_3052 aldo/keto reductase. (274 aa) |
| | Oant_2934 | KEGG: pol:Bpro_1029 putative methylisocitrate lyase. (288 aa) |
| | Oant_2962 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase; KEGG: sme:SMb20481 putative asparagine synthetase (glutamine amidotransferase) protein. (600 aa) |
| | Oant_2964 | PFAM: UbiA prenyltransferase; KEGG: bms:BRA0855 hypothetical protein. (479 aa) |
| | Oant_2968 | PFAM: aminotransferase class-III; KEGG: bms:BRA0851 aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (471 aa) |
| | Oant_2982 | PFAM: monooxygenase FAD-binding; KEGG: nwi:Nwi_2327 hypothetical protein. (419 aa) |
| | Oant_3013 | PFAM: aldo/keto reductase; KEGG: bmb:BruAb2_0178 oxidoreductase, aldo/keto reductase family. (276 aa) |
| | hisZ | tRNA synthetase class II (G H P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (376 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (231 aa) |
| | Oant_3030 | TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain; PFAM: Riboflavin kinase / FAD synthetase; KEGG: bme:BMEII1044 hypothetical protein; Belongs to the ribF family. (329 aa) |
| | Oant_3070 | PFAM: protein of unknown function DUF336; KEGG: pfl:PFL_3600 GlcG protein. (164 aa) |
| | Oant_3097 | 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; KEGG: sme:SMb20772 putative pyridoxal phosphate biosynthetic protein; Belongs to the PdxA family. (343 aa) |
| | Oant_3104 | PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: bmb:BruAb2_0769 SerA-2, D-3-phosphoglycerate dehydrogenase. (412 aa) |
| | Oant_3115 | PFAM: peptidase U32; KEGG: bmb:BruAb2_0892 hypothetical protease. (306 aa) |
| | Oant_3116 | PFAM: peptidase U32; KEGG: bmb:BruAb2_0891 peptidase, U32 family. (325 aa) |
| | Oant_3117 | KEGG: bms:BRA0291 hypothetical protein. (169 aa) |
| | Oant_3118 | TIGRFAM: UbiD family decarboxylase; PFAM: Carboxylyase-related protein; KEGG: bms:BRA0292 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Belongs to the UbiD family. (504 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (371 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | Oant_3342 | PFAM: SMP-30/Gluconolaconase/LRE domain protein; KEGG: sme:SMc04142 hypothetical protein. (294 aa) |
| | Oant_3343 | PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: rle:pRL120238 putative dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (577 aa) |
| | Oant_3390 | C-methyltransferase; PFAM: Methyltransferase type 12; Methyltransferase domain protein; C-methyltransferase; KEGG: bms:BRA0438 methyltransferase, putative. (420 aa) |
| | Oant_3433 | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: sme:SMb21312 putative methyltransferase protein. (279 aa) |
| | Oant_3450 | PFAM: GCN5-related N-acetyltransferase; KEGG: ret:RHE_CH00949 probable acetyltransferase protein. (172 aa) |
| | Oant_3472 | PFAM: aminotransferase class-III; KEGG: ret:RHE_PF00202 probable adenosylmethionine--8-amino-7-oxononanoate aminotransferaseprotein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (306 aa) |
| | Oant_3500 | PFAM: peptidase M20; KEGG: sme:SMb20697 putative peptidase, similar to arginine utilization protein RocB. (551 aa) |
| | hisC-2 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: sme:SMa0387 putative HisC3 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (374 aa) |
| | hisD-2 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (438 aa) |
| | Oant_3605 | PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: atu:Atu2022 NADP-dependent alcohol dehydrogenase. (348 aa) |
| | Oant_3635 | TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase FAD-binding; KEGG: bmb:BruAb2_0651 UbiH, 2-octaprenyl-6-methoxyphenol hydroxylase. (414 aa) |
| | Oant_3661 | PFAM: GCN5-related N-acetyltransferase; KEGG: mlo:mll0676 acetyl transferase. (158 aa) |
| | Oant_3723 | TIGRFAM: 4-hydroxybenzoate 3-monooxygenase; PFAM: monooxygenase FAD-binding; KEGG: bms:BRA0641 p-hydroxybenzoate hydroxylase. (389 aa) |
| | Oant_3773 | PFAM: aminotransferase class IV; KEGG: bmf:BAB2_0572 aminotransferase, class IV. (284 aa) |
| | Oant_3794 | Regulatory protein LysR; PFAM: glycosyl transferase family 3; regulatory protein LysR; KEGG: atc:AGR_L_1856 hypothetical protein. (491 aa) |
| | ribH-2 | 67-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (158 aa) |
| | Oant_3846 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1227 aa) |
| | Oant_3869 | PFAM: Creatininase; KEGG: vei:Veis_3147 creatininase. (266 aa) |
| | Oant_3881 | Glutamate--ammonia ligase; PFAM: glutamine synthetase catalytic region; KEGG: bms:BRA0732 glutamine synthetase family protein. (456 aa) |
| | Oant_3913 | Gluconolactonase; PFAM: SMP-30/Gluconolaconase/LRE domain protein; KEGG: atc:AGR_L_1647 possible gluconolactonase precursor. (306 aa) |
| | Oant_3936 | Glutamate--putrescine ligase; PFAM: glutamine synthetase catalytic region; KEGG: bms:BRA0768 glutamine synthetase family protein. (476 aa) |
| | Oant_3943 | PFAM: Prephenate dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: jan:Jann_3543 prephenate dehydrogenase. (281 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (299 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (280 aa) |
| | Oant_4073 | KEGG: bja:blr6818 hypothetical protein. (241 aa) |
| | Oant_4077 | KEGG: vei:Veis_0794 hypothetical protein. (237 aa) |
| | Oant_4125 | PFAM: protein of unknown function DUF336; KEGG: pde:Pden_1122 protein of unknown function DUF336. (160 aa) |
| | Oant_4141 | TIGRFAM: pyridoxal kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: rpd:RPD_2302 pyridoxal kinase; Belongs to the pyridoxine kinase family. (287 aa) |
| | Oant_4157 | Glutamate--ammonia ligase; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: atc:AGR_C_4385 glutamine synthetase II (glutamate--ammonia ligase II) (GSII). (352 aa) |
| | Oant_4174 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: bms:BRA1120 cobalamin synthesis protein/P47K family protein. (401 aa) |
| | Oant_4276 | TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: bmb:BruAb2_0055 GltD, glutamate synthase, small subunit. (484 aa) |
| | Oant_4277 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: bms:BRA0054 glutamate synthase, large subunit. (1583 aa) |
| | Oant_4345 | PFAM: periplasmic copper-binding; SMART: Parallel beta-helix repeat; Carbohydrate-binding and sugar hydrolysis; KEGG: bmb:BruAb2_0904 NosD, copper ABC transporter, periplasmic copper-binding protein. (462 aa) |
| | Oant_4352 | PFAM: GCN5-related N-acetyltransferase; KEGG: rle:pRL100226 putative acetyltransferase. (183 aa) |
| | Oant_4359 | PFAM: GCN5-related N-acetyltransferase; KEGG: rle:pRL100226 putative acetyltransferase. (208 aa) |
| | nbaC | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (182 aa) |
| | Oant_4403 | PFAM: dihydrodipicolinate synthetase; KEGG: sit:TM1040_1594 dihydrodipicolinate synthetase; Belongs to the DapA family. (318 aa) |
| | Oant_4414 | PFAM: UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; KEGG: bmb:BruAb2_0677 Ugd, UDP-glucose 6-dehydrogenase. (478 aa) |
| | Oant_4419 | PFAM: Asp/Glu racemase; KEGG: bja:blr5577 hydantoin Racemase. (243 aa) |
| | Oant_4426 | PFAM: UBA/THIF-type NAD/FAD binding protein; Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: sme:SMb20037 shikimate 5-dehydrogenase. (289 aa) |
| | Oant_4428 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; Xylose isomerase domain protein TIM barrel; KEGG: ret:RHE_PC00215 putative 4-hydroxyphenylpyruvate dioxygenase protein. (633 aa) |
