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rplJ rplJ rplL rplL rpmE2 rpmE2 rpsN rpsN rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpmG-2 rpmG-2 rpsU rpsU rpsN-2 rpsN-2 rpmF rpmF rpsT rpsT OMO_00690 OMO_00690 rplI rplI rpsR rpsR rpsF rpsF rpmH rpmH rnpA rnpA rplM rplM rpsI rpsI OMO_01564 OMO_01564 rpsD rpsD rpmB rpmB rpsO rpsO rplU rplU rpmA rpmA rplC rplC rplS rplS rpmF-2 rpmF-2 rpsL rpsL rpsG rpsG rpsJ rpsJ rpmI rpmI rpsB rpsB rpsP rpsP rpmG-3 rpmG-3 OMO_00842 OMO_00842 rplQ rplQ rpsK rpsK rpsM rpsM rpmJ rpmJ rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplT rplT rpmG rpmG rplK rplK rplA rplA rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsZ rpsZ rpsH rpsH rplF rplF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rplJUnannotated protein; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (166 aa)
rplLUnannotated protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa)
rpmE2Unannotated protein. (82 aa)
rpsNUnannotated protein; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (89 aa)
rplDUnannotated protein; Forms part of the polypeptide exit tunnel. (207 aa)
rplWUnannotated protein; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (95 aa)
rplBUnannotated protein; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa)
rpsSUnannotated protein; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rplVUnannotated protein; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (115 aa)
rpsCUnannotated protein; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (218 aa)
rplPUnannotated protein; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (144 aa)
rpmCUnannotated protein; Belongs to the universal ribosomal protein uL29 family. (62 aa)
rpmG-2Unannotated protein; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
rpsUUnannotated protein; Belongs to the bacterial ribosomal protein bS21 family. (58 aa)
rpsN-2Unannotated protein; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (91 aa)
rpmFUnannotated protein; Belongs to the bacterial ribosomal protein bL32 family. (59 aa)
rpsTUnannotated protein; Binds directly to 16S ribosomal RNA. (84 aa)
OMO_00690Unannotated protein. (100 aa)
rplIUnannotated protein; Binds to the 23S rRNA. (150 aa)
rpsRUnannotated protein; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (78 aa)
rpsFUnannotated protein; Binds together with S18 to 16S ribosomal RNA. (99 aa)
rpmHUnannotated protein; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
rnpAUnannotated protein; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (117 aa)
rplMUnannotated protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa)
rpsIUnannotated protein; Belongs to the universal ribosomal protein uS9 family. (130 aa)
OMO_01564Unannotated protein. (284 aa)
rpsDUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (203 aa)
rpmBUnannotated protein; Belongs to the bacterial ribosomal protein bL28 family. (62 aa)
rpsOUnannotated protein; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
rplUUnannotated protein; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa)
rpmAUnannotated protein; Belongs to the bacterial ribosomal protein bL27 family. (94 aa)
rplCUnannotated protein; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (209 aa)
rplSUnannotated protein; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (115 aa)
rpmF-2Unannotated protein; Belongs to the bacterial ribosomal protein bL32 family. (57 aa)
rpsLUnannotated protein; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (137 aa)
rpsGUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsJUnannotated protein; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rpmIUnannotated protein; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
rpsBUnannotated protein; Belongs to the universal ribosomal protein uS2 family. (263 aa)
rpsPUnannotated protein; Belongs to the bacterial ribosomal protein bS16 family. (91 aa)
rpmG-3Unannotated protein; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
OMO_00842Unannotated protein. (399 aa)
rplQUnannotated protein. (126 aa)
rpsKUnannotated protein; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
rpsMUnannotated protein; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa)
rpmJUnannotated protein; Belongs to the bacterial ribosomal protein bL36 family. (38 aa)
rplOUnannotated protein; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
rpmDUnannotated protein. (59 aa)
rpsEUnannotated protein; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (166 aa)
rplRUnannotated protein; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa)
rplTUnannotated protein; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa)
rpmGUnannotated protein; Belongs to the bacterial ribosomal protein bL33 family. (53 aa)
rplKUnannotated protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (140 aa)
rplAUnannotated protein; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
rpsQUnannotated protein; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (88 aa)
rplNUnannotated protein; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplXUnannotated protein; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (103 aa)
rplEUnannotated protein; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa)
rpsZUnannotated protein; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rpsHUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rplFUnannotated protein; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa)
Your Current Organism:
Enterococcus cecorum
NCBI taxonomy Id: 44008
Other names: ATCC 43198, CCUG 27299, CIP 103676, DSM 20682, E. cecorum, JCM 8724, LMG 12902, LMG:12902, NBRC 100674, NCDO 2674, NCIMB 702674, NCTC 12421, Streptococcus cecorum, strain A60
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