(85 nodes) Mixed, incl. Protein localization to mitochondrion, and Mitochondrial calcium ion transport network (Talaromyces stipitatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	TSTA_064180	Sensitive to high expression protein 9, mitochondrial; Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. (462 aa)
	TSTA_069590	Prohibitin, putative. (629 aa)
	TSTA_070510	Mitochondrial protein sorting (Msf1), putative. (189 aa)
	TSTA_060210	Uncharacterized protein. (430 aa)
	TSTA_071660	Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. (330 aa)
	TSTA_072940	Mitochondrial distribution and morphology protein, putative. (78 aa)
	TSTA_074180	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. (507 aa)
	TSTA_073610	MICOS complex subunit MIC12; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (122 aa)
	TSTA_074040	Cytochrome c oxidase assembly protein Cox19, putative. (96 aa)
	TSTA_074070	Stomatin family protein. (440 aa)
	TSTA_077080	Intermembrane space AAA protease IAP-1. (807 aa)
	TSTA_076180	TIM complex componenet Tim54. (515 aa)
	TSTA_078340	MCU domain-containing protein. (443 aa)
	TSTA_066390	Mitochondrial chaperone bcs1, putative; Belongs to the AAA ATPase family. (495 aa)
	TSTA_062360	Uncharacterized protein. (793 aa)
	mdm10	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the recepto [...] (472 aa)
	TSTA_068600	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (247 aa)
	TSTA_093160	Mitochondrial import protein Zim17, putative. (187 aa)
	TSTA_081900	Uncharacterized protein. (702 aa)
	TSTA_090150	Uncharacterized protein. (320 aa)
	TSTA_090580	Ankyrin repeat-containing protein, putative. (425 aa)
	TSTA_085900	Zn-dependent hydrolases of the beta-lactamase fold, putative. (303 aa)
	TSTA_087430	Prohibitin. (278 aa)
	TSTA_087940	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (97 aa)
	TSTA_087960	Mitochondrial outer membrane protein (Sam35), putative. (311 aa)
	mdm12	Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pat [...] (491 aa)
	TSTA_094670	N-acylethanolamine amidohydrolase, putative. (609 aa)
	TSTA_094860	WD repeat protein. (381 aa)
	TSTA_094940	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family. (128 aa)
	TSTA_095470	Uncharacterized protein. (539 aa)
	TSTA_096160	FYVE domain protein, putative. (280 aa)
	TSTA_096640	Mitochondrial co-chaperone GrpE, putative; Belongs to the GrpE family. (239 aa)
	TSTA_030350	Mitochondrial intermembrane space translocase subunit Tim9, putative. (90 aa)
	TSTA_031500	Mitochondrial chaperone BCS1, putative; Belongs to the AAA ATPase family. (502 aa)
	TSTA_027790	Stomatin family protein. (356 aa)
	TSTA_033830	Mitochondrial DnaJ chaperone (Tim14), putative. (105 aa)
	TSTA_033850	Mitochondrial inner membrane AAA protease Yta12, putative. (902 aa)
	TSTA_034310	Mitochondrial genome maintenance protein Mgr2, putative. (105 aa)
	TSTA_034990	Rhomboid family protein, putative. (629 aa)
	TSTA_035880	Mitochondrion biogenesis protein (Mdm31), putative. (750 aa)
	TSTA_030660	Mitochondrial import inner membrane translocase subunit TIM23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (206 aa)
	TSTA_032150	Anion exchange family protein. (691 aa)
	TSTA_032400	Uncharacterized protein. (375 aa)
	TSTA_036480	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (545 aa)
	TSTA_037160	Uncharacterized protein. (286 aa)
	TSTA_121110	Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. (331 aa)
	TSTA_121140	Mitochondrial outer membrane protein (Sam50), putative. (514 aa)
	TSTA_123470	Metallo-beta-lactamase superfamily protein. (355 aa)
	TSTA_124370	Presequence translocase-associated motor subunit Pam17, putative. (568 aa)
	TSTA_126080	Sulfhydryl oxidase. (217 aa)
	TSTA_115980	Mitochondrial import inner membrane translocase subunit (TIM22), putative. (174 aa)
	TSTA_116520	DnaJ domain protein. (754 aa)
	TSTA_121760	Magnesium and cobalt transport protein and translocase of inner mitochondrial membrane, putative; Belongs to the small Tim family. (91 aa)
	TSTA_122520	Uncharacterized protein. (246 aa)
	TSTA_122750	Mitochondrial genome maintenance protein Mgm101, putative. (273 aa)
	TSTA_020000	Mitochondrial import receptor subunit (Tom20), putative. (169 aa)
	TSTA_021150	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family. (88 aa)
	TSTA_018750	Mitochondrial intermembrane space translocase subunit Tim10, putative. (95 aa)
	TSTA_014330	Uncharacterized protein. (1136 aa)
	TSTA_021310	Zinc metallopeptidase, putative. (789 aa)
	TSTA_011140	ZIP family zinc transporter, putative. (434 aa)
	TSTA_050740	Mitochondrial intermembrane space protein Mia40. (309 aa)
	TSTA_046170	Cochaperone Pam16. (139 aa)
	TSTA_046210	Mitochondrial import receptor subunit (Tom37), putative. (434 aa)
	TSTA_046220	Plasma membrane low affinity zinc ion transporter, putative. (386 aa)
	MIC60	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity). (639 aa)
	TSTA_047240	Cytochrome c oxidase-assembly factor cox23, mitochondrial, putative. (95 aa)
	TSTA_043780	Mitochondrial import receptor subunit tom22. (161 aa)
	mdm34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. (564 aa)
	TSTA_049450	Mitochondrial intermembrane space translocase subunit Tim13, putative; Belongs to the small Tim family. (112 aa)
	TSTA_101510	CHCH domain protein. (166 aa)
	TSTA_098350	Mitochondrial inner membrane translocase subunit (TIM17), putative. (154 aa)
	TSTA_099180	Zn-dependent hydrolase/oxidoreductase family protein, putative. (424 aa)
	TSTA_099190	C6 transcription factor (Leu3), putative. (657 aa)
	TSTA_105170	PHB domain-containing protein. (262 aa)
	TSTA_053430	RHOMBOID-like protein. (526 aa)
	TSTA_002760	Mitochondrial outer membrane translocase receptor (TOM70), putative. (623 aa)
	TSTA_002820	MSF1 domain protein. (297 aa)
	TSTA_005580	Mitochondrial import receptor subunit (Tom40), putative. (355 aa)
	TSTA_001750	Lactamase_B domain-containing protein. (432 aa)
	TSTA_004500	Sulfhydryl oxidase. (192 aa)
	TSTA_005660	Uncharacterized protein. (85 aa)
	mmm1	Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 su [...] (493 aa)
	TSTA_108410	Mitochondrial chaperone bcs1, putative; Belongs to the AAA ATPase family. (470 aa)
	TSTA_109010	Uncharacterized protein. (767 aa)

Your Current Organism:

Talaromyces stipitatus

NCBI taxonomy Id: 441959
Other names: T. stipitatus ATCC 10500, Talaromyces stipitatus ATCC 10500

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MIC60	TSTA_002760	B8MJK3	B8MS34	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Mitochondrial outer membrane translocase receptor (TOM70), putative.	0.684
MIC60	TSTA_005580	B8MJK3	B8MSR3	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Mitochondrial import receptor subunit (Tom40), putative.	0.734
MIC60	TSTA_020000	B8MJK3	B8MEQ8	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Mitochondrial import receptor subunit (Tom20), putative.	0.633
MIC60	TSTA_030350	B8MJK3	B8M5G2	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Mitochondrial intermembrane space translocase subunit Tim9, putative.	0.420
MIC60	TSTA_036480	B8MJK3	B8M8B0	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.571
MIC60	TSTA_043780	B8MJK3	B8MKQ9	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Mitochondrial import receptor subunit tom22.	0.795
MIC60	TSTA_046210	B8MJK3	B8MJG7	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Mitochondrial import receptor subunit (Tom37), putative.	0.723
MIC60	TSTA_050740	B8MJK3	B8MIX4	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Mitochondrial intermembrane space protein Mia40.	0.444
MIC60	TSTA_068600	B8MJK3	B8LYS9	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.950
MIC60	TSTA_069590	B8MJK3	B8LT33	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Prohibitin, putative.	0.508
MIC60	TSTA_077080	B8MJK3	B8LVX5	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Intermembrane space AAA protease IAP-1.	0.499
MIC60	TSTA_087430	B8MJK3	B8M243	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Prohibitin.	0.532
MIC60	TSTA_087940	B8MJK3	B8M294	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.981
MIC60	TSTA_087960	B8MJK3	B8M296	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Mitochondrial outer membrane protein (Sam35), putative.	0.723
MIC60	TSTA_116520	B8MJK3	B8MBJ8	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	DnaJ domain protein.	0.790
MIC60	TSTA_121140	B8MJK3	B8MA41	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Mitochondrial outer membrane protein (Sam50), putative.	0.983
MIC60	TSTA_123470	B8MJK3	B8MAB3	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	Metallo-beta-lactamase superfamily protein.	0.434
TSTA_002760	MIC60	B8MS34	B8MJK3	Mitochondrial outer membrane translocase receptor (TOM70), putative.	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).	0.684
TSTA_002760	TSTA_005580	B8MS34	B8MSR3	Mitochondrial outer membrane translocase receptor (TOM70), putative.	Mitochondrial import receptor subunit (Tom40), putative.	0.985
TSTA_002760	TSTA_005660	B8MS34	B8MTQ0	Mitochondrial outer membrane translocase receptor (TOM70), putative.	Uncharacterized protein.	0.936