(26 nodes) Protein-lysine N-methyltransferase activity network (Talaromyces stipitatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	TSTA_022680	SET domain-containing protein. (409 aa)
	TSTA_110750	SET domain containing protein. (296 aa)
	TSTA_005100	Ribosomal lysine N-methyltransferase 4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates 60S ribosomal protein L42. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (480 aa)
	TSTA_101480	SET domain-containing protein. (426 aa)
	TSTA_101310	Histone-lysine N-methyltransferase (Ash1), putative. (865 aa)
	TSTA_048830	Peptidase family M20/M25/M40 protein. (1006 aa)
	TSTA_046630	Uncharacterized protein. (359 aa)
	TSTA_011460	SET and MYND domain protein, putative. (547 aa)
	TSTA_120160	SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (891 aa)
	TSTA_113280	Uncharacterized protein. (388 aa)
	TSTA_122380	Uncharacterized protein. (323 aa)
	TSTA_032390	PHD transcription factor, putative. (945 aa)
	TSTA_035740	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. (1155 aa)
	EFM4	Protein-lysine N-methyltransferase EFM4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family. (330 aa)
	EFM7	Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono-and dimethylation of 'Lys-3'. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family. (261 aa)
	TSTA_038830	Uncharacterized protein. (1162 aa)
	TSTA_094840	WD repeat protein. (454 aa)
	TSTA_087370	SET domain protein. (491 aa)
	TSTA_091230	SET domain protein. (634 aa)
	TSTA_086530	Glucose-inducible SAM-dependent methyltransferase Rrg1, putative. (343 aa)
	TSTA_066820	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (499 aa)
	TSTA_077590	SET domain protein. (739 aa)
	TSTA_075390	Histone-lysine N-methyltransferase Clr4. (642 aa)
	TSTA_073100	Uncharacterized protein. (569 aa)
	EFM6	Protein-lysine N-methyltransferase EFM6; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily. (264 aa)
	TSTA_059740	SET domain-containing protein. (149 aa)

Your Current Organism:

Talaromyces stipitatus

NCBI taxonomy Id: 441959
Other names: T. stipitatus ATCC 10500, Talaromyces stipitatus ATCC 10500

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EFM4	EFM6	B8M6R4	B8LTP5	Protein-lysine N-methyltransferase EFM4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	Protein-lysine N-methyltransferase EFM6; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.	0.546
EFM4	EFM7	B8M6R4	B8M570	Protein-lysine N-methyltransferase EFM4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono-and dimethylation of 'Lys-3'. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.	0.621
EFM4	TSTA_046630	B8M6R4	B8MJK9	Protein-lysine N-methyltransferase EFM4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	Uncharacterized protein.	0.517
EFM4	TSTA_086530	B8M6R4	B8M0N7	Protein-lysine N-methyltransferase EFM4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	Glucose-inducible SAM-dependent methyltransferase Rrg1, putative.	0.591
EFM6	EFM4	B8LTP5	B8M6R4	Protein-lysine N-methyltransferase EFM6; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.	Protein-lysine N-methyltransferase EFM4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	0.546
EFM6	EFM7	B8LTP5	B8M570	Protein-lysine N-methyltransferase EFM6; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.	Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono-and dimethylation of 'Lys-3'. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.	0.500
EFM6	TSTA_035740	B8LTP5	B8M7C8	Protein-lysine N-methyltransferase EFM6; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.	0.448
EFM7	EFM4	B8M570	B8M6R4	Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono-and dimethylation of 'Lys-3'. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.	Protein-lysine N-methyltransferase EFM4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	0.621
EFM7	EFM6	B8M570	B8LTP5	Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono-and dimethylation of 'Lys-3'. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.	Protein-lysine N-methyltransferase EFM6; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.	0.500
EFM7	TSTA_046630	B8M570	B8MJK9	Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono-and dimethylation of 'Lys-3'. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.	Uncharacterized protein.	0.403
TSTA_005100	TSTA_077590	B8MSN5	B8LWK3	Ribosomal lysine N-methyltransferase 4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates 60S ribosomal protein L42. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.	SET domain protein.	0.425
TSTA_011460	TSTA_035740	B8MDV9	B8M7C8	SET and MYND domain protein, putative.	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.	0.949
TSTA_011460	TSTA_038830	B8MDV9	B8M3T5	SET and MYND domain protein, putative.	Uncharacterized protein.	0.500
TSTA_011460	TSTA_048830	B8MDV9	B8ML27	SET and MYND domain protein, putative.	Peptidase family M20/M25/M40 protein.	0.407
TSTA_011460	TSTA_066820	B8MDV9	B8LXF6	SET and MYND domain protein, putative.	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	0.939
TSTA_011460	TSTA_075390	B8MDV9	B8LVN7	SET and MYND domain protein, putative.	Histone-lysine N-methyltransferase Clr4.	0.728
TSTA_011460	TSTA_077590	B8MDV9	B8LWK3	SET and MYND domain protein, putative.	SET domain protein.	0.448
TSTA_011460	TSTA_091230	B8MDV9	B8M1I6	SET and MYND domain protein, putative.	SET domain protein.	0.903
TSTA_011460	TSTA_094840	B8MDV9	B8M2Y3	SET and MYND domain protein, putative.	WD repeat protein.	0.754
TSTA_011460	TSTA_101310	B8MDV9	B8MLM8	SET and MYND domain protein, putative.	Histone-lysine N-methyltransferase (Ash1), putative.	0.905