(74 nodes) Winged helix DNA-binding domain superfamily network (Talaromyces stipitatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TSTA_064130	Nuclear pore complex subunit Nup192, putative; Belongs to the cullin family. (2516 aa)
	TSTA_001530	O-methyltransferase, putative. (965 aa)
	TSTA_052940	O-methyltransferase, putative. (398 aa)
	TSTA_058770	Transcription initiation factor iif, beta subunit. (363 aa)
	TSTA_058760	COP9 signalosome subunit CsnD. (421 aa)
	TSTA_053740	Curved DNA-binding protein (42 kDa protein). (411 aa)
	TSTA_052540	O-methyltransferase, putative. (491 aa)
	TSTA_105830	Hydroxyindole O-methyltransferase, putative. (430 aa)
	TSTA_104970	DEAD/DEAH box helicase, putative. (2030 aa)
	TSTA_102700	Histone H1. (205 aa)
	TSTA_102650	Proteasome regulatory particle subunit (RpnC), putative. (643 aa)
	TSTA_102030	Hydroxyindole O-methyltransferase, putative. (478 aa)
	TSTA_101010	Proteasome regulatory particle subunit (RpnE), putative. (487 aa)
	TSTA_100920	COP9 signalosome subunit 2 (CsnB), putative. (498 aa)
	TSTA_099010	O-methyltransferase, putative. (422 aa)
	TSTA_042480	O-methyltransferase, putative. (390 aa)
	TSTA_022860	O-methyltransferase, putative. (386 aa)
	TSTA_019340	DNA-directed DNA polymerase theta, putative. (946 aa)
	TSTA_014480	O-methyltransferase, putative. (450 aa)
	TSTA_014220	O-methyltransferase, putative. (420 aa)
	TSTA_012740	Pre-mRNA splicing helicase, putative. (3146 aa)
	TSTA_009050	O-methyltransferase. (404 aa)
	TSTA_020230	Possible replication factor-a protein. (320 aa)
	TSTA_016900	40S ribosomal protein S19. (148 aa)
	TSTA_016670	Forkhead domain protein. (458 aa)
	TSTA_012170	COP9 signalosome subunit 1 (CsnA), putative. (471 aa)
	TSTA_120410	Vacuolar protein sorting protein (Vps36), putative. (607 aa)
	TSTA_114260	Rho guanyl nucleotide exchange factor (Rom2), putative. (1213 aa)
	TSTA_113620	Stress response transcription factor SrrA/Skn7, putative. (619 aa)
	TSTA_126830	Uncharacterized protein. (435 aa)
	TSTA_121740	Forkhead transcription factor (Sep1), putative. (643 aa)
	TSTA_119980	DNA damage and replication checkpoint protein Rfx1, putative. (861 aa)
	TSTA_126120	O-methyltransferase family protein. (436 aa)
	NIP1	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (867 aa)
	TSTA_124100	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (263 aa)
	TSTA_112950	Proteasome regulatory particle subunit (RpnI), putative. (381 aa)
	TSTA_112860	40S ribosomal protein S10b. (161 aa)
	TSTA_112620	DEAD/DEAH box DNA helicase (Mer3), putative. (1363 aa)
	TSTA_121070	Flocculation suppression protein. (567 aa)
	TSTA_112180	Methionine aminopeptidase 2-2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (464 aa)
	TSTA_111460	O-methyltransferase, putative. (395 aa)
	TSTA_038430	Developmental regulator FlbA. (663 aa)
	TSTA_032340	Forkhead transcription factor Fkh1/2, putative. (732 aa)
	TSTA_034490	Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (244 aa)
	TSTA_027870	Proteasome regulatory particle subunit (RpnF), putative. (423 aa)
	TSTA_026170	Hydroxyindole O-methyltransferase, putative. (400 aa)
	TSTA_029850	O-methyltransferase, putative. (415 aa)
	INT6	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (452 aa)
	TSTA_092250	Dishevelled, Egl-10, and Pleckstrin domain protein. (1880 aa)
	TSTA_088600	RNA-binding La domain protein. (396 aa)
	TSTA_088070	SCF ubiquitin ligase complex subunit CulA, putative; Belongs to the cullin family. (788 aa)
	TSTA_093420	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (2142 aa)
	TSTA_093320	O-methyltransferase. (400 aa)
	TSTA_090450	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (353 aa)
	TSTA_086780	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (96 aa)
	TSTA_081720	Hydroxyindole O-methyltransferase, putative. (431 aa)
	TSTA_093150	SCF ubiquitin ligase subunit CulC, putative; Belongs to the cullin family. (823 aa)
	TSTA_089400	Cell division control protein; Belongs to the CDC6/cdc18 family. (638 aa)
	TSTA_069740	Double-strand-break repair protein rad21. (582 aa)
	TSTA_060020	O-methyltransferase, putative. (414 aa)
	TSTA_071420	Methionine aminopeptidase 2-1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (443 aa)
	TSTA_072990	Forkhead domain protein. (1232 aa)
	TSTA_074060	La domain family. (823 aa)
	TSTA_074930	Origin recognition complex subunit Orc1, putative. (801 aa)
	TSTA_076500	ESCRT-II complex component (Vps25), putative. (243 aa)
	TSTA_079210	Heat shock transcription factor Hsf1, putative. (800 aa)
	TSTA_089330	RhoGAP and Fes/CIP4 domain protein. (889 aa)
	TSTA_083330	O-methyltransferase, putative. (433 aa)
	TSTA_082890	O-methyltransferase, putative. (464 aa)
	TSTA_068940	Anaphase-promoting complex subunit ApcB, putative; Belongs to the cullin family. (913 aa)
	TSTA_068770	RecQ family helicase MusN. (1574 aa)
	TSTA_067450	Proteasome regulatory particle subunit (RpnG), putative. (493 aa)
	TSTA_067150	RIO1 family protein kinase, putative. (427 aa)
	TSTA_079590	Developmental regulator flbA, putative. (523 aa)

Your Current Organism:

Talaromyces stipitatus

NCBI taxonomy Id: 441959
Other names: T. stipitatus ATCC 10500, Talaromyces stipitatus ATCC 10500

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
INT6	NIP1	B8M4Z2	B8MAY1	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.999
INT6	TSTA_016900	B8M4Z2	B8MEI8	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S19.	0.983
INT6	TSTA_034490	B8M4Z2	B8M6Z1	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.999
INT6	TSTA_058760	B8M4Z2	B8MQI6	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	COP9 signalosome subunit CsnD.	0.451
INT6	TSTA_067450	B8M4Z2	B8LY63	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Proteasome regulatory particle subunit (RpnG), putative.	0.455
INT6	TSTA_086780	B8M4Z2	B8M0R2	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family.	0.987
INT6	TSTA_088600	B8M4Z2	B8M2G0	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	RNA-binding La domain protein.	0.518
INT6	TSTA_101010	B8M4Z2	B8MMV8	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Proteasome regulatory particle subunit (RpnE), putative.	0.823
INT6	TSTA_112860	B8M4Z2	B8MAN1	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S10b.	0.980
NIP1	INT6	B8MAY1	B8M4Z2	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.999
NIP1	TSTA_016900	B8MAY1	B8MEI8	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S19.	0.986
NIP1	TSTA_034490	B8MAY1	B8M6Z1	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.998
NIP1	TSTA_053740	B8MAY1	B8MPX0	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Curved DNA-binding protein (42 kDa protein).	0.731
NIP1	TSTA_074060	B8MAY1	B8LVK2	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	La domain family.	0.400
NIP1	TSTA_086780	B8MAY1	B8M0R2	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family.	0.982
NIP1	TSTA_088600	B8MAY1	B8M2G0	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	RNA-binding La domain protein.	0.525
NIP1	TSTA_101010	B8MAY1	B8MMV8	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Proteasome regulatory particle subunit (RpnE), putative.	0.531
NIP1	TSTA_112860	B8MAY1	B8MAN1	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S10b.	0.986
TSTA_012170	TSTA_058760	B8ME31	B8MQI6	COP9 signalosome subunit 1 (CsnA), putative.	COP9 signalosome subunit CsnD.	0.998
TSTA_012170	TSTA_064130	B8ME31	B8LSU8	COP9 signalosome subunit 1 (CsnA), putative.	Nuclear pore complex subunit Nup192, putative; Belongs to the cullin family.	0.967