65 items (Talaromyces marneffei) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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	PMAA_011020	Malic enzyme. (577 aa)
	PMAA_016870	Zn(2)-C6 fungal-type domain-containing protein. (777 aa)
	PMAA_027690	Pentafunctional AROM polypeptide, putative. (688 aa)
	PMAA_027850	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (466 aa)
	PMAA_027940	Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family. (413 aa)
	PMAA_018340	Para-aminobenzoate synthase PabaA. (816 aa)
	PMAA_018350	Aspartate transaminase, putative. (431 aa)
	PMAA_018400	Fumarate hydratase, putative. (531 aa)
	PMAA_038650	Quinate 5-dehydrogenase QutB, putative. (346 aa)
	PMAA_028730	NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (1137 aa)
	PMAA_028760	Shikimate 5-dehydrogenase, putative. (312 aa)
	PMAA_029440	ACN9 family domain containing protein, putative. (131 aa)
	PMAA_020210	Dihydroneopterin aldolase domain protein. (313 aa)
	PMAA_036070	Chorismate mutase. (311 aa)
	PMAA_026610	Chorismate synthase. (413 aa)
	PMAA_026740	Uncharacterized protein. (124 aa)
	PMAA_070220	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (535 aa)
	PMAA_070640	Malic enzyme. (660 aa)
	PMAA_071210	Dihydrofolate reductase, putative; Belongs to the dihydrofolate reductase family. (270 aa)
	PMAA_062440	Fungal_trans domain-containing protein. (691 aa)
	PMAA_073560	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (510 aa)
	PMAA_063860	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (518 aa)
	PMAA_064540	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (340 aa)
	PMAA_064700	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (576 aa)
	aroM-2	3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. In the 3rd section; belongs to the shikimate kinase family. In the C-terminal section; belongs to the shikimate dehydrogenase family. (1571 aa)
	PMAA_087170	Folic acid synthesis protein. (469 aa)
	PMAA_077810	Nitrilase family protein (Nit3), putative. (297 aa)
	PMAA_087360	Aspartate aminotransferase. (466 aa)
	PMAA_089650	Succinate-semialdehyde dehydrogenase. (531 aa)
	PMAA_082310	GTP cyclohydrolase I, putative. (307 aa)
	PMAA_084640	4-aminobutyrate transaminase GatA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (494 aa)
	PMAA_093370	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (632 aa)
	BNA5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (481 aa)
	PMAA_097140	Glutamate synthase Glt1, putative. (2124 aa)
	PMAA_100110	Oxalate decarboxylase, putative. (450 aa)
	PMAA_100590	Aspartate aminotransferase. (391 aa)
	PMAA_091680	Malate dehydrogenase. (340 aa)
	PMAA_092050	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (482 aa)
	PMAA_054740	Adenylosuccinate lyase, putative. (503 aa)
	PMAA_055860	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (527 aa)
	PMAA_056100	Maleylacetate reductase, putative. (357 aa)
	PMAA_056310	Ornithine aminotransferase. (462 aa)
	PMAA_056760	Phospho-2-dehydro-3-deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (477 aa)
	PMAA_056840	Uncharacterized protein. (213 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (510 aa)
	PMAA_058830	Uncharacterized protein. (1027 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (195 aa)
	PMAA_060810	Repressor protein. (821 aa)
	PMAA_051530	Ornithine aminotransferase. (455 aa)
	PMAA_052470	Succinate-semialdehyde dehydrogenase. (486 aa)
	PMAA_047390	Amidohydrolase, putative. (422 aa)
	BNA5-2	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (351 aa)
	PMAA_040380	Aspartate aminotransferase. (429 aa)
	PMAA_041660	Alpha-ketoglutarate dehydrogenase complex subunit Kgd1, putative. (1063 aa)
	PMAA_045410	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (471 aa)
	PMAA_048990	Succinate semialdehyde dehydrogenase, putative. (516 aa)
	PMAA_002480	Succinate-semialdehyde dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family. (1013 aa)
	PMAA_003050	Aspartate-semialdehyde dehydrogenase. (365 aa)
	PMAA_005020	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (316 aa)
	PMAA_006910	DUF1445 domain protein. (269 aa)
	PMAA_011500	Malate dehydrogenase. (331 aa)
	PMAA_014300	Uncharacterized protein. (293 aa)
	PMAA_008020	Uncharacterized protein. (187 aa)
	PMAA_008370	Chorismate synthase. (405 aa)
	aroM-1	3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. In the 3rd section; belongs to the shikimate kinase family. In the C-terminal section; belongs to the shikimate dehydrogenase family. (1573 aa)

Your Current Organism:

Talaromyces marneffei

NCBI taxonomy Id: 441960
Other names: Penicillium marneffei ATCC 18224, T. marneffei ATCC 18224, Talaromyces marneffei ATCC 18224

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA1	BNA4	B6QM36	B6QLM7	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.853
BNA1	BNA5	B6QM36	B6QIB8	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.986
BNA1	BNA5-2	B6QM36	B6QP86	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.986
BNA1	PMAA_005020	B6QM36	B6QTG0	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.659
BNA4	BNA1	B6QLM7	B6QM36	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.853
BNA4	BNA5	B6QLM7	B6QIB8	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.990
BNA4	BNA5-2	B6QLM7	B6QP86	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.986
BNA4	PMAA_005020	B6QLM7	B6QTG0	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.589
BNA5	BNA1	B6QIB8	B6QM36	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.986
BNA5	BNA4	B6QIB8	B6QLM7	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.990
BNA5	BNA5-2	B6QIB8	B6QP86	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.902
BNA5	PMAA_005020	B6QIB8	B6QTG0	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.444
BNA5-2	BNA1	B6QP86	B6QM36	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.986
BNA5-2	BNA4	B6QP86	B6QLM7	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.986
BNA5-2	BNA5	B6QP86	B6QIB8	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.902
BNA5-2	PMAA_005020	B6QP86	B6QTG0	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.444
PMAA_002480	PMAA_084640	B6QSI9	B6QG76	Succinate-semialdehyde dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family.	4-aminobutyrate transaminase GatA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.519
PMAA_003050	PMAA_008370	B6QSX9	B6QWH7	Aspartate-semialdehyde dehydrogenase.	Chorismate synthase.	0.537
PMAA_003050	PMAA_011500	B6QSX9	B6QV95	Aspartate-semialdehyde dehydrogenase.	Malate dehydrogenase.	0.451
PMAA_003050	PMAA_026610	B6QSX9	B6Q851	Aspartate-semialdehyde dehydrogenase.	Chorismate synthase.	0.537