89 items (Talaromyces marneffei) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	PMAA_042470	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (485 aa)
	PMAA_040900	Uncharacterized protein. (84 aa)
	PMAA_053180	Aldehyde dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family. (497 aa)
	PMAA_052560	3-hydroxyisobutyrate dehydrogenase. (342 aa)
	PMAA_052470	Succinate-semialdehyde dehydrogenase. (486 aa)
	PMAA_051530	Ornithine aminotransferase. (455 aa)
	PMAA_060880	Fructosyl amino acid oxidase, putative. (433 aa)
	PMAA_050650	Diaminopropionate ammonia-lyase, putative. (585 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (195 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (510 aa)
	PMAA_057560	Isochorismatase domain-containing protein. (190 aa)
	PMAA_056920	Beta-lactamase family protein. (433 aa)
	PMAA_056310	Ornithine aminotransferase. (462 aa)
	PMAA_056100	Maleylacetate reductase, putative. (357 aa)
	PMAA_055860	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (527 aa)
	PMAA_054880	Aldehyde dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family. (476 aa)
	PMAA_054730	Homogentisate 1,2-dioxygenase, putative. (621 aa)
	PMAA_102000	Homogentisate 1,2-dioxygenase, putative. (482 aa)
	PMAA_101510	Alanine racemase. (412 aa)
	PMAA_100150	Aldehyde dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family. (484 aa)
	PMAA_099050	Fumarylacetoacetase. (431 aa)
	PMAA_097800	3-hydroxyisobutyrate dehydrogenase, putative. (334 aa)
	PMAA_097760	3-hydroxyisobutyrate dehydrogenase, putative. (333 aa)
	PMAA_097710	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (170 aa)
	PMAA_097070	Indoleamine 2,3-dioxygenase pyrrole 2,3-dioxygenase. (468 aa)
	BNA5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (481 aa)
	PMAA_097050	C6 transcription factor, putative. (672 aa)
	PMAA_094670	Threonine dehydratase. (562 aa)
	PMAA_094390	L-serine dehydratase, putative. (452 aa)
	PMAA_093370	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (632 aa)
	PMAA_092540	Hydroxymethylglutaryl-CoA lyase. (362 aa)
	PMAA_081510	Catechol dioxygenase, putative. (312 aa)
	PMAA_080510	Homogentisate 1,2-dioxygenase, putative. (344 aa)
	PMAA_080500	Fumarylacetoacetase. (372 aa)
	PMAA_089650	Succinate-semialdehyde dehydrogenase. (531 aa)
	PMAA_089170	4-hydroxyphenylpyruvate dioxygenase. (407 aa)
	PMAA_088400	Phosphoglycerate mutase family protein, putative. (174 aa)
	PMAA_078550	Isovaleryl-CoA dehydrogenase IvdA, putative. (431 aa)
	PMAA_078540	3-methylcrotonyl-CoA carboxylase, beta subunit (MccB), putative. (597 aa)
	PMAA_046930	L-allo-threonine aldolase, putative. (446 aa)
	BNA5-2	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (351 aa)
	PMAA_040380	Aspartate aminotransferase. (429 aa)
	PMAA_039940	Methylmalonate-semialdehyde dehydrogenase, putative. (591 aa)
	PMAA_013570	Aldehyde dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family. (500 aa)
	PMAA_012880	Aldehyde dehydrogenase, putative. (514 aa)
	PMAA_012790	Sarcosine oxidase, putative. (481 aa)
	PMAA_009050	Alcohol dehydrogenase, putative. (350 aa)
	PMAA_005900	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1073 aa)
	PMAA_005300	Dihydrolipoamide succinyltransferase, putative. (476 aa)
	PMAA_004600	3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase. (564 aa)
	PMAA_003960	Uncharacterized protein. (74 aa)
	PMAA_002090	C6 transcription factor AlcR. (858 aa)
	PMAA_002040	Alcohol dehydrogenase, putative. (350 aa)
	PMAA_002030	Aldehyde dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family. (493 aa)
	PMAA_044350	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (293 aa)
	PMAA_018370	Uncharacterized protein. (583 aa)
	PMAA_019320	Arginase; Belongs to the arginase family. (324 aa)
	PMAA_028730	NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (1137 aa)
	PMAA_020140	Fructosyl amino acid oxidasesarcosine oxidase, putative. (459 aa)
	PMAA_030730	Alanine aminotransferase, putative. (534 aa)
	PMAA_021280	Indoleamine 2,3-dioxygenase subfamily. (485 aa)
	PMAA_031950	4-hydroxyphenylpyruvate dioxygenase. (415 aa)
	PMAA_031960	Homogentisate 1,2-dioxygenase (HmgA), putative. (454 aa)
	PMAA_031990	Fumarylacetoacetase. (436 aa)
	PMAA_032000	Maleylacetoacetate isomerase MaiA; Belongs to the GST superfamily. (229 aa)
	PMAA_032930	COPI-coated vesicle protein, putative. (132 aa)
	PMAA_033480	Phenylalanine ammonia-lyase. (705 aa)
	PMAA_024040	L-serine dehydratase, putative. (349 aa)
	PMAA_033670	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (489 aa)
	PMAA_024760	Cysteine dioxygenase. (212 aa)
	PMAA_035450	Homogentisate 1,2-dioxygenase, putative. (491 aa)
	PMAA_016000	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. (496 aa)
	PMAA_026490	3-hydroxyisobutyrate dehydrogenase, putative. (318 aa)
	PMAA_070220	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (535 aa)
	PMAA_072410	Acyl-CoA dehydrogenase, putative. (454 aa)
	PMAA_063200	Aldehyde dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family. (476 aa)
	PMAA_063340	C6 transcription factor, putative. (1553 aa)
	PMAA_063810	L-asparaginase, putative. (969 aa)
	PMAA_073560	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (510 aa)
	PMAA_063860	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (518 aa)
	PMAA_064020	APSES transcription factor Xbp1, putative. (604 aa)
	PMAA_064700	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (576 aa)
	PMAA_074550	Aldehyde dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family. (505 aa)
	PMAA_065490	Sarcosine oxidase, putative. (395 aa)
	PMAA_065680	Nucleoside-diphosphate-sugar epimerase, putative. (324 aa)
	PMAA_075540	Phenylalanine ammonia-lyase. (685 aa)
	PMAA_075700	Uncharacterized protein. (340 aa)
	PMAA_077640	Aldehyde dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family. (476 aa)
	PMAA_045410	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (471 aa)

Your Current Organism:

Talaromyces marneffei

NCBI taxonomy Id: 441960
Other names: Penicillium marneffei ATCC 18224, T. marneffei ATCC 18224, Talaromyces marneffei ATCC 18224

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA1	BNA4	B6QM36	B6QLM7	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.853
BNA1	BNA5	B6QM36	B6QIB8	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.986
BNA1	BNA5-2	B6QM36	B6QP86	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.986
BNA1	PMAA_021280	B6QM36	B6Q4I1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Indoleamine 2,3-dioxygenase subfamily.	0.465
BNA1	PMAA_097070	B6QM36	B6QIB9	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Indoleamine 2,3-dioxygenase pyrrole 2,3-dioxygenase.	0.465
BNA4	BNA1	B6QLM7	B6QM36	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.853
BNA4	BNA5	B6QLM7	B6QIB8	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.990
BNA4	BNA5-2	B6QLM7	B6QP86	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.986
BNA4	PMAA_021280	B6QLM7	B6Q4I1	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Indoleamine 2,3-dioxygenase subfamily.	0.442
BNA4	PMAA_097070	B6QLM7	B6QIB9	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Indoleamine 2,3-dioxygenase pyrrole 2,3-dioxygenase.	0.442
BNA5	BNA1	B6QIB8	B6QM36	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.986
BNA5	BNA4	B6QIB8	B6QLM7	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.990
BNA5	BNA5-2	B6QIB8	B6QP86	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.902
BNA5	PMAA_021280	B6QIB8	B6Q4I1	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Indoleamine 2,3-dioxygenase subfamily.	0.930
BNA5	PMAA_030730	B6QIB8	B6Q4F1	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Alanine aminotransferase, putative.	0.424
BNA5	PMAA_044350	B6QIB8	B6QRX8	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.439
BNA5	PMAA_097070	B6QIB8	B6QIB9	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Indoleamine 2,3-dioxygenase pyrrole 2,3-dioxygenase.	0.930
BNA5-2	BNA1	B6QP86	B6QM36	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.986
BNA5-2	BNA4	B6QP86	B6QLM7	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.986
BNA5-2	BNA5	B6QP86	B6QIB8	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.902