STRINGSTRING
purA purA fhs fhs BLA_0275 BLA_0275 guaB guaB purE purE purK purK purD purD purM purM purF purF BLA_1140 BLA_1140 purC purC purT purT purB purB BLA_1291 BLA_1291 purH purH xpt xpt pbuX pbuX guaA guaA folD folD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
fhsFormate-tetrahydrofolate ligase; COG2759: Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. (505 aa)
BLA_0275HAM1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (239 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (511 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (383 aa)
purDCOG0151: Phosphoribosylamine-glycine ligase; Belongs to the GARS family. (420 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; COG0150: Phosphoribosylaminoimidazole (AIR) synthetase. (344 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (518 aa)
BLA_1140COG0046: Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain. (1244 aa)
purCCOG0152: Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. (250 aa)
purTProbable phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (418 aa)
purBCOG0015: Adenylosuccinate lyase. (481 aa)
BLA_1291GMP reductase; COG0516: IMP dehydrogenase/GMP reductase. (373 aa)
purHBifunctional purine biosynthesis protein PurH; COG0138: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). (549 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (193 aa)
pbuXCOG2233: Xanthine/uracil permeases. (476 aa)
guaAGMP synthase glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. (520 aa)
folDBifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa)
Your Current Organism:
Bifidobacterium animalis
NCBI taxonomy Id: 442563
Other names: B. animalis subsp. lactis AD011, Bifidobacterium animalis subsp. lactis AD011, Bifidobacterium animalis subsp. lactis str. AD011, Bifidobacterium animalis subsp. lactis strain AD011, Bifidobacterium lactis AD011
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.