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| | gidB | Methyltransferase GidB; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (243 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (600 aa) |
| | tenA | Probable transcriptional activator; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (246 aa) |
| | BLA_1214 | Conserved hypothetical protein; COG1534: Predicted RNA-binding protein containing KH domain, possibly ribosomal protein. (101 aa) |
| | ligA | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (863 aa) |
| | BLA_1224 | Putative ATP-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (370 aa) |
| | BLA_1230 | COG0624: Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (455 aa) |
| | BLA_1241 | COG0566: rRNA methylases. (292 aa) |
| | argD | COG4992: Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (417 aa) |
| | BLA_1257 | HAD-superfamily hydrolase, subfamily IIA; COG0647: Predicted sugar phosphatases of the HAD superfamily. (346 aa) |
| | ppnK | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (322 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (437 aa) |
| | glmU | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the trans [...] (460 aa) |
| | BLA_1282 | Peptidase M22, glycoprotease; COG1214: Inactive homolog of metal-dependent proteases, putative molecular chaperone. (280 aa) |
| | def-2 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (160 aa) |
| | rlmN | Radical SAM enzyme, Cfr family protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (393 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine; Belongs to the TrpC family. (694 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (289 aa) |
| | rluB | Pseudouridine synthase; COG1187: 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. (257 aa) |
| | purH | Bifunctional purine biosynthesis protein PurH; COG0138: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). (549 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (355 aa) |
| | BLA_1344 | COG0217: Uncharacterized conserved protein. (251 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (692 aa) |
| | BLA_1354 | Putative phosphotransferase enzyme family protein; COG3001: Fructosamine-3-kinase. (264 aa) |
| | tkt | COG0021: Transketolase; Belongs to the transketolase family. (698 aa) |
| | BLA_1363 | Haloacid dehalogenase-like hydrolase family protein; COG0561: Predicted hydrolases of the HAD superfamily. (276 aa) |
| | aroE | COG0169: Shikimate 5-dehydrogenase. (308 aa) |
| | BLA_1382 | Thioredoxin reductase-like protein; COG0492: Thioredoxin reductase. (590 aa) |
| | BLA_1388 | MutT/nudix family protein; COG0494: NTP pyrophosphohydrolases including oxidative damage repair enzymes. (177 aa) |
| | pyrF-2 | COG0284: Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (316 aa) |
| | glnE | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (1044 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (767 aa) |
| | pntA | COG3288: NAD/NADP transhydrogenase alpha subunit. (384 aa) |
| | tnsR | Possible tRNA/rRNA methyltransferase; COG0566: rRNA methylases. (290 aa) |
| | BLA_1429 | COG2151: Predicted metal-sulfur cluster biosynthetic enzyme. (190 aa) |
| | BLA_1430 | SUF system FeS assembly protein, NifU family; COG0822: NifU homolog involved in Fe-S cluster formation. (191 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (561 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (154 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (396 aa) |
| | guaA | GMP synthase glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. (520 aa) |
| | pta | Phosphate acetyltransferase; COG0280: Phosphotransacetylase. (560 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (462 aa) |
| | BLA_1490 | Putative NGG1-interacting factor 3; COG0327: Uncharacterized conserved protein. (311 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (960 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (213 aa) |
| | rpsA | COG0539: Ribosomal protein S1. (493 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa) |
| | BLA_1509 | HAD-superfamily hydrolase subfamily IIB; COG0561: Predicted hydrolases of the HAD superfamily. (253 aa) |
| | ilvA | COG1171: Threonine dehydratase. (415 aa) |
| | mesJ | Possible cytidine and deoxycytidylate deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (152 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (193 aa) |
| | BLA_1531 | tRNA/rRNA methyltransferase; COG0566: rRNA methylases; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (331 aa) |
| | ksgA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (297 aa) |
| | BLA_1542 | NUDIX hydrolase; COG0494: NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family. (254 aa) |
| | trxB | COG0492: Thioredoxin reductase. (320 aa) |
| | BLA_0022 | COG0431: Predicted flavoprotein. (182 aa) |
| | araA | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (505 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (918 aa) |
| | trpS | COG0180: Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (367 aa) |
| | glgP | Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (818 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (445 aa) |
| | BLA_0099 | Hypothetical protein. (87 aa) |
| | BLA_0109 | Oxidoreductase; COG0667: Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (341 aa) |
| | BLA_0171 | Periplasmic solute binding protein precursor; COG3443: Predicted periplasmic or secreted protein. (527 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (213 aa) |
| | mutT | Probable MutT protein; COG0494: NTP pyrophosphohydrolases including oxidative damage repair enzymes. (353 aa) |
| | askA | COG0527: Aspartokinases; Belongs to the aspartokinase family. (254 aa) |
| | askB | COG0527: Aspartokinases. (180 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (356 aa) |
| | BLA_0209 | COG1260: Myo-inositol-1-phosphate synthase. (380 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (206 aa) |
| | BLA_0228 | COG1414: Transcriptional regulator. (272 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (226 aa) |
| | BLA_0246 | Probable PfkB family carbohydrate (Sugar) kinase; COG0524: Sugar kinases, ribokinase family. (351 aa) |
| | recG | ATP-dependent DNA helicase; COG1200: RecG-like helicase. (790 aa) |
| | rimM | 16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (217 aa) |
| | BLA_0262 | COG0518: GMP synthase - Glutamine amidotransferase domain. (245 aa) |
| | BLA_0267 | COG1399: Predicted metal-binding, possibly nucleic acid-binding protein. (198 aa) |
| | BLA_0271 | COG0667: Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (335 aa) |
| | BLA_0272 | Putative nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (486 aa) |
| | BLA_0273 | Permeases of the major facilitator superfamily. (206 aa) |
| | BLA_0275 | HAM1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (239 aa) |
| | pgi | COG0166: Glucose-6-phosphate isomerase; Belongs to the GPI family. (565 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (377 aa) |
| | nusG | Transcription termination/antitermination factor NusG; Participates in transcription elongation, termination and antitermination. (330 aa) |
| | fas | Probable fatty acid synthase Fas; COG4982: 3-oxoacyl-acyl-carrier protein reductase. (3105 aa) |
| | nrdF | Ribonucleoside-diphosphate reductase 2 beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (321 aa) |
| | BLA_0311 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (708 aa) |
| | nrdH | Glutaredoxin-like protein NrdH; COG0695: Glutaredoxin and related proteins. (87 aa) |
| | BLA_0314 | Possible oxidoreductase of the aldo/keto reductase family; COG0667: Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (287 aa) |
| | BLA_0316 | COG1496: Uncharacterized conserved protein. (363 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (275 aa) |
| | pcp | Pyrrolidone-carboxylate peptidase; Removes 5-oxoproline from various penultimate amino acid residues except L-proline. (225 aa) |
| | BLA_0321 | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (376 aa) |
| | BLA_0323 | COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase. (415 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (372 aa) |
| | BLA_0350 | Possible 2-hydroxyacid dehydrogenase; COG0111: Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (335 aa) |
| | malQ | COG1640: 4-alpha-glucanotransferase. (722 aa) |
| | rpsI | COG0103: Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (163 aa) |
| | rplC | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (216 aa) |
| | rpsC | Ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (277 aa) |
| | rpsQ | 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (86 aa) |
| | rplE | 50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (194 aa) |
| | rpsE | Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (243 aa) |
| | rpmD | COG1841: Ribosomal protein L30/L7E. (60 aa) |
| | rplO | Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (152 aa) |
| | nusA | N utilization substance-like protein; Participates in both transcription termination and antitermination. (358 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (350 aa) |
| | rpiA | Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (233 aa) |
| | pgm | Phosphoglucomutase, alpha-D-glucose phosphate-specific; COG0033: Phosphoglucomutase. (558 aa) |
| | metC | COG0626: Cystathionine beta-lyases/cystathionine gamma-synthases. (399 aa) |
| | BLA_0412 | COG2873: O-acetylhomoserine sulfhydrylase. (243 aa) |
| | BLA_0413 | COG2873: O-acetylhomoserine sulfhydrylase. (81 aa) |
| | manA | COG1482: Phosphomannose isomerase. (456 aa) |
| | BLA_0433 | COG1765: Predicted redox protein, regulator of disulfide bond formation. (137 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (266 aa) |
| | dfrA | COG0262: Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. (227 aa) |
| | ptpA | Low molecular weight protein-tyrosine-phosphatase; COG0394: Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (178 aa) |
| | galE | COG1087: UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (336 aa) |
| | tilS | tRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (382 aa) |
| | sulD | SulD. (289 aa) |
| | tesB | COG1946: Acyl-CoA thioesterase. (301 aa) |
| | fms | Polypeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins; Belongs to the polypeptide deformylase family. (142 aa) |
| | BLA_0480 | COG2873: O-acetylhomoserine sulfhydrylase. (428 aa) |
| | BLA_0506 | Predicted NADPH-dependent reductase; COG0431: Predicted flavoprotein. (188 aa) |
| | BLA_0515 | Possible glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (423 aa) |
| | def | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (217 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (253 aa) |
| | galK | COG0153: Galactokinase; Belongs to the GHMP kinase family. GalK subfamily. (416 aa) |
| | galT | COG1085: Galactose-1-phosphate uridylyltransferase. (423 aa) |
| | BLA_0557 | COG1349: Transcriptional regulators of sugar metabolism. (273 aa) |
| | baiC | Probable NADH-dependent flavin oxidoreductase YqjM; COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family. (376 aa) |
| | snoP | COG0095: Lipoate-protein ligase A. (387 aa) |
| | BLA_0573 | ADP-ribose pyrophosphatase. (200 aa) |
| | rfbA | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (296 aa) |
| | BLA_0582 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (483 aa) |
| | rfbB | COG1088: dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (347 aa) |
| | BLA_0610 | COG0394: Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (188 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (327 aa) |
| | argS | COG0018: Arginyl-tRNA synthetase. (598 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (676 aa) |
| | BLA_0673 | tRNA/rRNA methyltransferase; COG0566: rRNA methylases. (269 aa) |
| | BLA_0678 | Transposase. (132 aa) |
| | BLA_0682 | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. (285 aa) |
| | rbsK | Sugar kinase, PfkB family protein; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (322 aa) |
| | BLA_0715 | Deoxyribonuclease/rho motif-related TRAM; COG2265: SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (436 aa) |
| | BLA_0730 | Alcohol dehydrogenase, class IV. (186 aa) |
| | BLA_0741 | YbaK/prolyl-tRNA synthetase associated region; COG2606: Uncharacterized conserved protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (169 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (331 aa) |
| | folC | COG0285: Folylpolyglutamate synthase. (514 aa) |
| | BLA_0753 | Putative Nudix hydrolase family protein; COG0494: NTP pyrophosphohydrolases including oxidative damage repair enzymes. (175 aa) |
| | BLA_0756 | COG0524: Sugar kinases, ribokinase family. (298 aa) |
| | murF | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (496 aa) |
| | mraW | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (353 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (403 aa) |
| | hflX | GTP-binding proten HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (506 aa) |
| | BLA_0794 | COG2813: 16S RNA G1207 methylase RsmC. (231 aa) |
| | hisC | COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (388 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (466 aa) |
| | BLA_0806 | Pseudouridine synthase RluD; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (317 aa) |
| | glyS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (491 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (303 aa) |
| | BLA_0816 | COG0011: Uncharacterized conserved protein. (122 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (400 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (300 aa) |
| | glf | COG0562: UDP-galactopyranose mutase. (394 aa) |
| | BLA_0880 | Sec-independent protein TadD; COG0084: Mg-dependent DNase. (318 aa) |
| | BLA_0907 | Putative glycosilase; COG0366: Glycosidases. (534 aa) |
| | malQ-2 | COG1640: 4-alpha-glucanotransferase. (732 aa) |
| | trpS-2 | COG0180: Tryptophanyl-tRNA synthetase. (367 aa) |
| | miaB | RNA modification enzyme, MiaB family protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (491 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (344 aa) |
| | hpf | Sigma 54 modulation protein/ribosomal protein S30EA; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (228 aa) |
| | pflB | COG1882: Pyruvate-formate lyase. (792 aa) |
| | clpX | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (442 aa) |
| | BLA_0977 | COG1611: Predicted Rossmann fold nucleotide-binding protein; Belongs to the LOG family. (267 aa) |
| | safC | COG4122: Predicted O-methyltransferase. (223 aa) |
| | BLA_0984 | COG2240: Pyridoxal/pyridoxine/pyridoxamine kinase; Belongs to the pyridoxine kinase family. (289 aa) |
| | cysD | COG2873: O-acetylhomoserine sulfhydrylase. (440 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (264 aa) |
| | ychF | Putative GTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (364 aa) |
| | gnd | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (485 aa) |
| | pgl | Probable 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (263 aa) |
| | zwf | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (519 aa) |
| | BLA_1014 | COG3613: Nucleoside 2-deoxyribosyltransferase. (154 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | sdaA | COG1760: L-serine deaminase. (493 aa) |
| | greA | Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (160 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (365 aa) |
| | BLA_1057 | Sua5/YciO/YrdC family protein; COG0009: Putative translation factor (SUA5); Belongs to the SUA5 family. (222 aa) |
| | orn | Oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides. (217 aa) |
| | BLA_1061 | COG0561: Predicted hydrolases of the HAD superfamily. (282 aa) |
| | dapD | Transferase hexapeptide repeat protein; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (327 aa) |
| | glmS | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (630 aa) |
| | BLA_1087 | COG0564: Pseudouridylate synthases, 23S RNA-specific. (230 aa) |
| | metB | COG0626: Cystathionine beta-lyases/cystathionine gamma-synthases. (391 aa) |
| | cbsSV | Cystathionine beta-synthase; COG0031: Cysteine synthase. (339 aa) |
| | luxS | Autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (166 aa) |
| | dxs | Probable 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (615 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (383 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; COG0150: Phosphoribosylaminoimidazole (AIR) synthetase. (344 aa) |
| | BLA_1140 | COG0046: Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain. (1244 aa) |
| | purC | COG0152: Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. (250 aa) |
| | tal | Possible low specificity-threonine aldolase; COG2008: Threonine aldolase. (341 aa) |
| | rpsG | COG0049: Ribosomal protein S7; Belongs to the universal ribosomal protein uS7 family. (138 aa) |
| | BLA_1149 | Putative membrane protein. (224 aa) |
| | pyrF | COG0284: Orotidine-5'-phosphate decarboxylase. (323 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (408 aa) |
| | BLA_1160 | Possible cyclopropane-fatty-acyl-phospholipid synthase; COG2230: Cyclopropane fatty acid synthase and related methyltransferases. (427 aa) |
| | purB | COG0015: Adenylosuccinate lyase. (481 aa) |
