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| | GM18_0172 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: gbm:Gbem_0209 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain. (1182 aa) |
| | GM18_0229 | PFAM: alpha/beta hydrolase fold; KEGG: gem:GM21_0069 alpha/beta hydrolase fold protein. (279 aa) |
| | sucD | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa) |
| | sucC | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (385 aa) |
| | GM18_0310 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1148 aa) |
| | GM18_0316 | PFAM: Transketolase domain-containing protein; KEGG: gem:GM21_0264 transketolase domain protein. (274 aa) |
| | GM18_0317 | KEGG: gem:GM21_0265 transketolase central region; PFAM: Transketolase central region; Transketolase domain-containing protein; SMART: Transketolase central region. (310 aa) |
| | GM18_0357 | PFAM: Glu/Leu/Phe/Val dehydrogenase; KEGG: gur:Gura_0111 Glu/Leu/Phe/Val dehydrogenase, C terminal; SMART: Glu/Leu/Phe/Val dehydrogenase. (1033 aa) |
| | GM18_0381 | PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; Nitrate reductase gamma subunit; KEGG: gme:Gmet_2264 hypothetical protein. (661 aa) |
| | GM18_0382 | KEGG: gme:Gmet_2263 electron transfer flavoprotein subunit beta; PFAM: Electron transfer flavoprotein alpha/beta-subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (258 aa) |
| | GM18_0383 | KEGG: gme:Gmet_2262 electron transfer flavoprotein subunit alpha; PFAM: Electron transfer flavoprotein alpha subunit; Electron transfer flavoprotein alpha/beta-subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (302 aa) |
| | GM18_0385 | PFAM: Thiolase-like; KEGG: geo:Geob_0172 thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa) |
| | GM18_0386 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: geo:Geob_0163 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa) |
| | GM18_0387 | PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain-containing protein; KEGG: geo:Geob_0162 3-hydroxybutyryl-CoA dehydrogenase. (289 aa) |
| | GM18_0388 | PFAM: acyl-CoA dehydrogenase domain-containing protein; KEGG: geo:Geob_0169 acyl-CoA dehydrogenase domain protein. (582 aa) |
| | GM18_0395 | KEGG: gme:Gmet_2067 electron transfer flavoprotein subunit beta; PFAM: Electron transfer flavoprotein alpha/beta-subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (270 aa) |
| | GM18_0396 | KEGG: geo:Geob_0251 electron transfer flavoprotein alpha subunit; PFAM: Electron transfer flavoprotein alpha/beta-subunit; Electron transfer flavoprotein alpha subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (447 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa) |
| | GM18_0487 | KEGG: gbm:Gbem_0395 glycine cleavage system T protein; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel. (363 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa) |
| | gcvPA | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (445 aa) |
| | GM18_0490 | PFAM: aminotransferase class V; KEGG: gbm:Gbem_0398 glycine dehydrogenase subunit 2. (479 aa) |
| | GM18_0491 | PFAM: biotin/lipoate A/B protein ligase; KEGG: gbm:Gbem_0399 biotin/lipoate A/B protein ligase. (266 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (288 aa) |
| | GM18_0532 | PFAM: NUDIX hydrolase; KEGG: gbm:Gbem_3558 NUDIX hydrolase. (173 aa) |
| | GM18_0535 | Arylformamidase; KEGG: gbm:Gbem_3555 cyclase family protein; PFAM: cyclase family protein. (226 aa) |
| | GM18_0562 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: gem:GM21_3593 ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa) |
| | gpmA | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (234 aa) |
| | pgi | PFAM: phosphoglucose isomerase (PGI); KEGG: gem:GM21_3479 glucose-6-phosphate isomerase; Belongs to the GPI family. (530 aa) |
| | GM18_0779 | Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (541 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (362 aa) |
| | GM18_0874 | PFAM: alpha/beta hydrolase fold; KEGG: gbm:Gbem_1023 alpha/beta hydrolase fold. (287 aa) |
| | GM18_0958 | PFAM: AMP-dependent synthetase and ligase; KEGG: gme:Gmet_2340 AMP-dependent synthetase and ligase. (539 aa) |
| | GM18_1088 | KEGG: gbm:Gbem_1226 4Fe-4S ferredoxin iron-sulfur binding domain protein. (428 aa) |
| | GM18_1123 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; KEGG: gbm:Gbem_1265 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (528 aa) |
| | GM18_1155 | KEGG: gbm:Gbem_1294 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; TIGRFAM: aconitate hydratase 2; PFAM: Aconitase B; Aconitase B, HEAT-like; aconitate hydratase domain-containing protein; Belongs to the aconitase/IPM isomerase family. (839 aa) |
| | GM18_1181 | PFAM: phosphate acetyl/butaryl transferase; malic protein NAD-binding; malic protein domain protein; KEGG: gbm:Gbem_1324 malic enzyme. (749 aa) |
| | GM18_1183 | PFAM: ROK family protein; KEGG: gem:GM21_2957 ROK family protein. (302 aa) |
| | GM18_1192 | KEGG: gbm:Gbem_1333 Electron transfer flavoprotein alpha/beta-subunit; PFAM: Electron transfer flavoprotein alpha/beta-subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (258 aa) |
| | GM18_1193 | KEGG: gem:GM21_2949 electron transfer flavoprotein alpha subunit; PFAM: Electron transfer flavoprotein alpha subunit; Electron transfer flavoprotein alpha/beta-subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (303 aa) |
| | GM18_1214 | KEGG: gem:GM21_2928 electron transfer flavoprotein alpha/beta-subunit; PFAM: Electron transfer flavoprotein alpha/beta-subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (270 aa) |
| | GM18_1215 | KEGG: gbm:Gbem_1358 Electron transfer flavoprotein alpha subunit; PFAM: Electron transfer flavoprotein alpha/beta-subunit; Electron transfer flavoprotein alpha subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (448 aa) |
| | GM18_1241 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (691 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (381 aa) |
| | GM18_1246 | PFAM: Glu/Leu/Phe/Val dehydrogenase; KEGG: gme:Gmet_1728 Glu/Leu/Phe/Val dehydrogenase; SMART: Glu/Leu/Phe/Val dehydrogenase. (987 aa) |
| | icmF | methylmalonyl-CoA mutase, large subunit; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1082 aa) |
| | GM18_1285 | TIGRFAM: acetyl-CoA acetyltransferase; KEGG: gbm:Gbem_2835 acetyl-CoA acetyltransferase; PFAM: Thiolase-like; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | GM18_1286 | PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain-containing protein; KEGG: gur:Gura_3042 3-hydroxybutyryl-CoA dehydrogenase. (281 aa) |
| | GM18_1287 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: gur:Gura_3041 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa) |
| | GM18_1288 | PFAM: acyl-CoA dehydrogenase domain-containing protein; KEGG: gem:GM21_1381 butyryl-CoA dehydrogenase. (379 aa) |
| | GM18_1289 | PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; Nitrate reductase gamma subunit; KEGG: gur:Gura_3039 hypothetical protein. (706 aa) |
| | GM18_1290 | KEGG: gbm:Gbem_2830 Electron transfer flavoprotein alpha/beta-subunit; PFAM: Electron transfer flavoprotein alpha/beta-subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (258 aa) |
| | GM18_1291 | KEGG: gur:Gura_3037 electron transfer flavoprotein, alpha subunit; PFAM: Electron transfer flavoprotein alpha subunit; Electron transfer flavoprotein alpha/beta-subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (305 aa) |
| | GM18_1335 | KEGG: gem:GM21_2716 electron transfer flavoprotein alpha/beta-subunit; PFAM: Electron transfer flavoprotein alpha/beta-subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (270 aa) |
| | GM18_1336 | KEGG: gbm:Gbem_1501 Electron transfer flavoprotein alpha subunit; PFAM: Electron transfer flavoprotein alpha/beta-subunit; Electron transfer flavoprotein alpha subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (441 aa) |
| | GM18_1396 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (158 aa) |
| | GM18_1397 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa) |
| | gcvH-2 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa) |
| | GM18_1484 | KEGG: gem:GM21_2561 type I citrate synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family. (441 aa) |
| | GM18_1512 | PFAM: Aldehyde Dehydrogenase; KEGG: gbm:Gbem_1707 Aldehyde dehydrogenase. (539 aa) |
| | GM18_1602 | PFAM: AMP-dependent synthetase and ligase; KEGG: gme:Gmet_1469 AMP-dependent synthetase and ligase. (562 aa) |
| | GM18_1669 | PFAM: AMP-dependent synthetase and ligase; KEGG: gem:GM21_3179 AMP-dependent synthetase and ligase. (527 aa) |
| | GM18_1698 | TIGRFAM: phosphonopyruvate decarboxylase-related protein; proposed homoserine kinase; KEGG: gbm:Gbem_1879 cofactor-independent phosphoglycerate mutase; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein. (399 aa) |
| | GM18_1711 | PFAM: phosphate acetyl/butaryl transferase; malic protein NAD-binding; malic protein domain protein; KEGG: gem:GM21_2321 malic enzyme. (749 aa) |
| | fbp | PFAM: Inositol phosphatase/fructose-16-bisphosphatase; KEGG: gem:GM21_1808 fructose-1,6-bisphosphatase. (326 aa) |
| | GM18_1861 | Homocitrate synthase; KEGG: gbm:Gbem_2073 trans-homoaconitate synthase; TIGRFAM: homocitrate synthase; PFAM: pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (379 aa) |
| | GM18_1873 | KEGG: gbm:Gbem_2085 Electron transfer flavoprotein alpha/beta-subunit; PFAM: Electron transfer flavoprotein alpha/beta-subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (270 aa) |
| | GM18_1874 | KEGG: gbm:Gbem_2086 Electron transfer flavoprotein alpha subunit; PFAM: Electron transfer flavoprotein alpha/beta-subunit; Electron transfer flavoprotein alpha subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (437 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | pgk | KEGG: gem:GM21_1883 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | GM18_1893 | SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: gbm:Gbem_2336 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa) |
| | ackA-2 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (421 aa) |
| | GM18_1953 | TIGRFAM: phosphate acetyltransferase; KEGG: gbm:Gbem_2276 phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase. (333 aa) |
| | GM18_1971 | KEGG: gem:GM21_1966 aconitate hydratase; TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain-containing protein. (648 aa) |
| | pdhA | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (325 aa) |
| | GM18_1973 | Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa) |
| | GM18_1974 | PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; KEGG: gem:GM21_1974 branched-chain alpha-keto acid dehydrogenase subunit E2. (540 aa) |
| | GM18_2013 | KEGG: gem:GM21_2011 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; phosphopantetheine-binding; SMART: phospholipid/glycerol acyltransferase. (825 aa) |
| | GM18_2068 | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (934 aa) |
| | GM18_2085 | PFAM: acyl-CoA dehydrogenase domain-containing protein; KEGG: ade:Adeh_1647 butyryl-CoA dehydrogenase. (380 aa) |
| | GM18_2086 | Propanoyl-CoA C-acyltransferase; KEGG: tac:Ta0351 acetyl-CoA acetyltransferase; PFAM: Thiolase-like; Belongs to the thiolase-like superfamily. Thiolase family. (430 aa) |
| | GM18_2087 | PFAM: protein of unknown function DUF35; Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain-like; KEGG: tac:Ta0352 hypothetical protein. (159 aa) |
| | GM18_2088 | KEGG: dal:Dalk_3789 acetoacetyl-CoA synthase; TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase. (651 aa) |
| | GM18_2108 | PFAM: acyl-CoA dehydrogenase domain-containing protein; KEGG: gem:GM21_2089 acyl-CoA dehydrogenase domain protein. (592 aa) |
| | GM18_2109 | KEGG: gbm:Gbem_2127 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase-like; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa) |
| | GM18_2110 | PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain-containing protein; Enoyl-CoA hydratase/isomerase; KEGG: gbm:Gbem_2126 3-hydroxyacyl-CoA dehydrogenase NAD-binding. (791 aa) |
| | GM18_2111 | PFAM: AMP-dependent synthetase and ligase; KEGG: gem:GM21_2093 AMP-dependent synthetase and ligase. (603 aa) |
| | GM18_2186 | PFAM: Glu/Leu/Phe/Val dehydrogenase; KEGG: gur:Gura_0111 Glu/Leu/Phe/Val dehydrogenase, C terminal; SMART: Glu/Leu/Phe/Val dehydrogenase. (997 aa) |
| | glk | TIGRFAM: glucokinase; KEGG: gbm:Gbem_2002 glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family. (327 aa) |
| | GM18_2262 | KEGG: gbm:Gbem_1961 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region. (532 aa) |
| | GM18_2301 | PFAM: GCN5-related N-acetyltransferase; KEGG: gbm:Gbem_2443 acetyltransferase. (149 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | GM18_2558 | TIGRFAM: LAO/AO transport system ATPase; PFAM: ArgK protein; KEGG: gem:GM21_1549 LAO/AO transport system ATPase; SMART: AAA ATPase. (314 aa) |
| | GM18_2559 | PFAM: cobalamin B12-binding domain protein; KEGG: gem:GM21_1548 cobalamin B12-binding domain protein. (134 aa) |
| | GM18_2602 | PFAM: aconitate hydratase domain-containing protein; KEGG: gbm:Gbem_2736 aconitate hydratase domain protein; Belongs to the LeuD family. (175 aa) |
| | leuC | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (427 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa) |
| | GM18_2611 | KEGG: gem:GM21_1496 acetolactate synthase 3 regulatory subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (163 aa) |
| | GM18_2612 | KEGG: gem:GM21_1495 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein. (566 aa) |
| | ilvD | TIGRFAM: dihydroxy-acid dehydratase; KEGG: gbm:Gbem_2747 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | GM18_2624 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (490 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | GM18_2656 | PFAM: Glu/Leu/Phe/Val dehydrogenase; KEGG: gbm:Gbem_2777 Glu/Leu/Phe/Val dehydrogenase; SMART: Glu/Leu/Phe/Val dehydrogenase. (986 aa) |
| | GM18_2688 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (390 aa) |
| | GM18_2692 | PFAM: acyl-CoA dehydrogenase domain-containing protein; KEGG: gbm:Gbem_2826 acyl-CoA dehydrogenase domain protein. (385 aa) |
| | GM18_2693 | PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain-containing protein; KEGG: gem:GM21_1379 3-hydroxybutyryl-CoA dehydrogenase. (281 aa) |
| | GM18_2694 | TIGRFAM: acetyl-CoA acetyltransferase; KEGG: gem:GM21_1378 acetyl-CoA acetyltransferase; PFAM: Thiolase-like; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | GM18_2725 | KEGG: gem:GM21_1350 glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase; glutamate synthase alpha subunit domain protein; glutamine amidotransferase class-II. (1527 aa) |
| | GM18_2726 | KEGG: gem:GM21_1349 glutamate synthase, NADH/NADPH, small subunit; TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (493 aa) |
| | GM18_2783 | Pyruvate/ketoisovalerate oxidoreductase, gamma subunit; KEGG: gem:GM21_1329 pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (182 aa) |
| | GM18_2784 | PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; KEGG: gem:GM21_1328 2-oxoglutarate ferredoxin oxidoreductase subunit beta. (270 aa) |
| | GM18_2785 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: gem:GM21_1327 2-oxoglutarate ferredoxin oxidoreductase subunit alpha. (377 aa) |
| | GM18_2786 | KEGG: gbm:Gbem_2899 4Fe-4S ferredoxin iron-sulfur binding domain protein. (64 aa) |
| | mdh | Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (317 aa) |
| | GM18_2788 | TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: gem:GM21_1324 isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent monomeric type; Belongs to the monomeric-type IDH family. (742 aa) |
| | pfkA-2 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (361 aa) |
| | GM18_3017 | PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: glo:Glov_0945 succinate dehydrogenase. (503 aa) |
| | GM18_3018 | KEGG: glo:Glov_0946 fumarate reductase flavoprotein subunit precursor. (117 aa) |
| | GM18_3048 | KEGG: gbm:Gbem_3077 glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. (470 aa) |
| | GM18_3050 | PFAM: glutamine synthetase catalytic region; KEGG: gem:GM21_1182 glutamine synthetase catalytic region. (695 aa) |
| | GM18_3057 | PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: gbm:Gbem_3084 pyruvate/ketoisovalerate oxidoreductase, gamma subunit. (184 aa) |
| | GM18_3058 | PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; KEGG: gbm:Gbem_3085 thiamine pyrophosphate protein domain protein TPP-binding. (246 aa) |
| | GM18_3059 | Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: gbm:Gbem_3086 2-ketoisovalerate ferredoxin reductase; manually curated; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (358 aa) |
| | GM18_3060 | Manually curated; KEGG: gbm:Gbem_3087 4Fe-4S ferredoxin iron-sulfur binding domain protein. (67 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | GM18_3074 | TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; KEGG: gem:GM21_1159 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase. (148 aa) |
| | GM18_3214 | KEGG: gur:Gura_3554 electron transfer flavoprotein beta-subunit; PFAM: Electron transfer flavoprotein alpha/beta-subunit; SMART: Electron transfer flavoprotein alpha/beta-subunit. (297 aa) |
| | GM18_3215 | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; Could be a 3Fe-4S cluster-containing protein. (92 aa) |
| | GM18_3216 | Monooxygenase FAD-binding protein; Part of an electron transfer system. Belongs to the ETF-QO/FixC family. (432 aa) |
| | GM18_3217 | PFAM: Electron transfer flavoprotein alpha subunit; Electron transfer flavoprotein alpha/beta-subunit; KEGG: gur:Gura_3557 electron transfer flavoprotein, alpha subunit. (333 aa) |
| | GM18_3218 | PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: gur:Gura_3558 NADH:flavin oxidoreductase/NADH oxidase. (653 aa) |
| | GM18_3258 | TIGRFAM: pyruvate kinase; KEGG: gem:GM21_3093 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (479 aa) |
| | GM18_3272 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: gur:Gura_3483 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain. (1196 aa) |
| | sucD-2 | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa) |
| | sucC-2 | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa) |
| | GM18_3276 | PFAM: phosphate acetyl/butaryl transferase; malic protein NAD-binding; malic protein domain protein; KEGG: gem:GM21_2321 malic enzyme. (749 aa) |
| | GM18_3370 | PFAM: aminotransferase class I and II; KEGG: gem:GM21_0961 aspartate aminotransferase. (397 aa) |
| | GM18_3409 | KEGG: gem:GM21_0914 succinate dehydrogenase/fumarate reductase iron-sulfur subunit. (246 aa) |
| | GM18_3410 | TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; KEGG: gem:GM21_0913 succinate dehydrogenase flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (637 aa) |
| | GM18_3411 | KEGG: gem:GM21_0912 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; PFAM: succinate dehydrogenase cytochrome b subunit. (221 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (282 aa) |
| | GM18_3472 | PFAM: acylphosphatase; KEGG: gbm:Gbem_3384 acylphosphatase. (94 aa) |
| | GM18_3488 | PFAM: ketose-bisphosphate aldolase class-II; KEGG: gem:GM21_3253 ketose-bisphosphate aldolase class-II. (427 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa) |
| | GM18_3514 | PFAM: DRTGG domain protein; KEGG: gem:GM21_3278 BioD-like protein N-terminal domain of phosphotransacetylase-like protein. (364 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (618 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (529 aa) |
| | lipB | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (205 aa) |
| | GM18_3645 | KEGG: gem:GM21_0718 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (468 aa) |
| | GM18_3646 | 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (431 aa) |
| | GM18_3647 | SMART: Transketolase central region; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; KEGG: gbm:Gbem_0704 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase central region; dehydrogenase E1 component. (897 aa) |
| | GM18_3660 | PFAM: MaoC domain protein dehydratase; KEGG: rxy:Rxyl_0670 MaoC-like dehydratase. (166 aa) |
| | GM18_3668 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: gbm:Gbem_0684 methylmalonyl-CoA decarboxylase; Belongs to the enoyl-CoA hydratase/isomerase family. (259 aa) |
| | GM18_3705 | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase; KEGG: gbm:Gbem_0650 fumarylacetoacetate (FAA) hydrolase; PFAM: fumarylacetoacetate (FAA) hydrolase. (218 aa) |
| | GM18_3710 | TIGRFAM: pyruvate, phosphate dikinase; KEGG: gem:GM21_0657 pyruvate phosphate dikinase; PFAM: PEP-utilizing protein; pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; Belongs to the PEP-utilizing enzyme family. (913 aa) |
| | GM18_3713 | KEGG: gem:GM21_0654 mercuric reductase; TIGRFAM: mercuric reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (468 aa) |
| | GM18_3726 | PFAM: aminotransferase class I and II; KEGG: gbm:Gbem_0627 aminotransferase. (434 aa) |
| | tal-2 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (214 aa) |
| | GM18_3785 | TIGRFAM: branched-chain amino acid aminotransferase; KEGG: gem:GM21_0585 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. (357 aa) |
| | GM18_3794 | KEGG: gem:GM21_0575 propionyl-CoA carboxylase; PFAM: carboxyl transferase. (574 aa) |
| | GM18_3795 | KEGG: gem:GM21_0574 biotin/lipoyl attachment domain-containing protein; PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; Carbamoyl-phosphate synthase L chain ATP-binding; SMART: biotin carboxylase domain protein. (1015 aa) |
| | GM18_3796 | TIGRFAM: methylmalonyl-CoA mutase, large subunit; KEGG: gem:GM21_0572 methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase. (550 aa) |
| | GM18_3797 | KEGG: gbm:Gbem_0558 methylmalonyl-CoA epimerase; TIGRFAM: methylmalonyl-CoA epimerase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. (134 aa) |
| | GM18_3813 | PFAM: acyl-CoA dehydrogenase domain-containing protein; KEGG: gem:GM21_0556 acyl-CoA dehydrogenase domain protein. (385 aa) |
| | GM18_3822 | KEGG: gbm:Gbem_3597 flavocytochrome c; TIGRFAM: flavocytochrome c; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (584 aa) |
| | GM18_3827 | Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (589 aa) |
| | GM18_3910 | KEGG: gem:GM21_0485 acetyl-CoA hydrolase; PFAM: acetyl-CoA hydrolase/transferase. (532 aa) |
| | GM18_3917 | Glutamate dehydrogenase (NAD(P)(+)); PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: gem:GM21_0478 glutamate dehydrogenase (NAD(P)(+)); SMART: Glu/Leu/Phe/Val dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (363 aa) |
| | GM18_3918 | PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; KEGG: gbm:Gbem_0461 branched-chain alpha-keto acid dehydrogenase subunit E2. (406 aa) |
| | GM18_3919 | KEGG: gem:GM21_0476 transketolase central region; PFAM: Transketolase central region; Transketolase domain-containing protein; SMART: Transketolase central region. (320 aa) |
| | pdhA-2 | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (351 aa) |
| | GM18_3921 | PFAM: SNARE associated Golgi protein; KEGG: gem:GM21_0474 SNARE associated Golgi protein. (227 aa) |
| | GM18_3922 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: gbm:Gbem_0457 mercuric reductase. (508 aa) |
| | GM18_4130 | KEGG: gme:Gmet_0804 alcohol dehydrogenase; TIGRFAM: quinone oxidoreductase, YhdH/YhfP family; PFAM: Alcohol dehydrogenase zinc-binding domain protein. (334 aa) |
| | GM18_4219 | SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: gem:GM21_3873 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (481 aa) |
| | GM18_4462 | ADP-ribose diphosphatase; KEGG: ppd:Ppro_0866 NUDIX hydrolase; PFAM: NUDIX hydrolase; Belongs to the Nudix hydrolase family. (273 aa) |
