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GM18_0172 GM18_0172 sucD sucD sucC sucC GM18_0310 GM18_0310 ackA ackA GM18_0491 GM18_0491 lipA lipA GM18_0535 GM18_0535 GM18_0779 GM18_0779 leuB leuB GM18_0958 GM18_0958 GM18_1088 GM18_1088 GM18_1123 GM18_1123 GM18_1155 GM18_1155 GM18_1181 GM18_1181 GM18_1396 GM18_1396 GM18_1397 GM18_1397 GM18_1484 GM18_1484 GM18_1711 GM18_1711 GM18_1861 GM18_1861 ackA-2 ackA-2 GM18_1953 GM18_1953 GM18_1971 GM18_1971 pdhA pdhA GM18_1973 GM18_1973 GM18_1974 GM18_1974 GM18_2068 GM18_2068 GM18_2602 GM18_2602 leuC leuC leuA leuA GM18_2611 GM18_2611 GM18_2612 GM18_2612 ilvD ilvD GM18_2624 GM18_2624 GM18_2783 GM18_2783 GM18_2784 GM18_2784 GM18_2785 GM18_2785 GM18_2786 GM18_2786 mdh mdh GM18_2788 GM18_2788 GM18_3017 GM18_3017 GM18_3018 GM18_3018 GM18_3057 GM18_3057 GM18_3058 GM18_3058 GM18_3059 GM18_3059 GM18_3060 GM18_3060 accA accA GM18_3272 GM18_3272 sucD-2 sucD-2 sucC-2 sucC-2 GM18_3276 GM18_3276 GM18_3409 GM18_3409 GM18_3410 GM18_3410 GM18_3411 GM18_3411 accD accD GM18_3472 GM18_3472 GM18_3514 GM18_3514 pckG pckG pckA pckA lipB lipB GM18_3645 GM18_3645 GM18_3646 GM18_3646 GM18_3647 GM18_3647 GM18_3660 GM18_3660 GM18_3705 GM18_3705 GM18_3710 GM18_3710 GM18_3713 GM18_3713 GM18_3785 GM18_3785 GM18_3822 GM18_3822 GM18_3827 GM18_3827 GM18_3910 GM18_3910 GM18_3918 GM18_3918 GM18_3919 GM18_3919 pdhA-2 pdhA-2 GM18_3921 GM18_3921 GM18_3922 GM18_3922
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GM18_0172TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: gbm:Gbem_0209 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain. (1182 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (385 aa)
GM18_0310Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1148 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
GM18_0491PFAM: biotin/lipoate A/B protein ligase; KEGG: gbm:Gbem_0399 biotin/lipoate A/B protein ligase. (266 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (288 aa)
GM18_0535Arylformamidase; KEGG: gbm:Gbem_3555 cyclase family protein; PFAM: cyclase family protein. (226 aa)
GM18_0779Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (541 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (362 aa)
GM18_0958PFAM: AMP-dependent synthetase and ligase; KEGG: gme:Gmet_2340 AMP-dependent synthetase and ligase. (539 aa)
GM18_1088KEGG: gbm:Gbem_1226 4Fe-4S ferredoxin iron-sulfur binding domain protein. (428 aa)
GM18_1123TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; KEGG: gbm:Gbem_1265 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (528 aa)
GM18_1155KEGG: gbm:Gbem_1294 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; TIGRFAM: aconitate hydratase 2; PFAM: Aconitase B; Aconitase B, HEAT-like; aconitate hydratase domain-containing protein; Belongs to the aconitase/IPM isomerase family. (839 aa)
GM18_1181PFAM: phosphate acetyl/butaryl transferase; malic protein NAD-binding; malic protein domain protein; KEGG: gbm:Gbem_1324 malic enzyme. (749 aa)
GM18_1396acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (158 aa)
GM18_1397acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa)
GM18_1484KEGG: gem:GM21_2561 type I citrate synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family. (441 aa)
GM18_1711PFAM: phosphate acetyl/butaryl transferase; malic protein NAD-binding; malic protein domain protein; KEGG: gem:GM21_2321 malic enzyme. (749 aa)
GM18_1861Homocitrate synthase; KEGG: gbm:Gbem_2073 trans-homoaconitate synthase; TIGRFAM: homocitrate synthase; PFAM: pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (379 aa)
ackA-2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (421 aa)
GM18_1953TIGRFAM: phosphate acetyltransferase; KEGG: gbm:Gbem_2276 phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase. (333 aa)
GM18_1971KEGG: gem:GM21_1966 aconitate hydratase; TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain-containing protein. (648 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (325 aa)
GM18_1973Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa)
GM18_1974PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; KEGG: gem:GM21_1974 branched-chain alpha-keto acid dehydrogenase subunit E2. (540 aa)
GM18_2068Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (934 aa)
GM18_2602PFAM: aconitate hydratase domain-containing protein; KEGG: gbm:Gbem_2736 aconitate hydratase domain protein; Belongs to the LeuD family. (175 aa)
leuCHomoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (427 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa)
GM18_2611KEGG: gem:GM21_1496 acetolactate synthase 3 regulatory subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (163 aa)
GM18_2612KEGG: gem:GM21_1495 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein. (566 aa)
ilvDTIGRFAM: dihydroxy-acid dehydratase; KEGG: gbm:Gbem_2747 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (553 aa)
GM18_2624Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (490 aa)
GM18_2783Pyruvate/ketoisovalerate oxidoreductase, gamma subunit; KEGG: gem:GM21_1329 pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (182 aa)
GM18_2784PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; KEGG: gem:GM21_1328 2-oxoglutarate ferredoxin oxidoreductase subunit beta. (270 aa)
GM18_2785PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: gem:GM21_1327 2-oxoglutarate ferredoxin oxidoreductase subunit alpha. (377 aa)
GM18_2786KEGG: gbm:Gbem_2899 4Fe-4S ferredoxin iron-sulfur binding domain protein. (64 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (317 aa)
GM18_2788TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: gem:GM21_1324 isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent monomeric type; Belongs to the monomeric-type IDH family. (742 aa)
GM18_3017PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: glo:Glov_0945 succinate dehydrogenase. (503 aa)
GM18_3018KEGG: glo:Glov_0946 fumarate reductase flavoprotein subunit precursor. (117 aa)
GM18_3057PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: gbm:Gbem_3084 pyruvate/ketoisovalerate oxidoreductase, gamma subunit. (184 aa)
GM18_3058PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; KEGG: gbm:Gbem_3085 thiamine pyrophosphate protein domain protein TPP-binding. (246 aa)
GM18_3059Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: gbm:Gbem_3086 2-ketoisovalerate ferredoxin reductase; manually curated; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (358 aa)
GM18_3060Manually curated; KEGG: gbm:Gbem_3087 4Fe-4S ferredoxin iron-sulfur binding domain protein. (67 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
GM18_3272TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: gur:Gura_3483 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain. (1196 aa)
sucD-2succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
sucC-2succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa)
GM18_3276PFAM: phosphate acetyl/butaryl transferase; malic protein NAD-binding; malic protein domain protein; KEGG: gem:GM21_2321 malic enzyme. (749 aa)
GM18_3409KEGG: gem:GM21_0914 succinate dehydrogenase/fumarate reductase iron-sulfur subunit. (246 aa)
GM18_3410TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; KEGG: gem:GM21_0913 succinate dehydrogenase flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (637 aa)
GM18_3411KEGG: gem:GM21_0912 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; PFAM: succinate dehydrogenase cytochrome b subunit. (221 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (282 aa)
GM18_3472PFAM: acylphosphatase; KEGG: gbm:Gbem_3384 acylphosphatase. (94 aa)
GM18_3514PFAM: DRTGG domain protein; KEGG: gem:GM21_3278 BioD-like protein N-terminal domain of phosphotransacetylase-like protein. (364 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (618 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (529 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (205 aa)
GM18_3645KEGG: gem:GM21_0718 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (468 aa)
GM18_36462-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (431 aa)
GM18_3647SMART: Transketolase central region; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; KEGG: gbm:Gbem_0704 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase central region; dehydrogenase E1 component. (897 aa)
GM18_3660PFAM: MaoC domain protein dehydratase; KEGG: rxy:Rxyl_0670 MaoC-like dehydratase. (166 aa)
GM18_37055-carboxymethyl-2-hydroxymuconate Delta-isomerase; KEGG: gbm:Gbem_0650 fumarylacetoacetate (FAA) hydrolase; PFAM: fumarylacetoacetate (FAA) hydrolase. (218 aa)
GM18_3710TIGRFAM: pyruvate, phosphate dikinase; KEGG: gem:GM21_0657 pyruvate phosphate dikinase; PFAM: PEP-utilizing protein; pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; Belongs to the PEP-utilizing enzyme family. (913 aa)
GM18_3713KEGG: gem:GM21_0654 mercuric reductase; TIGRFAM: mercuric reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (468 aa)
GM18_3785TIGRFAM: branched-chain amino acid aminotransferase; KEGG: gem:GM21_0585 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. (357 aa)
GM18_3822KEGG: gbm:Gbem_3597 flavocytochrome c; TIGRFAM: flavocytochrome c; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (584 aa)
GM18_3827Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (589 aa)
GM18_3910KEGG: gem:GM21_0485 acetyl-CoA hydrolase; PFAM: acetyl-CoA hydrolase/transferase. (532 aa)
GM18_3918PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; KEGG: gbm:Gbem_0461 branched-chain alpha-keto acid dehydrogenase subunit E2. (406 aa)
GM18_3919KEGG: gem:GM21_0476 transketolase central region; PFAM: Transketolase central region; Transketolase domain-containing protein; SMART: Transketolase central region. (320 aa)
pdhA-2Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (351 aa)
GM18_3921PFAM: SNARE associated Golgi protein; KEGG: gem:GM21_0474 SNARE associated Golgi protein. (227 aa)
GM18_3922PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: gbm:Gbem_0457 mercuric reductase. (508 aa)
Your Current Organism:
Geobacter sp. M18
NCBI taxonomy Id: 443143
Other names: G. sp. M18
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