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GM21_0192 GM21_0192 GM21_0209 GM21_0209 sucD sucD sucC sucC GM21_0258 GM21_0258 GM21_0585 GM21_0585 GM21_0641 GM21_0641 GM21_0657 GM21_0657 pckA pckA pckG pckG GM21_0912 GM21_0912 GM21_0913 GM21_0913 GM21_0914 GM21_0914 sucC-2 sucC-2 sucD-2 sucD-2 GM21_1174 GM21_1174 GM21_1175 GM21_1175 GM21_1176 GM21_1176 GM21_1177 GM21_1177 GM21_1324 GM21_1324 mdh mdh GM21_1326 GM21_1326 GM21_1327 GM21_1327 GM21_1328 GM21_1328 GM21_1329 GM21_1329 GM21_1415 GM21_1415 GM21_1483 GM21_1483 ilvD ilvD GM21_1495 GM21_1495 GM21_1496 GM21_1496 leuA leuA leuC leuC GM21_1505 GM21_1505 GM21_1966 GM21_1966 GM21_2050 GM21_2050 GM21_2321 GM21_2321 GM21_2561 GM21_2561 sucD-3 sucD-3 sucC-3 sucC-3 GM21_2798 GM21_2798 GM21_2799 GM21_2799 GM21_2853 GM21_2853 GM21_2959 GM21_2959 GM21_2989 GM21_2989 GM21_2991 GM21_2991 GM21_3018 GM21_3018 leuB leuB GM21_3371 GM21_3371 GM21_3621 GM21_3621 GM21_3971 GM21_3971 GM21_3990 GM21_3990 GM21_4125 GM21_4125 GM21_4127 GM21_4127
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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GM21_0192TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: gbm:Gbem_0209 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (1183 aa)
GM21_0209Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (912 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (298 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
GM21_0258Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1148 aa)
GM21_0585KEGG: gbm:Gbem_0572 branched-chain amino acid aminotransferase; TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. (356 aa)
GM21_0641PFAM: aminotransferase class I and II; KEGG: gbm:Gbem_0627 aminotransferase class I and II. (434 aa)
GM21_0657KEGG: gbm:Gbem_0644 pyruvate, phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; PEP-utilizing protein; Belongs to the PEP-utilizing enzyme family. (914 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (529 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (647 aa)
GM21_0912TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; KEGG: gbm:Gbem_3334 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family. (221 aa)
GM21_0913KEGG: gbm:Gbem_3333 succinate dehydrogenase or fumarate reductase, flavoprotein subunit; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (637 aa)
GM21_0914PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: gbm:Gbem_3332 4Fe-4S ferredoxin iron-sulfur binding domain protein. (246 aa)
sucC-2succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa)
sucD-2succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
GM21_1174PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: gbm:Gbem_3087 4Fe-4S ferredoxin iron-sulfur binding domain protein. (67 aa)
GM21_1175PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: gbm:Gbem_3086 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (356 aa)
GM21_1176PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: gbm:Gbem_3085 thiamine pyrophosphate protein domain protein TPP-binding. (246 aa)
GM21_1177TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: gbm:Gbem_3084 pyruvate/ketoisovalerate oxidoreductase, gamma subunit. (183 aa)
GM21_1324KEGG: gbm:Gbem_2901 isocitrate dehydrogenase, NADP-dependent; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent monomeric type; Belongs to the monomeric-type IDH family. (743 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (317 aa)
GM21_1326PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: gbm:Gbem_2899 4Fe-4S ferredoxin iron-sulfur binding domain protein. (64 aa)
GM21_1327PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: gbm:Gbem_2898 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (377 aa)
GM21_1328PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: gbm:Gbem_2897 thiamine pyrophosphate protein domain protein TPP-binding. (270 aa)
GM21_1329PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: gbm:Gbem_2896 pyruvate ferredoxin/flavodoxin oxidoreductase. (182 aa)
GM21_1415PFAM: fumarate lyase; KEGG: gbm:Gbem_2795 fumarate lyase. (466 aa)
GM21_1483Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (490 aa)
ilvDKEGG: gbm:Gbem_2747 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (553 aa)
GM21_1495TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: gbm:Gbem_2746 acetolactate synthase, large subunit, biosynthetic type. (566 aa)
GM21_1496TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: gbm:Gbem_2745 acetolactate synthase, small subunit. (163 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa)
leuCHomoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (427 aa)
GM21_1505PFAM: aconitate hydratase domain protein; KEGG: gbm:Gbem_2736 aconitate hydratase domain protein; Belongs to the LeuD family. (175 aa)
GM21_1966TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain protein; KEGG: gbm:Gbem_2258 aconitate hydratase. (648 aa)
GM21_2050Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (934 aa)
GM21_2321PFAM: malic protein NAD-binding; malic protein domain protein; phosphate acetyl/butaryl transferase; KEGG: gbm:Gbem_1888 malic protein. (749 aa)
GM21_2561PFAM: Citrate synthase; KEGG: gbm:Gbem_1652 citrate synthase; Belongs to the citrate synthase family. (441 aa)
sucD-3succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (308 aa)
sucC-3succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa)
GM21_2798Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein NAD-binding; malic protein domain protein; KEGG: gbm:Gbem_1455 malic protein. (780 aa)
GM21_2799TIGRFAM: oxaloacetate decarboxylase alpha subunit; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; biotin/lipoyl attachment domain-containing protein; KEGG: gbm:Gbem_1454 oxaloacetate decarboxylase alpha subunit. (690 aa)
GM21_2853PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; FAD dependent oxidoreductase; KEGG: gme:Gmet_2118 FAD dependent oxidoreductase. (614 aa)
GM21_2959Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: malic protein NAD-binding; malic protein domain protein; phosphate acetyl/butaryl transferase; KEGG: gbm:Gbem_1324 malic protein. (749 aa)
GM21_2989TIGRFAM: aconitate hydratase 2; PFAM: Aconitase B, N-terminal; aconitate hydratase domain protein; KEGG: gbm:Gbem_1294 aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (839 aa)
GM21_2991KEGG: gbm:Gbem_1292 succinic semialdehyde dehydrogenase; TIGRFAM: succinic semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; Belongs to the aldehyde dehydrogenase family. (485 aa)
GM21_3018KEGG: gbm:Gbem_1265 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: LeuA allosteric (dimerisation) domain; pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (528 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (362 aa)
GM21_3371Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (541 aa)
GM21_3621PFAM: cyclase family protein; KEGG: gbm:Gbem_3555 cyclase family protein. (226 aa)
GM21_3971PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: gbm:Gbem_3883 4Fe-4S ferredoxin iron-sulfur binding domain protein. (84 aa)
GM21_3990PFAM: Citrate synthase; KEGG: gbm:Gbem_3905 citrate synthase; Belongs to the citrate synthase family. (454 aa)
GM21_4125TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: gbm:Gbem_4034 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (1238 aa)
GM21_4127KEGG: gbm:Gbem_4036 flavocytochrome c; TIGRFAM: flavocytochrome c; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; HI0933 family protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (598 aa)
Your Current Organism:
Geobacter sp. M21
NCBI taxonomy Id: 443144
Other names: G. sp. M21
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