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| | GM21_0002 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa) |
| | GM21_0014 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: gbm:Gbem_0015 radical SAM domain protein. (358 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (339 aa) |
| | GM21_0025 | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: gbm:Gbem_0026 oxidoreductase FAD/NAD(P)-binding domain protein. (280 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (317 aa) |
| | GM21_0046 | UbiA prenyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (272 aa) |
| | GM21_0048 | KEGG: gbm:Gbem_0049 pyridoxal phosphate-dependent acyltransferase; TIGRFAM: pyridoxal phosphate-dependent acyltransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; aromatic amino acid beta-eliminating lyase/threonine aldolase. (396 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (348 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (458 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (422 aa) |
| | GM21_0109 | TIGRFAM: DNA ligase D; DNA polymerase LigD, ligase domain protein; DNA ligase D, 3'-phosphoesterase domain protein; DNA polymerase LigD, polymerase domain protein; PFAM: ATP dependent DNA ligase; DNA primase small subunit; ATP dependent DNA ligase domain protein; mRNA capping enzyme; KEGG: gbm:Gbem_0128 DNA ligase D. (872 aa) |
| | GM21_0136 | KEGG: gbm:Gbem_0152 hypothetical protein. (104 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (392 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (752 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (579 aa) |
| | GM21_0243 | KEGG: gbm:Gbem_0258 iron-sulfur cluster-binding protein. (275 aa) |
| | GM21_0250 | PFAM: PHP domain protein; SMART: DNA polymerase X; phosphoesterase PHP domain protein; Helix-hairpin-helix DNA-binding class 1; KEGG: gbm:Gbem_0265 PHP domain protein. (578 aa) |
| | GM21_0280 | Adenylate/guanylate cyclase with Chase sensor; PFAM: CHASE2 domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SMART: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: gbm:Gbem_0296 adenylate/guanylate cyclase with CHASE sensor. (656 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (409 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (892 aa) |
| | GM21_0357 | KEGG: gbm:Gbem_0377 hypothetical protein. (234 aa) |
| | GM21_0358 | PFAM: pyridoxamine 5'-phosphate oxidase-related FMN-binding; KEGG: gur:Gura_3514 pyridoxamine 5'-phosphate oxidase-related, FMN-binding. (134 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (291 aa) |
| | GM21_0405 | TIGRFAM: siroheme synthase; KEGG: gbm:Gbem_0405 siroheme synthase. (224 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (434 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (318 aa) |
| | GM21_0409 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: gbm:Gbem_0409 uroporphyrin-III C-methyltransferase. (511 aa) |
| | GM21_0410 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: gbm:Gbem_0410 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (339 aa) |
| | GM21_0421 | KEGG: dps:DPPB61 hypothetical protein. (368 aa) |
| | pdhA | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (351 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | GM21_0516 | KEGG: gbm:Gbem_0499 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; SMART: phosphoesterase PHP domain protein. (1079 aa) |
| | GM21_0517 | DNA-directed DNA polymerase; PFAM: UMUC domain protein DNA-repair protein; KEGG: gbm:Gbem_0500 UMUC domain protein DNA-repair protein. (417 aa) |
| | GM21_0554 | PFAM: phosphoribosyltransferase; KEGG: gbm:Gbem_0541 phosphoribosyltransferase. (183 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | GM21_0586 | RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (285 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (323 aa) |
| | GM21_0622 | KEGG: gbm:Gbem_0608 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. (162 aa) |
| | GM21_0643 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: gbm:Gbem_0629 glyoxalase/bleomycin resistance protein/dioxygenase. (117 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa) |
| | thiG | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (260 aa) |
| | GM21_0667 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: gbm:Gbem_0654 thiamine biosynthesis protein ThiS. (75 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa) |
| | GM21_0770 | TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: gbm:Gbem_0755 DNA polymerase III, delta subunit. (329 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (516 aa) |
| | GM21_0800 | KEGG: gsu:GSU1363 RNA-directed DNA polymerase. (377 aa) |
| | GM21_0838 | PFAM: metal-dependent phosphohydrolase HD sub domain; KEGG: gbm:Gbem_0787 metal dependent phosphohydrolase. (191 aa) |
| | GM21_0860 | PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_3386 radical SAM domain protein. (441 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa) |
| | GM21_0882 | TIGRFAM: hopanoid biosynthesis associated radical SAM protein HpnH; PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_3363 hopanoid biosynthesis associated radical SAM protein HpnH. (332 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (635 aa) |
| | GM21_0889 | KEGG: gbm:Gbem_3356 hypothetical protein. (70 aa) |
| | queH | Protein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (176 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (282 aa) |
| | GM21_0897 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; KEGG: gbm:Gbem_3348 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (424 aa) |
| | GM21_0900 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (278 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (368 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | cmk | TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region; KEGG: gbm:Gbem_3257 cytidylate kinase. (233 aa) |
| | GM21_1000 | KEGG: rso:RSc2483 hypothetical protein. (430 aa) |
| | GM21_1023 | KEGG: gbm:Gbem_3238 bifunctional deaminase-reductase domain protein. (186 aa) |
| | GM21_1028 | PFAM: pyridoxamine 5'-phosphate oxidase-related FMN-binding; KEGG: gbm:Gbem_3237 pyridoxamine 5'-phosphate oxidase-related FMN-binding. (144 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (202 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (68 aa) |
| | GM21_1058 | TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: gbm:Gbem_3205 DNA polymerase III, delta prime subunit. (320 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (225 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A-like protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (205 aa) |
| | GM21_1110 | PFAM: Cupin 2 conserved barrel domain protein; phosphate acetyl/butaryl transferase; KEGG: gbm:Gbem_3151 cupin 2 conserved barrel domain protein. (503 aa) |
| | GM21_1169 | KEGG: gbm:Gbem_3092 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; SMART: phosphoesterase PHP domain protein. (1155 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | GM21_1200 | TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region; KEGG: gbm:Gbem_3050 molybdopterin-guanine dinucleotide biosynthesis protein B. (166 aa) |
| | GM21_1226 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (369 aa) |
| | GM21_1227 | KEGG: gbm:Gbem_3023 riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. (214 aa) |
| | ribBA | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (400 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (145 aa) |
| | GM21_1265 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: gbm:Gbem_2960 glyoxalase/bleomycin resistance protein/dioxygenase. (157 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (240 aa) |
| | GM21_1385 | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (176 aa) |
| | GM21_1409 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (449 aa) |
| | GM21_1411 | PFAM: dihydrofolate reductase region; KEGG: gbm:Gbem_2799 dihydrofolate reductase region. (306 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | GM21_1547 | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (176 aa) |
| | GM21_1557 | RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (333 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (171 aa) |
| | GM21_1584 | KEGG: gbm:Gbem_2650 putative anti-sigma regulatory factor, serine/threonine protein kinase. (141 aa) |
| | GM21_1596 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (278 aa) |
| | dacA | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (252 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (239 aa) |
| | GM21_1627 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; KEGG: gbm:Gbem_2599 riboflavin biosynthesis protein RibF; Belongs to the ribF family. (323 aa) |
| | purC | KEGG: gbm:Gbem_2511 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (296 aa) |
| | GM21_1749 | KEGG: gbm:Gbem_2468 putative anti-sigma regulatory factor, serine/threonine protein kinase. (147 aa) |
| | GM21_1754 | KEGG: gbm:Gbem_2463 dTDP-4-dehydrorhamnose 3 5-epimerase and related enzymes-like protein. (162 aa) |
| | nadK | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (288 aa) |
| | queA | S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (341 aa) |
| | tgt-2 | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (372 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (204 aa) |
| | purM | KEGG: gbm:Gbem_2402 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (348 aa) |
| | pyrK | Oxidoreductase FAD/NAD(P)-binding domain protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (269 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (305 aa) |
| | GM21_1824 | KEGG: gbm:Gbem_2395 BioD-like protein N-terminal domain of phosphotransacetylase-like protein. (363 aa) |
| | GM21_1886 | PFAM: beta-lactamase domain protein; KEGG: gbm:Gbem_2334 beta-lactamase domain protein. (257 aa) |
| | GM21_1887 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: gbm:Gbem_2333 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (996 aa) |
| | GM21_1890 | KEGG: gbm:Gbem_2330 phosphoribosylformylglycinamidine synthase I, putative. (274 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (477 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (182 aa) |
| | GM21_1902 | KEGG: gbm:Gbem_2321 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (276 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (254 aa) |
| | GM21_1911 | PFAM: transport-associated; KEGG: gbm:Gbem_2312 transport-associated. (271 aa) |
| | GM21_1936 | KEGG: gbm:Gbem_2287 nucleotide sugar dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase. (450 aa) |
| | GM21_1937 | PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; polysaccharide biosynthesis protein CapD; KEGG: gbm:Gbem_2286 NAD-dependent epimerase/dehydratase. (311 aa) |
| | ackA-2 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (421 aa) |
| | GM21_1948 | TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: molybdopterin binding domain; KEGG: gbm:Gbem_2275 molybdenum cofactor synthesis domain protein. (165 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (158 aa) |
| | GM21_1950 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (403 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (326 aa) |
| | fdhD | Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the MobA family. (468 aa) |
| | pdhA-2 | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (325 aa) |
| | GM21_2019 | KEGG: gbm:Gbem_2208 hypothetical protein. (375 aa) |
| | GM21_2031 | KEGG: gbm:Gbem_2196 hypothetical protein. (218 aa) |
| | GM21_2067 | TIGRFAM: deoxycytidine triphosphate deaminase; KEGG: gbm:Gbem_2156 deoxycytidine triphosphate deaminase. (172 aa) |
| | GM21_2072 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (409 aa) |
| | GM21_2078 | PFAM: Creatininase; KEGG: gbm:Gbem_2138 creatininase. (239 aa) |
| | GM21_2138 | PFAM: Dinitrogenase iron-molybdenum cofactor biosynthesis protein; KEGG: gbm:Gbem_2080 dinitrogenase iron-molybdenum cofactor biosynthesis protein. (109 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (328 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (239 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (455 aa) |
| | GM21_2239 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: gbm:Gbem_1981 thiamine biosynthesis protein ThiS. (70 aa) |
| | GM21_2240 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: gbm:Gbem_1980 UBA/ThiF-type NAD/FAD binding protein. (270 aa) |
| | GM21_2247 | PFAM: Oxidoreductase FAD-binding domain protein; oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: gbm:Gbem_1970 oxidoreductase FAD-binding domain protein. (283 aa) |
| | GM21_2253 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (484 aa) |
| | GM21_2254 | PFAM: isochorismatase hydrolase; KEGG: gbm:Gbem_1963 isochorismatase hydrolase. (210 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: gbm:Gbem_1960 N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (204 aa) |
| | trpB-2 | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (451 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: gbm:Gbem_1957 indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (266 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (352 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; RimK domain protein ATP-grasp; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: gbm:Gbem_1900 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1082 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; KEGG: gbm:Gbem_1898 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (374 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (425 aa) |
| | pyrB | KEGG: gbm:Gbem_1896 aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (161 aa) |
| | GM21_2336 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (533 aa) |
| | GM21_2372 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; KEGG: glo:Glov_2342 hypothetical protein. (293 aa) |
| | GM21_2391 | RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (325 aa) |
| | GM21_2404 | KEGG: ppd:Ppro_0225 hypothetical protein. (151 aa) |
| | GM21_2438 | PFAM: von Willebrand factor type A; SMART: von Willebrand factor type A; KEGG: gbm:Gbem_1812 von Willebrand factor type A. (315 aa) |
| | GM21_2439 | PFAM: von Willebrand factor type A; SMART: von Willebrand factor type A; KEGG: gbm:Gbem_1811 von Willebrand factor type A. (331 aa) |
| | GM21_2457 | PFAM: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); KEGG: hha:Hhal_0760 EpsP synthase (3-phosphoshikimate 1-carboxyvinyltransferase). (432 aa) |
| | GM21_2461 | PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_1786 radical SAM domain protein. (380 aa) |
| | GM21_2480 | KEGG: gbm:Gbem_1767 PEP-Cterm system TPR-repeat lipoprotein; TIGRFAM: PEP-CTERM system TPR-repeat lipoprotein; PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; SMART: Tetratricopeptide domain protein. (882 aa) |
| | dinB | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (409 aa) |
| | GM21_2538 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility domain; KR domain protein; short-chain dehydrogenase/reductase SDR; KEGG: gbm:Gbem_1683 NAD-dependent epimerase/dehydratase. (373 aa) |
| | GM21_2546 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (411 aa) |
| | mtnP | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (287 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (252 aa) |
| | mobA-2 | Formate dehydrogenase family accessory protein FdhD; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (235 aa) |
| | GM21_2654 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa) |
| | folD-2 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (281 aa) |
| | ribBA-2 | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (400 aa) |
| | fdhD-2 | Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (255 aa) |
| | moaA-2 | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (326 aa) |
| | GM21_2825 | TIGRFAM: benzoate-CoA ligase family; PFAM: AMP-dependent synthetase and ligase; KEGG: gme:Gmet_2143 benzoate-CoA ligase family. (519 aa) |
| | GM21_2831 | TIGRFAM: molybdenum hydroxylase accessory protein, YgfJ family; PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; KEGG: geo:Geob_0102 molybdenum hydroxylase accessory protein, YgfJ family. (216 aa) |
| | GM21_2835 | TIGRFAM: 4-hydroxybenzoyl-CoA reductase, alpha subunit; PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: gme:Gmet_2136 xanthine dehydrogenase, molybdenum binding subunit apoprotein. (797 aa) |
| | GM21_2840 | PFAM: phosphate acetyl/butaryl transferase; KEGG: gme:Gmet_2098 phosphate butyryltransferase. (298 aa) |
| | GM21_2841 | PFAM: thiamineS protein; KEGG: geo:Geob_0270 thiamineS protein. (75 aa) |
| | GM21_2879 | KEGG: gbm:Gbem_1404 hypothetical protein. (287 aa) |
| | GM21_2924 | PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_1360 radical SAM domain protein. (446 aa) |
| | moaA-3 | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (326 aa) |
| | GM21_2934 | PFAM: thiamineS protein; KEGG: gbm:Gbem_1351 thiamineS protein. (74 aa) |
| | GM21_2935 | PFAM: UBA/THIF-type NAD/FAD binding protein; KEGG: gbm:Gbem_1350 UBA/ThiF-type NAD/FAD binding protein. (282 aa) |
| | GM21_2936 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (407 aa) |
| | moaC-2 | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (158 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (251 aa) |
| | GM21_2966 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: gbm:Gbem_1317 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. (122 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (146 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (382 aa) |
| | fdhD-3 | Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (255 aa) |
| | dxs-2 | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (646 aa) |
| | fcl | NAD-dependent epimerase/dehydratase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (324 aa) |
| | GM21_3171 | PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_1091 radical SAM domain protein. (319 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (328 aa) |
| | GM21_3268 | KEGG: gbm:Gbem_0992 hypothetical protein. (75 aa) |
| | GM21_3278 | KEGG: gbm:Gbem_0982 BioD-like protein N-terminal domain of phosphotransacetylase-like protein. (364 aa) |
| | GM21_3287 | KEGG: gbm:Gbem_0973 hypothetical protein. (95 aa) |
| | GM21_3294 | TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: gbm:Gbem_0967 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (191 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (339 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1382 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1371 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (175 aa) |
| | dacA-2 | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (388 aa) |
| | GM21_3390 | RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (515 aa) |
| | hldE | rfaE bifunctional protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (487 aa) |
| | GM21_3403 | PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; short-chain dehydrogenase/reductase SDR; dTDP-4-dehydrorhamnose reductase; KEGG: gbm:Gbem_0861 NAD-dependent epimerase/dehydratase. (336 aa) |
| | bioC | Methyltransferase type 11; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (267 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (389 aa) |
| | GM21_3455 | PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_0807 radical SAM domain protein. (511 aa) |
| | GM21_3459 | Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (319 aa) |
| | nadE-2 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (273 aa) |
| | GM21_3512 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (292 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa) |
| | purD | KEGG: gbm:Gbem_3457 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; ATP-grasp domain protein; Belongs to the GARS family. (423 aa) |
| | purH | KEGG: gbm:Gbem_3458 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region. (520 aa) |
| | thiE-2 | Phosphomethylpyrimidine kinase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (484 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (437 aa) |
| | GM21_3577 | Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (381 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa) |
| | GM21_3603 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: gbm:Gbem_3537 L-threonine-O-3-phosphate decarboxylase. (370 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (319 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (772 aa) |
| | GM21_3606 | PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: gbm:Gbem_3540 cobalamin (vitamin B12) biosynthesis CbiG protein. (347 aa) |
| | GM21_3607 | KEGG: gbm:Gbem_3541 precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (261 aa) |
| | GM21_3608 | KEGG: gbm:Gbem_3542 precorrin-2 C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. (236 aa) |
| | GM21_3609 | KEGG: gbm:Gbem_3543 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Methyltransferase type 12. (405 aa) |
| | cbiD | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (356 aa) |
| | GM21_3611 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: gbm:Gbem_3545 precorrin-8X methylmutase CbiC/CobH. (216 aa) |
| | GM21_3612 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: gbm:Gbem_3546 cobalamin (vitamin B12) biosynthesis CbiX protein. (127 aa) |
| | GM21_3730 | PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: gbm:Gbem_3625 NCAIR mutase (PurE)-related protein-like protein. (251 aa) |
| | GM21_3733 | TIGRFAM: competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; KEGG: gbm:Gbem_3628 competence/damage-inducible protein CinA; Belongs to the CinA family. (414 aa) |
| | folE2 | Protein of unknown function DUF198; Converts GTP to 7,8-dihydroneopterin triphosphate. (267 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (225 aa) |
| | rpoD | RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (584 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (582 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (421 aa) |
| | thyX | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (229 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (415 aa) |
| | GM21_3811 | KEGG: gbm:Gbem_3716 hypothetical protein. (238 aa) |
| | GM21_3820 | PFAM: Radical SAM domain protein; Methyltransferase type 11; KEGG: met:M446_4900 radical SAM domain-containing protein. (515 aa) |
| | GM21_3848 | TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 4 domain protein; sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: gbm:Gbem_3764 RNA polymerase, sigma 28 subunit, FliA/WhiG. (250 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (216 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (373 aa) |
| | selA | L-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (468 aa) |
| | GM21_3890 | TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; KEGG: gbm:Gbem_3806 cobalt ABC transporter, inner membrane subunit CbiQ. (254 aa) |
| | cbiM | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (256 aa) |
| | GM21_3893 | TIGRFAM: thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC; KEGG: gbm:Gbem_3809 thiamine biosynthesis protein ThiC. (435 aa) |
| | cbiA | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (460 aa) |
| | cobS | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (251 aa) |
| | cobT | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (349 aa) |
| | GM21_3898 | Adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (174 aa) |
| | GM21_3919 | ATPase, FliI/YscN family; KEGG: gbm:Gbem_3835 flagellar protein export ATPase FliI; TIGRFAM: ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase. (434 aa) |
| | GM21_3931 | PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein; KEGG: gbm:Gbem_3847 rhodanese domain protein. (129 aa) |
| | GM21_3932 | PFAM: beta-lactamase domain protein; KEGG: gbm:Gbem_3848 beta-lactamase domain protein. (276 aa) |
| | GM21_3934 | TIGRFAM: C_GCAxxG_C_C family protein; KEGG: gbm:Gbem_3850 C_GCAxxG_C_C family protein. (142 aa) |
| | hemL | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: gbm:Gbem_3927 glutamate-1-semialdehyde-2,1-aminomutase. (427 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (229 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (91 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (138 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (470 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (502 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (180 aa) |
| | atpF | H+transporting two-sector ATPase B/B' subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (199 aa) |
| | atpF-2 | H+transporting two-sector ATPase B/B' subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (141 aa) |
| | GM21_4070 | PFAM: purine or other phosphorylase family 1; KEGG: mno:Mnod_2731 purine or other phosphorylase family 1. (265 aa) |
| | GM21_4112 | PFAM: glycosyl transferase group 1; KEGG: gbm:Gbem_4021 glycosyl transferase group 1. (385 aa) |
| | GM21_4138 | KEGG: gbm:Gbem_4048 cobyrinic acid a,c-diamide synthase family protein. (370 aa) |
