STRINGSTRING
GM21_0053 GM21_0053 GM21_0065 GM21_0065 GM21_0224 GM21_0224 prmA prmA GM21_0262 GM21_0262 GM21_0301 GM21_0301 GM21_0405 GM21_0405 GM21_0409 GM21_0409 GM21_0427 GM21_0427 GM21_0494 GM21_0494 rsmH rsmH GM21_0535 GM21_0535 GM21_0560 GM21_0560 GM21_0592 GM21_0592 GM21_0627 GM21_0627 GM21_0640 GM21_0640 GM21_0762 GM21_0762 GM21_0772 GM21_0772 GM21_0788 GM21_0788 GM21_0887 GM21_0887 GM21_0908 GM21_0908 trmL trmL GM21_0942 GM21_0942 GM21_1162 GM21_1162 GM21_1217 GM21_1217 GM21_1278 GM21_1278 GM21_1332 GM21_1332 GM21_1336 GM21_1336 GM21_1338 GM21_1338 GM21_1358 GM21_1358 GM21_1399 GM21_1399 GM21_1418 GM21_1418 trmB trmB trmFO trmFO GM21_1538 GM21_1538 trmJ trmJ pcm pcm GM21_1580 GM21_1580 GM21_1612 GM21_1612 GM21_1619 GM21_1619 GM21_1652 GM21_1652 GM21_1674 GM21_1674 GM21_1681 GM21_1681 GM21_1720 GM21_1720 GM21_1839 GM21_1839 GM21_1842 GM21_1842 GM21_1893 GM21_1893 rsmA rsmA GM21_1965 GM21_1965 GM21_2031 GM21_2031 GM21_2158 GM21_2158 GM21_2173 GM21_2173 GM21_2189 GM21_2189 GM21_2317 GM21_2317 GM21_2362 GM21_2362 rlmN rlmN GM21_2601 GM21_2601 GM21_2618 GM21_2618 GM21_2631 GM21_2631 GM21_2684 GM21_2684 GM21_2797 GM21_2797 GM21_2870 GM21_2870 GM21_3077 GM21_3077 GM21_3218 GM21_3218 GM21_3234 GM21_3234 pcm-2 pcm-2 GM21_3279 GM21_3279 GM21_3346 GM21_3346 ubiE ubiE GM21_3368 GM21_3368 bioC bioC rsmI rsmI GM21_3489 GM21_3489 trmD trmD GM21_3500 GM21_3500 GM21_3534 GM21_3534 GM21_3535 GM21_3535 GM21_3555 GM21_3555 GM21_3556 GM21_3556 GM21_3594 GM21_3594 GM21_3607 GM21_3607 GM21_3608 GM21_3608 GM21_3609 GM21_3609 cbiD cbiD prmC prmC GM21_3805 GM21_3805 thyX thyX rlmH rlmH GM21_3939 GM21_3939 GM21_4027 GM21_4027 GM21_4072 GM21_4072 GM21_4073 GM21_4073 rsmG rsmG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GM21_0053PFAM: protein of unknown function DUF323; Methyltransferase type 11; Methyltransferase type 12; KEGG: gbm:Gbem_0055 protein of unknown function DUF323. (701 aa)
GM21_0065PFAM: thiamine biosynthesis protein; KEGG: gbm:Gbem_0082 thiamine biosynthesis protein. (334 aa)
GM21_0224Protein of unknown function DUF558; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (246 aa)
prmARibosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (306 aa)
GM21_0262PFAM: homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; dihydropteroate synthase DHPS; KEGG: gbm:Gbem_0277 homocysteine S-methyltransferase. (813 aa)
GM21_0301PFAM: Radical SAM domain protein; KEGG: dat:HRM2_05160 putative methyltransferase. (537 aa)
GM21_0405TIGRFAM: siroheme synthase; KEGG: gbm:Gbem_0405 siroheme synthase. (224 aa)
GM21_0409TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: gbm:Gbem_0409 uroporphyrin-III C-methyltransferase. (511 aa)
GM21_0427TIGRFAM: type I restriction-modification system, M subunit; PFAM: N-6 DNA methylase; KEGG: dno:DNO_0223 type I restriction-modification system, M subunit. (827 aa)
GM21_0494PFAM: putative RNA methylase; THUMP domain protein; KEGG: gbm:Gbem_0477 putative RNA methylase; Belongs to the methyltransferase superfamily. (376 aa)
rsmHS-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (312 aa)
GM21_0535KEGG: gbm:Gbem_0519 hypothetical protein. (239 aa)
GM21_0560PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: gbm:Gbem_0548 radical SAM domain protein. (557 aa)
GM21_0592PFAM: protein of unknown function UPF0153; KEGG: gbm:Gbem_0579 protein of unknown function UPF0153. (76 aa)
GM21_0627PFAM: homocysteine S-methyltransferase; methylenetetrahydrofolate reductase; KEGG: gbm:Gbem_0613 homocysteine S-methyltransferase. (610 aa)
GM21_0640KEGG: gbm:Gbem_0626 MCP methyltransferase, CheR-type; PFAM: MCP methyltransferase CheR-type; SMART: MCP methyltransferase CheR-type. (277 aa)
GM21_0762MCP methyltransferase, CheR-type; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (288 aa)
GM21_0772PFAM: Methyltransferase type 11; Tellurite resistance methyltransferase, TehB, core; Methyltransferase type 12; KEGG: gbm:Gbem_0757 methyltransferase type 11. (209 aa)
GM21_0788Hypothetical protein; KEGG: mfa:Mfla_1177 XRE family transcriptional regulator. (93 aa)
GM21_0887PFAM: putative rRNA methylase; Methyltransferase type 12; KEGG: gbm:Gbem_3358 putative rRNA methylase. (195 aa)
GM21_0908KEGG: gbm:Gbem_3338 methylated-DNA--protein-cysteine methyltransferase; TIGRFAM: methylated-DNA/protein-cysteine methyltransferase; PFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding. (194 aa)
trmLtRNA/rRNA methyltransferase (SpoU); Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. (158 aa)
GM21_0942PFAM: Methyltransferase type 11; Methionine biosynthesis MetW protein; Methyltransferase type 12; KEGG: gbm:Gbem_3306 methyltransferase type 11. (249 aa)
GM21_1162PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: gbm:Gbem_3100 radical SAM domain protein. (295 aa)
GM21_1217KEGG: gbm:Gbem_3034 hypothetical protein. (177 aa)
GM21_1278PFAM: MCP methyltransferase CheR-type; SMART: MCP methyltransferase CheR-type; KEGG: gbm:Gbem_2943 MCP methyltransferase, CheR-type. (202 aa)
GM21_1332TIGRFAM: RNA methyltransferase, TrmA family; PFAM: (Uracil-5)-methyltransferase; KEGG: gbm:Gbem_2893 RNA methyltransferase, TrmA family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (447 aa)
GM21_1336TIGRFAM: RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; KEGG: gbm:Gbem_2889 RNA methyltransferase, TrmH family, group 3; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (249 aa)
GM21_1338PFAM: protein of unknown function UPF0066; KEGG: gbm:Gbem_2886 protein of unknown function UPF0066. (172 aa)
GM21_1358PFAM: protein of unknown function UPF0153; KEGG: gbm:Gbem_2855 protein of unknown function UPF0153. (225 aa)
GM21_1399PFAM: protein of unknown function UPF0153; KEGG: gbm:Gbem_2811 protein of unknown function UPF0153. (169 aa)
GM21_1418PFAM: protein of unknown function DUF185; KEGG: gbm:Gbem_2793 protein of unknown function DUF185. (385 aa)
trmBtRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (207 aa)
trmFOGid protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. (435 aa)
GM21_1538KEGG: gbm:Gbem_2702 SAM-dependent methyltransferase-like protein. (399 aa)
trmJRNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (245 aa)
pcmprotein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (206 aa)
GM21_1580Hemolysin A; KEGG: gbm:Gbem_2654 hemolysin A; TIGRFAM: hemolysin A; PFAM: RNA-binding S4 domain protein; ribosomal RNA methyltransferase RrmJ/FtsJ; SMART: RNA-binding S4 domain protein. (257 aa)
GM21_1612PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: gbm:Gbem_2617 methyltransferase type 11. (233 aa)
GM21_1619PFAM: GCN5-related N-acetyltransferase; KEGG: gbm:Gbem_2610 GCN5-related N-acetyltransferase. (162 aa)
GM21_1652PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: methylase. (279 aa)
GM21_1674PFAM: protein of unknown function DUF559; KEGG: gbm:Gbem_3620 protein of unknown function DUF559. (133 aa)
GM21_1681PFAM: protein of unknown function DUF559; KEGG: gur:Gura_1188 hypothetical protein. (117 aa)
GM21_1720KEGG: gbm:Gbem_2497 MCP methyltransferase, CheR-type; PFAM: MCP methyltransferase CheR-type; SMART: MCP methyltransferase CheR-type. (278 aa)
GM21_1839KEGG: gbm:Gbem_2379 MCP methyltransferase, CheR-type with Tpr repeats; PFAM: MCP methyltransferase CheR-type; TPR repeat-containing protein; Tetratricopeptide TPR_4; response regulator receiver; Tetratricopeptide TPR_2 repeat protein; SMART: MCP methyltransferase CheR-type; response regulator receiver; Tetratricopeptide domain protein. (611 aa)
GM21_1842PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: gbm:Gbem_2377 methyltransferase type 11. (190 aa)
GM21_1893PFAM: protein of unknown function UPF0153; KEGG: gbm:Gbem_2327 hypothetical protein. (229 aa)
rsmADimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (275 aa)
GM21_1965PFAM: protein of unknown function DUF488; KEGG: gbm:Gbem_2259 protein of unknown function DUF488. (117 aa)
GM21_2031KEGG: gbm:Gbem_2196 hypothetical protein. (218 aa)
GM21_2158KEGG: gbm:Gbem_2058 RNA methyltransferase, TrmA family; TIGRFAM: RNA methyltransferase, TrmA family; PFAM: (Uracil-5)-methyltransferase; deoxyribonuclease/rho motif-related TRAM; methyltransferase small; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (438 aa)
GM21_2173PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: gbm:Gbem_2045 methyltransferase type 11. (267 aa)
GM21_2189KEGG: gbm:Gbem_2030 MCP methyltransferase, CheR-type with Tpr repeats; PFAM: MCP methyltransferase CheR-type; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: MCP methyltransferase CheR-type; Tetratricopeptide domain protein. (481 aa)
GM21_2317TIGRFAM: methyltransferase; PFAM: Protein of unknown function methylase putative; putative RNA methylase; KEGG: gbm:Gbem_1892 methyltransferase. (193 aa)
GM21_2362MCP methyltransferase, CheR-type; KEGG: pzu:PHZ_c0691 chemotaxis protein methyltransferase CheR; PFAM: MCP methyltransferase CheR-type; SMART: MCP methyltransferase CheR-type; Tetratricopeptide domain protein. (478 aa)
rlmNRadical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (351 aa)
GM21_2601KEGG: spl:Spea_3274 hypothetical protein. (469 aa)
GM21_2618MCP methyltransferase, CheR-type; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (292 aa)
GM21_2631TIGRFAM: methyltransferase; KEGG: gbm:Gbem_1582 hypothetical protein. (354 aa)
GM21_2684Prepilin peptidase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (274 aa)
GM21_2797PFAM: Methyltransferase type 11; UbiE/COQ5 methyltransferase; Methyltransferase type 12; KEGG: gbm:Gbem_1456 methyltransferase type 11. (286 aa)
GM21_2870PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: gbm:Gbem_1410 radical SAM domain protein. (373 aa)
GM21_3077KEGG: plu:plu2710 hypothetical protein. (562 aa)
GM21_3218MCP methyltransferase, CheR-type; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (295 aa)
GM21_3234PFAM: Methyltransferase type 11; UbiE/COQ5 methyltransferase; Methyltransferase type 12; KEGG: gbm:Gbem_1026 methyltransferase type 11. (235 aa)
pcm-2protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (219 aa)
GM21_3279PFAM: protein of unknown function DUF512; KEGG: gbm:Gbem_0981 protein of unknown function DUF512. (432 aa)
GM21_3346PFAM: Radical SAM domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: gbm:Gbem_0915 radical SAM domain protein. (598 aa)
ubiEUbiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (235 aa)
GM21_3368PFAM: Methyltransferase type 12; Methyltransferase type 11; Tellurite resistance methyltransferase, TehB, core; thiopurine S-methyltransferase; KEGG: gbm:Gbem_0893 methyltransferase type 12. (190 aa)
bioCMethyltransferase type 11; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (267 aa)
rsmIUroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (276 aa)
GM21_3489KEGG: gbm:Gbem_3427 uncharacterized protein-like protein. (189 aa)
trmDtRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (249 aa)
GM21_3500PFAM: methyltransferase small; putative RNA methylase; KEGG: gbm:Gbem_3437 methyltransferase small; Belongs to the methyltransferase superfamily. (266 aa)
GM21_3534KEGG: gbm:Gbem_1164 hypothetical protein. (493 aa)
GM21_3535PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: gbm:Gbem_1163 radical SAM domain protein. (444 aa)
GM21_3555PFAM: Radical SAM domain protein; cobalamin B12-binding domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: geo:Geob_0058 radical SAM domain protein. (448 aa)
GM21_3556PFAM: Radical SAM domain protein; cobalamin B12-binding domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: geo:Geob_0058 radical SAM domain protein. (450 aa)
GM21_3594Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (448 aa)
GM21_3607KEGG: gbm:Gbem_3541 precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (261 aa)
GM21_3608KEGG: gbm:Gbem_3542 precorrin-2 C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. (236 aa)
GM21_3609KEGG: gbm:Gbem_3543 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Methyltransferase type 12. (405 aa)
cbiDCobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (356 aa)
prmCModification methylase, HemK family; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (285 aa)
GM21_3805PFAM: protein of unknown function DUF1385; KEGG: gbm:Gbem_3710 protein of unknown function DUF1385. (301 aa)
thyXThymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (229 aa)
rlmHProtein of unknown function DUF163; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (154 aa)
GM21_3939PFAM: Methyltransferase type 12; Methyltransferase type 11; KEGG: gbm:Gbem_3855 methyltransferase type 12. (249 aa)
GM21_4027MCP methyltransferase, CheR-type; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (290 aa)
GM21_4072PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: gur:Gura_3310 methyltransferase type 11. (192 aa)
GM21_4073PFAM: Methyltransferase type 11; UbiE/COQ5 methyltransferase; Methyltransferase type 12; KEGG: ppd:Ppro_1936 methyltransferase type 11. (208 aa)
rsmGMethyltransferase GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (217 aa)
Your Current Organism:
Geobacter sp. M21
NCBI taxonomy Id: 443144
Other names: G. sp. M21
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.