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| | GM21_2078 | PFAM: Creatininase; KEGG: gbm:Gbem_2138 creatininase. (239 aa) |
| | GM21_2112 | TIGRFAM: PfaD family protein; KEGG: gbm:Gbem_2106 PfaD family protein. (554 aa) |
| | GM21_2114 | PFAM: Beta-ketoacyl synthase; Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; KEGG: gbm:Gbem_2104 beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (2391 aa) |
| | dxs-2 | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (646 aa) |
| | acpS | Holo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (125 aa) |
| | GM21_3019 | KEGG: gbm:Gbem_1264 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (405 aa) |
| | GM21_3018 | KEGG: gbm:Gbem_1265 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: LeuA allosteric (dimerisation) domain; pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (528 aa) |
| | GM21_2985 | KEGG: gbm:Gbem_1298 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (458 aa) |
| | GM21_2966 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: gbm:Gbem_1317 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. (122 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (251 aa) |
| | GM21_2924 | PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_1360 radical SAM domain protein. (446 aa) |
| | tal-2 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (374 aa) |
| | GM21_2858 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (322 aa) |
| | GM21_2835 | TIGRFAM: 4-hydroxybenzoyl-CoA reductase, alpha subunit; PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: gme:Gmet_2136 xanthine dehydrogenase, molybdenum binding subunit apoprotein. (797 aa) |
| | GM21_2821 | PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; NAD-dependent epimerase/dehydratase; KEGG: gbm:Gbem_1433 short-chain dehydrogenase/reductase SDR. (237 aa) |
| | GM21_2800 | PFAM: carboxyl transferase; KEGG: gbm:Gbem_1453 carboxyl transferase. (585 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa) |
| | GM21_3180 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II; KEGG: gbm:Gbem_1081 asparagine synthase (glutamine-hydrolyzing). (660 aa) |
| | GM21_3177 | KEGG: gbm:Gbem_1084 hypothetical protein. (100 aa) |
| | GM21_3171 | PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_1091 radical SAM domain protein. (319 aa) |
| | GM21_3130 | PFAM: dihydrodipicolinate reductase; KEGG: ppd:Ppro_3262 dihydrodipicolinate reductase; Belongs to the DapB family. (254 aa) |
| | GM21_3127 | KEGG: ppd:Ppro_1080 GCN5-related N-acetyltransferase. (306 aa) |
| | GM21_3083 | PFAM: major royal jelly protein; KEGG: gbm:Gbem_1195 hypothetical protein. (396 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (417 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (267 aa) |
| | dapL | Aminotransferase class I and II; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (411 aa) |
| | fabH-2 | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (326 aa) |
| | GM21_3939 | PFAM: Methyltransferase type 12; Methyltransferase type 11; KEGG: gbm:Gbem_3855 methyltransferase type 12. (249 aa) |
| | GM21_3934 | TIGRFAM: C_GCAxxG_C_C family protein; KEGG: gbm:Gbem_3850 C_GCAxxG_C_C family protein. (142 aa) |
| | GM21_3932 | PFAM: beta-lactamase domain protein; KEGG: gbm:Gbem_3848 beta-lactamase domain protein. (276 aa) |
| | GM21_3898 | Adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (174 aa) |
| | cobT | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (349 aa) |
| | cobS | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (251 aa) |
| | cbiA | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (460 aa) |
| | GM21_3893 | TIGRFAM: thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC; KEGG: gbm:Gbem_3809 thiamine biosynthesis protein ThiC. (435 aa) |
| | cbiM | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (256 aa) |
| | GM21_3890 | TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; KEGG: gbm:Gbem_3806 cobalt ABC transporter, inner membrane subunit CbiQ. (254 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (373 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | GM21_3820 | PFAM: Radical SAM domain protein; Methyltransferase type 11; KEGG: met:M446_4900 radical SAM domain-containing protein. (515 aa) |
| | hisG-2 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (212 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (429 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: gbm:Gbem_3703 imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (207 aa) |
| | hisA | KEGG: gbm:Gbem_3701 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. (243 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisE | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: gbm:Gbem_3699 phosphoribosyl-ATP diphosphatase. (109 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (225 aa) |
| | GM21_3784 | TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; KEGG: gbm:Gbem_3689 threonine dehydratase. (402 aa) |
| | mtnA | Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (346 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: gbm:Gbem_3641 argininosuccinate lyase. (458 aa) |
| | argG | KEGG: gbm:Gbem_3638 argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | GM21_3742 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (303 aa) |
| | argD | KEGG: gbm:Gbem_3636 acetylornithine and succinylornithine aminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (397 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (292 aa) |
| | GM21_3729 | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: pca:Pcar_1364 putative glucose/ribitol dehydrogenase. (249 aa) |
| | GM21_3627 | PFAM: NAD-dependent epimerase/dehydratase; NmrA family protein; Male sterility domain; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; KEGG: gbm:Gbem_3561 NAD-dependent epimerase/dehydratase. (295 aa) |
| | GM21_3611 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: gbm:Gbem_3545 precorrin-8X methylmutase CbiC/CobH. (216 aa) |
| | cbiD | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (356 aa) |
| | GM21_3609 | KEGG: gbm:Gbem_3543 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Methyltransferase type 12. (405 aa) |
| | GM21_3608 | KEGG: gbm:Gbem_3542 precorrin-2 C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. (236 aa) |
| | GM21_3607 | KEGG: gbm:Gbem_3541 precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (261 aa) |
| | GM21_3606 | PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: gbm:Gbem_3540 cobalamin (vitamin B12) biosynthesis CbiG protein. (347 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (772 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (319 aa) |
| | GM21_3603 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II; KEGG: gbm:Gbem_3537 L-threonine-O-3-phosphate decarboxylase. (370 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa) |
| | gpmA | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (234 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (437 aa) |
| | thiE-2 | Phosphomethylpyrimidine kinase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (484 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (379 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (343 aa) |
| | GM21_3525 | KEGG: gbm:Gbem_3459 uncharacterized metal-binding protein-like protein. (417 aa) |
| | pgi | PFAM: phosphoglucose isomerase (PGI); KEGG: gbm:Gbem_3417 phosphoglucose isomerase (PGI); Belongs to the GPI family. (530 aa) |
| | GM21_3455 | PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_0807 radical SAM domain protein. (511 aa) |
| | aroC-2 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (360 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (389 aa) |
| | bioC | Methyltransferase type 11; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (267 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (144 aa) |
| | GM21_3383 | PFAM: purine or other phosphorylase family 1; KEGG: gbm:Gbem_0877 purine or other phosphorylase family 1. (255 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (235 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (362 aa) |
| | asd-2 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (365 aa) |
| | GM21_0014 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: gbm:Gbem_0015 radical SAM domain protein. (358 aa) |
| | GM21_0048 | KEGG: gbm:Gbem_0049 pyridoxal phosphate-dependent acyltransferase; TIGRFAM: pyridoxal phosphate-dependent acyltransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; aromatic amino acid beta-eliminating lyase/threonine aldolase. (396 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (348 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (422 aa) |
| | GM21_0112 | KEGG: gbm:Gbem_0131 hypothetical protein. (145 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (201 aa) |
| | GM21_0215 | TIGRFAM: UbiD family decarboxylase; PFAM: Carboxylyase-related protein; KEGG: gbm:Gbem_0231 UbiD family decarboxylase; Belongs to the UbiD family. (448 aa) |
| | GM21_0216 | TIGRFAM: 4-hydroxybenzoate polyprenyltransferase; PFAM: UbiA prenyltransferase; KEGG: gbm:Gbem_0232 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. (289 aa) |
| | mqnE | Radical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (358 aa) |
| | mqnC | Radical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (357 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: gbm:Gbem_0236 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (350 aa) |
| | GM21_0243 | KEGG: gbm:Gbem_0258 iron-sulfur cluster-binding protein. (275 aa) |
| | GM21_0256 | PFAM: nitrite and sulphite reductase 4Fe-4S region; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; KEGG: gbm:Gbem_0271 nitrite and sulphite reductase 4Fe-4S region. (426 aa) |
| | GM21_0258 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1148 aa) |
| | GM21_0262 | PFAM: homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; dihydropteroate synthase DHPS; KEGG: gbm:Gbem_0277 homocysteine S-methyltransferase. (813 aa) |
| | GM21_0317 | PFAM: carboxyl transferase; KEGG: gbm:Gbem_0335 carboxyl transferase. (514 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (376 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa) |
| | GM21_0354 | PFAM: NAD-dependent epimerase/dehydratase; NmrA family protein; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility domain; dTDP-4-dehydrorhamnose reductase; KEGG: gbm:Gbem_0374 NAD-dependent epimerase/dehydratase. (310 aa) |
| | GM21_0358 | PFAM: pyridoxamine 5'-phosphate oxidase-related FMN-binding; KEGG: gur:Gura_3514 pyridoxamine 5'-phosphate oxidase-related, FMN-binding. (134 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (291 aa) |
| | GM21_0405 | TIGRFAM: siroheme synthase; KEGG: gbm:Gbem_0405 siroheme synthase. (224 aa) |
| | GM21_0457 | PFAM: ABC-1 domain protein; KEGG: gbm:Gbem_0438 ABC-1 domain protein. (475 aa) |
| | GM21_0554 | PFAM: phosphoribosyltransferase; KEGG: gbm:Gbem_0541 phosphoribosyltransferase. (183 aa) |
| | GM21_0559 | KEGG: gbm:Gbem_0547 acyl carrier protein. (85 aa) |
| | hisZ | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (440 aa) |
| | GM21_0575 | Propionyl-CoA carboxylase; PFAM: carboxyl transferase; KEGG: gbm:Gbem_0562 carboxyl transferase. (574 aa) |
| | GM21_0585 | KEGG: gbm:Gbem_0572 branched-chain amino acid aminotransferase; TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. (356 aa) |
| | mqnB | Purine or other phosphorylase family 1; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (242 aa) |
| | mqnD | Protein of unknown function DUF191; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (288 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (323 aa) |
| | GM21_0622 | KEGG: gbm:Gbem_0608 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. (162 aa) |
| | GM21_0627 | PFAM: homocysteine S-methyltransferase; methylenetetrahydrofolate reductase; KEGG: gbm:Gbem_0613 homocysteine S-methyltransferase. (610 aa) |
| | GM21_0628 | PFAM: nitrite and sulphite reductase 4Fe-4S region; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; KEGG: gbm:Gbem_0614 nitrite and sulphite reductase 4Fe-4S region. (234 aa) |
| | GM21_0643 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: gbm:Gbem_0629 glyoxalase/bleomycin resistance protein/dioxygenase. (117 aa) |
| | GM21_0657 | KEGG: gbm:Gbem_0644 pyruvate, phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; PEP-utilizing protein; Belongs to the PEP-utilizing enzyme family. (914 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa) |
| | thiG | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (260 aa) |
| | GM21_0667 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: gbm:Gbem_0654 thiamine biosynthesis protein ThiS. (75 aa) |
| | GM21_0732 | KEGG: gbm:Gbem_0719 hypothetical protein. (89 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (125 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (290 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (529 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (647 aa) |
| | GM21_0772 | PFAM: Methyltransferase type 11; Tellurite resistance methyltransferase, TehB, core; Methyltransferase type 12; KEGG: gbm:Gbem_0757 methyltransferase type 11. (209 aa) |
| | GM21_0783 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: gbm:Gbem_0766 HAD-superfamily hydrolase, subfamily IA, variant 1. (222 aa) |
| | GM21_0839 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (307 aa) |
| | GM21_0860 | PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_3386 radical SAM domain protein. (441 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa) |
| | GM21_0882 | TIGRFAM: hopanoid biosynthesis associated radical SAM protein HpnH; PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_3363 hopanoid biosynthesis associated radical SAM protein HpnH. (332 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (635 aa) |
| | queH | Protein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (176 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (282 aa) |
| | GM21_0897 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; KEGG: gbm:Gbem_3348 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (424 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (368 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | GM21_0935 | TIGRFAM: NAD(P)H quinone oxidoreductase, PIG3 family; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: gbm:Gbem_3311 NAD(P)H quinone oxidoreductase, PIG3 family. (329 aa) |
| | GM21_0946 | PFAM: methylenetetrahydrofolate reductase; KEGG: gbm:Gbem_3302 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (291 aa) |
| | GM21_0990 | TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; Chorismate mutase; KEGG: gbm:Gbem_3260 chorismate mutase. (359 aa) |
| | GM21_0991 | PFAM: Prephenate dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: gbm:Gbem_3259 prephenate dehydrogenase. (286 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (429 aa) |
| | GM21_1023 | KEGG: gbm:Gbem_3238 bifunctional deaminase-reductase domain protein. (186 aa) |
| | GM21_1028 | PFAM: pyridoxamine 5'-phosphate oxidase-related FMN-binding; KEGG: gbm:Gbem_3237 pyridoxamine 5'-phosphate oxidase-related FMN-binding. (144 aa) |
| | GM21_1085 | PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: gbm:Gbem_3178 peptidase M20. (403 aa) |
| | GM21_1096 | TIGRFAM: cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: gbm:Gbem_3163 cysteine synthase. (299 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (352 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (326 aa) |
| | GM21_1155 | TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: gbm:Gbem_3107 malonyl CoA-acyl carrier protein transacylase. (311 aa) |
| | GM21_1156 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (77 aa) |
| | GM21_1158 | 3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (410 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | GM21_1168 | SMART: zinc finger CDGSH-type domain protein; KEGG: gbm:Gbem_3093 zinc finger CDGSH-type domain protein. (77 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | GM21_1184 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: gbm:Gbem_3077 glutamine synthetase, type I. (470 aa) |
| | GM21_1219 | KEGG: gbm:Gbem_3032 hypothetical protein. (247 aa) |
| | GM21_1226 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (369 aa) |
| | GM21_1227 | KEGG: gbm:Gbem_3023 riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. (214 aa) |
| | ribBA | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (400 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa) |
| | GM21_1231 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: gbm:Gbem_3019 homoserine dehydrogenase. (436 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (289 aa) |
| | panC | Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (279 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (134 aa) |
| | GM21_1265 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: gbm:Gbem_2960 glyoxalase/bleomycin resistance protein/dioxygenase. (157 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa) |
| | GM21_1349 | TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: gbm:Gbem_2867 glutamate synthase, NADH/NADPH, small subunit. (493 aa) |
| | GM21_1350 | PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; KEGG: gbm:Gbem_2866 ferredoxin-dependent glutamate synthase. (1527 aa) |
| | GM21_1355 | PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: gbm:Gbem_2859 Orn/DAP/Arg decarboxylase 2. (421 aa) |
| | GM21_1385 | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (176 aa) |
| | GM21_1396 | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: gbm:Gbem_2814 short-chain dehydrogenase/reductase SDR. (256 aa) |
| | GM21_1408 | KEGG: gbm:Gbem_2802 hypothetical protein. (427 aa) |
| | GM21_1411 | PFAM: dihydrofolate reductase region; KEGG: gbm:Gbem_2799 dihydrofolate reductase region. (306 aa) |
| | GM21_1483 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (490 aa) |
| | GM21_1489 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (249 aa) |
| | ilvD | KEGG: gbm:Gbem_2747 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | GM21_1496 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: gbm:Gbem_2745 acetolactate synthase, small subunit. (163 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa) |
| | leuC | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (427 aa) |
| | GM21_1505 | PFAM: aconitate hydratase domain protein; KEGG: gbm:Gbem_2736 aconitate hydratase domain protein; Belongs to the LeuD family. (175 aa) |
| | GM21_1517 | KEGG: gbm:Gbem_2723 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase class II. (450 aa) |
| | GM21_1547 | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (176 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (171 aa) |
| | GM21_1579 | TIGRFAM: UbiD family decarboxylase; PFAM: Carboxylyase-related protein; KEGG: gbm:Gbem_2656 carboxylyase-related protein; Belongs to the UbiD family. (613 aa) |
| | GM21_1596 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (278 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (239 aa) |
| | GM21_1619 | PFAM: GCN5-related N-acetyltransferase; KEGG: gbm:Gbem_2610 GCN5-related N-acetyltransferase. (162 aa) |
| | GM21_1627 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; KEGG: gbm:Gbem_2599 riboflavin biosynthesis protein RibF; Belongs to the ribF family. (323 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa) |
| | GM21_1642 | PFAM: UbiA prenyltransferase; KEGG: gbm:Gbem_2584 UbiA prenyltransferase; Belongs to the UbiA prenyltransferase family. (280 aa) |
| | GM21_1652 | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: methylase. (279 aa) |
| | GM21_1774 | PFAM: GCN5-related N-acetyltransferase; KEGG: gbm:Gbem_2443 GCN5-related N-acetyltransferase; Belongs to the acetyltransferase family. (149 aa) |
| | queA | S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (341 aa) |
| | tgt-2 | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (372 aa) |
| | GM21_1806 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1004 aa) |
| | fbp | Fructose-bisphosphatase; PFAM: Inositol phosphatase/fructose-16-bisphosphatase; KEGG: gbm:Gbem_2410 inositol phosphatase/fructose-16-bisphosphatase. (326 aa) |
| | GM21_1871 | PFAM: Ferritin Dps family protein; KEGG: gbm:Gbem_0131 hypothetical protein. (148 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | GM21_1886 | PFAM: beta-lactamase domain protein; KEGG: gbm:Gbem_2334 beta-lactamase domain protein. (257 aa) |
| | GM21_1896 | PFAM: membrane bound O-acyl transferase MBOAT family protein; KEGG: sfu:Sfum_0781 membrane bound O-acyl transferase, MBOAT family protein; Belongs to the membrane-bound acyltransferase family. (472 aa) |
| | GM21_1936 | KEGG: gbm:Gbem_2287 nucleotide sugar dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase. (450 aa) |
| | GM21_2031 | KEGG: gbm:Gbem_2196 hypothetical protein. (218 aa) |
| | GM21_2115 | PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; KEGG: gbm:Gbem_2102 3-oxoacyl-(acyl-carrier-protein (ACP)) synthase III domain protein. (347 aa) |
| | GM21_2138 | PFAM: Dinitrogenase iron-molybdenum cofactor biosynthesis protein; KEGG: gbm:Gbem_2080 dinitrogenase iron-molybdenum cofactor biosynthesis protein. (109 aa) |
| | GM21_2146 | TIGRFAM: homocitrate synthase; PFAM: pyruvate carboxyltransferase; KEGG: gbm:Gbem_2073 homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (382 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (328 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (239 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (455 aa) |
| | GM21_2173 | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: gbm:Gbem_2045 methyltransferase type 11. (267 aa) |
| | GM21_2184 | PFAM: protein of unknown function DUF479; KEGG: gbm:Gbem_2033 protein of unknown function DUF479. (196 aa) |
| | ribBA-2 | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (400 aa) |
| | folD-2 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (281 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (391 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (393 aa) |
| | aroK-2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (170 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (362 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa) |
| | GM21_2655 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (157 aa) |
| | GM21_2654 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa) |
| | mqnA | Protein of unknown function DUF178; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (273 aa) |
| | kdsA | TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: gbm:Gbem_1601 2-dehydro-3-deoxyphosphooctonate aldolase. (273 aa) |
| | GM21_2569 | TIGRFAM: serine O-acetyltransferase; KEGG: gbm:Gbem_1644 serine O-acetyltransferase. (222 aa) |
| | mtnP | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (287 aa) |
| | GM21_2469 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II; KEGG: gbm:Gbem_1778 asparagine synthase (glutamine-hydrolyzing). (629 aa) |
| | GM21_2468 | KEGG: gbm:Gbem_1779 transferase hexapeptide repeat containing protein. (175 aa) |
| | GM21_2461 | PFAM: Radical SAM domain protein; KEGG: gbm:Gbem_1786 radical SAM domain protein. (380 aa) |
| | GM21_2434 | PFAM: 3-dehydroquinate synthase; KEGG: gbm:Gbem_1816 3-dehydroquinate synthase. (402 aa) |
| | GM21_2426 | PFAM: UbiA prenyltransferase; KEGG: gbm:Gbem_1824 UbiA prenyltransferase. (250 aa) |
| | GM21_2404 | KEGG: ppd:Ppro_0225 hypothetical protein. (151 aa) |
| | GM21_2335 | PFAM: Chorismate mutase; KEGG: gbm:Gbem_1875 chorismate mutase. (91 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; KEGG: gbm:Gbem_1898 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (374 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; RimK domain protein ATP-grasp; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: gbm:Gbem_1900 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1082 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (352 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: gbm:Gbem_1957 indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (266 aa) |
| | trpB-2 | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (451 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: gbm:Gbem_1960 N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (204 aa) |
| | GM21_2256 | TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; KEGG: gbm:Gbem_1961 D-3-phosphoglycerate dehydrogenase. (532 aa) |
| | GM21_2255 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (362 aa) |
| | GM21_2239 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: gbm:Gbem_1981 thiamine biosynthesis protein ThiS. (70 aa) |
| | GM21_2237 | TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: gbm:Gbem_1983 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (317 aa) |
