(53 nodes) Meiosis I cell cycle process network (Coccidioides posadasii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CPSG_00396	Uncharacterized protein. (656 aa)
	CPSG_01269	WD domain-containing protein. (308 aa)
	CPSG_00864	Uncharacterized protein. (355 aa)
	CPSG_00949	PH domain-containing protein. (1533 aa)
	CPSG_03177	MutL_C domain-containing protein. (995 aa)
	CPSG_03065	Mating-type switching protein swi10. (356 aa)
	CPSG_03005	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (605 aa)
	CPSG_01485	DEAD/DEAH box DNA helicase Mer3. (1424 aa)
	CPSG_02712	Uncharacterized protein. (303 aa)
	CPSG_02509	Crossover junction endonuclease mus81. (647 aa)
	CPSG_02319	MIND kinetochore complex component Nnf1. (224 aa)
	CPSG_02928	RING-type domain-containing protein. (362 aa)
	CPSG_02818	Casein kinase I. (377 aa)
	CPSG_02742	DNA repair and recombination protein RAD26. (961 aa)
	CPSG_08549	Uncharacterized protein. (745 aa)
	CPSG_08404	RECA_2 domain-containing protein. (343 aa)
	CPSG_07590	Uncharacterized protein. (234 aa)
	CPSG_07589	Meiotic nuclear division protein 1; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (219 aa)
	CPSG_07206	Meiosis-specific topoisomerase Spo11. (383 aa)
	CPSG_07067	DNA mismatch repair protein Msh5. (933 aa)
	CPSG_06561	Casein kinase I isoform epsilon; Belongs to the protein kinase superfamily. (402 aa)
	CPSG_06542	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (634 aa)
	CPSG_06820	Cell cycle protein kinase. (486 aa)
	CPSG_06814	TBPIP domain-containing protein. (200 aa)
	CPSG_05774	Plus3 domain-containing protein. (622 aa)
	CPSG_05571	Csm1 domain-containing protein. (527 aa)
	CPSG_05517	Serine/threonine protein kinase. (1166 aa)
	CPSG_05515	DNA mismatch repair protein mutL. (814 aa)
	CPSG_05477	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1204 aa)
	CPSG_04956	Uncharacterized protein. (639 aa)
	CPSG_05127	Uncharacterized protein. (296 aa)
	CPSG_04502	Uncharacterized protein. (227 aa)
	CPSG_04480	Uncharacterized protein. (216 aa)
	CPSG_04383	DNA repair protein RAD1. (988 aa)
	CPSG_04249	Mis12 domain-containing protein. (323 aa)
	CPSG_04752	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa)
	CPSG_04560	Oxidoreductase; Belongs to the aldehyde dehydrogenase family. (636 aa)
	CPSG_03722	DNA mismatch repair protein mutL. (777 aa)
	CPSG_03688	HTH APSES-type domain-containing protein. (435 aa)
	CPSG_08558	DNA mismatch repair protein. (939 aa)
	CPSG_08707	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1717 aa)
	CPSG_09336	Meiotic recombination protein dmc1; Belongs to the RecA family. (338 aa)
	CPSG_09410	DUF1767 domain-containing protein. (251 aa)
	CPSG_09528	RECA_2 domain-containing protein. (591 aa)
	CPSG_09681	SUN domain-containing protein. (628 aa)
	CPSG_09736	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (788 aa)
	CPSG_09772	AAA_23 domain-containing protein. (322 aa)
	CPSG_09911	Uncharacterized protein. (161 aa)
	CPSG_09927	Uncharacterized protein. (606 aa)
	CPSG_10076	DNA mismatch repair protein Msh4. (869 aa)
	CPSG_10080	Pachytene checkpoint component Pch2; Belongs to the AAA ATPase family. (434 aa)
	CPSG_01431	SNF2 family domain-containing protein. (797 aa)
	CPSG_01480	HORMA domain-containing protein. (728 aa)

Your Current Organism:

Coccidioides posadasii

NCBI taxonomy Id: 443226
Other names: C. posadasii str. Silveira, Coccidioides posadasii str. Silveira

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPSG_00396	CPSG_05571	E9CRX4	E9D6R2	Uncharacterized protein.	Csm1 domain-containing protein.	0.419
CPSG_00396	CPSG_09911	E9CRX4	E9DJB2	Uncharacterized protein.	Uncharacterized protein.	0.621
CPSG_00864	CPSG_01480	E9CTH3	E9CVJ7	Uncharacterized protein.	HORMA domain-containing protein.	0.410
CPSG_00864	CPSG_02509	E9CTH3	E9CXI9	Uncharacterized protein.	Crossover junction endonuclease mus81.	0.626
CPSG_00864	CPSG_04383	E9CTH3	E9D444	Uncharacterized protein.	DNA repair protein RAD1.	0.493
CPSG_00864	CPSG_04502	E9CTH3	E9D4G3	Uncharacterized protein.	Uncharacterized protein.	0.439
CPSG_00864	CPSG_04752	E9CTH3	E9D3L1	Uncharacterized protein.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.681
CPSG_00864	CPSG_06814	E9CTH3	E9DAC4	Uncharacterized protein.	TBPIP domain-containing protein.	0.431
CPSG_00864	CPSG_07067	E9CTH3	E9DB65	Uncharacterized protein.	DNA mismatch repair protein Msh5.	0.433
CPSG_00864	CPSG_08404	E9CTH3	E9DF04	Uncharacterized protein.	RECA_2 domain-containing protein.	0.590
CPSG_00864	CPSG_09336	E9CTH3	E9DHN7	Uncharacterized protein.	Meiotic recombination protein dmc1; Belongs to the RecA family.	0.590
CPSG_00864	CPSG_09528	E9CTH3	E9DI79	Uncharacterized protein.	RECA_2 domain-containing protein.	0.611
CPSG_00864	CPSG_09736	E9CTH3	E9DIU3	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.652
CPSG_00864	CPSG_09772	E9CTH3	E9DIX3	Uncharacterized protein.	AAA_23 domain-containing protein.	0.656
CPSG_00864	CPSG_10076	E9CTH3	E9DJS7	Uncharacterized protein.	DNA mismatch repair protein Msh4.	0.486
CPSG_00864	CPSG_10080	E9CTH3	E9DJT1	Uncharacterized protein.	Pachytene checkpoint component Pch2; Belongs to the AAA ATPase family.	0.449
CPSG_00949	CPSG_05517	E9CU14	E9D6K8	PH domain-containing protein.	Serine/threonine protein kinase.	0.439
CPSG_00949	CPSG_09927	E9CU14	E9DJC8	PH domain-containing protein.	Uncharacterized protein.	0.509
CPSG_01269	CPSG_04502	E9CS49	E9D4G3	WD domain-containing protein.	Uncharacterized protein.	0.432
CPSG_01269	CPSG_05774	E9CS49	E9D7H2	WD domain-containing protein.	Plus3 domain-containing protein.	0.947