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calB calB gapA gapA calA calA mhcA mhcA mlcE mlcE mlcR mlcR myoA myoA mlkA mlkA myoB myoB myoD myoD myoC myoC mhkA mhkA hspC hspC myoH myoH myoJ myoJ fhkA fhkA mlcB mlcB DDB_G0289563 DDB_G0289563 ctxA ctxA rgaA rgaA cbpD1 cbpD1 DDB0218211 DDB0218211 ctxB ctxB DDB_G0269864 DDB_G0269864 mtpn mtpn vwkA vwkA mlcD mlcD iplA iplA myoI myoI numA numA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
calBCalmodulin-like protein; Mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) ions. Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). (149 aa)
gapARas GTPase-activating-like protein gapA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA in the absence of rgaA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of the dividing cell. (860 aa)
calACalmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (152 aa)
mhcAMyosin-2 heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2116 aa)
mlcEMyosin, essential light chain. (150 aa)
mlcRMyosin regulatory light chain. (161 aa)
myoAMyosin IA heavy chain; Actin-based motor protein, possibly involved in a wide range of motile processes, such as cell movement across a surface, and extension and retraction of pseudopodia or lamellipodia; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (994 aa)
mlkAMyosin light chain kinase A; Phosphorylates a specific serine in the N-terminus of a myosin light chain (By similarity). Phosphorylates regulatory myosin light chain (mlcR) during chemotaxis. (295 aa)
myoBMyosin IB heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Myosin IB may have a role in chemotaxis and aggregation; it could serve to stabilize and even retract cortical structures, such as pseudopods and lamellopods. Involved in the whole cell motility of aggregation-stages cells. Overexpression results in significant decrease in the rate of cellular translocation and fluid-phase pinocytosis and abnormalities in the normal rearrangement of the actin cytoskeleton. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myos [...] (1111 aa)
myoDMyosin ID heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Myosin id may have a role in chemotaxis and aggregation; it could serve to stabilize and even retract cortical structures, such as pseudopods and lamellopods. Involved in the process of phagocytosis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1109 aa)
myoCMyosin IC heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Involved in the process of phagocytosis and appears to support streaming behavior. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1182 aa)
mhkAMyosin heavy chain kinase A; Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament. Requires autophosphorylation for activity. (1146 aa)
hspC32 kDa heat shock protein. (281 aa)
myoHMyosin-H heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1771 aa)
myoJMyosin-J heavy chain; Processive motor protein that can move over long distances along F-actin without disassociating; processiveness depends on high physiological Mg(2+) concentrations. Presents a high actin affinity in the presence of ADP, fast ATP hydrolysis, and a high steady-state ATPase activity in the presence of actin that is rate limited by ADP release. Physiological decrease of free Mg(2+) ions leads to an increased rate of ADP release and shortening of the fraction of time it spends in the strong acting binding states. (2245 aa)
fhkAProbable serine/threonine-protein kinase fhkA; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily. (593 aa)
mlcBMyosin-IB light chain; Functions as the light chain for myosin-B. Binds calcium with submicromolar affinity and may sense physiological calcium changes. (73 aa)
DDB_G0289563Calcium-binding EF-hand domain-containing protein. (74 aa)
ctxACortexillin-1; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1; Belongs to the cortexillin family. (444 aa)
rgaARas GTPase-activating-like protein rgaA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell. Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cyt [...] (822 aa)
cbpD1Calcium-binding protein 4a. (162 aa)
DDB0218211DJ-1_PfpI domain-containing protein. (233 aa)
ctxBCortexillin-2; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1 (By similarity); Belongs to the cortexillin family. (441 aa)
DDB_G0269864Uncharacterized protein. (466 aa)
mtpnMyotrophin homolog; May regulate NF-kappa-B transcription factor activity. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity). Belongs to the myotrophin family. (120 aa)
vwkAAlpha-protein kinase vwkA; Displays a modest preference for threonine over serine residues. Does not phosphorylate myosin II, however can phosphorylate MBP, in vitro. May be involved in the regulation of myosin II function during cytokinesis. Overexpression leads to impaired cell proliferation in suspension culture and fails to develop beyond the mound stage. Both overexpression and absence of the gene can result in defects in cytokinesis and alterations in myosin II abundance and assembly. (625 aa)
mlcDMyosin-ID light chain; Functions as the light chain for myosin-D. Has low affinity for calcium. (147 aa)
iplAInositol 1,4,5-trisphosphate receptor-like protein A; May be a receptor for inositol 1,4,5 trisphosphate which governs calcium fluxes from the endoplasmic reticulum stores into the cytosol. May be involved in autophagic cell death. (3177 aa)
myoIMyosin-I heavy chain; Myosins are actin-based motor molecules with ATPase activity. Involved in the early steps of phagocytosis and adhesion. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2357 aa)
numANucleomorphin. (756 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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