(19 nodes) Myosin, and Alpha-catenin binding network (Dictyostelium discoideum)

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Your Input:
	calB	Calmodulin-like protein; Mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) ions. Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). (149 aa)
	gapA	Ras GTPase-activating-like protein gapA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA in the absence of rgaA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of the dividing cell. (860 aa)
	calA	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (152 aa)
	mhcA	Myosin-2 heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2116 aa)
	mlcE	Myosin, essential light chain. (150 aa)
	mlcR	Myosin regulatory light chain. (161 aa)
	myoB	Myosin IB heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Myosin IB may have a role in chemotaxis and aggregation; it could serve to stabilize and even retract cortical structures, such as pseudopods and lamellopods. Involved in the whole cell motility of aggregation-stages cells. Overexpression results in significant decrease in the rate of cellular translocation and fluid-phase pinocytosis and abnormalities in the normal rearrangement of the actin cytoskeleton. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myos [...] (1111 aa)
	myoD	Myosin ID heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Myosin id may have a role in chemotaxis and aggregation; it could serve to stabilize and even retract cortical structures, such as pseudopods and lamellopods. Involved in the process of phagocytosis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1109 aa)
	myoC	Myosin IC heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Involved in the process of phagocytosis and appears to support streaming behavior. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1182 aa)
	myoJ	Myosin-J heavy chain; Processive motor protein that can move over long distances along F-actin without disassociating; processiveness depends on high physiological Mg(2+) concentrations. Presents a high actin affinity in the presence of ADP, fast ATP hydrolysis, and a high steady-state ATPase activity in the presence of actin that is rate limited by ADP release. Physiological decrease of free Mg(2+) ions leads to an increased rate of ADP release and shortening of the fraction of time it spends in the strong acting binding states. (2245 aa)
	mlcB	Myosin-IB light chain; Functions as the light chain for myosin-B. Binds calcium with submicromolar affinity and may sense physiological calcium changes. (73 aa)
	DDB_G0289563	Calcium-binding EF-hand domain-containing protein. (74 aa)
	ctxA	Cortexillin-1; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1; Belongs to the cortexillin family. (444 aa)
	rgaA	Ras GTPase-activating-like protein rgaA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell. Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cyt [...] (822 aa)
	DDB0218211	DJ-1_PfpI domain-containing protein. (233 aa)
	ctxB	Cortexillin-2; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1 (By similarity); Belongs to the cortexillin family. (441 aa)
	vwkA	Alpha-protein kinase vwkA; Displays a modest preference for threonine over serine residues. Does not phosphorylate myosin II, however can phosphorylate MBP, in vitro. May be involved in the regulation of myosin II function during cytokinesis. Overexpression leads to impaired cell proliferation in suspension culture and fails to develop beyond the mound stage. Both overexpression and absence of the gene can result in defects in cytokinesis and alterations in myosin II abundance and assembly. (625 aa)
	mlcD	Myosin-ID light chain; Functions as the light chain for myosin-D. Has low affinity for calcium. (147 aa)
	iplA	Inositol 1,4,5-trisphosphate receptor-like protein A; May be a receptor for inositol 1,4,5 trisphosphate which governs calcium fluxes from the endoplasmic reticulum stores into the cytosol. May be involved in autophagic cell death. (3177 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDB0218211	DDB_G0289563	Q54W12	Q54HC2	DJ-1_PfpI domain-containing protein.	Calcium-binding EF-hand domain-containing protein.	0.451
DDB0218211	calA	Q54W12	P02599	DJ-1_PfpI domain-containing protein.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	0.451
DDB0218211	calB	Q54W12	O00897	DJ-1_PfpI domain-containing protein.	Calmodulin-like protein; Mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) ions. Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity).	0.451
DDB0218211	mhcA	Q54W12	P08799	DJ-1_PfpI domain-containing protein.	Myosin-2 heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.652
DDB0218211	mlcD	Q54W12	Q7Z2B8	DJ-1_PfpI domain-containing protein.	Myosin-ID light chain; Functions as the light chain for myosin-D. Has low affinity for calcium.	0.451
DDB0218211	mlcE	Q54W12	P09402	DJ-1_PfpI domain-containing protein.	Myosin, essential light chain.	0.451
DDB0218211	mlcR	Q54W12	P13833	DJ-1_PfpI domain-containing protein.	Myosin regulatory light chain.	0.451
DDB_G0289563	DDB0218211	Q54HC2	Q54W12	Calcium-binding EF-hand domain-containing protein.	DJ-1_PfpI domain-containing protein.	0.451
DDB_G0289563	gapA	Q54HC2	O00899	Calcium-binding EF-hand domain-containing protein.	Ras GTPase-activating-like protein gapA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA in the absence of rgaA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of the dividing cell.	0.713
DDB_G0289563	iplA	Q54HC2	Q9NA13	Calcium-binding EF-hand domain-containing protein.	Inositol 1,4,5-trisphosphate receptor-like protein A; May be a receptor for inositol 1,4,5 trisphosphate which governs calcium fluxes from the endoplasmic reticulum stores into the cytosol. May be involved in autophagic cell death.	0.677
DDB_G0289563	mhcA	Q54HC2	P08799	Calcium-binding EF-hand domain-containing protein.	Myosin-2 heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.601
DDB_G0289563	mlcR	Q54HC2	P13833	Calcium-binding EF-hand domain-containing protein.	Myosin regulatory light chain.	0.602
DDB_G0289563	myoC	Q54HC2	P42522	Calcium-binding EF-hand domain-containing protein.	Myosin IC heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Involved in the process of phagocytosis and appears to support streaming behavior. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.925
DDB_G0289563	myoJ	Q54HC2	P54697	Calcium-binding EF-hand domain-containing protein.	Myosin-J heavy chain; Processive motor protein that can move over long distances along F-actin without disassociating; processiveness depends on high physiological Mg(2+) concentrations. Presents a high actin affinity in the presence of ADP, fast ATP hydrolysis, and a high steady-state ATPase activity in the presence of actin that is rate limited by ADP release. Physiological decrease of free Mg(2+) ions leads to an increased rate of ADP release and shortening of the fraction of time it spends in the strong acting binding states.	0.576
DDB_G0289563	rgaA	Q54HC2	Q54K32	Calcium-binding EF-hand domain-containing protein.	Ras GTPase-activating-like protein rgaA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell. Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cyt [...]	0.445
calA	DDB0218211	P02599	Q54W12	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	DJ-1_PfpI domain-containing protein.	0.451
calA	gapA	P02599	O00899	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Ras GTPase-activating-like protein gapA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA in the absence of rgaA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of the dividing cell.	0.738
calA	iplA	P02599	Q9NA13	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Inositol 1,4,5-trisphosphate receptor-like protein A; May be a receptor for inositol 1,4,5 trisphosphate which governs calcium fluxes from the endoplasmic reticulum stores into the cytosol. May be involved in autophagic cell death.	0.736
calA	mhcA	P02599	P08799	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Myosin-2 heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.636
calA	mlcB	P02599	Q54GL7	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Myosin-IB light chain; Functions as the light chain for myosin-B. Binds calcium with submicromolar affinity and may sense physiological calcium changes.	0.491