STRINGSTRING
ap1s2 ap1s2 DDB_G0295849 DDB_G0295849 vacA vacA clua clua chcA chcA apm2 apm2 hipA hipA DDB_G0278881 DDB_G0278881 GxcKK GxcKK vps35 vps35 DDB0219802 DDB0219802 DDB_G0292878 DDB_G0292878 api5 api5 DDB0184385 DDB0184385 epnA epnA mroh1 mroh1 arpin arpin DDB0189102 DDB0189102 tom1 tom1 Sort1 Sort1 DDB0219504 DDB0219504 DDB0188601 DDB0188601 ap2s1 ap2s1 apm1 apm1 DDB0188159 DDB0188159 vps29 vps29 washc5 washc5 DDB0187809 DDB0187809 DDB0187425 DDB0187425 eps15 eps15 DDB_G0286065 DDB_G0286065 dlpB dlpB DDB0186347 DDB0186347 DDB0186310 DDB0186310 DDB0186267 DDB0186267 ap4s1 ap4s1 washc4 washc4 ap4b1 ap4b1 rabV rabV DDB0204229 DDB0204229 tbc1d5B tbc1d5B DDB0204578 DDB0204578 DDB0204153 DDB0204153 DDB0204098 DDB0204098 DDB0204023 DDB0204023 DDB0205235 DDB0205235 ap4e1 ap4e1 tbc1d5A tbc1d5A DDB_0206311 DDB_0206311 ap3d1 ap3d1 ap1s1 ap1s1 ap1b1 ap1b1 ClmA ClmA fszA fszA washc2 washc2 ap3s1 ap3s1 DDB_G0274695 DDB_G0274695 DDB0167979 DDB0167979 ap3b-1 ap3b-1 dlpC dlpC DDB0191053 DDB0191053 DDB0190902 DDB0190902 vps26 vps26 DDB0190421 DDB0190421 gxcB gxcB dlpA dlpA washc3 washc3 DDB_G0271676 DDB_G0271676 DDB0167099 DDB0167099 Vps5 Vps5 DDB0167821 DDB0167821 ap2a1-1 ap2a1-1 ap1g1 ap1g1 clc clc dymA dymA apm4 apm4 apm3 apm3 fszB fszB dymB dymB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ap1s2AP-1 complex subunit sigma-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Also involved in early steps of phagocytosis and macropinocytosis. (154 aa)
DDB_G0295849RHOMBOID-like protein. (489 aa)
vacAVacuolin-A; Belongs to the vacuolin family. (598 aa)
cluaClustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. (1320 aa)
chcAClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. (1694 aa)
apm2AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. (439 aa)
hipAI/LWEQ domain-containing protein. (960 aa)
DDB_G0278881Putative uncharacterized protein DDB_G0278881. (372 aa)
GxcKKUncharacterized protein. (667 aa)
vps35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to- Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be involved in cargo selection. (781 aa)
DDB0219802SIR2_2 domain-containing protein. (1167 aa)
DDB_G0292878WAS protein family homolog DDB_G0292878; Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization. (472 aa)
api5Apoptosis inhibitor 5 homolog; May be an antiapoptotic factor. (606 aa)
DDB0184385Rhomboid domain-containing protein. (440 aa)
epnAEpsin; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). (686 aa)
mroh1Maestro heat-like repeat-containing protein family member 1. (1647 aa)
arpinArpin; Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex (By similarity). Involved in steering cell migration by controlling its directional persistence. Belongs to the Arpin family. (224 aa)
DDB0189102Uncharacterized protein. (1544 aa)
tom1Target of Myb protein 1; May contribute to the sorting of ubiquitinated proteins and transfer them for further sorting/trafficking processes to the endosomal multivesicular bodies (MVBs) pathway. Binds to phospholipids, such as phosphatidylinositol PtdIns(3)P and PtdIns(3,5)P2. These phospholipids are involved in the recruitment of the ESCRT machinery to endosomal membranes (By similarity). (663 aa)
Sort1Sortilin. (771 aa)
DDB0219504Uncharacterized protein. (904 aa)
DDB0188601PX domain-containing protein. (186 aa)
ap2s1AP-2 complex subunit sigma; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). (142 aa)
apm1AP-1 complex subunit mu; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Also involved in early steps of phagocytosis and macropinocytosis. (428 aa)
DDB0188159Uncharacterized protein. (464 aa)
vps29Vacuolar protein sorting-associated protein 29; Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to- Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be involved in cargo selection. (183 aa)
washc5WASH complex subunit 5. (1164 aa)
DDB0187809Uncharacterized protein. (947 aa)
DDB0187425G domain-containing protein. (711 aa)
eps15Epidermal growth factor receptor substrate 15 homolog; May be involved in clathrin-mediated endocytosis. (1196 aa)
DDB_G0286065Uncharacterized ENTR1 family protein; Belongs to the ENTR1 family. (517 aa)
dlpBDynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP. (808 aa)
DDB0186347MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (585 aa)
DDB0186310Uncharacterized protein. (374 aa)
DDB0186267Rhomboid domain-containing protein. (341 aa)
ap4s1AP-4 complex subunit sigma; Probable component of an adaptor protein complex. Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. (139 aa)
washc4WASH complex subunit 4. (1135 aa)
ap4b1AP-4 complex subunit beta; Probable component of an adaptor protein complex. Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. (838 aa)
rabVRas-related protein RabV; Belongs to the small GTPase superfamily. Rab family. (233 aa)
DDB0204229Uncharacterized protein. (1398 aa)
tbc1d5BTBC1 domain family member 5 homolog B; May act as a GTPase-activating protein for Rab family protein(s). (1016 aa)
DDB0204578GB1/RHD3-type G domain-containing protein. (796 aa)
DDB0204153Uncharacterized protein. (2167 aa)
DDB0204098DUF1681 domain-containing protein. (329 aa)
DDB0204023Uncharacterized protein. (895 aa)
DDB0205235RWP-RK domain-containing protein. (838 aa)
ap4e1AP-4 complex subunit epsilon; Probable component of an adaptor protein complex. Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. (1080 aa)
tbc1d5ATBC1 domain family member 5 homolog A; May act as a GTPase-activating protein for Rab family protein(s). (1173 aa)
DDB_0206311Protein SEY1 homolog; Probable GTP-binding protein that may be involved in cell development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily. (894 aa)
ap3d1AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is essential for the compartmentalization of the endocytic pathway. (1143 aa)
ap1s1AP-1 complex subunit sigma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Also involved in early steps of phagocytosis and macropinocytosis. (156 aa)
ap1b1AP-1 complex subunit beta; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Also involved in early steps of phagocytosis and macropinocytosis. (942 aa)
ClmAENTH domain-containing protein. (695 aa)
fszAMitochondrial division protein fszA; Probably involved in mitochondrion division process. When overexpressed, induces mitochondrial tubule formation. Binds to and hydrolyzes GTP (By similarity); Belongs to the FtsZ family. (517 aa)
washc2WASH complex subunit 2. (1479 aa)
ap3s1AP-3 complex subunit sigma; Part of the AP-3 complex, an adaptor-related complex which is essential for the compartmentalization of the endocytic pathway. (171 aa)
DDB_G0274695SH3 and F-BAR domain-containing protein DDB_G0274695. (389 aa)
DDB0167979Uncharacterized protein. (102 aa)
ap3b-1AP-3 complex subunit beta; Part of the AP-3 complex, an adaptor-related complex which is essential for the compartmentalization of the endocytic pathway. (1108 aa)
dlpCDynamin-like protein C; Involved in cytokinesis. May hydrolyze GTP. (904 aa)
DDB0191053Uncharacterized protein. (229 aa)
DDB0190902Uncharacterized protein. (1333 aa)
vps26Vacuolar protein sorting-associated protein 26; Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to- Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be involved in cargo selection. (349 aa)
DDB0190421Uncharacterized protein. (404 aa)
gxcBRac guanine nucleotide exchange factor B; Involved in the regulation of the late steps of the endocytic pathway. (1198 aa)
dlpADynamin-like protein A; Involved in cytokinesis. May hydrolyze GTP. (880 aa)
washc3WASH complex subunit 3. (354 aa)
DDB_G0271676SH3 and F-BAR domain-containing protein DDB_G0271676. (533 aa)
DDB0167099PX domain-containing protein. (104 aa)
Vps5PX domain-containing protein. (545 aa)
DDB0167821RWP-RK domain-containing protein. (548 aa)
ap2a1-1AP-2 complex subunit alpha-2; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). (989 aa)
ap1g1AP-1 complex subunit gamma; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Also involved in early steps of phagocytosis and macropinocytosis. (895 aa)
clcClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (194 aa)
dymADynamin-A; Function in membrane trafficking processes along the endo- lysosomal pathway. (853 aa)
apm4AP-4 complex subunit mu; Probable component of an adaptor protein complex. Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. (530 aa)
apm3AP-3 complex subunit mu; Part of the AP-3 complex, an adaptor-related complex which is essential for the compartmentalization of the endocytic pathway. (421 aa)
fszBMitochondrial division protein fszB; Probably involved in mitochondrion division process. Binds to and hydrolyzes GTP (By similarity); Belongs to the FtsZ family. (366 aa)
dymBDynamin-B; Enzyme hydrolyzing GTP; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (920 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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