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| | pip5k3 | 1-phosphatidylinositol 3-phosphate 5-kinase; Catalyzes the phosphorylation of phosphatidylinositol 3- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. (2656 aa) |
| | atg17 | Probable autophagy-related protein 17; Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity); Belongs to the ATG17 family. (488 aa) |
| | DDB_G0295483 | RUN domain-containing protein. (1398 aa) |
| | tipD | Protein tipD; Not known; disruption of the gene for tipD results in morphological defects. (612 aa) |
| | pdiA | Cyclic nucleotide phosphodiesterase inhibitor; PDI acts by binding stoichiometrically to cyclic nucleotide phosphodiesterase, changing the KM of the enzyme for cAMP from 10 uM to 2 mM. (237 aa) |
| | rab21 | Ras-related protein Rab-21; Involved in the regulation of phagocytosis. (212 aa) |
| | pikA | Phosphatidylinositol 3-kinase 1. (1571 aa) |
| | pikB | Phosphatidylinositol 3-kinase 2. (1857 aa) |
| | pikC | Phosphatidylinositol 3-kinase 3. (1697 aa) |
| | pikE | Phosphatidylinositol 3-kinase VPS34-like. (816 aa) |
| | pikD | Phosphatidylinositol 4-kinase; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. (1180 aa) |
| | DDB_G0288731 | GRAM domain-containing protein. (1227 aa) |
| | DDB0192215 | Uncharacterized protein. (1558 aa) |
| | DDB0192040 | CRAL-TRIO domain-containing protein. (351 aa) |
| | DDB0192013 | RUN domain-containing protein. (1353 aa) |
| | psenen | Probable gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. (97 aa) |
| | DDB0191855 | Myotubularin phosphatase domain-containing protein. (1192 aa) |
| | DDB0191697 | Uncharacterized protein. (453 aa) |
| | DDB0191673 | PUL domain-containing protein. (494 aa) |
| | Dd5P3 | Inositol 5-phosphatase. (1379 aa) |
| | psenB | Presenilin-B; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity (By similarity); Belongs to the peptidase A22A family. (473 aa) |
| | DDB_G0292252 | Putative protein DDB_G0292252. (1256 aa) |
| | DDB0219722 | PIPK domain-containing protein. (944 aa) |
| | DDB_G0291918 | Probable serine/threonine-protein kinase DDB_G0291918; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (669 aa) |
| | DDB0183850 | PI3K/PI4K domain-containing protein. (401 aa) |
| | psenA | Presenilin-A; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity (By similarity); Belongs to the peptidase A22A family. (622 aa) |
| | DDB0183790 | Uncharacterized protein. (522 aa) |
| | PikH | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1820 aa) |
| | DDB0188979 | Uncharacterized protein. (228 aa) |
| | DDB0219574 | Uncharacterized protein. (1717 aa) |
| | DDB_G0290491 | Autophagy-related protein 8-like protein DDB_G0290491. (126 aa) |
| | DDB0188848 | Vesicle transport protein; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family. (206 aa) |
| | DDB0219543 | Uncharacterized protein. (946 aa) |
| | DDB_G0290005 | Myotubularin-related protein DDB_G0290005; Phosphatase that acts on lipids with a phosphoinositol headgroup; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. (1324 aa) |
| | atg5 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3- like enzyme which is required for lipidation of atg8 and its association to the vesicle membranes (By similarity). (398 aa) |
| | DDB0219484 | Uncharacterized protein. (922 aa) |
| | DDB0188537 | Uncharacterized protein. (281 aa) |
| | DDB0188533 | Uncharacterized protein. (356 aa) |
| | DDB_G0289609 | CBS domain-containing protein DDB_G0289609. (145 aa) |
| | DDB0188326 | Uncharacterized protein. (801 aa) |
| | ugt52 | UDP-sugar-dependent glycosyltransferase 52; Involved in the biosynthesis of sterol glucoside. Can use different sterols such as cholesterol, sitosterol, and ergosterol as sugar acceptors; Belongs to the glycosyltransferase 28 family. (1697 aa) |
| | DDB0187979 | Uncharacterized protein. (719 aa) |
| | DDB_G0288371 | VPS74-like protein DDB_G0288371; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. May be involved in vacuolar protein sorting (By similarity). Belongs to the GOLPH3/VPS74 family. (262 aa) |
| | DDB0219658 | Uncharacterized protein. (334 aa) |
| | DDB0187874 | Uncharacterized protein. (186 aa) |
| | DDB0187826 | Uncharacterized protein. (313 aa) |
| | DDB0219315 | Uncharacterized protein. (824 aa) |
| | atg6B | Beclin-1-like protein B; Involved in autophagy. May be required to recruit the atg8- phosphatidylinositol conjugate and the atg12-atg5 conjugate to the pre- autophagosomal structure (By similarity); Belongs to the beclin family. (855 aa) |
| | DDB0187710 | Uncharacterized protein. (1864 aa) |
| | ncstn | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex (By similarity). (659 aa) |
| | DDB_G0287617 | Bax inhibitor 1 homolog. (254 aa) |
| | DDB_G0286995 | CTLH domain-containing protein. (611 aa) |
| | DDB0218818 | PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (1167 aa) |
| | DDB_G0286325 | Fe2OG dioxygenase domain-containing protein. (117 aa) |
| | DDB0186852 | Fe2OG dioxygenase domain-containing protein; Belongs to the iron/ascorbate-dependent oxidoreductase family. (341 aa) |
| | DDB0186851 | Fe2OG dioxygenase domain-containing protein; Belongs to the iron/ascorbate-dependent oxidoreductase family. (281 aa) |
| | DDB_G0286115 | Phosphatidylinositol-4-phosphate 5-kinase family protein. (1271 aa) |
| | DDB_G0285967 | LIM-type zinc finger-containing protein. (998 aa) |
| | mrkB | Probable serine/threonine-protein kinase MARK-B; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. (715 aa) |
| | DDB0218733 | Ubiquitin-like domain-containing protein. (1374 aa) |
| | DDB0186587 | Uncharacterized protein. (389 aa) |
| | atg18 | Autophagy-related protein 18; May be involved in cytoplasm to vacuole transport and autophagy; Belongs to the WD repeat SVP1 family. (372 aa) |
| | atg9 | Autophagy-related protein 9; Involved in autophagy vesicles formation. May recruit atg8 to the pre-autophagosomal structure (By similarity). Required for lipopolysaccharide (LPS)-enhanced bacterial clearance through the autophagic pathway; Belongs to the ATG9 family. (699 aa) |
| | vmp1 | Vacuole membrane protein 1 homolog; Required for organelle biogenesis, protein secretion, and development. Required for maintaining integrity of the endoplasmic reticulum. May play a role in autophagy. (403 aa) |
| | Rad54b | Uncharacterized protein. (989 aa) |
| | DDB0186160 | Uncharacterized protein. (303 aa) |
| | DDB0186027 | Myotubularin phosphatase domain-containing protein. (1028 aa) |
| | DDB_G0284253 | Protein EI24 homolog. (307 aa) |
| | DDB_G0284213 | Putative uncharacterized protein DDB_G0284213. (702 aa) |
| | DDB0185872 | PB1 domain-containing protein. (1050 aa) |
| | DDB0185711 | Uncharacterized protein. (351 aa) |
| | DDB0218520 | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (551 aa) |
| | DDB0185622 | Uncharacterized protein. (293 aa) |
| | DDB_G0283291 | Probable iron/ascorbate oxidoreductase DDB_G0283291. (363 aa) |
| | DDB0185272 | Uncharacterized protein. (467 aa) |
| | DDB0204972 | Uncharacterized protein. (903 aa) |
| | DDB0218403 | Uncharacterized protein. (779 aa) |
| | vps15 | Probable serine/threonine-protein kinase vps15; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1966 aa) |
| | PikG | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1671 aa) |
| | Wdr45l | Uncharacterized protein. (350 aa) |
| | DDB0205282 | Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (568 aa) |
| | DDB0205113 | DUF862 domain-containing protein. (314 aa) |
| | DDB0204242 | Myotubularin phosphatase domain-containing protein. (1343 aa) |
| | DDB0204548 | Uncharacterized protein. (342 aa) |
| | DDB0205575 | SAC domain-containing protein. (1391 aa) |
| | Prkab | AMPKBI domain-containing protein. (347 aa) |
| | DDB0218256 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1229 aa) |
| | DDB0206034 | Uncharacterized protein. (371 aa) |
| | DDB0206452 | Uncharacterized protein. (2176 aa) |
| | DDB_G0280377 | Uncharacterized protein. (784 aa) |
| | DDB_G0279719 | Probable serine/threonine-protein kinase DDB_G0279719. (942 aa) |
| | lkb1 | Serine/threonine-protein kinase stk11 homolog; Serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. (586 aa) |
| | ipo13B | Importin-13 homolog B; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. (1119 aa) |
| | DDB_G0279405 | Probable serine/threonine-protein kinase DDB_G0279405; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (695 aa) |
| | DDB0205432 | Uncharacterized protein. (894 aa) |
| | DDB0205364 | Myotubularin phosphatase domain-containing protein. (1002 aa) |
| | snfA | 5'-AMP-activated serine/threonine-protein kinase catalytic subunit alpha; Activated enzyme phosphorylates target proteins and initiates downstream signaling pathways that shift metabolism from anabolic to catabolic pathways. Acts as a highly sensitive cellular energy sensor. (727 aa) |
| | sqpA | Uncharacterized protein. (722 aa) |
| | DDB_G0277537 | Phosphatidylinositol 4-kinase; Belongs to the PI3/PI4-kinase family. (2460 aa) |
| | atg3 | Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), and autophagy. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8. The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8 from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8. The formation of the atg8- phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt) (By similarity). (338 aa) |
| | DDB0231293 | Putative transmembrane protein; Belongs to the BI1 family. (236 aa) |
| | DDB_G0272638 | Phosphatidylinositol-4-phosphate 5-kinase family protein. (1079 aa) |
| | DDB0202990 | Uncharacterized protein. (251 aa) |
| | atg4-1 | Cysteine protease atg4; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of atg8 to reveal a C-terminal glycine. Exposure of the glycine at the C- terminus is essential for atg8 conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity); Belongs to the peptidase C54 family. (745 aa) |
| | DDB0217053 | BCAS3 domain-containing protein. (1209 aa) |
| | DDB0217048 | Uncharacterized protein. (243 aa) |
| | sac1 | Phosphatidylinositide phosphatase SAC1; Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. (581 aa) |
| | DDB0216866 | Myotubularin phosphatase domain-containing protein. (1738 aa) |
| | U81000 | ATG13 domain-containing protein. (798 aa) |
| | DDB0190850 | Uncharacterized protein; Belongs to the BI1 family. (214 aa) |
| | atg6A | Beclin-1-like protein A; Involved in autophagy. May be required to recruit the atg8-phosphatidylinositol conjugate and the atg12-atg5 conjugate to the pre-autophagosomal structure (By similarity). Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium. (1368 aa) |
| | DDB0190801 | Uncharacterized protein. (646 aa) |
| | DDB0190271 | Uncharacterized protein. (1292 aa) |
| | pats1 | Probable serine/threonine-protein kinase pats1; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor (By similarity). Essential regulator of cytokinesis involved in the binding to actomyosin cytoskeleton. (3184 aa) |
| | DDB0190199 | Uncharacterized protein. (322 aa) |
| | DDB0190143 | Uncharacterized protein. (1214 aa) |
| | atg10 | Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of atg12 to atg5. atg12 conjugation to atg5 is required for autophagy. Likely serves as an atg5-recognition molecule (By similarity); Belongs to the ATG10 family. (230 aa) |
| | DDB0189842 | Glyco_tran_28_C domain-containing protein. (511 aa) |
| | DDB0189769 | Glyco_hydro_18 domain-containing protein. (260 aa) |
| | aph1 | Gamma-secretase subunit Aph-1; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors precursor protein. It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). (328 aa) |
| | PikF | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1382 aa) |
| | Ugt3 | Glyco_transf_28 domain-containing protein. (437 aa) |
| | Ugt2 | Glyco_transf_28 domain-containing protein. (437 aa) |
| | DDB0202116 | PH domain-containing protein. (1226 aa) |
| | DDB0189395 | Uncharacterized protein. (1712 aa) |
| | DDB_G0267588 | Probable phosphatidylinositol phosphate kinase DDB_G0267588; May be involved in signaling events that underlie chemotaxis via the chemoattractant-mediated pkgB phosphorylation. (719 aa) |
| | DDB0189354 | Arf-GAP domain-containing protein. (607 aa) |
| | ChLim | Calponin homology and LIM domain-containing protein; Involved in the regulation of phagocytosis. May repress rab21. (686 aa) |
| | tmcB | Tiny macrocysts protein B; Regulator of the cAMP signaling pathway specific to sexual development. Controls the levels of external cAMP by regulating the expression of phosphodiesterase pdsA and its inhibitor pdiA. (1416 aa) |
| | tmcC | Tiny macrocysts protein C. (1400 aa) |
| | DDB_G0272180 | Uncharacterized protein. (335 aa) |
| | DDB0169337 | Uncharacterized protein. (226 aa) |
| | DDB_G0275457 | Uncharacterized protein. (259 aa) |
| | htt | HD protein homolog; May play a role in microtubule-mediated transport or vesicle function; Belongs to the huntingtin family. (3095 aa) |
| | DDB0167630 | Uncharacterized protein. (1414 aa) |
| | PIPkinA | Uncharacterized protein. (1589 aa) |
| | DDB_G0271538 | Probable serine/threonine-protein kinase DDB_G0271538; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (527 aa) |
| | atg12 | Ubiquitin-like protein atg12; Ubiquitin-like protein involved in autophagy vesicles formation. Required for atg8 association to the vesicle membranes. Conjugated to atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme is essential for its function (By similarity); Belongs to the ATG12 family. (124 aa) |
| | atg8 | Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. Participates in membrane fusion events that take place in the secretory pathway (By similarity); Belongs to the ATG8 family. (122 aa) |
| | atg7 | Ubiquitin-like modifier-activating enzyme atg7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the atg8 association to autophagosomes membranes (By similarity). Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium. (707 aa) |
| | atg1 | Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in autophagy. Involved in the control of autophagic vacuolar cell death. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium. (668 aa) |
| | rpkA | RpkA. (828 aa) |
| | DDB0167294 | Arf-GAP domain-containing protein. (930 aa) |
| | DDB0167633 | Uncharacterized protein. (353 aa) |
| | DDB0169043 | Uncharacterized protein. (173 aa) |
| | limF | LIM domain-containing protein F; Involved in the regulation of phagocytosis. May repress ChLim and activate rab21. (197 aa) |
| | DDB0169091 | Uncharacterized protein. (322 aa) |
| | Dd5P4 | Inositol 5-phosphatase 4. (787 aa) |
| | DDB0169228 | Uncharacterized protein. (2625 aa) |
| | prkag | 5'-AMP-activated protein kinase subunit gamma; AMPK may be responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. (577 aa) |
| | pteN | 3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa) |
