(53 nodes) Synthesis of PIPs at the plasma membrane, and Phosphatidylinositol kinase activity network (Dictyostelium discoideum)

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Your Input:
	pip5k3	1-phosphatidylinositol 3-phosphate 5-kinase; Catalyzes the phosphorylation of phosphatidylinositol 3- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. (2656 aa)
	rab21	Ras-related protein Rab-21; Involved in the regulation of phagocytosis. (212 aa)
	pikA	Phosphatidylinositol 3-kinase 1. (1571 aa)
	pikB	Phosphatidylinositol 3-kinase 2. (1857 aa)
	pikC	Phosphatidylinositol 3-kinase 3. (1697 aa)
	pikD	Phosphatidylinositol 4-kinase; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. (1180 aa)
	DDB_G0288731	GRAM domain-containing protein. (1227 aa)
	DDB0191855	Myotubularin phosphatase domain-containing protein. (1192 aa)
	DDB0191697	Uncharacterized protein. (453 aa)
	Dd5P3	Inositol 5-phosphatase. (1379 aa)
	DDB_G0292252	Putative protein DDB_G0292252. (1256 aa)
	DDB0219722	PIPK domain-containing protein. (944 aa)
	DDB0183850	PI3K/PI4K domain-containing protein. (401 aa)
	PikH	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1820 aa)
	DDB0219574	Uncharacterized protein. (1717 aa)
	DDB_G0290005	Myotubularin-related protein DDB_G0290005; Phosphatase that acts on lipids with a phosphoinositol headgroup; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. (1324 aa)
	DDB0219484	Uncharacterized protein. (922 aa)
	DDB0188326	Uncharacterized protein. (801 aa)
	DDB_G0288371	VPS74-like protein DDB_G0288371; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. May be involved in vacuolar protein sorting (By similarity). Belongs to the GOLPH3/VPS74 family. (262 aa)
	DDB0187710	Uncharacterized protein. (1864 aa)
	DDB_G0286995	CTLH domain-containing protein. (611 aa)
	DDB0218818	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (1167 aa)
	DDB_G0286115	Phosphatidylinositol-4-phosphate 5-kinase family protein. (1271 aa)
	DDB_G0285967	LIM-type zinc finger-containing protein. (998 aa)
	Rad54b	Uncharacterized protein. (989 aa)
	DDB0186027	Myotubularin phosphatase domain-containing protein. (1028 aa)
	DDB_G0284213	Putative uncharacterized protein DDB_G0284213. (702 aa)
	DDB0218403	Uncharacterized protein. (779 aa)
	PikG	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1671 aa)
	DDB0204242	Myotubularin phosphatase domain-containing protein. (1343 aa)
	DDB0205575	SAC domain-containing protein. (1391 aa)
	DDB0218256	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1229 aa)
	DDB_G0280377	Uncharacterized protein. (784 aa)
	DDB0205432	Uncharacterized protein. (894 aa)
	DDB0205364	Myotubularin phosphatase domain-containing protein. (1002 aa)
	DDB_G0277537	Phosphatidylinositol 4-kinase; Belongs to the PI3/PI4-kinase family. (2460 aa)
	DDB_G0272638	Phosphatidylinositol-4-phosphate 5-kinase family protein. (1079 aa)
	sac1	Phosphatidylinositide phosphatase SAC1; Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. (581 aa)
	DDB0216866	Myotubularin phosphatase domain-containing protein. (1738 aa)
	DDB0190271	Uncharacterized protein. (1292 aa)
	pats1	Probable serine/threonine-protein kinase pats1; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor (By similarity). Essential regulator of cytokinesis involved in the binding to actomyosin cytoskeleton. (3184 aa)
	DDB0190143	Uncharacterized protein. (1214 aa)
	PikF	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1382 aa)
	DDB0202116	PH domain-containing protein. (1226 aa)
	DDB0189395	Uncharacterized protein. (1712 aa)
	DDB_G0267588	Probable phosphatidylinositol phosphate kinase DDB_G0267588; May be involved in signaling events that underlie chemotaxis via the chemoattractant-mediated pkgB phosphorylation. (719 aa)
	ChLim	Calponin homology and LIM domain-containing protein; Involved in the regulation of phagocytosis. May repress rab21. (686 aa)
	PIPkinA	Uncharacterized protein. (1589 aa)
	rpkA	RpkA. (828 aa)
	DDB0169043	Uncharacterized protein. (173 aa)
	limF	LIM domain-containing protein F; Involved in the regulation of phagocytosis. May repress ChLim and activate rab21. (197 aa)
	Dd5P4	Inositol 5-phosphatase 4. (787 aa)
	pteN	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ChLim	limF	Q55GV9	Q86I44	Calponin homology and LIM domain-containing protein; Involved in the regulation of phagocytosis. May repress rab21.	LIM domain-containing protein F; Involved in the regulation of phagocytosis. May repress ChLim and activate rab21.	0.919
ChLim	rab21	Q55GV9	P34142	Calponin homology and LIM domain-containing protein; Involved in the regulation of phagocytosis. May repress rab21.	Ras-related protein Rab-21; Involved in the regulation of phagocytosis.	0.842
DDB0169043	rab21	Q86HX6	P34142	Uncharacterized protein.	Ras-related protein Rab-21; Involved in the regulation of phagocytosis.	0.583
DDB0183850	DDB0218818	Q54ES0	Q54LR9	PI3K/PI4K domain-containing protein.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.485
DDB0183850	DDB_G0277537	Q54ES0	Q54ZN9	PI3K/PI4K domain-containing protein.	Phosphatidylinositol 4-kinase; Belongs to the PI3/PI4-kinase family.	0.707
DDB0183850	DDB_G0288371	Q54ES0	Q54J20	PI3K/PI4K domain-containing protein.	VPS74-like protein DDB_G0288371; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. May be involved in vacuolar protein sorting (By similarity). Belongs to the GOLPH3/VPS74 family.	0.445
DDB0183850	pikD	Q54ES0	P54677	PI3K/PI4K domain-containing protein.	Phosphatidylinositol 4-kinase; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.	0.485
DDB0186027	DDB0190143	Q54PL3	Q55EE1	Myotubularin phosphatase domain-containing protein.	Uncharacterized protein.	0.472
DDB0186027	DDB0190271	Q54PL3	Q55E04	Myotubularin phosphatase domain-containing protein.	Uncharacterized protein.	0.470
DDB0186027	DDB0191855	Q54PL3	Q54C52	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.523
DDB0186027	DDB0204242	Q54PL3	Q54TD5	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.503
DDB0186027	DDB0205364	Q54PL3	Q54YC2	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.502
DDB0186027	DDB0216866	Q54PL3	Q55AZ2	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.503
DDB0186027	DDB0219484	Q54PL3	Q54H00	Myotubularin phosphatase domain-containing protein.	Uncharacterized protein.	0.400
DDB0186027	DDB_G0284213	Q54PL3	Q54PZ6	Myotubularin phosphatase domain-containing protein.	Putative uncharacterized protein DDB_G0284213.	0.400
DDB0186027	DDB_G0288731	Q54PL3	Q1ZXD2	Myotubularin phosphatase domain-containing protein.	GRAM domain-containing protein.	0.497
DDB0186027	DDB_G0290005	Q54PL3	Q54GQ1	Myotubularin phosphatase domain-containing protein.	Myotubularin-related protein DDB_G0290005; Phosphatase that acts on lipids with a phosphoinositol headgroup; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily.	0.518
DDB0186027	Dd5P3	Q54PL3	Q54D97	Myotubularin phosphatase domain-containing protein.	Inositol 5-phosphatase.	0.434
DDB0186027	pats1	Q54PL3	Q55E58	Myotubularin phosphatase domain-containing protein.	Probable serine/threonine-protein kinase pats1; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor (By similarity). Essential regulator of cytokinesis involved in the binding to actomyosin cytoskeleton.	0.400
DDB0186027	rab21	Q54PL3	P34142	Myotubularin phosphatase domain-containing protein.	Ras-related protein Rab-21; Involved in the regulation of phagocytosis.	0.440