6 items (Dictyostelium discoideum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pikA	Phosphatidylinositol 3-kinase 1. (1571 aa)
	pikB	Phosphatidylinositol 3-kinase 2. (1857 aa)
	pikC	Phosphatidylinositol 3-kinase 3. (1697 aa)
	PikG	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1671 aa)
	PikF	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1382 aa)
	pteN	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PikF	PikG	Q55FX5	Q54S78	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.937
PikF	pikA	Q55FX5	P54673	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase 1.	0.929
PikF	pikB	Q55FX5	P54674	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase 2.	0.928
PikF	pikC	Q55FX5	P54675	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase 3.	0.929
PikF	pteN	Q55FX5	Q8T9S7	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...]	0.900
PikG	PikF	Q54S78	Q55FX5	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.937
PikG	pikA	Q54S78	P54673	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase 1.	0.939
PikG	pikB	Q54S78	P54674	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase 2.	0.943
PikG	pikC	Q54S78	P54675	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase 3.	0.941
PikG	pteN	Q54S78	Q8T9S7	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...]	0.900
pikA	PikF	P54673	Q55FX5	Phosphatidylinositol 3-kinase 1.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.929
pikA	PikG	P54673	Q54S78	Phosphatidylinositol 3-kinase 1.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.939
pikA	pikB	P54673	P54674	Phosphatidylinositol 3-kinase 1.	Phosphatidylinositol 3-kinase 2.	0.930
pikA	pikC	P54673	P54675	Phosphatidylinositol 3-kinase 1.	Phosphatidylinositol 3-kinase 3.	0.936
pikA	pteN	P54673	Q8T9S7	Phosphatidylinositol 3-kinase 1.	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...]	0.950
pikB	PikF	P54674	Q55FX5	Phosphatidylinositol 3-kinase 2.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.928
pikB	PikG	P54674	Q54S78	Phosphatidylinositol 3-kinase 2.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.943
pikB	pikA	P54674	P54673	Phosphatidylinositol 3-kinase 2.	Phosphatidylinositol 3-kinase 1.	0.930
pikB	pikC	P54674	P54675	Phosphatidylinositol 3-kinase 2.	Phosphatidylinositol 3-kinase 3.	0.938
pikB	pteN	P54674	Q8T9S7	Phosphatidylinositol 3-kinase 2.	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...]	0.940