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| | pde3 | cGMP-specific 3',5'-cGMP phosphodiesterase 3; Phosphodiesterase specific for cGMP, which is not activated by cGMP. Involved in the degradation of intracellular cGMP. (466 aa) |
| | pkaR | cAMP-dependent protein kinase regulatory subunit. (327 aa) |
| | csaA | Contact site A protein; This cell-surface glycoprotein mediates cell-cell binding via homophilic interaction. (514 aa) |
| | carA-1 | Cyclic AMP receptor 1; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. (392 aa) |
| | gpaB | Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family. (357 aa) |
| | gpaA | Guanine nucleotide-binding protein alpha-1 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (356 aa) |
| | capA-1 | cAMP-binding protein 1; Belongs to the CAPAB/TerDEXZ family. (333 aa) |
| | gpaD | Guanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-4 plays a role in morphogenesis of the multicellular structure. (345 aa) |
| | gpaE | Guanine nucleotide-binding protein alpha-5 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. (347 aa) |
| | gpaF | Guanine nucleotide-binding protein alpha-6 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-6 is involved in the folic acid chemotaxis signal transduction pathway. (347 aa) |
| | gpaG | Guanine nucleotide-binding protein alpha-7 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (390 aa) |
| | gpaH | Guanine nucleotide-binding protein alpha-8 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-8 is a potential analog for the G(s)-like G-proteins which stimulate adenylate cyclase in mammals. (403 aa) |
| | pkaC | cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis. (648 aa) |
| | pkaD | Developmentally-regulated protein kinase 1. (714 aa) |
| | pkgD | Protein kinase 4; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (992 aa) |
| | carB | Cyclic AMP receptor 2; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. Plays a key role during tip formation and late development; involved in cAMP-directed patterning of pre stalk cells as they sort before and during tip formation; Belongs to the G-protein coupled receptor 5 family. (375 aa) |
| | carC | Cyclic AMP receptor 3; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (490 aa) |
| | gpbA | Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development. (347 aa) |
| | gskA | Glycogen synthase kinase-3; During cellular differentiation, may mediate an extracellular cyclic AMP stimulated signal transduction pathway that regulates prespore and prestalk B-cell proportions through inhibition of stalk cell formation and induction of prespore cell differentiation. The cAMP receptor carC appears to activate gskA via the tyrosine kinases zakA and zak2, to stimulate prespore differentiation, while carD appears to negatively regulate gskA, to promote prestalk formation. (467 aa) |
| | cadA | Calcium-dependent cell adhesion molecule 1; Mediates calcium-dependent cell-cell adhesion during the early stage of development. (213 aa) |
| | acaA | Adenylate cyclase, aggregation specific; Coordinates cell aggregation by synthesizing the cAMP that influences differentiation and morphogenesis of cells within a developing multicellular structure. (1407 aa) |
| | acgA | Adenylate cyclase, germination specific; Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain. (858 aa) |
| | fslQ | Frizzled and smoothened-like protein Q. (578 aa) |
| | DDB_G0292556 | Putative uncharacterized protein DDB_G0292556. (1527 aa) |
| | fscJ | Frizzled/smoothened-like sans CRD protein J. (407 aa) |
| | fscH | Frizzled/smoothened-like sans CRD protein H. (533 aa) |
| | grlE | Metabotropic glutamate receptor-like protein E; May be involved in early development in cAMP sensing and subsequent chemotactic response. Probable receptor of GABA and glutamate, leading respectively to the induction or inhibition of SDF-2 formation. (816 aa) |
| | grlP | Metabotropic glutamate receptor-like protein P; Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (1407 aa) |
| | pde7 | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase 7; Phosphodiesterase with dual cAMP/cGMP specificity. However, displays a preference for cAMP over cGMP. Seems to regulate cAMP/cGMP concentration especially during cell aggregation. (425 aa) |
| | cnrN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN; Protein phosphatase that negatively regulates PI3K-dependent pathways. Regulates cAMP signal transduction to control territory size. During development, a lawn of Dictyostelium cells breaks up into territories where cells aggregate in dendritic streams to form groups of 20'000 cells. (639 aa) |
| | grlQ | Metabotropic glutamate receptor-like protein Q. (1187 aa) |
| | grlR | Metabotropic glutamate receptor-like protein R; Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (1604 aa) |
| | gpaC | Guanine nucleotide-binding protein alpha-3 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-3 plays a role in development. G alpha-3 mutants fail to aggregate; Belongs to the G-alpha family. (570 aa) |
| | grlD | Metabotropic glutamate receptor-like protein D; In the N-terminal section; belongs to the BMP lipoprotein family. (791 aa) |
| | bzpN | Probable basic-leucine zipper transcription factor N; Probable transcriptional regulator; Belongs to the bZIP family. (999 aa) |
| | DDB0218792 | RGS domain-containing protein. (475 aa) |
| | DDB_G0285265 | Calcium-binding protein. (139 aa) |
| | fslA | Frizzled and smoothened-like protein A. (594 aa) |
| | fslK | Frizzled and smoothened-like protein K. (580 aa) |
| | gpaI | Guanine nucleotide-binding protein alpha-9 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-9 antagonizes broad chemotactic response. It functions rapidly following receptor stimulation to negatively regulate PI3K/PTEN, adenylyl cyclase, and guanylyl cyclase pathways. (342 aa) |
| | DDB_G0282583 | RGS domain-containing protein. (152 aa) |
| | grlH | Metabotropic glutamate receptor-like protein H; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (764 aa) |
| | cfaD | Counting factor associated protein D; Inhibitor that slows proliferation of secreting cells (also known as chalone). Requires aprA for activity. (531 aa) |
| | crlA | Cyclic AMP receptor-like protein A; Receptor for cAMP which may play a role in prestalk cell differentiation. May act as a negative regulator of cell growth. Belongs to the G-protein coupled receptor 5 family. (369 aa) |
| | gbqA | Developmental protein DG1120. (581 aa) |
| | gpaL | Guanine nucleotide-binding protein alpha-12 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (354 aa) |
| | DDB0206269 | RGS domain-containing protein. (217 aa) |
| | PlaA | PNPLA domain-containing protein. (386 aa) |
| | sgcA | Guanylyl cyclase. (2843 aa) |
| | nmt | Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. (413 aa) |
| | gca | Guanylyl cyclase, membrane; Synthesizes cyclic GMP (cGMP) from GTP, after activation by heterotrimeric or monomeric G proteins. Involved in chemotaxis. (1483 aa) |
| | fslH | Frizzled and smoothened-like protein H; Belongs to the G-protein coupled receptor Fz/Smo family. (621 aa) |
| | DDB0217098 | RGS domain-containing protein. (1565 aa) |
| | fscE | Frizzled/smoothened-like sans CRD protein E; Belongs to the G-protein coupled receptor Fz/Smo family. (443 aa) |
| | grlA | Metabotropic glutamate receptor-like protein A; May play an important role in the terminal differentiation. In the N-terminal section; belongs to the BMP lipoprotein family. (798 aa) |
| | fslB | Frizzled and smoothened-like protein B; Belongs to the G-protein coupled receptor Fz/Smo family. (642 aa) |
| | pakD | Serine/threonine-protein kinase pakD. (1678 aa) |
| | gdt4 | Probable serine/threonine-protein kinase gdt4; In the C-terminal section; belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1620 aa) |
| | DDB0216650 | Uncharacterized protein. (506 aa) |
| | stlA | Probable polyketide synthase 1; Probable polyketide synthase (By similarity). Produces only acylpyrones; in vitro. (3147 aa) |
| | gpaJ | Guanine nucleotide-binding protein-like alpha-10 subunit; Belongs to the G-alpha family. (349 aa) |
| | aprA | Autocrine proliferation repressor protein A; Inhibitor that slows proliferation of secreting cells (also known as chalone). May function by binding to cell surface receptors. Requires cfaD for activity. Overexpression slows proliferation. Belongs to the pqaA family. (494 aa) |
| | zakA | Dual specificity protein kinase zakA; Positive regulator of gsk3/gskA activity required for cell pattern formation and a downstream effector of carC. The kinases, gsk3/gskA, zakA and zak2, form part of a signaling pathway that responds to extracellular cyclic AMP. The pathway has a role in transcriptional regulation; required to direct prespore/spore fates during development. ZakA negatively regulates prestalk differentiation by regulating expression of ecmB. Phosphorylates Y-214 of gsk3/gskA, in vitro; In the C-terminal section; belongs to the protein kinase superfamily. TKL Tyr prote [...] (781 aa) |
| | grlJ | Metabotropic glutamate receptor-like protein J; May act during the development and be a negative regulator. In the N-terminal section; belongs to the BMP lipoprotein family. (783 aa) |
| | DDB0167833 | Uncharacterized protein. (314 aa) |
| | DDB0167340 | Uncharacterized protein. (726 aa) |
| | grlB | Metabotropic glutamate receptor-like protein B; In the N-terminal section; belongs to the BMP lipoprotein family. (755 aa) |
| | pdeD | cGMP-dependent 3',5'-cGMP phosphodiesterase A; Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP. Involved in the degradation of intracellular cGMP. (867 aa) |
| | pdeE | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B; Dual specificity cAMP and cGMP phosphodiesterase with marked preference for cyclic AMP, which is activated by cAMP and cGMP. Likely functions as a cAMP-stimulated cAMP-phosphodiesterase which may play a role in regulating the cAMP relay response. Belongs to the metallo-beta-lactamase superfamily. cNMP phosphodiesterase family. (1096 aa) |
| | gpaK | Guanine nucleotide-binding protein-like alpha-11 subunit; Belongs to the G-alpha family. (359 aa) |
| | gpgA | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. This major G-protein of the squid photoreceptor is involved in visual transduction. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity). Required for normal chemotaxis in response to cAMP. (69 aa) |
| | carD | Cyclic AMP receptor 4; Receptor for cAMP. Regulates axial patterning and cellular differentiation during late development. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (443 aa) |
