(10 nodes) SCAR complex, and Engulfment of apoptotic cell network (Dictyostelium discoideum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	racF1	Rho-related protein racF1; Might act in concert and/or share functions with other members of the RHO family in the regulation of a subset of cytoskeletal rearrangements that are required for these processes. (193 aa)
	rac1C	Rho-related protein rac1C; Overexpression promotes the formation of filopodia and membrane ruffles. (193 aa)
	racQ	Rho GTPase. (185 aa)
	racM	Rho-related protein racM. (189 aa)
	scrA	Protein SCAR; Involved in regulation of actin and microtubule organization. Regulates phagocytosis and macropinocytosis. Belongs to the SCAR/WAVE family. (443 aa)
	brk1	Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family. (68 aa)
	abiA	Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family. (332 aa)
	pirA	Protein pirA; Involved in regulation of actin and microtubule organization. (1336 aa)
	napA	Nck-associated protein 1 homolog; Involved in regulation of actin and microtubule organization. Involved in cell adhesion. (1160 aa)
	racL	Rho-related protein racL. (196 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
abiA	brk1	Q55FT9	Q54X65	Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family.	Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family.	0.988
abiA	napA	Q55FT9	Q869Q3	Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family.	Nck-associated protein 1 homolog; Involved in regulation of actin and microtubule organization. Involved in cell adhesion.	0.991
abiA	pirA	Q55FT9	Q6UK63	Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family.	Protein pirA; Involved in regulation of actin and microtubule organization.	0.990
abiA	rac1C	Q55FT9	P34146	Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family.	Rho-related protein rac1C; Overexpression promotes the formation of filopodia and membrane ruffles.	0.599
abiA	racF1	Q55FT9	O96390	Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family.	Rho-related protein racF1; Might act in concert and/or share functions with other members of the RHO family in the regulation of a subset of cytoskeletal rearrangements that are required for these processes.	0.599
abiA	racL	Q55FT9	Q9GPQ8	Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family.	Rho-related protein racL.	0.599
abiA	racM	Q55FT9	Q54HZ7	Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family.	Rho-related protein racM.	0.599
abiA	racQ	Q55FT9	Q1ZXJ6	Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family.	Rho GTPase.	0.599
abiA	scrA	Q55FT9	Q54NF8	Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family.	Protein SCAR; Involved in regulation of actin and microtubule organization. Regulates phagocytosis and macropinocytosis. Belongs to the SCAR/WAVE family.	0.992
brk1	abiA	Q54X65	Q55FT9	Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family.	Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family.	0.988
brk1	napA	Q54X65	Q869Q3	Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family.	Nck-associated protein 1 homolog; Involved in regulation of actin and microtubule organization. Involved in cell adhesion.	0.999
brk1	pirA	Q54X65	Q6UK63	Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family.	Protein pirA; Involved in regulation of actin and microtubule organization.	0.999
brk1	rac1C	Q54X65	P34146	Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family.	Rho-related protein rac1C; Overexpression promotes the formation of filopodia and membrane ruffles.	0.735
brk1	racF1	Q54X65	O96390	Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family.	Rho-related protein racF1; Might act in concert and/or share functions with other members of the RHO family in the regulation of a subset of cytoskeletal rearrangements that are required for these processes.	0.680
brk1	racL	Q54X65	Q9GPQ8	Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family.	Rho-related protein racL.	0.681
brk1	racM	Q54X65	Q54HZ7	Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family.	Rho-related protein racM.	0.684
brk1	racQ	Q54X65	Q1ZXJ6	Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family.	Rho GTPase.	0.698
brk1	scrA	Q54X65	Q54NF8	Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family.	Protein SCAR; Involved in regulation of actin and microtubule organization. Regulates phagocytosis and macropinocytosis. Belongs to the SCAR/WAVE family.	0.991
napA	abiA	Q869Q3	Q55FT9	Nck-associated protein 1 homolog; Involved in regulation of actin and microtubule organization. Involved in cell adhesion.	Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family.	0.991
napA	brk1	Q869Q3	Q54X65	Nck-associated protein 1 homolog; Involved in regulation of actin and microtubule organization. Involved in cell adhesion.	Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family.	0.999