STRINGSTRING
cofA cofA proA proA racA racA talB talB ctnnA ctnnA VilD VilD DDB_G0271356 DDB_G0271356 vasp vasp EnlA EnlA paxB paxB proC proC racJ racJ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cofACofilin-1A; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family. (137 aa)
proAProfilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. (126 aa)
racARho-related protein racA. (598 aa)
talBTalin-B; Actin-binding protein required for multicellular morphogenesis. Substrate of pkgB and/or pkbA. (2614 aa)
ctnnAProbable vinculin; Involved in cell adhesion. Thought to play an important role in cytokinesis B, probably by providing substrate adhesion and traction forces. Required to organize and polarize the tip epithelium during cytokinesis. Required for the normal distribution of myosin in the tip epithelium. Involved in the localization of ctxA, ctxB, dcsA, exoc6 and rgaA. Thought to form a complex with ctxA, ctxB, and rgaA which regulates myosin accumulation to the apical plasma membrane. Belongs to the vinculin/alpha-catenin family. (842 aa)
VilDHP domain-containing protein. (1775 aa)
DDB_G0271356LIM domain-containing protein DDB_G0271356. (186 aa)
vaspProtein VASP homolog; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as lamellipodial and filopodial dynamics in migrating cells. Plays a crucial role in filopodia formation, cell-substratum adhesion, and proper chemotaxis. Nucleates and bundles actin filaments. When complexed with fotH in filopodial tips, may support formin- mediated filament elongation by bundling nascent actin filaments. Belongs to the Ena/VASP family. (380 aa)
EnlAFimbrin. (1503 aa)
paxBPaxillin-B; Required for cell-substrate adhesion, cell sorting, slug migration, and cell differentiation. May function upstream of limB. (569 aa)
proCProfilin-3; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity). (126 aa)
racJRho-related protein racJ. (205 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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