STRINGSTRING
rasD rasD rasG rasG splA splA splB splB rapA rapA pkgB pkgB rasB rasB rasC rasC rasS rasS erkA erkA DDB_G0267566 DDB_G0267566 kxcB kxcB mrkA mrkA DDB_G0291516 DDB_G0291516 DDB_G0291510 DDB_G0291510 GefAA GefAA Nek4 Nek4 DDB0188227 DDB0188227 DDB_G0288147 DDB_G0288147 gefA gefA DDB0185880 DDB0185880 phg2 phg2 rsmA rsmA DDB0185273 DDB0185273 gbpD gbpD DDB_G0282417 DDB_G0282417 DDB0205121 DDB0205121 mrkC mrkC gefP gefP rsmB rsmB DDB_G0280437 DDB_G0280437 GflD GflD gacN gacN ngap ngap DDB_G0276181 DDB_G0276181 gefY gefY ZizC ZizC DDB_G0272254 DDB_G0272254 DDB_G0271806 DDB_G0271806 DDB0190874 DDB0190874 rasZ rasZ rasU rasU rasY rasY rasX rasX rasV rasV rasW rasW gefX gefX GxcD GxcD roco7 roco7 roco9 roco9 rapgap1 rapgap1 DDB0217806 DDB0217806 gefQ gefQ rapB rapB gefJ gefJ gefE gefE gefD gefD gefC gefC gefB gefB gbpC gbpC gefR gefR gefM gefM DDB0167574 DDB0167574
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rasDRas-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (187 aa)
rasGRas-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
splADual specificity protein kinase splA; Essential for spore differentiation; Belongs to the protein kinase superfamily. TKL Tyr protein kinase family. (2410 aa)
splBDual specificity protein kinase splB. (1155 aa)
rapARas-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells. (186 aa)
pkgBProtein kinase 2; Required for morphogenesis during multicellular development. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (479 aa)
rasBRas-like protein rasB; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (197 aa)
rasCRas-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
rasSRas-like protein rasS; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (194 aa)
erkAExtracellular signal-regulated kinase 1; Kinase involved in a signal transduction pathway. (529 aa)
DDB_G0267566Probable serine/threonine-protein kinase DDB_G0267566; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (844 aa)
kxcBKinase and exchange factor for Rac B. (1125 aa)
mrkAProbable serine/threonine-protein kinase MARK-A; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. (1060 aa)
DDB_G0291516Probable serine/threonine-protein kinase DDB_G0291516. (965 aa)
DDB_G0291510GTPase-activating protein DDB_G0291510. (1031 aa)
GefAAUncharacterized protein. (1371 aa)
Nek4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (498 aa)
DDB0188227Uncharacterized protein. (1589 aa)
DDB_G0288147Probable serine/threonine-protein kinase DDB_G0288147; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1347 aa)
gefARas guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (605 aa)
DDB0185880Ras-GAP domain-containing protein. (1056 aa)
phg2Serine/threonine-protein kinase phg2; Serine/threonine kinase regulating cell substrate adhesion, phagocytosis, motility, chemotaxis, and actin cytoskeleton organization. It is a downstream component of Rap1-regulated adhesion, and it is a regulator of myosin II phosphorylation. It is also a negative regulator of development initiation. (1387 aa)
rsmASmall GTPase. (219 aa)
DDB0185273Ras-GAP domain-containing protein. (608 aa)
gbpDCyclic GMP-binding protein D; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Induces the formation of substrate-attached pseudopodia, that leads to increased adhesion and thereby negatively influencing cell speed and polarity. (1312 aa)
DDB_G0282417Probable serine/threonine-protein kinase DDB_G0282417; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (528 aa)
DDB0205121Uncharacterized protein. (464 aa)
mrkCProbable serine/threonine-protein kinase MARK-C; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. (773 aa)
gefPRas guanine nucleotide exchange factor P; Promotes the exchange of Ras-bound GDP by GTP. (1502 aa)
rsmBSmall GTPase. (260 aa)
DDB_G0280437Ras GTPase. (298 aa)
GflDRas-GEF domain-containing protein. (1765 aa)
gacNRho GTPase-activating protein gacN; Rho GTPase-activating protein involved in the signal transduction pathway. (611 aa)
ngapProbable Ras GTPase-activating-like protein ngap; May function as a Ras GTPase-activating protein. (877 aa)
DDB_G0276181Probable serine/threonine-protein kinase DDB_G0276181; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1555 aa)
gefYRas guanine nucleotide exchange factor Y; Promotes the exchange of Ras-bound GDP by GTP. (1508 aa)
ZizCUncharacterized protein; Belongs to the DOCK family. (2621 aa)
DDB_G0272254Probable serine/threonine-protein kinase DDB_G0272254. (1331 aa)
DDB_G0271806PH and Rap-GAP domain-containing protein DDB_G0271806. (1167 aa)
DDB0190874Uncharacterized protein. (687 aa)
rasZRas-like protein rasZ; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (214 aa)
rasURas-like protein rasU; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (213 aa)
rasYRas-like protein rasY; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (216 aa)
rasXRas-like protein rasX; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (213 aa)
rasVRas-like protein rasV; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (229 aa)
rasWRas-like protein rasW; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (216 aa)
gefXRasGEF domain-containing serine/threonine-protein kinase X; Promotes the exchange of Ras-bound GDP by GTP; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (960 aa)
GxcDUncharacterized protein. (1063 aa)
roco7Probable serine/threonine-protein kinase roco7; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2615 aa)
roco9Probable serine/threonine-protein kinase roco9; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (3365 aa)
rapgap1RapA guanosine triphosphatase-activating protein 1; Mediates the deactivation of rap1 and plays an important role in spatially and temporally regulating cell adhesion and chemotaxis by controlling attachment disassembly in the leading edge through the regulation of myosin II assembly and disassembly. Overexpression leads to defective chemotaxis. (1055 aa)
DDB0217806Rap-GAP domain-containing protein. (855 aa)
gefQRas guanine nucleotide exchange factor Q; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis. (1298 aa)
rapBRas-related protein rapB. (205 aa)
gefJRas guanine nucleotide exchange factor J; Promotes the exchange of Ras-bound GDP by GTP. (812 aa)
gefERas guanine nucleotide exchange factor E; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis. (1037 aa)
gefDRas guanine nucleotide exchange factor D; Promotes the exchange of Ras-bound GDP by GTP. (668 aa)
gefCRas guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP. (1457 aa)
gefBRas guanine nucleotide exchange factor B; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Involved in phagocytosis, fluid-phase endocytosis, regulation of macropinocytosis and control of cell movement. (1529 aa)
gbpCCyclic GMP-binding protein C; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2631 aa)
gefRRas guanine nucleotide exchange factor R; Promotes the exchange of Ras-bound GDP by GTP. May also play a role in the activation of rasG. (1721 aa)
gefMRas guanine nucleotide exchange factor M; Promotes the exchange of Ras-bound GDP by GTP. (929 aa)
DDB0167574Ras-GAP domain-containing protein. (1728 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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