(14 nodes) p38MAPK events, and Guanine nucleotide exchange factor for Ras-like GTPases network (Dictyostelium discoideum)

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Your Input:
	rasD	Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (187 aa)
	rasG	Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
	pkgB	Protein kinase 2; Required for morphogenesis during multicellular development. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (479 aa)
	rasB	Ras-like protein rasB; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (197 aa)
	rasC	Ras-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
	GefAA	Uncharacterized protein. (1371 aa)
	gefA	Ras guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (605 aa)
	gefP	Ras guanine nucleotide exchange factor P; Promotes the exchange of Ras-bound GDP by GTP. (1502 aa)
	gefY	Ras guanine nucleotide exchange factor Y; Promotes the exchange of Ras-bound GDP by GTP. (1508 aa)
	rasX	Ras-like protein rasX; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (213 aa)
	gefQ	Ras guanine nucleotide exchange factor Q; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis. (1298 aa)
	gefE	Ras guanine nucleotide exchange factor E; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis. (1037 aa)
	gefC	Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP. (1457 aa)
	gefM	Ras guanine nucleotide exchange factor M; Promotes the exchange of Ras-bound GDP by GTP. (929 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GefAA	gefC	Q54H95	Q8IS20	Uncharacterized protein.	Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP.	0.512
GefAA	gefE	Q54H95	Q8IS18	Uncharacterized protein.	Ras guanine nucleotide exchange factor E; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis.	0.400
GefAA	gefM	Q54H95	Q8SSQ3	Uncharacterized protein.	Ras guanine nucleotide exchange factor M; Promotes the exchange of Ras-bound GDP by GTP.	0.400
GefAA	gefP	Q54H95	Q54TK8	Uncharacterized protein.	Ras guanine nucleotide exchange factor P; Promotes the exchange of Ras-bound GDP by GTP.	0.400
GefAA	gefQ	Q54H95	Q86G47	Uncharacterized protein.	Ras guanine nucleotide exchange factor Q; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis.	0.400
GefAA	gefY	Q54H95	Q552M5	Uncharacterized protein.	Ras guanine nucleotide exchange factor Y; Promotes the exchange of Ras-bound GDP by GTP.	0.400
GefAA	rasB	Q54H95	P32252	Uncharacterized protein.	Ras-like protein rasB; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	0.497
GefAA	rasC	Q54H95	P32253	Uncharacterized protein.	Ras-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.497
GefAA	rasD	Q54H95	P03967	Uncharacterized protein.	Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.497
GefAA	rasG	Q54H95	P15064	Uncharacterized protein.	Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.497
GefAA	rasX	Q54H95	Q55CB8	Uncharacterized protein.	Ras-like protein rasX; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.497
gefA	pkgB	Q54PQ4	P28178	Ras guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway.	Protein kinase 2; Required for morphogenesis during multicellular development. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.576
gefA	rasB	Q54PQ4	P32252	Ras guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway.	Ras-like protein rasB; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	0.592
gefA	rasC	Q54PQ4	P32253	Ras guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway.	Ras-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.861
gefA	rasD	Q54PQ4	P03967	Ras guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway.	Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.811
gefA	rasG	Q54PQ4	P15064	Ras guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway.	Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.809
gefC	GefAA	Q8IS20	Q54H95	Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP.	Uncharacterized protein.	0.512
gefC	gefE	Q8IS20	Q8IS18	Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP.	Ras guanine nucleotide exchange factor E; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis.	0.515
gefC	gefM	Q8IS20	Q8SSQ3	Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP.	Ras guanine nucleotide exchange factor M; Promotes the exchange of Ras-bound GDP by GTP.	0.528
gefC	gefP	Q8IS20	Q54TK8	Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP.	Ras guanine nucleotide exchange factor P; Promotes the exchange of Ras-bound GDP by GTP.	0.513