STRINGSTRING
DDB_G0284307 DDB_G0284307 svkA svkA krsA krsA piaA piaA fhkC fhkC pkgC pkgC pkbA pkbA myoF myoF DDB_G0278845 DDB_G0278845 kinX kinX pakE pakE mobC mobC DDB_G0293276 DDB_G0293276 mobB mobB DDB_G0292624 DDB_G0292624 lst8 lst8 DDB_G0292354 DDB_G0292354 dst3 dst3 DDB_G0290859 DDB_G0290859 DDB_G0290471 DDB_G0290471 shkE shkE DDB0188869 DDB0188869 kinY kinY drkB drkB drkA drkA ndrD ndrD DDB_G0288795 DDB_G0288795 ndrB ndrB shkB shkB dst4 dst4 mkcC mkcC DDB_G0287001 DDB_G0287001 DDB_G0286841 DDB_G0286841 mkcA mkcA gacT gacT ndrC ndrC DDB_G0284661 DDB_G0284661 pdkB pdkB DDB_G0284251 DDB_G0284251 nek1 nek1 DDB0185712 DDB0185712 DDB_G0283821 DDB_G0283821 mob2 mob2 DDB_G0283397 DDB_G0283397 mkkA mkkA shkA shkA iksA iksA DDB_G0283065 DDB_G0283065 pakG pakG DDB0204990 DDB0204990 dwwA dwwA drkC drkC DDB_G0281745 DDB_G0281745 drkD drkD mkcE mkcE pdkA pdkA DDB_G0280855 DDB_G0280855 DDB_G0280717 DDB_G0280717 DDB_G0280643 DDB_G0280643 DDB_G0280557 DDB_G0280557 DDB0218242 DDB0218242 DDB_G0280461 DDB_G0280461 DDB_G0280111 DDB_G0280111 DDB_G0279831 DDB_G0279831 mobA mobA DDB_G0278901 DDB_G0278901 ndrA ndrA shkC shkC DDB0218071 DDB0218071 dcx dcx GnrC GnrC pkgA pkgA DDB0217695 DDB0217695 DDB0217636 DDB0217636 pakH-1 pakH-1 DDB_G0271402 DDB_G0271402 DDB_G0270146 DDB_G0270146 mkcF mkcF DDB0190764 DDB0190764 mekA mekA pakA pakA DDB_G0268656 DDB_G0268656 krsB krsB DDB_G0268550 DDB_G0268550 DDB_G0267514 DDB_G0267514 pakF pakF DDB_G0275057 DDB_G0275057 DDB_G0275165 DDB_G0275165 DDB_G0271550 DDB_G0271550 spkA-1 spkA-1 tor tor DDB_G0271682 DDB_G0271682 DDB_G0276461 DDB_G0276461 nek3 nek3 DDB_G0277449 DDB_G0277449 mkcD mkcD AY055590 AY055590 mkcB mkcB ripA ripA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB_G0284307Mo25-like family protein. (363 aa)
svkASerine/threonine-protein kinase svkA; Involved in regulation of actin cytoskeleton organization during cell motility; F-actin fragmenting and capping protein allowing dynamic rearrangements of the actin cytoskeleton. Also part of a regulatory pathway from the centrosome to the midzone, thus regulating the completion of cell division; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (478 aa)
krsASerine/threonine-protein kinase 4 homolog A; Regulates both cAMP signaling during early development and the stress response. Functions as an activator of adenylylcyclase. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (461 aa)
piaAProtein pianissimo A; Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Required for chemoattractant receptor and G protein- mediated activation of the 12 transmembrane domain adenylyl cyclase. Functions as a part of protein complex TORC2. TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2, but not TORC1, negatively regulates phagocytosis. This protein and dagA protein CRAC, a cytosolic regulator, are both essential for activation of the enzyme adenylyl cyclase. This protein and CRAC do not function re [...] (1148 aa)
fhkCProbable serine/threonine-protein kinase fhkC; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily. (595 aa)
pkgCProtein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (910 aa)
pkbARAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. (444 aa)
myoFMyosin IF heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1071 aa)
DDB_G0278845Probable serine/threonine-protein kinase DDB_G0278845; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
kinXProbable serine/threonine-protein kinase kinX; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1094 aa)
pakESerine/threonine-protein kinase pakE; May play a role in responding to changes in chemoattractant levels. (926 aa)
mobCMOB kinase activator-like 1 homolog C; Belongs to the MOB1/phocein family. (216 aa)
DDB_G0293276Probable serine/threonine-protein kinase DDB_G0293276; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (516 aa)
mobBMOB kinase activator-like 1 homolog B; Belongs to the MOB1/phocein family. (216 aa)
DDB_G0292624Probable myosin light chain kinase DDB_G0292624; May phosphorylate a specific serine in the N-terminus of a myosin light chain; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (313 aa)
lst8Protein LST8 homolog; Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay; Belongs to the WD repeat LST8 family. (304 aa)
DDB_G0292354Probable serine/threonine-protein kinase DDB_G0292354; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. (495 aa)
dst3Serine/threonine-protein kinase dst3. (562 aa)
DDB_G0290859Probable serine/threonine-protein kinase DDB_G0290859; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (419 aa)
DDB_G0290471Probable tyrosine-protein kinase DDB_G0290471. (352 aa)
shkEDual specificity protein kinase shkE; Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily. (710 aa)
DDB0188869Uncharacterized protein. (1089 aa)
kinYProbable serine/threonine-protein kinase kinY. (579 aa)
drkBProbable serine/threonine-protein kinase drkB. (690 aa)
drkAProbable serine/threonine-protein kinase drkA. (642 aa)
ndrDProbable serine/threonine-protein kinase ndrD; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2112 aa)
DDB_G0288795Probable serine/threonine-protein kinase DDB_G0288795. (641 aa)
ndrBProbable serine/threonine-protein kinase ndrB. (542 aa)
shkBDual specificity protein kinase shkB; Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity); Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily. (653 aa)
dst4Serine/threonine-protein kinase dst4. (485 aa)
mkcCProbable serine/threonine-protein kinase mkcC. (891 aa)
DDB_G0287001Probable LIM domain-containing serine/threonine-protein kinase DDB_G0287001; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (650 aa)
DDB_G0286841Probable serine/threonine-protein kinase DDB_G0286841; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (462 aa)
mkcAProbable serine/threonine-protein kinase mkcA; Coordinates organism morphology with cellular differentiation during development. Negative regulator of sporulation, synchronizing encapsulation with culmination. May have an additional function in prestalk cells. (860 aa)
gacTRho GTPase-activating protein gacT; Rho GTPase-activating protein involved in the signal transduction pathway. (1009 aa)
ndrCProbable serine/threonine-protein kinase ndrC; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1335 aa)
DDB_G0284661Probable myosin light chain kinase DDB_G0284661; May phosphorylate a specific serine in the N-terminus of a myosin light chain; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (481 aa)
pdkB3-phosphoinositide-dependent protein kinase B. (908 aa)
DDB_G0284251Probable serine/threonine-protein kinase DDB_G0284251. (496 aa)
nek1Probable serine/threonine-protein kinase nek1; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. (485 aa)
DDB0185712Uncharacterized protein. (905 aa)
DDB_G0283821Serine/threonine-protein kinase DDB_G0283821; May play a role in responding to changes in cAMP levels. (941 aa)
mob2MOB kinase activator-like 2; Belongs to the MOB1/phocein family. (217 aa)
DDB_G0283397Probable tyrosine-protein kinase DDB_G0283397. (918 aa)
mkkAMitogen-activated protein kinase kinase kinase A; Regulates cell-type differentiation and spatial patterning, required for the proper induction and maintenance of prespore cell differentiation; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (942 aa)
shkADual specificity protein kinase shkA; Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level. (527 aa)
iksAProbable serine/threonine-protein kinase iksA. (979 aa)
DDB_G0283065Probable serine/threonine-protein kinase DDB_G0283065; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (637 aa)
pakGSerine/threonine-protein kinase pakG. (1179 aa)
DDB0204990Cnn_1N domain-containing protein. (1381 aa)
dwwAWW domain-containing protein A; Involved in regulation of actin cytoskeleton organization and cytokinesis. (568 aa)
drkCProbable serine/threonine-protein kinase drkC. (749 aa)
DDB_G0281745Probable serine/threonine-protein kinase DDB_G0281745; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (597 aa)
drkDProbable serine/threonine-protein kinase drkD; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1288 aa)
mkcEProbable serine/threonine-protein kinase mkcE. (715 aa)
pdkAProbable serine/threonine-protein kinase pdkA. (686 aa)
DDB_G0280855Probable inactive serine/threonine-protein kinase DDB_G0280855. (392 aa)
DDB_G0280717Probable serine/threonine-protein kinase DDB_G0280717; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (411 aa)
DDB_G0280643Probable serine/threonine-protein kinase kinase DDB_G0280643; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (442 aa)
DDB_G0280557Probable serine/threonine-protein kinase kinase DDB_G0280557; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (460 aa)
DDB0218242Rap-GAP domain-containing protein. (2935 aa)
DDB_G0280461Probable serine/threonine-protein kinase DDB_G0280461; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (418 aa)
DDB_G0280111Probable serine/threonine-protein kinase DDB_G0280111; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1126 aa)
DDB_G0279831Probable myosin light chain kinase DDB_G0279831; May phosphorylate a specific serine in the N-terminus of a myosin light chain; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (928 aa)
mobAMOB kinase activator-like 1 homolog A; Belongs to the MOB1/phocein family. (213 aa)
DDB_G0278901Probable serine/threonine-protein kinase DDB_G0278901. (1495 aa)
ndrAProbable serine/threonine-protein kinase ndrA. (530 aa)
shkCDual specificity protein kinase shkC; Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity); Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily. (506 aa)
DDB0218071Uncharacterized protein. (717 aa)
dcxProtein doublecortin; Has a cytoskeleton-independent function in chemotactic signaling during development. (308 aa)
GnrCCRIB domain-containing protein. (2104 aa)
pkgAProbable serine/threonine-protein kinase pkgA; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1367 aa)
DDB0217695Uncharacterized protein. (527 aa)
DDB0217636Uncharacterized protein. (2868 aa)
pakH-1Serine/threonine-protein kinase pakH; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (513 aa)
DDB_G0271402Probable serine/threonine-protein kinase DDB_G0271402; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (765 aa)
DDB_G0270146Probable serine/threonine-protein kinase DDB_G0270146. (635 aa)
mkcFProbable serine/threonine-protein kinase mkcF. (677 aa)
DDB0190764Uncharacterized protein. (601 aa)
mekADual specificity mitogen-activated protein kinase kinase 1; Required for cAMP-mediated activation of guanylyl cyclase activity and plays an essential role in aggregation, morphogenesis, and chemotaxis. Appears to act upstream of erk1 but not erk2. (660 aa)
pakASerine/threonine-protein kinase pakA; Regulator of the myosin II component of the cytoskeleton: required for regulation of cytokinesis. Functions during chemotaxis, required for maintaining the direction of cell movement, suppressing lateral pseudopod extension, and proper retraction of the posterior of chemotaxing cells; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (1197 aa)
DDB_G0268656Probable inactive serine/threonine-protein kinase DDB_G0268656. (317 aa)
krsBSerine/threonine-protein kinase 4 homolog B; Probable serine/threonine-protein kinase; In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (1105 aa)
DDB_G0268550Probable serine/threonine-protein kinase DDB_G0268550. (536 aa)
DDB_G0267514Probable serine/threonine-protein kinase DDB_G0267514; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (916 aa)
pakFSerine/threonine-protein kinase pakF. (1176 aa)
DDB_G0275057Probable myosin light chain kinase DDB_G0275057; May phosphorylate a specific serine in the N-terminus of a myosin light chain; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (349 aa)
DDB_G0275165Probable serine/threonine-protein kinase DDB_G0275165; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (921 aa)
DDB_G0271550Probable myosin light chain kinase DDB_G0271550; May phosphorylate a specific serine in the N-terminus of a myosin light chain. (392 aa)
spkA-1Stress-activated protein kinase alpha; May be involved in cortical F-actin organization and resistance to osmotic stress. Activated upon cell detachment, in vitro. (638 aa)
torSerine/threonine-protein kinase tor; Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Functions as a part of 2 distinct protein complexes TORC1 and TORC2. TORC1 is a rapamycin-sensitive complex that controls cell growth in response to nutrients and growth factors. The second TOR complex, TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2 but not TORC1 negatively regulates phagocytosis. TORC2-dependent regulation of the cytoskeleton may follow differential phosphorylation of pkbA. May have some protein [...] (2380 aa)
DDB_G0271682Probable serine/threonine-protein kinase DDB_G0271682. (1024 aa)
DDB_G0276461Probable serine/threonine-protein kinase DDB_G0276461; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (798 aa)
nek3Probable serine/threonine-protein kinase nek3; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. (1123 aa)
DDB_G0277449Probable serine/threonine-protein kinase DDB_G0277449; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (456 aa)
mkcDProbable serine/threonine-protein kinase mkcD. (652 aa)
AY055590Dipeptidyl aminopeptidase. (700 aa)
mkcBProbable serine/threonine-protein kinase mkcB; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (714 aa)
ripARas-interacting protein RIP3; Component of a Ras-regulated pathway involved in integrating chemotaxis and signal relay pathways that are essential for aggregation. (838 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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