11 items (Dictyostelium discoideum) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

gene neighborhood

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Your Input:
	cdk10	Probable cyclin-dependent kinase 10. (366 aa)
	cdk1	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (296 aa)
	DDB_G0268078	Probable serine/threonine-protein kinase DDB_G0268078; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (507 aa)
	Cdk9-1	Protein kinase domain-containing protein. (694 aa)
	DDB_G0272797	Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (680 aa)
	DDB_G0278487	Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487. (636 aa)
	cdk11	Cyclin-dependent kinase 11; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (358 aa)
	cdk8	Probable cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) [...] (380 aa)
	DDB_G0292550	Probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (1397 aa)
	cdk7	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation. (360 aa)
	cdk5	Cyclin-dependent kinase 5 homolog. (292 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdk9-1	cdk7	Q556Z2	P54685	Protein kinase domain-containing protein.	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	0.730
DDB_G0268078	DDB_G0272797	Q55FJ6	Q556J6	Probable serine/threonine-protein kinase DDB_G0268078; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.454
DDB_G0268078	cdk1	Q55FJ6	P34112	Probable serine/threonine-protein kinase DDB_G0268078; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.401
DDB_G0272797	DDB_G0268078	Q556J6	Q55FJ6	Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Probable serine/threonine-protein kinase DDB_G0268078; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.454
DDB_G0272797	cdk7	Q556J6	P54685	Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	0.709
DDB_G0278487	cdk7	Q54Y06	P54685	Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487.	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	0.455
DDB_G0292550	cdk7	Q54D75	P54685	Probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	0.683
cdk1	DDB_G0268078	P34112	Q55FJ6	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Probable serine/threonine-protein kinase DDB_G0268078; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.401
cdk1	cdk7	P34112	P54685	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	0.817
cdk5	cdk7	P34117	P54685	Cyclin-dependent kinase 5 homolog.	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	0.710
cdk7	Cdk9-1	P54685	Q556Z2	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	Protein kinase domain-containing protein.	0.730
cdk7	DDB_G0272797	P54685	Q556J6	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.709
cdk7	DDB_G0278487	P54685	Q54Y06	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487.	0.455
cdk7	DDB_G0292550	P54685	Q54D75	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	Probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.683
cdk7	cdk1	P54685	P34112	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.817
cdk7	cdk5	P54685	P34117	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	Cyclin-dependent kinase 5 homolog.	0.710
cdk7	cdk8	P54685	Q95YH0	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	Probable cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) [...]	0.477
cdk8	cdk7	Q95YH0	P54685	Probable cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) [...]	Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.	0.477