STRINGSTRING
dyrk1 dyrk1 zakA zakA roco4 roco4 roco11 roco11 mekA mekA shkC shkC shkD shkD drkC drkC shkA shkA DDB_G0283397 DDB_G0283397 yakA yakA dhkG dhkG DDB_G0284881 DDB_G0284881 7tmk1 7tmk1 shkB shkB pyk3 pyk3 drkA drkA shkE shkE DDB_G0290471 DDB_G0290471 DDB_G0291842 DDB_G0291842 dyrk2 dyrk2 splB splB splA splA zak2 zak2 qkgA-1 qkgA-1 DDB_G0277539 DDB_G0277539 twfA twfA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dyrk1Probable serine/threonine-protein kinase dyrk1. (836 aa)
zakADual specificity protein kinase zakA; Positive regulator of gsk3/gskA activity required for cell pattern formation and a downstream effector of carC. The kinases, gsk3/gskA, zakA and zak2, form part of a signaling pathway that responds to extracellular cyclic AMP. The pathway has a role in transcriptional regulation; required to direct prespore/spore fates during development. ZakA negatively regulates prestalk differentiation by regulating expression of ecmB. Phosphorylates Y-214 of gsk3/gskA, in vitro; In the C-terminal section; belongs to the protein kinase superfamily. TKL Tyr prote [...] (781 aa)
roco4Probable serine/threonine-protein kinase roco4; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (1726 aa)
roco11Probable serine/threonine-protein kinase roco11; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (1487 aa)
mekADual specificity mitogen-activated protein kinase kinase 1; Required for cAMP-mediated activation of guanylyl cyclase activity and plays an essential role in aggregation, morphogenesis, and chemotaxis. Appears to act upstream of erk1 but not erk2. (660 aa)
shkCDual specificity protein kinase shkC; Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity); Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily. (506 aa)
shkDDual specificity protein kinase shkD; Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily. (744 aa)
drkCProbable serine/threonine-protein kinase drkC. (749 aa)
shkADual specificity protein kinase shkA; Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level. (527 aa)
DDB_G0283397Probable tyrosine-protein kinase DDB_G0283397. (918 aa)
yakAProbable serine/threonine-protein kinase yakA; General sensor of environmental conditions, such as heat stress, effecting changes through pkaC. Essential for survival to nitrosoative and oxidative stresses. Required for cell cycle control, not only at the onset but also during development (aggregation process and postaggregative development). (1458 aa)
dhkGHybrid signal transduction histidine kinase G; Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity). (3432 aa)
DDB_G0284881FABD domain-containing protein. (203 aa)
7tmk1Seven transmembrane domain-containing tyrosine-protein kinase 1; Belongs to the protein kinase superfamily. TKL Tyr protein kinase family. (691 aa)
shkBDual specificity protein kinase shkB; Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity); Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily. (653 aa)
pyk3Dual specificity protein kinase pyk3; Involved in the development. Negatively regulates tyrosine phosphorylation and activation state of dstC/STATc, probably by activating a dstC/STATc phosphatase; Belongs to the protein kinase superfamily. TKL Tyr protein kinase family. (1338 aa)
drkAProbable serine/threonine-protein kinase drkA. (642 aa)
shkEDual specificity protein kinase shkE; Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily. (710 aa)
DDB_G0290471Probable tyrosine-protein kinase DDB_G0290471. (352 aa)
DDB_G0291842Probable protein kinase DDB_G0291842; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (352 aa)
dyrk2Probable serine/threonine-protein kinase dyrk2. (915 aa)
splBDual specificity protein kinase splB. (1155 aa)
splADual specificity protein kinase splA; Essential for spore differentiation; Belongs to the protein kinase superfamily. TKL Tyr protein kinase family. (2410 aa)
zak2Dual specificity protein kinase zak2; Positive regulator of gsk3/gskA activity required for cell pattern formation and a downstream effector of carC. The kinases, gsk3/gskA, zakA and zak2, form part of a signaling pathway that responds to extracellular cyclic AMP. The pathway has a role in transcriptional regulation; required to direct prespore/spore fates during development. Zak2 negatively regulates prestalk differentiation by regulating expression of ecmA. Phosphorylates Y-214 of gsk3/gskA, in vitro; In the C-terminal section; belongs to the protein kinase superfamily. TKL Tyr prote [...] (635 aa)
qkgA-1Probable serine/threonine-protein kinase qkgA; Involved in growth, and during development, in aggregation. (1553 aa)
DDB_G0277539Probable protein kinase DDB_G0277539; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (998 aa)
twfATwinfilin; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin (By similarity). (335 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.