16 items (Dictyostelium discoideum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	psmD1	26S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (975 aa)
	Wdr45l	Uncharacterized protein. (350 aa)
	rheb	GTP-binding protein Rheb homolog; Binds GTP and exhibits intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rheb family. (185 aa)
	raptor	Protein raptor homolog. (1509 aa)
	DDB0190801	Uncharacterized protein. (646 aa)
	DDB0190062	Uncharacterized protein. (529 aa)
	rab24	Ras-related protein Rab-24; May be involved in autophagy-related processes. Belongs to the small GTPase superfamily. Rab family. (202 aa)
	atg8	Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. Participates in membrane fusion events that take place in the secretory pathway (By similarity); Belongs to the ATG8 family. (122 aa)
	tipD	Protein tipD; Not known; disruption of the gene for tipD results in morphological defects. (612 aa)
	rab7A	Ras-related protein Rab-7A; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Involved in lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity); Belongs to the small GTPase superfamily. Rab family. (203 aa)
	DDB_G0292160	Uncharacterized protein DDB_G0292160. (174 aa)
	psmD2	26S proteasome non-ATPase regulatory subunit 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (893 aa)
	lst8	Protein LST8 homolog; Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay; Belongs to the WD repeat LST8 family. (304 aa)
	DDB_G0290491	Autophagy-related protein 8-like protein DDB_G0290491. (126 aa)
	amtA	Ammonium transporter 1; Ammonium transporter that mediates the excretion of ammonium. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development; Belongs to the ammonia transporter channel (TC 1.A.11.2) family. (463 aa)
	atg1	Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in autophagy. Involved in the control of autophagic vacuolar cell death. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium. (668 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDB0190801	DDB_G0290491	Q55CE3	Q54G11	Uncharacterized protein.	Autophagy-related protein 8-like protein DDB_G0290491.	0.998
DDB0190801	Wdr45l	Q55CE3	Q54SA0	Uncharacterized protein.	Uncharacterized protein.	0.700
DDB0190801	atg1	Q55CE3	Q86CS2	Uncharacterized protein.	Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in autophagy. Involved in the control of autophagic vacuolar cell death. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium.	0.650
DDB0190801	atg8	Q55CE3	Q86CR8	Uncharacterized protein.	Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. Participates in membrane fusion events that take place in the secretory pathway (By similarity); Belongs to the ATG8 family.	0.998
DDB0190801	raptor	Q55CE3	Q55BR7	Uncharacterized protein.	Protein raptor homolog.	0.555
DDB0190801	tipD	Q55CE3	O15736	Uncharacterized protein.	Protein tipD; Not known; disruption of the gene for tipD results in morphological defects.	0.752
DDB_G0290491	DDB0190801	Q54G11	Q55CE3	Autophagy-related protein 8-like protein DDB_G0290491.	Uncharacterized protein.	0.998
DDB_G0290491	atg1	Q54G11	Q86CS2	Autophagy-related protein 8-like protein DDB_G0290491.	Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in autophagy. Involved in the control of autophagic vacuolar cell death. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium.	0.918
DDB_G0290491	atg8	Q54G11	Q86CR8	Autophagy-related protein 8-like protein DDB_G0290491.	Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. Participates in membrane fusion events that take place in the secretory pathway (By similarity); Belongs to the ATG8 family.	0.904
DDB_G0290491	tipD	Q54G11	O15736	Autophagy-related protein 8-like protein DDB_G0290491.	Protein tipD; Not known; disruption of the gene for tipD results in morphological defects.	0.764
DDB_G0292160	atg1	Q1ZXA8	Q86CS2	Uncharacterized protein DDB_G0292160.	Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in autophagy. Involved in the control of autophagic vacuolar cell death. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium.	0.499
DDB_G0292160	lst8	Q1ZXA8	Q54D08	Uncharacterized protein DDB_G0292160.	Protein LST8 homolog; Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay; Belongs to the WD repeat LST8 family.	0.499
DDB_G0292160	rab7A	Q1ZXA8	P36411	Uncharacterized protein DDB_G0292160.	Ras-related protein Rab-7A; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Involved in lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity); Belongs to the small GTPase superfamily. Rab family.	0.400
DDB_G0292160	raptor	Q1ZXA8	Q55BR7	Uncharacterized protein DDB_G0292160.	Protein raptor homolog.	0.501
DDB_G0292160	rheb	Q1ZXA8	Q550Q4	Uncharacterized protein DDB_G0292160.	GTP-binding protein Rheb homolog; Binds GTP and exhibits intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rheb family.	0.499
Wdr45l	DDB0190801	Q54SA0	Q55CE3	Uncharacterized protein.	Uncharacterized protein.	0.700
Wdr45l	atg1	Q54SA0	Q86CS2	Uncharacterized protein.	Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in autophagy. Involved in the control of autophagic vacuolar cell death. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium.	0.625
Wdr45l	atg8	Q54SA0	Q86CR8	Uncharacterized protein.	Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. Participates in membrane fusion events that take place in the secretory pathway (By similarity); Belongs to the ATG8 family.	0.490
Wdr45l	tipD	Q54SA0	O15736	Uncharacterized protein.	Protein tipD; Not known; disruption of the gene for tipD results in morphological defects.	0.504
atg1	DDB0190801	Q86CS2	Q55CE3	Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in autophagy. Involved in the control of autophagic vacuolar cell death. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium.	Uncharacterized protein.	0.650