54 items (Dictyostelium discoideum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DDB0191697	Uncharacterized protein. (453 aa)
	DDB0191668	Uncharacterized protein. (610 aa)
	DDB_G0292024	Probable protein tyrosine phosphatase type IVA A; Belongs to the protein-tyrosine phosphatase family. (166 aa)
	DDB0188712	PPM-type phosphatase domain-containing protein. (539 aa)
	smkA	Suppressor of Mek1; Suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects. Required for proper cytokinesis during vegetative growth, timely exit from the mound stage during development, and myosin II assembly. May be a regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) and may control localization of PP4 to the nucleus. Involved in the regulation of some ppp4c functions, such as developmental progression, chemotaxis, expression of stress response genes and cell movement; Belongs to the SMEK family. (1046 aa)
	DDB0188064	Uncharacterized protein. (985 aa)
	cnrN	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN; Protein phosphatase that negatively regulates PI3K-dependent pathways. Regulates cAMP signal transduction to control territory size. During development, a lawn of Dictyostelium cells breaks up into territories where cells aggregate in dendritic streams to form groups of 20'000 cells. (639 aa)
	cnbB	Calcineurin subunit B type 2; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity). (183 aa)
	DDB_G0285967	LIM-type zinc finger-containing protein. (998 aa)
	DDB0186743	TYR_PHOSPHATASE_2 domain-containing protein. (181 aa)
	DDB0186499	Uncharacterized protein. (746 aa)
	DDB0185918	PPM-type phosphatase domain-containing protein. (403 aa)
	DDB_G0283919	Protein phosphatase 2C-related protein. (1080 aa)
	cdc25	M-phase inducer phosphatase; Tyrosine protein phosphatase which may function as a dosage- dependent inducer in mitotic control; Belongs to the MPI phosphatase family. (1053 aa)
	pppA	Protein phosphatase 2A scaffold subunit; Scaffolding molecule which may coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (584 aa)
	DDB_G0283417	Probable dual specificity protein phosphatase DDB_G0283417; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (230 aa)
	DDB0185382	Uncharacterized protein. (514 aa)
	DDB_G0282105	Probable protein phosphatase DDB_G0282105; In the C-terminal section; belongs to the PP2C family. (958 aa)
	DDB_G0281963	Probable dual specificity protein phosphatase DDB_G0281963; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
	ppr1	Protein phosphatase 4 regulatory subunit 1. (726 aa)
	DDB0206306	EF-hand domain-containing protein. (781 aa)
	DDB_G0279461	Probable protein phosphatase DDB_G0279461. (1006 aa)
	DDB_G0278499	Protein phosphatase 2C. (307 aa)
	mpl3	MAP kinase phosphatase with leucine-rich repeats protein 3; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (856 aa)
	DDB_G0277071	Probable serine/threonine-protein kinase DDB_G0277071. (2454 aa)
	DDB0217695	Uncharacterized protein. (527 aa)
	Ublcp1-1	Uncharacterized protein. (399 aa)
	DDB_G0273199	Probable rhodanese domain-containing dual specificity protein phosphatase; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (476 aa)
	ssu72	RNA polymerase II subunit A C-terminal domain phosphatase SSU72; May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination; Belongs to the SSU72 phosphatase family. (214 aa)
	acp1	Low molecular weight phosphotyrosine protein phosphatase; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (179 aa)
	DDB0168463	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (782 aa)
	DDB0168928	PPM-type phosphatase domain-containing protein. (1148 aa)
	PLIP	Phosphatidylinositol phosphatase. (232 aa)
	DDB_G0272662	Probable protein tyrosine phosphatase type IVA B; Belongs to the protein-tyrosine phosphatase family. (163 aa)
	ppp4r2	Serine/threonine-protein phosphatase 4 regulatory subunit 2; Probable regulatory subunit of serine/threonine-protein phosphatase 4 (PP4); Belongs to the PPP4R2 family. (283 aa)
	DDB0167523	PPM-type phosphatase domain-containing protein. (643 aa)
	DDB0168530	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (560 aa)
	pteN	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa)
	mkpA	MkpA protein. (1543 aa)
	DDB0167475	RTR1-type domain-containing protein. (537 aa)
	spnA	Probable guanine nucleotide-binding protein spalten; Involved in cell-type differentiation and morphogenesis. Dephosphorylates casein; in vitro. May also be involved as modulators or transducers in various transmembrane signaling systems. In the C-terminal section; belongs to the PP2C family. (975 aa)
	ptpA1-1	Tyrosine-protein phosphatase 1; May have a role in growth and in the early stages of development. Affects the timing of development; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (522 aa)
	ptpB	Tyrosine-protein phosphatase 2. (377 aa)
	ptpC	Tyrosine-protein phosphatase 3; Seems to dephosphorylate a protein of 130 kDa (p130). (990 aa)
	DG1060	Probable tyrosine-protein phosphatase DG1060; Belongs to the protein-tyrosine phosphatase family. (166 aa)
	canA	Serine/threonine-protein phosphatase 2B catalytic subunit; Catalytic subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Belongs to the PPP phosphatase family. PP-2B subfamily. (623 aa)
	mpl1	MAP kinase phosphatase with leucine-rich repeats protein 1; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins (By similarity). Dephosphorylates pNPP, in vitro. Essential for proper regulation of erkB (erk2) and optimal motility during development; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (834 aa)
	DDB0190861	PPM-type phosphatase domain-containing protein. (1359 aa)
	DDB_G0271350	Probable dual specificity protein phosphatase DDB_G0271350; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (275 aa)
	cnbA	Calcineurin subunit B type 1; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Important for stalk formation. (180 aa)
	pats1	Probable serine/threonine-protein kinase pats1; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor (By similarity). Essential regulator of cytokinesis involved in the binding to actomyosin cytoskeleton. (3184 aa)
	DDB_G0269404	Probable dual specificity protein phosphatase DDB_G0269404; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (212 aa)
	mpl2	MAP kinase phosphatase with leucine-rich repeats protein 2; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (695 aa)
	DDB_G0277367	Uncharacterized protein. (161 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDB0167475	DDB0168463	Q8ST13	Q75JA4	RTR1-type domain-containing protein.	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	0.463
DDB0167475	DDB0188064	Q8ST13	Q54IJ8	RTR1-type domain-containing protein.	Uncharacterized protein.	0.469
DDB0167475	ssu72	Q8ST13	Q558Z3	RTR1-type domain-containing protein.	RNA polymerase II subunit A C-terminal domain phosphatase SSU72; May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination; Belongs to the SSU72 phosphatase family.	0.807
DDB0168463	DDB0167475	Q75JA4	Q8ST13	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	RTR1-type domain-containing protein.	0.463
DDB0168463	Ublcp1-1	Q75JA4	Q556S4	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.589
DDB0168463	ssu72	Q75JA4	Q558Z3	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	RNA polymerase II subunit A C-terminal domain phosphatase SSU72; May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination; Belongs to the SSU72 phosphatase family.	0.530
DDB0186499	DDB0191668	Q54N84	Q54CK7	Uncharacterized protein.	Uncharacterized protein.	0.407
DDB0186499	DDB_G0271350	Q54N84	Q55BI8	Uncharacterized protein.	Probable dual specificity protein phosphatase DDB_G0271350; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.406
DDB0186499	DDB_G0273199	Q54N84	Q556Y8	Uncharacterized protein.	Probable rhodanese domain-containing dual specificity protein phosphatase; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.406
DDB0188064	DDB0167475	Q54IJ8	Q8ST13	Uncharacterized protein.	RTR1-type domain-containing protein.	0.469
DDB0188064	Ublcp1-1	Q54IJ8	Q556S4	Uncharacterized protein.	Uncharacterized protein.	0.589
DDB0188064	ssu72	Q54IJ8	Q558Z3	Uncharacterized protein.	RNA polymerase II subunit A C-terminal domain phosphatase SSU72; May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination; Belongs to the SSU72 phosphatase family.	0.525
DDB0191668	DDB0186499	Q54CK7	Q54N84	Uncharacterized protein.	Uncharacterized protein.	0.407
DDB0191668	DDB_G0271350	Q54CK7	Q55BI8	Uncharacterized protein.	Probable dual specificity protein phosphatase DDB_G0271350; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.400
DDB0191668	DDB_G0273199	Q54CK7	Q556Y8	Uncharacterized protein.	Probable rhodanese domain-containing dual specificity protein phosphatase; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.400
DDB0191697	DDB_G0285967	Q54CH3	Q54MG8	Uncharacterized protein.	LIM-type zinc finger-containing protein.	0.913
DDB0191697	pteN	Q54CH3	Q8T9S7	Uncharacterized protein.	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...]	0.916
DDB0206306	canA	Q54W95	Q7YSW8	EF-hand domain-containing protein.	Serine/threonine-protein phosphatase 2B catalytic subunit; Catalytic subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Belongs to the PPP phosphatase family. PP-2B subfamily.	0.706
DDB0206306	cnbA	Q54W95	Q55G87	EF-hand domain-containing protein.	Calcineurin subunit B type 1; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Important for stalk formation.	0.540
DDB0206306	cnbB	Q54W95	Q54MF3	EF-hand domain-containing protein.	Calcineurin subunit B type 2; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity).	0.540