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| | fbxA | F-box/WD repeat-containing protein A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May target the cAMP phosphodiesterase regA for degradation leading to an increase in cAMP and PKA activity. Promotes development of prestalk cells as opposed to prespores within the developing fruiting body. Required for culmination and fruiting body development. (1247 aa) |
| | culB | Cullin-2; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Appears to ensure that the proper number of prestalk cells differentiate at the appropriate time in development. May govern prestalk cell differentiation. (771 aa) |
| | grp94 | Endoplasmin homolog; May play a role in late differentiation as well as in starvation response. When overexpressed, suppresses the ability to form normal fruiting bodies and impairs prespore differentiation as well as maturation into spores; Belongs to the heat shock protein 90 family. (768 aa) |
| | ubqln | Ubiquilin; Stable protein which acts as an antagonist of nosA by repressing cellular differentiation after the tight-aggregate stage, when cells differentiate into two precursor cell types, prespore and prestalk cells, prior to the formation of fruiting bodies. (523 aa) |
| | ubcB | Ubiquitin conjugating enzyme E2 B; Involved in protein ubiquitination and degradation during development. Mediates protein ubiquitination at the mound and finger stage required for subsequent development and may be an essential component of the developmental transition between the induction of postaggregative gene expression and subsequent cell-type differentiation and morphogenesis. ubcB and ubpB differentially control ubiquitination/deubiquitination and degradation of mkkA protein in a cell-type-specific and temporally regulated manner. (148 aa) |
| | bip2 | Luminal-binding protein 2; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER; Belongs to the heat shock protein 70 family. (658 aa) |
| | alxA | ALG-2 interacting protein X; Unknown. Required for development but not for cell death. (794 aa) |
| | DDB0167500 | RBR-type E3 ubiquitin transferase. (522 aa) |
| | DDB0167572 | USP domain-containing protein; Belongs to the peptidase C19 family. (1258 aa) |
| | psmC2 | 26S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (428 aa) |
| | DDB0217499 | Ubiquitin carboxyl-terminal hydrolase. (919 aa) |
| | DDB0167853 | Uncharacterized protein. (490 aa) |
| | psmD14 | 26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). Belongs to the peptidase M67A family. PSMD14 subfamily. (306 aa) |
| | DDB0167459 | RING-type domain-containing protein. (482 aa) |
| | DDB0217687 | PRKCSH domain-containing protein. (318 aa) |
| | atg12 | Ubiquitin-like protein atg12; Ubiquitin-like protein involved in autophagy vesicles formation. Required for atg8 association to the vesicle membranes. Conjugated to atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme is essential for its function (By similarity); Belongs to the ATG12 family. (124 aa) |
| | anapc8 | Anaphase-promoting complex subunit 8; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC8/CDC23 family. (592 aa) |
| | DDB0167912 | UBX domain-containing protein. (662 aa) |
| | Usp7 | Uncharacterized protein; Belongs to the peptidase C19 family. (1306 aa) |
| | DDB0167344 | Ubiquitin-like domain-containing protein. (184 aa) |
| | DDB0168794 | Uncharacterized protein. (630 aa) |
| | DDB0168784 | Uncharacterized protein. (538 aa) |
| | DDB0169450 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (2230 aa) |
| | DDB0168503 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (171 aa) |
| | rbrA | Probable E3 ubiquitin-protein ligase rbrA; Might act as an E3 ubiquitin-protein ligase. Appears to be required for normal cell-type proportioning and cell sorting during multicellular development. In addition to being necessary for a normal percentage of prestalk cells and the organization of the slug, rbrA is also necessary for spore cell viability. (520 aa) |
| | psmB6 | Proteasome subunit beta type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (214 aa) |
| | vps25 | Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (By similarity). (194 aa) |
| | DDB0189563 | Uncharacterized protein. (665 aa) |
| | DDB0216561 | F-box domain-containing protein. (676 aa) |
| | psmA5 | Proteasome subunit alpha type-5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (241 aa) |
| | ube2w | Probable ubiquitin-conjugating enzyme E2 W; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family. (149 aa) |
| | DDB0190003 | UBX domain-containing protein. (409 aa) |
| | anapc10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC10 family. (188 aa) |
| | DDB0190095 | Ubiquitinyl hydrolase 1. (2125 aa) |
| | DDB0202360 | BTB domain-containing protein. (346 aa) |
| | ate1 | Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity); Belongs to the R-transferase family. (629 aa) |
| | bzpE | Probable basic-leucine zipper transcription factor E; Probable transcriptional regulator; Belongs to the bZIP family. (418 aa) |
| | vps37 | Vacuolar protein sorting-associated protein 37; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. (333 aa) |
| | DDB0201756 | ANK_REP_REGION domain-containing protein. (787 aa) |
| | armc8 | Armadillo repeat-containing protein. (702 aa) |
| | psmB3 | Proteasome subunit beta type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (205 aa) |
| | DDB0190543 | UBX domain-containing protein. (264 aa) |
| | DDB0190829 | RBR-type E3 ubiquitin transferase. (588 aa) |
| | psmD6 | 26S proteasome non-ATPase regulatory subunit 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (382 aa) |
| | DDB0190877 | Uncharacterized protein. (1154 aa) |
| | uba1 | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. (1017 aa) |
| | psmC1 | 26S proteasome regulatory subunit 4 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Plays an important role in regulating both growth and multicellular development. (439 aa) |
| | ubxd7 | UBX domain-containing protein 7 homolog. (503 aa) |
| | DDB0191043 | Ubiquitin carboxyl-terminal hydrolase. (881 aa) |
| | DDB0191056 | RING-type domain-containing protein. (954 aa) |
| | ufd1 | Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway; Belongs to the UFD1 family. (330 aa) |
| | DDB0202883 | USP domain-containing protein; Belongs to the peptidase C19 family. (1037 aa) |
| | yod1 | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. (325 aa) |
| | Usp14 | Ubiquitin carboxyl-terminal hydrolase. (512 aa) |
| | cnxA | Uncharacterized protein. (536 aa) |
| | DDB_G0271798 | Ubiquitin carboxyl-terminal hydrolase. (836 aa) |
| | DDB0231292 | RBR-type E3 ubiquitin transferase. (875 aa) |
| | DDB_G0272975 | BTB domain-containing protein. (692 aa) |
| | DDB0217070 | Uncharacterized protein. (572 aa) |
| | DDB0185981 | Uncharacterized protein; Belongs to the peptidase C19 family. (1089 aa) |
| | psmC3 | 26S proteasome regulatory subunit 6A homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (421 aa) |
| | maea | Uncharacterized protein. (423 aa) |
| | psmC6 | 26S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (393 aa) |
| | DDB0218617 | Uncharacterized protein. (982 aa) |
| | DDB0186240 | Skp1 domain-containing protein. (404 aa) |
| | culC | Cullin-3; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity); Belongs to the cullin family. (769 aa) |
| | psmD13 | 26S proteasome non-ATPase regulatory subunit 13; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (385 aa) |
| | derl2 | Probable derlin-2 homolog; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Belongs to the derlin family. (254 aa) |
| | DDB0186377 | Uncharacterized protein. (473 aa) |
| | anapc4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC4 family. (837 aa) |
| | DDB_G0285261 | Regulator of chromosome condensation domain-containing protein. (421 aa) |
| | vps28 | Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. (288 aa) |
| | DDB0186444 | RING-type domain-containing protein. (281 aa) |
| | anapc1 | Anaphase-promoting complex subunit 1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC1 family. (2269 aa) |
| | atg9 | Autophagy-related protein 9; Involved in autophagy vesicles formation. May recruit atg8 to the pre-autophagosomal structure (By similarity). Required for lipopolysaccharide (LPS)-enhanced bacterial clearance through the autophagic pathway; Belongs to the ATG9 family. (699 aa) |
| | uch2 | Ubiquitin carboxyl-terminal hydrolase isozyme L5; Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome (By similarity). Belongs to the peptidase C12 family. (343 aa) |
| | cdc20 | Anaphase-promoting complex subunit cdc20; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the WD repeat CDC20/Fizzy family. (499 aa) |
| | DDB0218731 | RBR-type E3 ubiquitin transferase. (386 aa) |
| | DDB0186668 | RING-CH-type domain-containing protein. (1088 aa) |
| | DDB0186757 | Uncharacterized protein. (906 aa) |
| | DDB0186907 | RBR-type E3 ubiquitin transferase. (611 aa) |
| | rcbA | UV excision repair protein RAD23 homolog; May play a role both in proteasomal degradation of misfolded proteins and DNA repair; Belongs to the RAD23 family. (342 aa) |
| | ube2j2 | Ubiquitin-conjugating enzyme E2 J2; Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum; Belongs to the ubiquitin-conjugating enzyme family. (241 aa) |
| | anapc11 | Anaphase-promoting complex subunit 11; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the RING-box family. (87 aa) |
| | DDB0187369 | HECT domain-containing protein. (1898 aa) |
| | cdh1 | Anaphase-promoting complex subunit cdh1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the WD repeat CDC20/Fizzy family. (754 aa) |
| | DDB0187476 | Uncharacterized protein. (1012 aa) |
| | rbx1 | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). (104 aa) |
| | DDB0215923 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1580 aa) |
| | DDB0187644 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1814 aa) |
| | DDB0187676 | RING-type domain-containing protein. (688 aa) |
| | psmD1 | 26S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (975 aa) |
| | DDB0187732 | Vac14_Fab1_bd domain-containing protein. (1878 aa) |
| | DDB0187780 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa) |
| | ddi1 | Protein DDI1 homolog; Probable aspartic protease. (450 aa) |
| | anapc3 | Anaphase-promoting complex subunit 3; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC3/CDC27 family. (970 aa) |
| | DDB0187898 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (517 aa) |
| | DDB0187912 | Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (549 aa) |
| | DDB0219336 | Uncharacterized protein. (970 aa) |
| | DDB0219346 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (2023 aa) |
| | DDB0188049 | RBR-type E3 ubiquitin transferase. (853 aa) |
| | DDB0188059 | Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (585 aa) |
| | derl1 | Probable derlin-1 homolog; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Belongs to the derlin family. (242 aa) |
| | ube2s | Ubiquitin-conjugating enzyme E2 S; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. (215 aa) |
| | DDB0188232 | RBR-type E3 ubiquitin transferase. (1818 aa) |
| | tirA | Protein tirA; May regulate responses to pathogens. Required by to respond appropriately to bacteria during vegetative foraging. (1336 aa) |
| | DDB0188474 | Uncharacterized protein. (1268 aa) |
| | Usp40 | USP domain-containing protein; Belongs to the peptidase C19 family. (1677 aa) |
| | atg5 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3- like enzyme which is required for lipidation of atg8 and its association to the vesicle membranes (By similarity). (398 aa) |
| | tom1 | Target of Myb protein 1; May contribute to the sorting of ubiquitinated proteins and transfer them for further sorting/trafficking processes to the endosomal multivesicular bodies (MVBs) pathway. Binds to phospholipids, such as phosphatidylinositol PtdIns(3)P and PtdIns(3,5)P2. These phospholipids are involved in the recruitment of the ESCRT machinery to endosomal membranes (By similarity). (663 aa) |
| | Ube3a | HECT domain-containing protein. (720 aa) |
| | nploc4 | Nuclear protein localization protein 4 homolog; May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. Belongs to the NPL4 family. (576 aa) |
| | ascc3 | Activating signal cointegrator 1 complex subunit 3. (2195 aa) |
| | usp12 | Ubiquitin carboxyl-terminal hydrolase. (475 aa) |
| | DDB0188947 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | DDB0189195 | F-box domain-containing protein. (789 aa) |
| | DDB0189206 | Uncharacterized protein. (865 aa) |
| | DDB0189210 | RBR-type E3 ubiquitin transferase. (972 aa) |
| | DDB0189211 | Uncharacterized protein. (382 aa) |
| | DDB0189261 | Uncharacterized protein. (938 aa) |
| | DDB0183778 | Uncharacterized protein. (543 aa) |
| | DDB0191588 | Uncharacterized protein. (502 aa) |
| | csn3 | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. (418 aa) |
| | DDB0184076 | Uncharacterized protein. (956 aa) |
| | Wdr23 | WD_REPEATS_REGION domain-containing protein. (661 aa) |
| | DDB0184183 | USP domain-containing protein; Belongs to the peptidase C19 family. (3240 aa) |
| | cnrK | RBR-type E3 ubiquitin transferase. (1214 aa) |
| | psmA2 | Proteasome subunit alpha type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (232 aa) |
| | DDB0184243 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (388 aa) |
| | DDB0184244 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1569 aa) |
| | DDB0184314 | UBR-type domain-containing protein. (933 aa) |
| | DDB0184379 | BTB domain-containing protein. (400 aa) |
| | anapc7 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC7 family. (580 aa) |
| | DDB0184460 | Uncharacterized protein. (455 aa) |
| | DDB_G0292642 | Uncharacterized protein DDB_G0292642. (903 aa) |
| | culD | Cullin-4; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). (802 aa) |
| | cdc26 | Anaphase-promoting complex subunit cdc26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the CDC26 family. (69 aa) |
| | nsfl1c | NSFL1 cofactor p47 homolog; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). (415 aa) |
| | psmB5 | Proteasome subunit beta type-5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (272 aa) |
| | psmD2 | 26S proteasome non-ATPase regulatory subunit 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (893 aa) |
| | DDB0192113 | Uncharacterized protein; Belongs to the peptidase C19 family. (1085 aa) |
| | DDB_G0294380 | Ubiquitin-conjugating enzyme E2 J2-like; Catalyzes the covalent attachment of ubiquitin to other proteins. (170 aa) |
| | psmA3 | Proteasome subunit alpha type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1A family. (248 aa) |
| | psmA1 | Proteasome subunit alpha type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1A family. (248 aa) |
| | crtA | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). (424 aa) |
| | anapc6 | Anaphase-promoting complex subunit 6; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC6/CDC16 family. (865 aa) |
| | DDB_G0288313 | Uncharacterized protein. (1040 aa) |
| | psmD3 | 26S proteasome non-ATPase regulatory subunit 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (504 aa) |
| | cdcD | Cell division cycle protein 48; Belongs to the AAA ATPase family. (793 aa) |
| | ubpA | Ubiquitin carboxyl-terminal hydrolase A; Required for development but not growth. Belongs to the peptidase C19 family. (837 aa) |
| | fpaA | SCF ubiquitin ligase complex protein SKP1a(4-162); Belongs to the SKP1 family. (162 aa) |
| | psmC5 | 26S proteasome regulatory subunit 8; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (403 aa) |
| | psmC4 | 26S proteasome regulatory subunit 6B homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (403 aa) |
| | psmA7 | Proteasome subunit alpha type-7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1A family. (250 aa) |
| | psmA4 | Proteasome subunit alpha type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1A family. (250 aa) |
| | DDB_G0349043 | WD repeat-containing protein DDB_G0349043. (588 aa) |
| | DDB_G0295729 | J domain-containing protein DDB_G0295729. (1346 aa) |
| | DDB_G0295713 | RCC1 domain-containing protein DDB_G0295713. (704 aa) |
| | psmD8-1 | Probable 26S proteasome non-ATPase regulatory subunit 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (263 aa) |
| | ubpB | Ubiquitin hydrolase B; Required for proper prespore cell patterning. Plays a role in stabilizing mkkA by preventing it from being targeted for degradation. ubcB and ubpB differentially control ubiquitination/deubiquitination and degradation of mkkA in a cell-type-specific and temporally regulated manner. (451 aa) |
| | ubcC | Ubiquitin-conjugating enzyme protein UbcC; Belongs to the ubiquitin-conjugating enzyme family. (235 aa) |
| | culA | Cullin-1; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Required at several stages during development. CulA and fbxA regulate multicellular development by targeting regA for degradation via a pathway that requires erkB function, leading to an increase in cAMP and PKA activity. (770 aa) |
| | nosA | NOSA. (1089 aa) |
| | tipD | Protein tipD; Not known; disruption of the gene for tipD results in morphological defects. (612 aa) |
| | DDB_G0285063 | Uncharacterized protein. (3792 aa) |
| | repE | DNA damage-binding protein 1; Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). (1181 aa) |
| | DDB_G0293770 | Peptidase C19 family protein; Belongs to the peptidase C19 family. (1021 aa) |
| | fpaB-1 | SCF ubiquitin ligase complex protein SKP1b(4-162). (162 aa) |
| | adrm1-1 | Proteasomal ubiquitin receptor ADRM1 homolog; Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme uchl5 at the 26S proteasome and promotes its activity (By similarity). Plays a role in the transition from growth to differentiation. (287 aa) |
| | DDB0217477 | Uncharacterized protein; Belongs to the peptidase C19 family. (1357 aa) |
| | DDB0217500 | CTLH domain-containing protein. (414 aa) |
| | rnf160 | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to cdcD/CDC48 recruitment for extraction and degradation of the incomplete translation product; Belongs to the LTN1 family. (1864 aa) |
| | DDB0217570 | DUSP domain-containing protein. (404 aa) |
| | DDB0217656 | Uncharacterized protein; Belongs to the peptidase C19 family. (2991 aa) |
| | ubc2 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. (151 aa) |
| | psmD4 | 26S proteasome non-ATPase regulatory subunit 4; Binds and presumably selects ubiquitin-conjugates for destruction; Belongs to the proteasome subunit S5A family. (349 aa) |
| | anapc2 | Anaphase-promoting complex subunit 2; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the cullin family. (907 aa) |
| | Ercc8 | Uncharacterized protein. (513 aa) |
| | DDB0217880 | UBA_e1_C domain-containing protein. (1160 aa) |
| | DDB0217882 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (632 aa) |
| | DDB0217990 | RBR-type E3 ubiquitin transferase. (317 aa) |
| | DDB0218023 | Uncharacterized protein. (586 aa) |
| | DDB_G0278075 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (232 aa) |
| | DDB_G0278327 | TPR_REGION domain-containing protein. (558 aa) |
| | DDB0205456 | Uncharacterized protein. (353 aa) |
| | ube2c | Probable ubiquitin-conjugating enzyme E2 C; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. (153 aa) |
| | psmA6 | Proteasome subunit alpha type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (250 aa) |
| | DDB0215276 | RING-type domain-containing protein. (355 aa) |
| | DDB0215278 | RBR-type E3 ubiquitin transferase. (563 aa) |
| | culE | Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). (750 aa) |
| | DDB0215292 | Uncharacterized protein. (775 aa) |
| | DDB0205685 | Uncharacterized protein. (742 aa) |
| | DDB_G0279265 | Glucose-induced degradation protein 8 homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation; Belongs to the GID8 family. (228 aa) |
| | Amfr | RING-type domain-containing protein. (679 aa) |
| | DDB_G0279421 | Ubiquitin-like domain-containing protein. (271 aa) |
| | DDB0205758 | BTB domain-containing protein. (1238 aa) |
| | psmD7 | 26S proteasome non-ATPase regulatory subunit 7; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (325 aa) |
| | DDB0205932 | Uncharacterized protein. (1010 aa) |
| | DDB0206368 | RING-type domain-containing protein. (457 aa) |
| | DDB0206370 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (185 aa) |
| | anapc5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC5 family. (1017 aa) |
| | sgt | Small glutamine-rich tetratricopeptide repeat-containing protein; May act as a co-chaperone and regulate the ATPase activity of heat shock proteins. (334 aa) |
| | DDB0206533 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (125 aa) |
| | DDB0205191 | UBX domain-containing protein. (362 aa) |
| | ascc2 | Activating signal cointegrator 1 complex subunit 2 homolog; Enhances NF-kappa-B, SRF and AP1 transactivation. Belongs to the ASCC2 family. (941 aa) |
| | DDB_G0280895 | WD40 repeat-containing protein. (1501 aa) |
| | psmD11 | 26S proteasome non-ATPase regulatory subunit 11; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmD11 is required for proteasome assembly (By similarity); Belongs to the proteasome subunit S9 family. (413 aa) |
| | DDB0218298 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (401 aa) |
| | DDB0204548 | Uncharacterized protein. (342 aa) |
| | DDB0204663 | J domain-containing protein. (445 aa) |
| | DDB0204665 | SIAH-type domain-containing protein. (407 aa) |
| | uch1 | Probable ubiquitin carboxyl-terminal hydrolase; Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or nedd8 (By similarity). (255 aa) |
| | vps36 | Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (By similarity). (611 aa) |
| | DDB_G0282185 | RING zinc finger-containing protein. (790 aa) |
| | PsmF1 | Uncharacterized protein. (326 aa) |
| | DDB0204986 | J domain-containing protein. (407 aa) |
| | DDB0185326 | WD_REPEATS_REGION domain-containing protein. (891 aa) |
| | snf8 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (By similarity). (246 aa) |
| | migA | Uncharacterized protein. (863 aa) |
| | DDB0185513 | RBR-type E3 ubiquitin transferase. (1103 aa) |
| | DDB0185543 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (2375 aa) |
| | DDB0185644 | Uncharacterized protein. (1071 aa) |
| | DDB0218548 | HECT domain-containing protein. (1120 aa) |
| | DDB0185762 | RBR-type E3 ubiquitin transferase. (1051 aa) |
| | DDB0185786 | Ubiquitin-like domain-containing protein. (836 aa) |
| | DDB0218563 | PlsC domain-containing protein. (310 aa) |
| | DDB0218570 | Uncharacterized protein. (438 aa) |
| | DDB0218572 | Uncharacterized protein. (232 aa) |
| | tceb1 | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). (109 aa) |
| | DDB0218596 | RBR-type E3 ubiquitin transferase. (700 aa) |
