STRINGSTRING
DDB_G0279829 DDB_G0279829 DDB0189717 DDB0189717 eif4e eif4e DDB_G0269418 DDB_G0269418 DDB_G0274237 DDB_G0274237 gapA gapA svkA svkA pyk3 pyk3 PgtB PgtB cln3 cln3 adcA adcA abcB1 abcB1 smt1 smt1 PgtC PgtC yakA yakA psmD11 psmD11 krsA krsA arpB arpB dstC dstC psmD2 psmD2 comA comA rtoA rtoA psmC4 psmC4 corA corA proB proB rapA rapA splB splB abpC abpC cofA cofA cprA cprA abpA abpA act1 act1 fcpA fcpA myoM myoM abcG21 abcG21 rabR rabR DDB0168979 DDB0168979 napA napA DDB0169197 DDB0169197 sigF sigF sigJ sigJ dhkJ dhkJ DDB0218006 DDB0218006 vasp vasp cpiC cpiC DDB_G0267924 DDB_G0267924
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB_G0279829Uncharacterized protein. (267 aa)
DDB0189717Response regulatory domain-containing protein. (382 aa)
eif4eEukaryotic translation initiation factor 4E; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures; Belongs to the eukaryotic initiation factor 4E family. (250 aa)
DDB_G0269418Osmotically inducible family protein. (162 aa)
DDB_G0274237DUF614 family protein. (109 aa)
gapARas GTPase-activating-like protein gapA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA in the absence of rgaA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of the dividing cell. (860 aa)
svkASerine/threonine-protein kinase svkA; Involved in regulation of actin cytoskeleton organization during cell motility; F-actin fragmenting and capping protein allowing dynamic rearrangements of the actin cytoskeleton. Also part of a regulatory pathway from the centrosome to the midzone, thus regulating the completion of cell division; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (478 aa)
pyk3Dual specificity protein kinase pyk3; Involved in the development. Negatively regulates tyrosine phosphorylation and activation state of dstC/STATc, probably by activating a dstC/STATc phosphatase; Belongs to the protein kinase superfamily. TKL Tyr protein kinase family. (1338 aa)
PgtBUncharacterized protein. (1338 aa)
cln3Battenin. (421 aa)
adcAArrestin domain-containing protein A. (580 aa)
abcB1ABC transporter B family member 1. (909 aa)
smt1Probable cycloartenol-C-24-methyltransferase 1; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of cycloartenol to form 24-methylene cycloartenol. (354 aa)
PgtCUncharacterized protein. (1065 aa)
yakAProbable serine/threonine-protein kinase yakA; General sensor of environmental conditions, such as heat stress, effecting changes through pkaC. Essential for survival to nitrosoative and oxidative stresses. Required for cell cycle control, not only at the onset but also during development (aggregation process and postaggregative development). (1458 aa)
psmD1126S proteasome non-ATPase regulatory subunit 11; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmD11 is required for proteasome assembly (By similarity); Belongs to the proteasome subunit S9 family. (413 aa)
krsASerine/threonine-protein kinase 4 homolog A; Regulates both cAMP signaling during early development and the stress response. Functions as an activator of adenylylcyclase. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (461 aa)
arpBActin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general role in [...] (392 aa)
dstCSignal transducer and activator of transcription C; Transcription factor that regulates gene expression during development. May play a role in regulating gene expression in response to osmotic stress. (931 aa)
psmD226S proteasome non-ATPase regulatory subunit 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (893 aa)
comAComitin; May have a role in cell motility. It has high affinity for both G-actin and F-actin. Binds to vesicle membranes via mannose residues and, by way of its interaction with actin, links these membranes to the cytoskeleton. (185 aa)
rtoAProtein rtoA; May have dual functions, one in vegetative cells at starvation involving cell-type choice and a later function involving progression to the tipped mound stage. Involved in vesicle fusion in endo- and exocytosis. Involved in L.pneumophila intracellular growth. (367 aa)
psmC426S proteasome regulatory subunit 6B homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (403 aa)
corACoronin-A; Required for normal motility. Participates in cytokinesis. (445 aa)
proBProfilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. (124 aa)
rapARas-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells. (186 aa)
splBDual specificity protein kinase splB. (1155 aa)
abpCGelation factor; F-actin cross-linking protein. (857 aa)
cofACofilin-1A; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family. (137 aa)
cprACysteine proteinase 1; Cysteine proteinases 1 and 2 are believed to participate in the breakdown of protein during differentiation of Dictyostelium as a response to starvation. (343 aa)
abpAAlpha-actinin A; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Increases the actin-stimulated ATPase activity of myosin. Involved in vegetative cell growth, phagocytosis, motility and development, probably through stabilization of the actin network in the cortical cytoskeleton. (861 aa)
act1Major actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction. (376 aa)
fcpAProbable C-terminal domain small phosphatase; May function as a phosphatase involved in the regulation of cell growth and differentiation. (306 aa)
myoMMyosin-M heavy chain; Myosins are actin-based motor molecules with ATPase activity. Involved in macropinocytosis and remodeling of actin cytoskeleton. (1737 aa)
abcG21ABC transporter G family member 21. (1449 aa)
rabRRas-related protein RabR. (307 aa)
DDB0168979MFS domain-containing protein. (471 aa)
napANck-associated protein 1 homolog; Involved in regulation of actin and microtubule organization. Involved in cell adhesion. (1160 aa)
DDB0169197Uncharacterized protein. (798 aa)
sigFSrfA-induced gene F protein. (231 aa)
sigJSrfA-induced gene J protein. (357 aa)
dhkJHybrid signal transduction histidine kinase J; Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity). (2062 aa)
DDB0218006CYCLIN domain-containing protein; Belongs to the cyclin family. (463 aa)
vaspProtein VASP homolog; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as lamellipodial and filopodial dynamics in migrating cells. Plays a crucial role in filopodia formation, cell-substratum adhesion, and proper chemotaxis. Nucleates and bundles actin filaments. When complexed with fotH in filopodial tips, may support formin- mediated filament elongation by bundling nascent actin filaments. Belongs to the Ena/VASP family. (380 aa)
cpiCCystatin-A3; Intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (94 aa)
DDB_G0267924P-type ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1109 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.