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| | crlE | Cyclic AMP receptor-like protein E; Receptor for cAMP; Belongs to the G-protein coupled receptor 5 family. (330 aa) |
| | rasG | Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | gpaB | Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family. (357 aa) |
| | gpaA | Guanine nucleotide-binding protein alpha-1 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (356 aa) |
| | ndkC-1 | Nucleoside diphosphate kinase, cytosolic; Major role in the synthesis of nucleoside triphosphates other than ATP; Belongs to the NDK family. (155 aa) |
| | mlkA | Myosin light chain kinase A; Phosphorylates a specific serine in the N-terminus of a myosin light chain (By similarity). Phosphorylates regulatory myosin light chain (mlcR) during chemotaxis. (295 aa) |
| | rasC | Ras-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | gpaD | Guanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-4 plays a role in morphogenesis of the multicellular structure. (345 aa) |
| | gpaE | Guanine nucleotide-binding protein alpha-5 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. (347 aa) |
| | gpaF | Guanine nucleotide-binding protein alpha-6 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-6 is involved in the folic acid chemotaxis signal transduction pathway. (347 aa) |
| | gpaG | Guanine nucleotide-binding protein alpha-7 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (390 aa) |
| | gpaH | Guanine nucleotide-binding protein alpha-8 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-8 is a potential analog for the G(s)-like G-proteins which stimulate adenylate cyclase in mammals. (403 aa) |
| | pkaC | cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis. (648 aa) |
| | dgkA | Diacylglycerol kinase A; Belongs to the eukaryotic diacylglycerol kinase family. (887 aa) |
| | carB | Cyclic AMP receptor 2; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. Plays a key role during tip formation and late development; involved in cAMP-directed patterning of pre stalk cells as they sort before and during tip formation; Belongs to the G-protein coupled receptor 5 family. (375 aa) |
| | carC | Cyclic AMP receptor 3; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (490 aa) |
| | dagA | Protein CRAC; Couples activated G protein to adenylyl cyclase signal transduction from surface cAMP receptor. Pianissimo a cytosolic regulator and CRAC, are both essential for activation of the enzyme adenylyl cyclase. Pianissimo and CRAC do not function redundantly. Both proteins are integral components of the adenylyl cyclase activation pathway. (698 aa) |
| | gpbA | Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development. (347 aa) |
| | gbfA | G-box-binding factor; cAMP-responsive transcriptional activator regulating late gene expression. Essential component of the developmental switch between early and late development. Binds to a number of CA/GT-rich gene regulatory elements. (708 aa) |
| | erkA | Extracellular signal-regulated kinase 1; Kinase involved in a signal transduction pathway. (529 aa) |
| | gskA | Glycogen synthase kinase-3; During cellular differentiation, may mediate an extracellular cyclic AMP stimulated signal transduction pathway that regulates prespore and prestalk B-cell proportions through inhibition of stalk cell formation and induction of prespore cell differentiation. The cAMP receptor carC appears to activate gskA via the tyrosine kinases zakA and zak2, to stimulate prespore differentiation, while carD appears to negatively regulate gskA, to promote prestalk formation. (467 aa) |
| | fttB | 14-3-3-like protein; Belongs to the 14-3-3 family. (252 aa) |
| | pikA | Phosphatidylinositol 3-kinase 1. (1571 aa) |
| | pikB | Phosphatidylinositol 3-kinase 2. (1857 aa) |
| | acaA | Adenylate cyclase, aggregation specific; Coordinates cell aggregation by synthesizing the cAMP that influences differentiation and morphogenesis of cells within a developing multicellular structure. (1407 aa) |
| | grlK | Metabotropic glutamate receptor-like protein K; In the N-terminal section; belongs to the BMP lipoprotein family. (704 aa) |
| | DDB_G0292252 | Putative protein DDB_G0292252. (1256 aa) |
| | DDB0184177 | Uncharacterized protein. (437 aa) |
| | grlE | Metabotropic glutamate receptor-like protein E; May be involved in early development in cAMP sensing and subsequent chemotactic response. Probable receptor of GABA and glutamate, leading respectively to the induction or inhibition of SDF-2 formation. (816 aa) |
| | DDB0183829 | GpcrRhopsn4 domain-containing protein. (420 aa) |
| | grlP | Metabotropic glutamate receptor-like protein P; Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (1407 aa) |
| | crlF | Cyclic AMP receptor-like protein F; Receptor for cAMP; Belongs to the G-protein coupled receptor 5 family. (318 aa) |
| | ctxA | Cortexillin-1; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1; Belongs to the cortexillin family. (444 aa) |
| | fslF | Frizzled and smoothened-like protein F. (591 aa) |
| | DDB_G0288147 | Probable serine/threonine-protein kinase DDB_G0288147; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1347 aa) |
| | grlQ | Metabotropic glutamate receptor-like protein Q. (1187 aa) |
| | grlR | Metabotropic glutamate receptor-like protein R; Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (1604 aa) |
| | gpaC | Guanine nucleotide-binding protein alpha-3 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-3 plays a role in development. G alpha-3 mutants fail to aggregate; Belongs to the G-alpha family. (570 aa) |
| | grlD | Metabotropic glutamate receptor-like protein D; In the N-terminal section; belongs to the BMP lipoprotein family. (791 aa) |
| | grlM | Metabotropic glutamate receptor-like protein M; In the N-terminal section; belongs to the BMP lipoprotein family. (749 aa) |
| | lrlA | Latrophilin receptor-like protein A. (306 aa) |
| | DDB0186763 | GpcrRhopsn4 domain-containing protein. (463 aa) |
| | DDB0186214 | GpcrRhopsn4 domain-containing protein. (414 aa) |
| | DDB0186213 | GpcrRhopsn4 domain-containing protein. (333 aa) |
| | erkB | Extracellular signal-regulated kinase 2; Implicated in the relay of the cAMP chemotactic signal and cell differentiation. Important for receptor-mediated activation of adenylyl cyclase. (369 aa) |
| | grlN | Metabotropic glutamate receptor-like protein N; Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (891 aa) |
| | yakA | Probable serine/threonine-protein kinase yakA; General sensor of environmental conditions, such as heat stress, effecting changes through pkaC. Essential for survival to nitrosoative and oxidative stresses. Required for cell cycle control, not only at the onset but also during development (aggregation process and postaggregative development). (1458 aa) |
| | crlD | Cyclic AMP receptor-like protein D; Receptor for cAMP; Belongs to the G-protein coupled receptor 5 family. (470 aa) |
| | gpaI | Guanine nucleotide-binding protein alpha-9 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-9 antagonizes broad chemotactic response. It functions rapidly following receptor stimulation to negatively regulate PI3K/PTEN, adenylyl cyclase, and guanylyl cyclase pathways. (342 aa) |
| | srfB | Serum response factor homolog B. (467 aa) |
| | grlC | Metabotropic glutamate receptor-like protein C; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (800 aa) |
| | grlH | Metabotropic glutamate receptor-like protein H; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (764 aa) |
| | grlF | Metabotropic glutamate receptor-like protein F; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (770 aa) |
| | tbc1d5B | TBC1 domain family member 5 homolog B; May act as a GTPase-activating protein for Rab family protein(s). (1016 aa) |
| | crlA | Cyclic AMP receptor-like protein A; Receptor for cAMP which may play a role in prestalk cell differentiation. May act as a negative regulator of cell growth. Belongs to the G-protein coupled receptor 5 family. (369 aa) |
| | dhkA | Hybrid signal transduction histidine kinase A; Acts as a receptor histidine kinase for the cytokinin SDF-2 in a signal transduction pathway that regulates prestalk gene expression and controls terminal differentiation of prespore cells. Binding of SDF-2 to this protein inhibits phosphorelay and induces rapid sporulation. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. (2150 aa) |
| | far1 | Metabotropic glutamate receptor-like protein L; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (708 aa) |
| | gbqA | Developmental protein DG1120. (581 aa) |
| | gpaL | Guanine nucleotide-binding protein alpha-12 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (354 aa) |
| | crlG | Cyclic AMP receptor-like protein G; Receptor for cAMP; Belongs to the G-protein coupled receptor 5 family. (515 aa) |
| | adprt1A | Poly [ADP-ribose] polymerase. (938 aa) |
| | rckA | RGS domain-containing serine/threonine-protein kinase A; Serine/threonine kinase involved in negative regulation of chemotaxis. (1125 aa) |
| | DDB0204509 | GpcrRhopsn4 domain-containing protein. (439 aa) |
| | dcx | Protein doublecortin; Has a cytoskeleton-independent function in chemotactic signaling during development. (308 aa) |
| | ctxB | Cortexillin-2; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1 (By similarity); Belongs to the cortexillin family. (441 aa) |
| | ifkA | Probable serine/threonine-protein kinase ifkA; Phosphorylates eIF2-alpha, from 1 to 7 hours after the onset of development or during the preaggregation state, resulting in a shift from polysomes to free ribosomes for bulk mRNA. (2258 aa) |
| | grlA | Metabotropic glutamate receptor-like protein A; May play an important role in the terminal differentiation. In the N-terminal section; belongs to the BMP lipoprotein family. (798 aa) |
| | grlO | Metabotropic glutamate receptor-like protein O; In the N-terminal section; belongs to the BMP lipoprotein family. (819 aa) |
| | gpaJ | Guanine nucleotide-binding protein-like alpha-10 subunit; Belongs to the G-alpha family. (349 aa) |
| | crlB | Cyclic AMP receptor-like protein B; Receptor for cAMP. (442 aa) |
| | crlC | Cyclic AMP receptor-like protein C; Receptor for cAMP. (361 aa) |
| | zakA | Dual specificity protein kinase zakA; Positive regulator of gsk3/gskA activity required for cell pattern formation and a downstream effector of carC. The kinases, gsk3/gskA, zakA and zak2, form part of a signaling pathway that responds to extracellular cyclic AMP. The pathway has a role in transcriptional regulation; required to direct prespore/spore fates during development. ZakA negatively regulates prestalk differentiation by regulating expression of ecmB. Phosphorylates Y-214 of gsk3/gskA, in vitro; In the C-terminal section; belongs to the protein kinase superfamily. TKL Tyr prote [...] (781 aa) |
| | grlG | Metabotropic glutamate receptor-like protein G; In the N-terminal section; belongs to the BMP lipoprotein family. (772 aa) |
| | grlJ | Metabotropic glutamate receptor-like protein J; May act during the development and be a negative regulator. In the N-terminal section; belongs to the BMP lipoprotein family. (783 aa) |
| | gtaC | GATA zinc finger domain-containing protein 3. (587 aa) |
| | htt | HD protein homolog; May play a role in microtubule-mediated transport or vesicle function; Belongs to the huntingtin family. (3095 aa) |
| | DG1106 | Development protein DG1106. (1207 aa) |
| | dhkK | Hybrid signal transduction histidine kinase K; Involved in a signal transduction pathway that regulates morphogenesis and controls entry into the culmination stage. May act via the regA pathway, being activated by a morphogenesis-stimulated ligand, reducing phosphodiesterase regA levels and allowing cAMP level to rise to promote the culmination stage. This protein probably undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. (1213 aa) |
| | rpkA | RpkA. (828 aa) |
| | grlB | Metabotropic glutamate receptor-like protein B; In the N-terminal section; belongs to the BMP lipoprotein family. (755 aa) |
| | lis1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the coupling of the nucleus and centrosome and dynein/dynactin-mediated interactions of microtubule tips with the cell cortex; Belongs to the WD repeat LIS1/nudF family. (419 aa) |
| | pdeE | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B; Dual specificity cAMP and cGMP phosphodiesterase with marked preference for cyclic AMP, which is activated by cAMP and cGMP. Likely functions as a cAMP-stimulated cAMP-phosphodiesterase which may play a role in regulating the cAMP relay response. Belongs to the metallo-beta-lactamase superfamily. cNMP phosphodiesterase family. (1096 aa) |
| | gpaK | Guanine nucleotide-binding protein-like alpha-11 subunit; Belongs to the G-alpha family. (359 aa) |
| | DDB0217518 | GpcrRhopsn4 domain-containing protein. (394 aa) |
| | pteN | 3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa) |
| | gpgA | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. This major G-protein of the squid photoreceptor is involved in visual transduction. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity). Required for normal chemotaxis in response to cAMP. (69 aa) |
| | mfeA | Peroxisomal multifunctional enzyme A; Enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Protects the cells from the increase of the harmful xenobiotic fatty acids incorporated from their diets and optimizes cellular lipid composition for proper development. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (441 aa) |
| | carD | Cyclic AMP receptor 4; Receptor for cAMP. Regulates axial patterning and cellular differentiation during late development. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (443 aa) |
| | spnA | Probable guanine nucleotide-binding protein spalten; Involved in cell-type differentiation and morphogenesis. Dephosphorylates casein; in vitro. May also be involved as modulators or transducers in various transmembrane signaling systems. In the C-terminal section; belongs to the PP2C family. (975 aa) |
| | dia2 | Differentiation-associated protein 2; Has an essential role in the initiation of differentiation. Also required for cAMP signaling. (151 aa) |
| | rasD | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (187 aa) |
| | pdsA | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase A; Phosphodiesterase which displays a preference for cAMP over cGMP. Involved in the degradation of extracellular cAMP. Maintains the responsiveness of cells to the chemoattractant cAMP during the aggregation phase of development. (452 aa) |
| | carA-1 | Cyclic AMP receptor 1; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. (392 aa) |
