STRINGSTRING
ripA ripA rheb rheb pakD pakD DDB0189538 DDB0189538 DDB0169375 DDB0169375 ctnA ctnA DDB_G0274833 DDB_G0274833 DDB0169145 DDB0169145 gefH gefH gefB gefB gbpC gbpC gefM gefM qkgA-1 qkgA-1 pteN pteN piaA piaA carA-1 carA-1 rasG rasG splB splB rapA rapA rasC rasC gpaD gpaD gpaH gpaH pkaC pkaC racC racC dagA dagA gpbA gpbA erkA erkA gskA gskA pkbA pkbA pikA pikA pikB pikB DDB_G0292160 DDB_G0292160 racE racE lst8 lst8 DDB_G0292252 DDB_G0292252 DDB_G0292056 DDB_G0292056 sec13 sec13 DDB0184177 DDB0184177 DDB_G0291948 DDB_G0291948 mapbpip mapbpip rblA rblA pyk3 pyk3 ragA ragA DDB_G0288147 DDB_G0288147 cnrN cnrN wdr24 wdr24 scrA scrA RagC RagC pdkB pdkB gefA gefA phg2 phg2 DDB_G0283567 DDB_G0283567 grlH grlH cfaD cfaD iplA iplA pdkA pdkA far1 far1 DDB0204021 DDB0204021 DDB0206467 DDB0206467 STK19 STK19 PlaA PlaA scaA scaA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ripARas-interacting protein RIP3; Component of a Ras-regulated pathway involved in integrating chemotaxis and signal relay pathways that are essential for aggregation. (838 aa)
rhebGTP-binding protein Rheb homolog; Binds GTP and exhibits intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rheb family. (185 aa)
pakDSerine/threonine-protein kinase pakD. (1678 aa)
DDB0189538Uncharacterized protein. (1426 aa)
DDB0169375Uncharacterized protein. (312 aa)
ctnACountin-1; Cell-counting factor that limits the maximum size of the multicellular structure. May down-regulate the expression of gp24, which mediates cell adhesion. (258 aa)
DDB_G0274833Ragulator complex protein LAMTOR3 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids (By similarity); Belongs to the LAMTOR3 family. (132 aa)
DDB0169145Uncharacterized protein; Belongs to the WD repeat SEC13 family. (467 aa)
gefHRas guanine nucleotide exchange factor H; Promotes the exchange of Ras-bound GDP by GTP. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (604 aa)
gefBRas guanine nucleotide exchange factor B; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Involved in phagocytosis, fluid-phase endocytosis, regulation of macropinocytosis and control of cell movement. (1529 aa)
gbpCCyclic GMP-binding protein C; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2631 aa)
gefMRas guanine nucleotide exchange factor M; Promotes the exchange of Ras-bound GDP by GTP. (929 aa)
qkgA-1Probable serine/threonine-protein kinase qkgA; Involved in growth, and during development, in aggregation. (1553 aa)
pteN3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa)
piaAProtein pianissimo A; Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Required for chemoattractant receptor and G protein- mediated activation of the 12 transmembrane domain adenylyl cyclase. Functions as a part of protein complex TORC2. TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2, but not TORC1, negatively regulates phagocytosis. This protein and dagA protein CRAC, a cytosolic regulator, are both essential for activation of the enzyme adenylyl cyclase. This protein and CRAC do not function re [...] (1148 aa)
carA-1Cyclic AMP receptor 1; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. (392 aa)
rasGRas-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
splBDual specificity protein kinase splB. (1155 aa)
rapARas-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells. (186 aa)
rasCRas-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
gpaDGuanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-4 plays a role in morphogenesis of the multicellular structure. (345 aa)
gpaHGuanine nucleotide-binding protein alpha-8 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-8 is a potential analog for the G(s)-like G-proteins which stimulate adenylate cyclase in mammals. (403 aa)
pkaCcAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis. (648 aa)
racCRho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa)
dagAProtein CRAC; Couples activated G protein to adenylyl cyclase signal transduction from surface cAMP receptor. Pianissimo a cytosolic regulator and CRAC, are both essential for activation of the enzyme adenylyl cyclase. Pianissimo and CRAC do not function redundantly. Both proteins are integral components of the adenylyl cyclase activation pathway. (698 aa)
gpbAGuanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development. (347 aa)
erkAExtracellular signal-regulated kinase 1; Kinase involved in a signal transduction pathway. (529 aa)
gskAGlycogen synthase kinase-3; During cellular differentiation, may mediate an extracellular cyclic AMP stimulated signal transduction pathway that regulates prespore and prestalk B-cell proportions through inhibition of stalk cell formation and induction of prespore cell differentiation. The cAMP receptor carC appears to activate gskA via the tyrosine kinases zakA and zak2, to stimulate prespore differentiation, while carD appears to negatively regulate gskA, to promote prestalk formation. (467 aa)
pkbARAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. (444 aa)
pikAPhosphatidylinositol 3-kinase 1. (1571 aa)
pikBPhosphatidylinositol 3-kinase 2. (1857 aa)
DDB_G0292160Uncharacterized protein DDB_G0292160. (174 aa)
racERho-related protein racE; Specifically required for cytokinesis; Belongs to the small GTPase superfamily. Rho family. (223 aa)
lst8Protein LST8 homolog; Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay; Belongs to the WD repeat LST8 family. (304 aa)
DDB_G0292252Putative protein DDB_G0292252. (1256 aa)
DDB_G0292056WD repeat-containing protein DDB_G0292056. (1823 aa)
sec13Protein SEC13 homolog; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 [...] (301 aa)
DDB0184177Uncharacterized protein. (437 aa)
DDB_G0291948Ragulator complex protein LAMTOR4 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity). (87 aa)
mapbpipRobl_LC7 domain-containing protein. (123 aa)
rblARetinoblastoma-like protein A; Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin- modifying enzymes to promoters (By similarity). Plays a dual role, regulating cell-cycle progression and transcriptional events leading to terminal differentiation. In the absence of a G1 phase, functions in late G2 contro [...] (1312 aa)
pyk3Dual specificity protein kinase pyk3; Involved in the development. Negatively regulates tyrosine phosphorylation and activation state of dstC/STATc, probably by activating a dstC/STATc phosphatase; Belongs to the protein kinase superfamily. TKL Tyr protein kinase family. (1338 aa)
ragARas-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the TOR signaling cascade; Belongs to the GTR/RAG GTP-binding protein family. (301 aa)
DDB_G0288147Probable serine/threonine-protein kinase DDB_G0288147; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1347 aa)
cnrNPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN; Protein phosphatase that negatively regulates PI3K-dependent pathways. Regulates cAMP signal transduction to control territory size. During development, a lawn of Dictyostelium cells breaks up into territories where cells aggregate in dendritic streams to form groups of 20'000 cells. (639 aa)
wdr24GATOR complex protein WDR24; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. (1023 aa)
scrAProtein SCAR; Involved in regulation of actin and microtubule organization. Regulates phagocytosis and macropinocytosis. Belongs to the SCAR/WAVE family. (443 aa)
RagCUncharacterized protein. (360 aa)
pdkB3-phosphoinositide-dependent protein kinase B. (908 aa)
gefARas guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (605 aa)
phg2Serine/threonine-protein kinase phg2; Serine/threonine kinase regulating cell substrate adhesion, phagocytosis, motility, chemotaxis, and actin cytoskeleton organization. It is a downstream component of Rap1-regulated adhesion, and it is a regulator of myosin II phosphorylation. It is also a negative regulator of development initiation. (1387 aa)
DDB_G0283567Ragulator complex protein LAMTOR5 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity). (89 aa)
grlHMetabotropic glutamate receptor-like protein H; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (764 aa)
cfaDCounting factor associated protein D; Inhibitor that slows proliferation of secreting cells (also known as chalone). Requires aprA for activity. (531 aa)
iplAInositol 1,4,5-trisphosphate receptor-like protein A; May be a receptor for inositol 1,4,5 trisphosphate which governs calcium fluxes from the endoplasmic reticulum stores into the cytosol. May be involved in autophagic cell death. (3177 aa)
pdkAProbable serine/threonine-protein kinase pdkA. (686 aa)
far1Metabotropic glutamate receptor-like protein L; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (708 aa)
DDB0204021UDENN FLCN/SMCR8-type domain-containing protein. (656 aa)
DDB0206467Uncharacterized protein. (298 aa)
STK19Serine/threonine-protein kinase 19 homolog; Serine/threonine-protein kinase. (391 aa)
PlaAPNPLA domain-containing protein. (386 aa)
scaASca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. (1582 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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