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iplA iplA atp1 atp1 H3a H3a DDB0187042 DDB0187042 arpB arpB mhcA mhcA glpD glpD dgkA dgkA cycB cycB arpC arpC pkbA pkbA acaA acaA cpnF cpnF catA catA H2Bv3 H2Bv3 mipp1 mipp1 DDB0186283 DDB0186283 cpnC cpnC DDB0185845 DDB0185845 sodB sodB sodC sodC rbbD rbbD nola4 nola4 DDB_G0291342 DDB_G0291342 DDB0219651 DDB0219651 ccs ccs cpnE cpnE sodE sodE Rfa1 Rfa1 impact impact DDB_G0289141 DDB_G0289141 hspI hspI sodD sodD sodF sodF impa1 impa1 ArpD ArpD trrA trrA wdr12 wdr12 gcn1 gcn1 adprt1B adprt1B DDB0218156 DDB0218156 adprt1A adprt1A ngap ngap CRTF CRTF DDB0217949 DDB0217949 nhe1 nhe1 DDB0217691 DDB0217691 prdx4 prdx4 PARTg PARTg DDB0203614 DDB0203614 sod2 sod2 H3b H3b DDB0190694 DDB0190694 atp5f1b atp5f1b ITPK1 ITPK1 cpnD cpnD hspL hspL sodA sodA adprt4 adprt4 DDB0231494 DDB0231494 H4a H4a htt htt cpnA cpnA prep prep hspK hspK cpnB-1 cpnB-1 PARTf PARTf adprt2 adprt2 bip2 bip2 aoxA aoxA dhkC dhkC AF318287 AF318287 DDB0184460 DDB0184460 DDB_G0292440 DDB_G0292440 adprt3 adprt3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
iplAInositol 1,4,5-trisphosphate receptor-like protein A; May be a receptor for inositol 1,4,5 trisphosphate which governs calcium fluxes from the endoplasmic reticulum stores into the cytosol. May be involved in autophagic cell death. (3177 aa)
atp1ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (519 aa)
H3aHistone H3.3 type a; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (139 aa)
DDB0187042Poly [ADP-ribose] polymerase; Belongs to the 14-3-3 family. (2563 aa)
arpBActin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general role in [...] (392 aa)
mhcAMyosin-2 heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2116 aa)
glpDGlycogen phosphorylase 2; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (993 aa)
dgkADiacylglycerol kinase A; Belongs to the eukaryotic diacylglycerol kinase family. (887 aa)
cycBG2/mitotic-specific cyclin-B; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (436 aa)
arpCActin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general role in [...] (418 aa)
pkbARAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. (444 aa)
acaAAdenylate cyclase, aggregation specific; Coordinates cell aggregation by synthesizing the cAMP that influences differentiation and morphogenesis of cells within a developing multicellular structure. (1407 aa)
cpnFCopine-F. (550 aa)
catACatalase-A; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (496 aa)
H2Bv3Histone H2B.v3; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (154 aa)
mipp1Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (By similarity). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. Belongs to the histidine acid phosphatase family. MINPP1 subfamily. (635 aa)
DDB0186283AMP-binding domain-containing protein. (424 aa)
cpnCCopine-C. (539 aa)
DDB0185845PfkB domain-containing protein. (491 aa)
sodBExtracellular superoxide dismutase [Cu-Zn] 2; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxyde radicals into hydrogen peroxyde and oxygen. (427 aa)
sodCExtracellular superoxide dismutase [Cu-Zn] 3; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxyde radicals into hydrogen peroxyde and oxygen. (407 aa)
rbbDProbable histone-binding protein rbbD; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism (By similarity). (423 aa)
nola4Probable H/ACA ribonucleoprotein complex subunit 4; Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity); Belongs to the pseudouridine synthase TruB family. (540 aa)
DDB_G0291342C2H2-type zinc finger-containing protein. (810 aa)
DDB0219651Peptidase C83 domain-containing protein. (626 aa)
ccsProbable copper chaperone for superoxide dismutase; Delivers copper to copper zinc superoxide dismutases. In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. (316 aa)
cpnECopine-E. (579 aa)
sodESuperoxide dismutase [Cu-Zn] 5; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (152 aa)
Rfa1Uncharacterized protein. (679 aa)
impactProtein IMPACT homolog; Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. (345 aa)
DDB_G0289141Poly [ADP-ribose] polymerase. (1803 aa)
hspISmall heat shock protein hspI, mitochondrial. (223 aa)
sodDSuperoxide dismutase [Cu-Zn] 4; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity). Protects spores from cellular damage caused by UV LIGHT. (151 aa)
sodFProbable superoxide dismutase [Cu-Zn] 6; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (151 aa)
impa1Inositol monophosphatase; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. Has broad substrate specificity and can use myo-inositol monophosphates, myo- inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo- inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. (272 aa)
ArpDUncharacterized protein; Belongs to the actin family. (440 aa)
trrAThioredoxin reductase; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. (319 aa)
wdr12Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit. (463 aa)
gcn1eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the gcn2 protein kinase activity in response to amino acid starvation. Forms a complex with eif2ak4/gcn2 on translating ribosomes; during this process, gcn1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of eif2ak4/gcn2, and hence stimulating eif2ak4/gcn2 kinase activity. Participates in the repression of global protein synthesis and in gene- specific mRNA translation activation, such as the transcriptional activator atf4, by promoting [...] (2667 aa)
adprt1BPoly [ADP-ribose] polymerase. (804 aa)
DDB0218156Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1158 aa)
adprt1APoly [ADP-ribose] polymerase. (938 aa)
ngapProbable Ras GTPase-activating-like protein ngap; May function as a Ras GTPase-activating protein. (877 aa)
CRTFCAR1 transcription factor; Nuclear transcription factor with zinc-dependent sequence binding specificity. Required for carA-1 and carA-2 expression in early development. Also required throughout later developmental stages - where it has a cell-autonomous role that is distinct from its capacity to control carA-1 and carA-2 expression. Required for terminal spore differentiation but not essential for cell differentiation and cell sorting. May function to help insulate distinct pathways from simultaneous and universal activation by cAMP. (876 aa)
DDB0217949Sod_Fe_C domain-containing protein. (133 aa)
nhe1Sodium/hydrogen exchanger 1; Regulation of intracellular pH homeostasis in response to cAMP, which is essential for chemotaxis. Necessary for F-actin localization and the kinetics of actin polymerization during chemotaxis and cell polarity but not for directional sensing. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (674 aa)
DDB0217691Uncharacterized protein. (290 aa)
prdx4Peroxiredoxin-4; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (259 aa)
PARTgPoly [ADP-ribose] polymerase. (1618 aa)
DDB0203614Kinase; Belongs to the inositol phosphokinase (IPK) family. (307 aa)
sod2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (226 aa)
H3bHistone H3.3 type b; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
DDB0190694Uncharacterized protein. (794 aa)
atp5f1bATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] (651 aa)
ITPK1Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (326 aa)
cpnDCopine-D. (530 aa)
hspLSmall heat shock protein hspL; Belongs to the small heat shock protein (HSP20) family. (132 aa)
sodASuperoxide dismutase [Cu-Zn] 1; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
adprt4Poly [ADP-ribose] polymerase. (644 aa)
DDB0231494RNA-binding region RNP-1 domain-containing protein. (299 aa)
H4aHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (108 aa)
httHD protein homolog; May play a role in microtubule-mediated transport or vesicle function; Belongs to the huntingtin family. (3095 aa)
cpnACopine-A; Required for cytokinesis, contractile vacuole function and development; Belongs to the copine family. (600 aa)
prepProlyl endopeptidase; Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long; Belongs to the peptidase S9A family. (760 aa)
hspKSmall heat shock protein hspK; Belongs to the small heat shock protein (HSP20) family. (179 aa)
cpnB-1Copine-B. (530 aa)
PARTfPoly [ADP-ribose] polymerase. (610 aa)
adprt2Poly [ADP-ribose] polymerase. (700 aa)
bip2Luminal-binding protein 2; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER; Belongs to the heat shock protein 70 family. (658 aa)
aoxAAlternative oxidase. (337 aa)
dhkCHybrid signal transduction histidine kinase C; Acts in a signal transduction pathway that regulates the slug versus culmination choice. Believed to be the first component of a phosphorelay that couples the sensing of ammonia to the modulation of PKA activity and hence activates culmination and spore germination. Ammonium transporters amtA and amtC are thought to respectively activate and inhibit dhkC phosphorelay. This protein probably undergoes an ATP-dependent autophosphorylation at conserved His residue in the kinase core, and a phosphoryl group is then transferred to a conserved as [...] (1225 aa)
AF318287Putative calmodulin-binding protein CamBP64. (581 aa)
DDB0184460Uncharacterized protein. (455 aa)
DDB_G0292440Uncharacterized sugar kinase; Belongs to the carbohydrate kinase PfkB family. (355 aa)
adprt3Poly [ADP-ribose] polymerase. (2536 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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