STRINGSTRING
ctnnA ctnnA forH forH scrA scrA midA midA far1 far1 anapc5 anapc5 DDB_G0278327 DDB_G0278327 nhe1 nhe1 med26 med26 glkA glkA DDB0190346 DDB0190346 mtpn mtpn pfdn2 pfdn2 anapc8 anapc8 DDB0167099 DDB0167099 p2xA p2xA pdeD pdeD anapc7 anapc7 proC proC racG racG wasA wasA DDB0189211 DDB0189211 DDB0216142 DDB0216142 ctxA ctxA aarA aarA anapc3 anapc3 rgaA rgaA DDB_G0287165 DDB_G0287165 anapc11 anapc11 gflB gflB DDB_G0286065 DDB_G0286065 lst8 lst8 forG forG anapc6 anapc6 aip1 aip1 gskA gskA arpC arpC gpbA gpbA racC racC rac1B rac1B rac1A rac1A proB proB proA proA rapA rapA napA napA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ctnnAProbable vinculin; Involved in cell adhesion. Thought to play an important role in cytokinesis B, probably by providing substrate adhesion and traction forces. Required to organize and polarize the tip epithelium during cytokinesis. Required for the normal distribution of myosin in the tip epithelium. Involved in the localization of ctxA, ctxB, dcsA, exoc6 and rgaA. Thought to form a complex with ctxA, ctxB, and rgaA which regulates myosin accumulation to the apical plasma membrane. Belongs to the vinculin/alpha-catenin family. (842 aa)
forHFormin-H; Formins play an important role in the nucleation of actin and the formation of linear actin filaments. Important for cell migration and formation, elongation and maintenance of filopodia. Specifically controls filopodial dynamics by regulating actin turnover at the barbed ends of actin filaments; Belongs to the formin homology family. Diaphanous subfamily. (1087 aa)
scrAProtein SCAR; Involved in regulation of actin and microtubule organization. Regulates phagocytosis and macropinocytosis. Belongs to the SCAR/WAVE family. (443 aa)
midAProtein arginine methyltransferase NDUFAF7 homolog, mitochondrial; Involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts as an arginine methyltransferase and probably acts by mediating arginine methylation of ndufs2 (By similarity). Belongs to the NDUFAF7 family. (484 aa)
far1Metabotropic glutamate receptor-like protein L; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (708 aa)
anapc5Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC5 family. (1017 aa)
DDB_G0278327TPR_REGION domain-containing protein. (558 aa)
nhe1Sodium/hydrogen exchanger 1; Regulation of intracellular pH homeostasis in response to cAMP, which is essential for chemotaxis. Necessary for F-actin localization and the kinetics of actin polymerization during chemotaxis and cell polarity but not for directional sensing. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (674 aa)
med26Putative mediator of RNA polymerase II transcription subunit 26; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (2073 aa)
glkAProbable serine/threonine-protein kinase glkA; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. (473 aa)
DDB0190346C2 domain-containing protein. (1546 aa)
mtpnMyotrophin homolog; May regulate NF-kappa-B transcription factor activity. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity). Belongs to the myotrophin family. (120 aa)
pfdn2Probable prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit beta family. (116 aa)
anapc8Anaphase-promoting complex subunit 8; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC8/CDC23 family. (592 aa)
DDB0167099PX domain-containing protein. (104 aa)
p2xAP2X receptor A; P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Inward currents evoked by intracellular ATP and ATP analogs. Exclusively selective for ATP over other nucleotides. Insensitive to P2 receptor antagonists PPADS, suramin and 2',3'-O-(2,4,6-trinitrophenyl)-ATP but inhibited by nanomolar concentrations of copper and sodium ion. More permeable to ammonium than either sodium or potassium ions and less permeable to choline. It has been reported that p2xA is not es [...] (378 aa)
pdeDcGMP-dependent 3',5'-cGMP phosphodiesterase A; Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP. Involved in the degradation of intracellular cGMP. (867 aa)
anapc7Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC7 family. (580 aa)
proCProfilin-3; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity). (126 aa)
racGRho-related protein racG. (201 aa)
wasAWiscott-Aldrich syndrome protein. (399 aa)
DDB0189211Uncharacterized protein. (382 aa)
DDB0216142Zinc_ribbon_10 domain-containing protein. (452 aa)
ctxACortexillin-1; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1; Belongs to the cortexillin family. (444 aa)
aarAProtein aardvark; Required to regulate pattern formation during multi-cellular stages of development and for the formation of adherens junctions. Plays a structural role during the regulation of stalk formation. Involved in cell signaling. Required for spore-cell differentiation. Overexpression increases number and size of cell junctions and reduces spore-cell formation; Belongs to the beta-catenin family. (757 aa)
anapc3Anaphase-promoting complex subunit 3; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC3/CDC27 family. (970 aa)
rgaARas GTPase-activating-like protein rgaA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell. Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cyt [...] (822 aa)
DDB_G0287165Spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the microtubule organizing center following nucleation; Belongs to the AAA ATPase family. Spastin subfamily. (655 aa)
anapc11Anaphase-promoting complex subunit 11; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the RING-box family. (87 aa)
gflBRas guanine nucleotide exchange factor glfB; GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways. Acts also as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways. (1601 aa)
DDB_G0286065Uncharacterized ENTR1 family protein; Belongs to the ENTR1 family. (517 aa)
lst8Protein LST8 homolog; Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay; Belongs to the WD repeat LST8 family. (304 aa)
forGFormin-G; Formins play an important role in the nucleation of actin and the formation of linear actin filaments. (1074 aa)
anapc6Anaphase-promoting complex subunit 6; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC6/CDC16 family. (865 aa)
aip1Actin-interacting protein 1; Implicated in both actin filament depolymerization and polymerization. May enhance chemotaxis by promoting cofilin-dependent actin assembly at cell leading edges. (597 aa)
gskAGlycogen synthase kinase-3; During cellular differentiation, may mediate an extracellular cyclic AMP stimulated signal transduction pathway that regulates prespore and prestalk B-cell proportions through inhibition of stalk cell formation and induction of prespore cell differentiation. The cAMP receptor carC appears to activate gskA via the tyrosine kinases zakA and zak2, to stimulate prespore differentiation, while carD appears to negatively regulate gskA, to promote prestalk formation. (467 aa)
arpCActin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general role in [...] (418 aa)
gpbAGuanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development. (347 aa)
racCRho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa)
rac1BRho-related protein rac1B; Overexpression promotes the formation of filopodia and membrane ruffles. (194 aa)
rac1ARho-related protein rac1A; Overexpression promotes the formation of filopodia and membrane ruffles; Belongs to the small GTPase superfamily. Rho family. (194 aa)
proBProfilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. (124 aa)
proAProfilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. (126 aa)
rapARas-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells. (186 aa)
napANck-associated protein 1 homolog; Involved in regulation of actin and microtubule organization. Involved in cell adhesion. (1160 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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