13 items (Dictyostelium discoideum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pteN	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa)
	racC	Rho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa)
	pikA	Phosphatidylinositol 3-kinase 1. (1571 aa)
	pikB	Phosphatidylinositol 3-kinase 2. (1857 aa)
	pikC	Phosphatidylinositol 3-kinase 3. (1697 aa)
	DDB0191697	Uncharacterized protein. (453 aa)
	PikH	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1820 aa)
	cnrN	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN; Protein phosphatase that negatively regulates PI3K-dependent pathways. Regulates cAMP signal transduction to control territory size. During development, a lawn of Dictyostelium cells breaks up into territories where cells aggregate in dendritic streams to form groups of 20'000 cells. (639 aa)
	DDB_G0285967	LIM-type zinc finger-containing protein. (998 aa)
	PikG	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1671 aa)
	DDB0218256	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1229 aa)
	DDB0217695	Uncharacterized protein. (527 aa)
	PikF	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1382 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDB0191697	DDB_G0285967	Q54CH3	Q54MG8	Uncharacterized protein.	LIM-type zinc finger-containing protein.	0.913
DDB0191697	PikF	Q54CH3	Q55FX5	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.900
DDB0191697	PikG	Q54CH3	Q54S78	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.900
DDB0191697	PikH	Q54CH3	Q54F55	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.900
DDB0191697	pikA	Q54CH3	P54673	Uncharacterized protein.	Phosphatidylinositol 3-kinase 1.	0.923
DDB0191697	pikB	Q54CH3	P54674	Uncharacterized protein.	Phosphatidylinositol 3-kinase 2.	0.923
DDB0191697	pikC	Q54CH3	P54675	Uncharacterized protein.	Phosphatidylinositol 3-kinase 3.	0.900
DDB0191697	pteN	Q54CH3	Q8T9S7	Uncharacterized protein.	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...]	0.916
DDB0217695	DDB_G0285967	Q553B4	Q54MG8	Uncharacterized protein.	LIM-type zinc finger-containing protein.	0.838
DDB0218256	PikF	Q54UU9	Q55FX5	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.540
DDB0218256	PikG	Q54UU9	Q54S78	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.540
DDB0218256	PikH	Q54UU9	Q54F55	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.540
DDB0218256	pikA	Q54UU9	P54673	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase 1.	0.540
DDB0218256	pikB	Q54UU9	P54674	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase 2.	0.540
DDB0218256	pikC	Q54UU9	P54675	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase 3.	0.540
DDB_G0285967	DDB0191697	Q54MG8	Q54CH3	LIM-type zinc finger-containing protein.	Uncharacterized protein.	0.913
DDB_G0285967	DDB0217695	Q54MG8	Q553B4	LIM-type zinc finger-containing protein.	Uncharacterized protein.	0.838
DDB_G0285967	PikF	Q54MG8	Q55FX5	LIM-type zinc finger-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.900
DDB_G0285967	PikG	Q54MG8	Q54S78	LIM-type zinc finger-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.902
DDB_G0285967	PikH	Q54MG8	Q54F55	LIM-type zinc finger-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.901