STRINGSTRING
DDB0187092 DDB0187092 ampA ampA mlcE mlcE abpC abpC racC racC pikA pikA pikB pikB pikC pikC DDB_G0293920 DDB_G0293920 DDB0192162 DDB0192162 DDB0183780 DDB0183780 PikH PikH gacW gacW DDB0188132 DDB0188132 gmfA gmfA DDB0205303 DDB0205303 DDB_G0281669 DDB_G0281669 DDB0220008 DDB0220008 DDB0218256 DDB0218256 forA forA DDB0218071 DDB0218071 nhe1 nhe1 corB corB ate1 ate1 DDB0189644 DDB0189644 PikF PikF nudE nudE DDB0168311 DDB0168311 napA napA DG1112 DG1112 paxB paxB torA torA carmil carmil DDB0218778 DDB0218778 DDB_G0285081 DDB_G0285081 DDB0185955 DDB0185955 DDB0185522 DDB0185522 sglA sglA PikG PikG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB0187092Uncharacterized protein. (813 aa)
ampAPrestalk D11 protein. (284 aa)
mlcEMyosin, essential light chain. (150 aa)
abpCGelation factor; F-actin cross-linking protein. (857 aa)
racCRho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa)
pikAPhosphatidylinositol 3-kinase 1. (1571 aa)
pikBPhosphatidylinositol 3-kinase 2. (1857 aa)
pikCPhosphatidylinositol 3-kinase 3. (1697 aa)
DDB_G0293920Uncharacterized protein. (861 aa)
DDB0192162Uncharacterized protein. (800 aa)
DDB0183780Uncharacterized protein. (1583 aa)
PikHUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1820 aa)
gacWRho GTPase-activating protein gacW; Rho GTPase-activating protein involved in the signal transduction pathway. (1115 aa)
DDB0188132Uncharacterized protein. (995 aa)
gmfAADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. GMF subfamily. (138 aa)
DDB0205303Uncharacterized protein. (874 aa)
DDB_G0281669LMBR1 domain-containing protein 2 homolog B. (790 aa)
DDB0220008SAP DNA-binding domain-containing protein. (1216 aa)
DDB0218256Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1229 aa)
forAFormin-A; Formins play an important role in the nucleation of actin and the formation of linear actin filaments. (1218 aa)
DDB0218071Uncharacterized protein. (717 aa)
nhe1Sodium/hydrogen exchanger 1; Regulation of intracellular pH homeostasis in response to cAMP, which is essential for chemotaxis. Necessary for F-actin localization and the kinetics of actin polymerization during chemotaxis and cell polarity but not for directional sensing. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (674 aa)
corBCoronin-B; Involved in phagocytosis and cell motility. Binds to actin filaments and protects them against depolymerization. Belongs to the WD repeat coronin family. (962 aa)
ate1Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity); Belongs to the R-transferase family. (629 aa)
DDB0189644Uncharacterized protein. (517 aa)
PikFUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1382 aa)
nudELis-interacting protein. (398 aa)
DDB0168311Uncharacterized protein. (882 aa)
napANck-associated protein 1 homolog; Involved in regulation of actin and microtubule organization. Involved in cell adhesion. (1160 aa)
DG1112Developmental gene product DG1112. (1057 aa)
paxBPaxillin-B; Required for cell-substrate adhesion, cell sorting, slug migration, and cell differentiation. May function upstream of limB. (569 aa)
torAProtein tortoise; Required for efficient chemotaxis. (808 aa)
carmilProtein CARMIL; Serves as the scaffold for the assembly of a complex that links key players in the nucleation and termination of actin filament assembly with a ubiquitous barbed end-directed motor. This complex is composed of at least capping proteins (acpA and acpB), the Arp2/3 complex, type I myosins (myoB and myoC) and carmil. It has at least a modest ability to activate Arp2/3-dependent actin nucleation. CARMIL localizes along with the Arp2/3 complex, myoB, and myoC in the leading edge of cells and it plays a significant role in the structure and function of these actin-rich cellul [...] (1050 aa)
DDB0218778Uncharacterized protein. (1070 aa)
DDB_G0285081Leucine-rich repeat-containing protein. (1471 aa)
DDB0185955Uncharacterized protein. (1272 aa)
DDB0185522Calponin-homology (CH) domain-containing protein. (971 aa)
sglASphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (By similarity). Sphingosine-1-phosphate (S1P) probably acts intracellularly as a second messenger perhaps by promoting cell proliferation; the absence of S1P lyase increases its concentration. This leads to increased lateral pseudopod formation as well as defects in the efficiency of chemotaxis. Overexpression of S1P lyase causes decreased growth rates, entry into stationary phase at lower cell density and increased sensitivity to [...] (528 aa)
PikGUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1671 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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