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gbpD gbpD pde3 pde3 carA-1 carA-1 mlkA mlkA carC carC ptpC ptpC cap cap DDB0183788 DDB0183788 DDB0219460 DDB0219460 p2xD p2xD p2xE p2xE cnbB cnbB DDB0205063 DDB0205063 sgcA sgcA p2xC p2xC p2xB p2xB gca gca glkA glkA cnbA cnbA tmcB tmcB canA canA rcnA rcnA p2xA p2xA pdeD pdeD pdeE pdeE gbpC gbpC alxA alxA iplA iplA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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gbpDCyclic GMP-binding protein D; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Induces the formation of substrate-attached pseudopodia, that leads to increased adhesion and thereby negatively influencing cell speed and polarity. (1312 aa)
pde3cGMP-specific 3',5'-cGMP phosphodiesterase 3; Phosphodiesterase specific for cGMP, which is not activated by cGMP. Involved in the degradation of intracellular cGMP. (466 aa)
carA-1Cyclic AMP receptor 1; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. (392 aa)
mlkAMyosin light chain kinase A; Phosphorylates a specific serine in the N-terminus of a myosin light chain (By similarity). Phosphorylates regulatory myosin light chain (mlcR) during chemotaxis. (295 aa)
carCCyclic AMP receptor 3; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (490 aa)
ptpCTyrosine-protein phosphatase 3; Seems to dephosphorylate a protein of 130 kDa (p130). (990 aa)
capAdenylyl cyclase-associated protein; May have a regulatory bifunctional role. Binds G-actin and PIP2. Involved in microfilament reorganization near the plasma membrane in a PIP2-regulated manner. (464 aa)
DDB0183788PKD_channel domain-containing protein. (823 aa)
DDB0219460Uncharacterized protein. (943 aa)
p2xDP2X receptor D; P2X receptors are ligand-gated ion channels that play a role in intracellular calcium signaling. ATP does not evoke inward currents in p2xD. Not essential for osmoregulation. (407 aa)
p2xEP2X receptor E; P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Not essential for osmoregulation. Inward currents evoked by intracellular ATP. ATP analog beta, gamma-imido-ATP is a weak partial agonist of p2xE. Exclusively selective for ATP over other nucleotides. Insensitive to copper and P2 receptor antagonists PPADS and suramin but strongly inhibited by sodium ions. More permeable to ammonium than either sodium or potassium ions and less permeable to choline. Permeabl [...] (388 aa)
cnbBCalcineurin subunit B type 2; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity). (183 aa)
DDB0205063Uncharacterized protein. (223 aa)
sgcAGuanylyl cyclase. (2843 aa)
p2xCP2X receptor C; P2X receptors are ligand-gated ion channels that play a role in intracellular calcium signaling. ATP does not evoke inward currents in p2xC. Not essential for osmoregulation. (368 aa)
p2xBP2X receptor B; P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Not essential for osmoregulation. Inward currents are evoked by intracellular ATP and ATP analogs. Insensitive to the P2 receptor antagonists PPADS and suramin, and also copper ions. Inhibited by sodium ions. Permeable to chloride ions. (369 aa)
gcaGuanylyl cyclase, membrane; Synthesizes cyclic GMP (cGMP) from GTP, after activation by heterotrimeric or monomeric G proteins. Involved in chemotaxis. (1483 aa)
glkAProbable serine/threonine-protein kinase glkA; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. (473 aa)
cnbACalcineurin subunit B type 1; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Important for stalk formation. (180 aa)
tmcBTiny macrocysts protein B; Regulator of the cAMP signaling pathway specific to sexual development. Controls the levels of external cAMP by regulating the expression of phosphodiesterase pdsA and its inhibitor pdiA. (1416 aa)
canASerine/threonine-protein phosphatase 2B catalytic subunit; Catalytic subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Belongs to the PPP phosphatase family. PP-2B subfamily. (623 aa)
rcnAModulatory calcineurin-interacting protein. (405 aa)
p2xAP2X receptor A; P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Inward currents evoked by intracellular ATP and ATP analogs. Exclusively selective for ATP over other nucleotides. Insensitive to P2 receptor antagonists PPADS, suramin and 2',3'-O-(2,4,6-trinitrophenyl)-ATP but inhibited by nanomolar concentrations of copper and sodium ion. More permeable to ammonium than either sodium or potassium ions and less permeable to choline. It has been reported that p2xA is not es [...] (378 aa)
pdeDcGMP-dependent 3',5'-cGMP phosphodiesterase A; Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP. Involved in the degradation of intracellular cGMP. (867 aa)
pdeEcAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B; Dual specificity cAMP and cGMP phosphodiesterase with marked preference for cyclic AMP, which is activated by cAMP and cGMP. Likely functions as a cAMP-stimulated cAMP-phosphodiesterase which may play a role in regulating the cAMP relay response. Belongs to the metallo-beta-lactamase superfamily. cNMP phosphodiesterase family. (1096 aa)
gbpCCyclic GMP-binding protein C; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2631 aa)
alxAALG-2 interacting protein X; Unknown. Required for development but not for cell death. (794 aa)
iplAInositol 1,4,5-trisphosphate receptor-like protein A; May be a receptor for inositol 1,4,5 trisphosphate which governs calcium fluxes from the endoplasmic reticulum stores into the cytosol. May be involved in autophagic cell death. (3177 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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