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| | fam49 | Protein FAM49 homolog; Belongs to the FAM49 family. (315 aa) |
| | rabggtb | Probable geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal; Belongs to the protein prenyltransferase subunit beta family. (339 aa) |
| | gefL | Ras guanine nucleotide exchange factor L; Promotes the exchange of Ras-bound GDP by GTP. (2356 aa) |
| | gapA | Ras GTPase-activating-like protein gapA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA in the absence of rgaA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of the dividing cell. (860 aa) |
| | darA | Darlin; Part of a signaling pathway that initiates the aggregation and leads to the formation of aggregation centers or streams. Not essential for cytokinesis, pinocytosis or phagocytosis. Not essential for development, except in starvation-induced aggregation. Belongs to the RAP1GDS1 family. (766 aa) |
| | phgA | Drainin; May act as a GTPase-activating protein for Rab family protein(s) (By similarity). Required for osmotic regulation by the contractile vacuole in hypo-osmotic environments. Essential for periodic fusion of the contractile vacuole with the plasma membrane and consequent expulsion of water from the cell body. (438 aa) |
| | rapA | Ras-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells. (186 aa) |
| | pikA | Phosphatidylinositol 3-kinase 1. (1571 aa) |
| | pikB | Phosphatidylinositol 3-kinase 2. (1857 aa) |
| | pikC | Phosphatidylinositol 3-kinase 3. (1697 aa) |
| | gxcDD | Guanine exchange factor for Rac 30; GTPase-activating protein for Rac involved in streaming and development. (1632 aa) |
| | exoc6 | Exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (1025 aa) |
| | DDB0191923 | Uncharacterized protein. (1142 aa) |
| | ipo13A | Importin-13 homolog A; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. (1064 aa) |
| | docA | Uncharacterized protein; Belongs to the DOCK family. (2221 aa) |
| | DocC | DHR-2 domain-containing protein; Belongs to the DOCK family. (1736 aa) |
| | xpo2 | Exportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity); Belongs to the XPO2/CSE1 family. (951 aa) |
| | xpo1 | Exportin-1; Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES). (1057 aa) |
| | DDB0219647 | Uncharacterized protein. (1918 aa) |
| | DDB0188445 | VPS9 domain-containing protein. (1197 aa) |
| | DDB0188195 | Ras-GAP domain-containing protein. (817 aa) |
| | rgaA | Ras GTPase-activating-like protein rgaA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell. Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cyt [...] (822 aa) |
| | ranbp1 | Ran-specific GTPase-activating protein homolog; Belongs to the RANBP1 family. (194 aa) |
| | gflB | Ras guanine nucleotide exchange factor glfB; GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways. Acts also as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways. (1601 aa) |
| | mog1 | Probable ran guanine nucleotide release factor; May regulate the intracellular trafficking of ran. (195 aa) |
| | forH | Formin-H; Formins play an important role in the nucleation of actin and the formation of linear actin filaments. Important for cell migration and formation, elongation and maintenance of filopodia. Specifically controls filopodial dynamics by regulating actin turnover at the barbed ends of actin filaments; Belongs to the formin homology family. Diaphanous subfamily. (1087 aa) |
| | DDB0218662 | VPS9 domain-containing protein. (726 aa) |
| | DocD | Uncharacterized protein; Belongs to the DOCK family. (1924 aa) |
| | xpo5 | Exportin-5; Mediates the nuclear export of proteins bearing a double- stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). Belongs to the exportin family. (1135 aa) |
| | phg2 | Serine/threonine-protein kinase phg2; Serine/threonine kinase regulating cell substrate adhesion, phagocytosis, motility, chemotaxis, and actin cytoskeleton organization. It is a downstream component of Rap1-regulated adhesion, and it is a regulator of myosin II phosphorylation. It is also a negative regulator of development initiation. (1387 aa) |
| | DDB0218513 | Importin N-terminal domain-containing protein. (981 aa) |
| | xpot | Exportin-T; Mediates the nuclear export of aminoacylated tRNAs. Belongs to the exportin family. (1088 aa) |
| | forB | Formin-B; Formins play an important role in the nucleation of actin and the formation of linear actin filaments. (1126 aa) |
| | yipf1 | Protein YIPF1 homolog; Belongs to the YIP1 family. (347 aa) |
| | DDB_G0280955 | RabGAP/TBC domain-containing protein. (733 aa) |
| | DDB0206416 | VPS9 domain-containing protein. (812 aa) |
| | DDB0206402 | Rab proteins geranylgeranyltransferase component; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins; Belongs to the Rab GDI family. (661 aa) |
| | DDB0205871 | VPS9 domain-containing protein. (1107 aa) |
| | DDB0205990 | Importin N-terminal domain-containing protein. (1025 aa) |
| | forA | Formin-A; Formins play an important role in the nucleation of actin and the formation of linear actin filaments. (1218 aa) |
| | elmoE | ELMO domain-containing protein E. (1677 aa) |
| | ipo13B | Importin-13 homolog B; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. (1119 aa) |
| | cnrP | Putative countin receptor Cnr17. (1110 aa) |
| | DDB0203662 | VPS9 domain-containing protein. (715 aa) |
| | DDB0216929 | Uncharacterized protein. (1603 aa) |
| | DDB0216773 | Uncharacterized protein. (1369 aa) |
| | DocB | Uncharacterized protein; Belongs to the DOCK family. (2176 aa) |
| | Ipo4 | Importin N-terminal domain-containing protein. (1103 aa) |
| | tnpo | Transportin; Functions in nuclear protein import via a substrate-importin alpha-beta transport complex that passes though the nuclear pore complexes (NPC). Mediates docking of the substrate-importin complex to distinct nucleoporins (By similarity). (931 aa) |
| | DDB_G0269860 | Probable importin-7 homolog; May function in nuclear protein import; Belongs to the importin beta family. (1065 aa) |
| | rabggta | Geranylgeranyl transferase type-2 subunit alpha; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to proteins with a C-terminal sequence motif -XCC or -XCXC, where both cysteines may become modified. (311 aa) |
| | gefV | Ras guanine nucleotide exchange factor V; Promotes the exchange of Ras-bound GDP by GTP. (1982 aa) |
| | dennd10 | DENN domain-containing protein 10; Guanine nucleotide exchange factor (GEF) which may be involved in the regulation of homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. (366 aa) |
| | PikF | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1382 aa) |
| | pakC | Serine/threonine-protein kinase pakC; Has role in the regulation of chemotaxis. (477 aa) |
| | forD | Formin-D; Formins play an important role in the nucleation of actin and the formation of linear actin filaments; Belongs to the formin homology family. Diaphanous subfamily. (1214 aa) |
| | forF | Formin-F; Formins play an important role in the nucleation of actin and the formation of linear actin filaments; Belongs to the formin homology family. Diaphanous subfamily. (1220 aa) |
| | forE | Formin-E; Formins play an important role in the nucleation of actin and the formation of linear actin filaments; Belongs to the formin homology family. Diaphanous subfamily. (1561 aa) |
| | pirA | Protein pirA; Involved in regulation of actin and microtubule organization. (1336 aa) |
| | cnrF | RabGAP/TBC domain-containing protein. (986 aa) |
| | pakB | Serine/threonine-protein kinase pakB; Regulator of the myosin I component of the cytoskeleton: required for regulation of cytokinesis, phagocytosis and pinocytosis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (852 aa) |
| | nutf2 | Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. (127 aa) |
| | p2xA | P2X receptor A; P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Inward currents evoked by intracellular ATP and ATP analogs. Exclusively selective for ATP over other nucleotides. Insensitive to P2 receptor antagonists PPADS, suramin and 2',3'-O-(2,4,6-trinitrophenyl)-ATP but inhibited by nanomolar concentrations of copper and sodium ion. More permeable to ammonium than either sodium or potassium ions and less permeable to choline. It has been reported that p2xA is not es [...] (378 aa) |
| | lis1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the coupling of the nucleus and centrosome and dynein/dynactin-mediated interactions of microtubule tips with the cell cortex; Belongs to the WD repeat LIS1/nudF family. (419 aa) |
| | rdiA | Putative rho GDP-dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (By similarity). Regulates the Rac-dependent signaling pathways controlling cytokinesis, actin reorganization and the contractile vacuole. Required for efficient accumulation of cap at the cell cortex. (197 aa) |
| | wasA | Wiscott-Aldrich syndrome protein. (399 aa) |
| | ripA | Ras-interacting protein RIP3; Component of a Ras-regulated pathway involved in integrating chemotaxis and signal relay pathways that are essential for aggregation. (838 aa) |
