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| | dagA | Protein CRAC; Couples activated G protein to adenylyl cyclase signal transduction from surface cAMP receptor. Pianissimo a cytosolic regulator and CRAC, are both essential for activation of the enzyme adenylyl cyclase. Pianissimo and CRAC do not function redundantly. Both proteins are integral components of the adenylyl cyclase activation pathway. (698 aa) |
| | myoK | Myosin-K heavy chain; Myosins are actin-based motor molecules with ATPase activity. Involved in phagocytosis and motility, and in the maintenance and dynamics of cell cortex; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (858 aa) |
| | dymB | Dynamin-B; Enzyme hydrolyzing GTP; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (920 aa) |
| | myoI | Myosin-I heavy chain; Myosins are actin-based motor molecules with ATPase activity. Involved in the early steps of phagocytosis and adhesion. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2357 aa) |
| | myoM | Myosin-M heavy chain; Myosins are actin-based motor molecules with ATPase activity. Involved in macropinocytosis and remodeling of actin cytoskeleton. (1737 aa) |
| | dct | Dynacortin. (354 aa) |
| | wasA | Wiscott-Aldrich syndrome protein. (399 aa) |
| | racF2 | Rho-related protein racF2. (193 aa) |
| | racG | Rho-related protein racG. (201 aa) |
| | racH | Rho-related protein racH. (200 aa) |
| | racJ | Rho-related protein racJ. (205 aa) |
| | racL | Rho-related protein racL. (196 aa) |
| | limC | LIM domain-containing protein C; Binds to F-actin and may modulate the chemotactic response during early development and contribute to the maintenance of the strength of the actin cytoskeleton. (182 aa) |
| | limD-2 | LIM domain-containing protein D; Binds to F-actin and may modulate the chemotactic response during early development and contribute to the maintenance of the strength of the actin cytoskeleton. (198 aa) |
| | carmil | Protein CARMIL; Serves as the scaffold for the assembly of a complex that links key players in the nucleation and termination of actin filament assembly with a ubiquitous barbed end-directed motor. This complex is composed of at least capping proteins (acpA and acpB), the Arp2/3 complex, type I myosins (myoB and myoC) and carmil. It has at least a modest ability to activate Arp2/3-dependent actin nucleation. CARMIL localizes along with the Arp2/3 complex, myoB, and myoC in the leading edge of cells and it plays a significant role in the structure and function of these actin-rich cellul [...] (1050 aa) |
| | eb1 | Microtubule-associated protein RP/EB family member 1; Involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes; Belongs to the MAPRE family. (506 aa) |
| | pteN | 3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa) |
| | qkgA-1 | Probable serine/threonine-protein kinase qkgA; Involved in growth, and during development, in aggregation. (1553 aa) |
| | paxB | Paxillin-B; Required for cell-substrate adhesion, cell sorting, slug migration, and cell differentiation. May function upstream of limB. (569 aa) |
| | sbds | Ribosome maturation protein SBDS; Required for the assembly of mature ribosomes and ribosome biogenesis. Triggers the GTP-dependent release of ribosome maturation factors from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity). (274 aa) |
| | sgkA | Sphingosine kinase A; Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), which probably acts intracellularly as a second messenger perhaps by promoting cell proliferation. Overexpression of sgkA leads to increased growth rates on solid media and an increased resistance to the antitumor agents cisplatin and carboplatin. (624 aa) |
| | DG1112 | Developmental gene product DG1112. (1057 aa) |
| | napA | Nck-associated protein 1 homolog; Involved in regulation of actin and microtubule organization. Involved in cell adhesion. (1160 aa) |
| | mlcD | Myosin-ID light chain; Functions as the light chain for myosin-D. Has low affinity for calcium. (147 aa) |
| | DDB0168311 | Uncharacterized protein. (882 aa) |
| | pirA | Protein pirA; Involved in regulation of actin and microtubule organization. (1336 aa) |
| | vasp | Protein VASP homolog; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as lamellipodial and filopodial dynamics in migrating cells. Plays a crucial role in filopodia formation, cell-substratum adhesion, and proper chemotaxis. Nucleates and bundles actin filaments. When complexed with fotH in filopodial tips, may support formin- mediated filament elongation by bundling nascent actin filaments. Belongs to the Ena/VASP family. (380 aa) |
| | forE | Formin-E; Formins play an important role in the nucleation of actin and the formation of linear actin filaments; Belongs to the formin homology family. Diaphanous subfamily. (1561 aa) |
| | forF | Formin-F; Formins play an important role in the nucleation of actin and the formation of linear actin filaments; Belongs to the formin homology family. Diaphanous subfamily. (1220 aa) |
| | abiA | Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family. (332 aa) |
| | ate1 | Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity); Belongs to the R-transferase family. (629 aa) |
| | DDB0190143 | Uncharacterized protein. (1214 aa) |
| | corB | Coronin-B; Involved in phagocytosis and cell motility. Binds to actin filaments and protects them against depolymerization. Belongs to the WD repeat coronin family. (962 aa) |
| | pakD | Serine/threonine-protein kinase pakD. (1678 aa) |
| | pakA | Serine/threonine-protein kinase pakA; Regulator of the myosin II component of the cytoskeleton: required for regulation of cytokinesis. Functions during chemotaxis, required for maintaining the direction of cell movement, suppressing lateral pseudopod extension, and proper retraction of the posterior of chemotaxing cells; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (1197 aa) |
| | DDB0190683 | Uncharacterized protein. (2044 aa) |
| | DDB_G0271806 | PH and Rap-GAP domain-containing protein DDB_G0271806. (1167 aa) |
| | cosA | Protein costars; Modulates actin dynamics and cell motility. (82 aa) |
| | abpE-1 | Drebrin-like protein; Actin-binding adapter protein. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G- actin. Controls pseudopodium number and motility in early stages of chemotactic aggregation. (481 aa) |
| | act22 | Putative actin-22; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction (By similarity); Belongs to the actin family. (376 aa) |
| | DDB0217695 | Uncharacterized protein. (527 aa) |
| | racO | Rho-related protein racO. (276 aa) |
| | racN | Rho-related protein racN. (219 aa) |
| | DDB0218071 | Uncharacterized protein. (717 aa) |
| | brk1 | Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family. (68 aa) |
| | aurK | Aurora kinase; Part of a chromosomal passenger complex. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. (384 aa) |
| | pldB | Phospholipase D B; Plays a role in cell growth. Hydrolyzes membrane phospholipids, such as PtdCho (phosphatidylcholine), producing the free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own). Involved in the inhibition of actin-based motility and endocytosis. Its inhibition causes complete collapse of F-actin organization. Plays an important role in cell migration by localizing along the anterior cell membrane. Overexpression leads to the inability to aggregate even at higher cell density. Also known as a negative regulator of quorum sensing. (1216 aa) |
| | exoc8 | Exocyst complex component 8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (815 aa) |
| | DDB_G0280565 | Calponin-homology (CH) domain-containing protein. (842 aa) |
| | DDB0204021 | UDENN FLCN/SMCR8-type domain-containing protein. (656 aa) |
| | DDB_G0281669 | LMBR1 domain-containing protein 2 homolog B. (790 aa) |
| | DDB0205303 | Uncharacterized protein. (874 aa) |
| | DDB0185522 | Calponin-homology (CH) domain-containing protein. (971 aa) |
| | DDB0185859 | Calponin-homology (CH) domain-containing protein. (977 aa) |
| | exoc4 | Exocyst complex component 4; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (1182 aa) |
| | DDB0186279 | Uncharacterized protein. (759 aa) |
| | DDB_G0285081 | Leucine-rich repeat-containing protein. (1471 aa) |
| | scrA | Protein SCAR; Involved in regulation of actin and microtubule organization. Regulates phagocytosis and macropinocytosis. Belongs to the SCAR/WAVE family. (443 aa) |
| | RacP | Rho GTPase. (376 aa) |
| | forH | Formin-H; Formins play an important role in the nucleation of actin and the formation of linear actin filaments. Important for cell migration and formation, elongation and maintenance of filopodia. Specifically controls filopodial dynamics by regulating actin turnover at the barbed ends of actin filaments; Belongs to the formin homology family. Diaphanous subfamily. (1087 aa) |
| | DDB_G0285967 | LIM-type zinc finger-containing protein. (998 aa) |
| | DDB0218778 | Uncharacterized protein. (1070 aa) |
| | DDB0187092 | Uncharacterized protein. (813 aa) |
| | gflB | Ras guanine nucleotide exchange factor glfB; GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways. Acts also as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways. (1601 aa) |
| | talB | Talin-B; Actin-binding protein required for multicellular morphogenesis. Substrate of pkgB and/or pkbA. (2614 aa) |
| | cnrN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN; Protein phosphatase that negatively regulates PI3K-dependent pathways. Regulates cAMP signal transduction to control territory size. During development, a lawn of Dictyostelium cells breaks up into territories where cells aggregate in dendritic streams to form groups of 20'000 cells. (639 aa) |
| | DDB0188132 | Uncharacterized protein. (995 aa) |
| | racM | Rho-related protein racM. (189 aa) |
| | act10 | Actin-10; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction (By similarity); Belongs to the actin family. (376 aa) |
| | gacW | Rho GTPase-activating protein gacW; Rho GTPase-activating protein involved in the signal transduction pathway. (1115 aa) |
| | DDB0183780 | Uncharacterized protein. (1583 aa) |
| | DDB0191697 | Uncharacterized protein. (453 aa) |
| | exoc3 | Exocyst complex component 3; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (783 aa) |
| | DDB0192162 | Uncharacterized protein. (800 aa) |
| | DDB_G0293920 | Uncharacterized protein. (861 aa) |
| | racE | Rho-related protein racE; Specifically required for cytokinesis; Belongs to the small GTPase superfamily. Rho family. (223 aa) |
| | forG | Formin-G; Formins play an important role in the nucleation of actin and the formation of linear actin filaments. (1074 aa) |
| | racQ | Rho GTPase. (185 aa) |
| | myoE | Myosin IE heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. May play a role in moving membranes relative to actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1005 aa) |
| | acaA | Adenylate cyclase, aggregation specific; Coordinates cell aggregation by synthesizing the cAMP that influences differentiation and morphogenesis of cells within a developing multicellular structure. (1407 aa) |
| | myoF | Myosin IF heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1071 aa) |
| | aip1 | Actin-interacting protein 1; Implicated in both actin filament depolymerization and polymerization. May enhance chemotaxis by promoting cofilin-dependent actin assembly at cell leading edges. (597 aa) |
| | fimA | Fimbrin; Binds to actin. (610 aa) |
| | pikB | Phosphatidylinositol 3-kinase 2. (1857 aa) |
| | pikA | Phosphatidylinositol 3-kinase 1. (1571 aa) |
| | cadA | Calcium-dependent cell adhesion molecule 1; Mediates calcium-dependent cell-cell adhesion during the early stage of development. (213 aa) |
| | cap | Adenylyl cyclase-associated protein; May have a regulatory bifunctional role. Binds G-actin and PIP2. Involved in microfilament reorganization near the plasma membrane in a PIP2-regulated manner. (464 aa) |
| | arpC | Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general role in [...] (418 aa) |
| | myoC | Myosin IC heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Involved in the process of phagocytosis and appears to support streaming behavior. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1182 aa) |
| | racD | Rho-related protein racD; Belongs to the small GTPase superfamily. Rho family. (254 aa) |
| | racC | Rho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa) |
| | racB | Rho-related protein racB; Belongs to the small GTPase superfamily. Rho family. (195 aa) |
| | racA | Rho-related protein racA. (598 aa) |
| | rac1C | Rho-related protein rac1C; Overexpression promotes the formation of filopodia and membrane ruffles. (193 aa) |
| | rac1B | Rho-related protein rac1B; Overexpression promotes the formation of filopodia and membrane ruffles. (194 aa) |
| | rac1A | Rho-related protein rac1A; Overexpression promotes the formation of filopodia and membrane ruffles; Belongs to the small GTPase superfamily. Rho family. (194 aa) |
| | rab1A | Ras-related protein Rab-1A. (202 aa) |
| | myoD | Myosin ID heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Myosin id may have a role in chemotaxis and aggregation; it could serve to stabilize and even retract cortical structures, such as pseudopods and lamellopods. Involved in the process of phagocytosis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1109 aa) |
| | myoB | Myosin IB heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Myosin IB may have a role in chemotaxis and aggregation; it could serve to stabilize and even retract cortical structures, such as pseudopods and lamellopods. Involved in the whole cell motility of aggregation-stages cells. Overexpression results in significant decrease in the rate of cellular translocation and fluid-phase pinocytosis and abnormalities in the normal rearrangement of the actin cytoskeleton. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myos [...] (1111 aa) |
| | corA | Coronin-A; Required for normal motility. Participates in cytokinesis. (445 aa) |
| | abpB | Calcium-regulated actin-bundling protein; May contribute to the structure and reorganization of filopodia and pseudopodia accompanying cell movements. (295 aa) |
| | myoA | Myosin IA heavy chain; Actin-based motor protein, possibly involved in a wide range of motile processes, such as cell movement across a surface, and extension and retraction of pseudopodia or lamellipodia; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (994 aa) |
| | abpC | Gelation factor; F-actin cross-linking protein. (857 aa) |
| | cofA | Cofilin-1A; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family. (137 aa) |
| | eef1a2 | Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. It is also an abundant actin filament bundling protein. (453 aa) |
| | eef1a1 | Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. It is also an abundant actin filament bundling protein. (453 aa) |
| | talA | Talin-A; Actin-binding protein that may be involved in the control of cell motility and chemotaxis. (1279 aa) |
| | mhcA | Myosin-2 heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2116 aa) |
| | csaA | Contact site A protein; This cell-surface glycoprotein mediates cell-cell binding via homophilic interaction. (514 aa) |
| | act1 | Major actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction. (376 aa) |
| | act3 | Actin-3; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction; Belongs to the actin family. (376 aa) |
| | abpA | Alpha-actinin A; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Increases the actin-stimulated ATPase activity of myosin. Involved in vegetative cell growth, phagocytosis, motility and development, probably through stabilization of the actin network in the cortical cytoskeleton. (861 aa) |
| | arcE | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general [...] (138 aa) |
| | arcD | Actin-related protein 2/3 complex subunit 4; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general [...] (169 aa) |
| | arcC | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general [...] (174 aa) |
| | arcB | Actin-related protein 2/3 complex subunit 2; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general [...] (293 aa) |
| | arcA | Actin-related protein 2/3 complex subunit 1; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general [...] (369 aa) |
| | arpB | Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general role in [...] (392 aa) |
| | racF1 | Rho-related protein racF1; Might act in concert and/or share functions with other members of the RHO family in the regulation of a subset of cytoskeletal rearrangements that are required for these processes. (193 aa) |
| | limE | LIM domain-containing protein E; Associates with the actin cytoskeleton and may regulate actin polymerization in lamellipodia, through a rac1-dependent signaling pathway. May play a role in cell motility. Involved in cytokinesis by regulating the microtubule system and linking it to the cortical actin network. (199 aa) |
| | spnA | Probable guanine nucleotide-binding protein spalten; Involved in cell-type differentiation and morphogenesis. Dephosphorylates casein; in vitro. May also be involved as modulators or transducers in various transmembrane signaling systems. In the C-terminal section; belongs to the PP2C family. (975 aa) |
| | gapA | Ras GTPase-activating-like protein gapA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA in the absence of rgaA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of the dividing cell. (860 aa) |
| | DDB_G0274805 | SH3 domain-containing protein. (357 aa) |
