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| | scrA | Protein SCAR; Involved in regulation of actin and microtubule organization. Regulates phagocytosis and macropinocytosis. Belongs to the SCAR/WAVE family. (443 aa) |
| | DDB0186309 | Rab-GAP TBC domain-containing protein. (290 aa) |
| | DDB0186216 | Rap-GAP domain-containing protein. (1640 aa) |
| | pdkB | 3-phosphoinositide-dependent protein kinase B. (908 aa) |
| | gefA | Ras guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (605 aa) |
| | DDB0185814 | Rap-GAP domain-containing protein. (366 aa) |
| | erkB | Extracellular signal-regulated kinase 2; Implicated in the relay of the cAMP chemotactic signal and cell differentiation. Important for receptor-mediated activation of adenylyl cyclase. (369 aa) |
| | mob2 | MOB kinase activator-like 2; Belongs to the MOB1/phocein family. (217 aa) |
| | DDB0185432 | Rab-GAP TBC domain-containing protein. (1455 aa) |
| | DDB0218425 | Rap-GAP domain-containing protein. (1049 aa) |
| | DDB0185275 | Rap-GAP domain-containing protein. (1069 aa) |
| | DDB0218424 | Rab-GAP TBC domain-containing protein. (400 aa) |
| | gbpD | Cyclic GMP-binding protein D; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Induces the formation of substrate-attached pseudopodia, that leads to increased adhesion and thereby negatively influencing cell speed and polarity. (1312 aa) |
| | GxcF | DH domain-containing protein. (932 aa) |
| | grlH | Metabotropic glutamate receptor-like protein H; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (764 aa) |
| | DDB0204167 | Uncharacterized protein. (787 aa) |
| | rapgapB | RapA guanosine triphosphatase-activating protein B; Mediates the deactivation of rap1 during multicellular development and is required for normal morphogenesis. Also required for the correct patterning of specific subtypes of prestalk cells. (418 aa) |
| | nvl | Putative ribosome biogenesis ATPase nvl; Involved in ribosome biogenesis. Belongs to the AAA ATPase family. (867 aa) |
| | DDB0205121 | Uncharacterized protein. (464 aa) |
| | tbc1d5B | TBC1 domain family member 5 homolog B; May act as a GTPase-activating protein for Rab family protein(s). (1016 aa) |
| | gefP | Ras guanine nucleotide exchange factor P; Promotes the exchange of Ras-bound GDP by GTP. (1502 aa) |
| | cfaD | Counting factor associated protein D; Inhibitor that slows proliferation of secreting cells (also known as chalone). Requires aprA for activity. (531 aa) |
| | pdkA | Probable serine/threonine-protein kinase pdkA. (686 aa) |
| | far1 | Metabotropic glutamate receptor-like protein L; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (708 aa) |
| | DDB_G0281137 | RabGAP/TBC domain-containing protein. (597 aa) |
| | DDB0204021 | UDENN FLCN/SMCR8-type domain-containing protein. (656 aa) |
| | DDB_G0280955 | RabGAP/TBC domain-containing protein. (733 aa) |
| | DDB0218242 | Rap-GAP domain-containing protein. (2935 aa) |
| | psrA | Serine/threonine-protein phosphatase 2A regulatory subunit psrA; Involved in developmental cell fate decision. Belongs to the phosphatase 2A regulatory subunit B56 family. (628 aa) |
| | DDB0205190 | Methyltranfer_dom domain-containing protein. (217 aa) |
| | DDB0206540 | Uncharacterized protein. (303 aa) |
| | tbc1d5A | TBC1 domain family member 5 homolog A; May act as a GTPase-activating protein for Rab family protein(s). (1173 aa) |
| | DDB0205958 | Uncharacterized protein. (1333 aa) |
| | lkb1 | Serine/threonine-protein kinase stk11 homolog; Serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. (586 aa) |
| | GflD | Ras-GEF domain-containing protein. (1765 aa) |
| | DDB0205813 | Rab-GAP TBC domain-containing protein. (1229 aa) |
| | gcn1 | eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the gcn2 protein kinase activity in response to amino acid starvation. Forms a complex with eif2ak4/gcn2 on translating ribosomes; during this process, gcn1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of eif2ak4/gcn2, and hence stimulating eif2ak4/gcn2 kinase activity. Participates in the repression of global protein synthesis and in gene- specific mRNA translation activation, such as the transcriptional activator atf4, by promoting [...] (2667 aa) |
| | mobA | MOB kinase activator-like 1 homolog A; Belongs to the MOB1/phocein family. (213 aa) |
| | GefBB | Uncharacterized protein. (2050 aa) |
| | fray1 | Serine/threonine-protein kinase fray1; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (574 aa) |
| | PlaA | PNPLA domain-containing protein. (386 aa) |
| | scaA | Sca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. (1582 aa) |
| | DDB_G0278267 | Uncharacterized protein. (876 aa) |
| | xrcc4 | DNA repair protein xrcc4; May be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (lig4). The lig4-xrcc4 complex is responsible for the NHEJ ligation step, and xrcc4 enhances the joining activity of lig4. Binding of the lig4-xrcc4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (By similarity). (454 aa) |
| | DDB0204481 | Uncharacterized protein. (933 aa) |
| | racgef1 | Rac guanyl-nucleotide exchange factor. (1218 aa) |
| | DDB_G0277967 | RabGAP/TBC domain-containing protein. (1047 aa) |
| | AF310892_3 | Rab-GAP TBC domain-containing protein. (511 aa) |
| | fray2 | Serine/threonine-protein kinase fray2; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (1028 aa) |
| | DDB0217791 | Uncharacterized protein. (843 aa) |
| | zak2 | Dual specificity protein kinase zak2; Positive regulator of gsk3/gskA activity required for cell pattern formation and a downstream effector of carC. The kinases, gsk3/gskA, zakA and zak2, form part of a signaling pathway that responds to extracellular cyclic AMP. The pathway has a role in transcriptional regulation; required to direct prespore/spore fates during development. Zak2 negatively regulates prestalk differentiation by regulating expression of ecmA. Phosphorylates Y-214 of gsk3/gskA, in vitro; In the C-terminal section; belongs to the protein kinase superfamily. TKL Tyr prote [...] (635 aa) |
| | gefY | Ras guanine nucleotide exchange factor Y; Promotes the exchange of Ras-bound GDP by GTP. (1508 aa) |
| | Mbtps2 | Peptidase_M50 domain-containing protein. (562 aa) |
| | DDB0202560 | Rab-GAP TBC domain-containing protein. (702 aa) |
| | DDB_G0275421 | Uncharacterized protein. (1223 aa) |
| | ZizC | Uncharacterized protein; Belongs to the DOCK family. (2621 aa) |
| | adrm1-1 | Proteasomal ubiquitin receptor ADRM1 homolog; Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme uchl5 at the 26S proteasome and promotes its activity (By similarity). Plays a role in the transition from growth to differentiation. (287 aa) |
| | DDB_G0271806 | PH and Rap-GAP domain-containing protein DDB_G0271806. (1167 aa) |
| | nfaA | Neurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB. (920 aa) |
| | raptor | Protein raptor homolog. (1509 aa) |
| | DDB0190714 | Rab-GAP TBC domain-containing protein. (544 aa) |
| | ahsa | Activator of 90 kDa heat shock protein ATPase homolog; Co-chaperone that stimulates hspD/HSP90 ATPase activity. (383 aa) |
| | pakD | Serine/threonine-protein kinase pakD. (1678 aa) |
| | DDB0216649 | Rab-GAP TBC domain-containing protein. (831 aa) |
| | ZizD | Uncharacterized protein; Belongs to the DOCK family. (2162 aa) |
| | bub2 | Putative mitotic check point protein BUB2; Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis; Belongs to the BUB2 family. (366 aa) |
| | DDB0216614 | Rab-GAP TBC domain-containing protein. (604 aa) |
| | gefV | Ras guanine nucleotide exchange factor V; Promotes the exchange of Ras-bound GDP by GTP. (1982 aa) |
| | aph1 | Gamma-secretase subunit Aph-1; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors precursor protein. It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). (328 aa) |
| | tsuA | Probable serine/threonine-protein kinase tsuA; Plays a role in chemotaxis and seems to be involved in polarization. (2247 aa) |
| | tbck | TBC domain-containing protein kinase-like protein. (1033 aa) |
| | gefW | Ras guanine nucleotide exchange factor W; Promotes the exchange of Ras-bound GDP by GTP. (1172 aa) |
| | DDB_G0267588 | Probable phosphatidylinositol phosphate kinase DDB_G0267588; May be involved in signaling events that underlie chemotaxis via the chemoattractant-mediated pkgB phosphorylation. (719 aa) |
| | DDB0189319 | 2Fe-2S ferredoxin-type domain-containing protein. (159 aa) |
| | aprA | Autocrine proliferation repressor protein A; Inhibitor that slows proliferation of secreting cells (also known as chalone). May function by binding to cell surface receptors. Requires cfaD for activity. Overexpression slows proliferation. Belongs to the pqaA family. (494 aa) |
| | rapgap1 | RapA guanosine triphosphatase-activating protein 1; Mediates the deactivation of rap1 and plays an important role in spatially and temporally regulating cell adhesion and chemotaxis by controlling attachment disassembly in the leading edge through the regulation of myosin II assembly and disassembly. Overexpression leads to defective chemotaxis. (1055 aa) |
| | cnrF | RabGAP/TBC domain-containing protein. (986 aa) |
| | zakA | Dual specificity protein kinase zakA; Positive regulator of gsk3/gskA activity required for cell pattern formation and a downstream effector of carC. The kinases, gsk3/gskA, zakA and zak2, form part of a signaling pathway that responds to extracellular cyclic AMP. The pathway has a role in transcriptional regulation; required to direct prespore/spore fates during development. ZakA negatively regulates prestalk differentiation by regulating expression of ecmB. Phosphorylates Y-214 of gsk3/gskA, in vitro; In the C-terminal section; belongs to the protein kinase superfamily. TKL Tyr prote [...] (781 aa) |
| | pakB | Serine/threonine-protein kinase pakB; Regulator of the myosin I component of the cytoskeleton: required for regulation of cytokinesis, phagocytosis and pinocytosis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (852 aa) |
| | DDB0217806 | Rap-GAP domain-containing protein. (855 aa) |
| | DDB0168975 | Uncharacterized protein. (738 aa) |
| | atg1 | Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in autophagy. Involved in the control of autophagic vacuolar cell death. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium. (668 aa) |
| | gefQ | Ras guanine nucleotide exchange factor Q; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis. (1298 aa) |
| | ZizA | Uncharacterized protein; Belongs to the DOCK family. (2284 aa) |
| | DDB_G0272016 | DCN1-like protein 2. (267 aa) |
| | gefO | Ras guanine nucleotide exchange factor O; Promotes the exchange of Ras-bound GDP by GTP. (944 aa) |
| | gefN | Ras guanine nucleotide exchange factor N; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May play a role in chemotaxis. (1138 aa) |
| | gefJ | Ras guanine nucleotide exchange factor J; Promotes the exchange of Ras-bound GDP by GTP. (812 aa) |
| | gefI | Ras guanine nucleotide exchange factor I; Promotes the exchange of Ras-bound GDP by GTP. (824 aa) |
| | gefH | Ras guanine nucleotide exchange factor H; Promotes the exchange of Ras-bound GDP by GTP. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (604 aa) |
| | gefE | Ras guanine nucleotide exchange factor E; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis. (1037 aa) |
| | gefD | Ras guanine nucleotide exchange factor D; Promotes the exchange of Ras-bound GDP by GTP. (668 aa) |
| | gefC | Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP. (1457 aa) |
| | gefB | Ras guanine nucleotide exchange factor B; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Involved in phagocytosis, fluid-phase endocytosis, regulation of macropinocytosis and control of cell movement. (1529 aa) |
| | gbpC | Cyclic GMP-binding protein C; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2631 aa) |
| | SUMO | Small ubiquitin-like protein. (98 aa) |
| | gefR | Ras guanine nucleotide exchange factor R; Promotes the exchange of Ras-bound GDP by GTP. May also play a role in the activation of rasG. (1721 aa) |
| | gefM | Ras guanine nucleotide exchange factor M; Promotes the exchange of Ras-bound GDP by GTP. (929 aa) |
| | qkgA-1 | Probable serine/threonine-protein kinase qkgA; Involved in growth, and during development, in aggregation. (1553 aa) |
| | gefS | Ras guanine nucleotide exchange factor S; Promotes the exchange of Ras-bound GDP by GTP. (1043 aa) |
| | gefG | Ras guanine nucleotide exchange factor G; Promotes the exchange of Ras-bound GDP by GTP. (1556 aa) |
| | pteN | 3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa) |
| | psmE3 | Proteasome activator 28; Subunit of the 11S REG (also called PA28) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates preferentially the trypsin-like catalytic subunit of the proteasome. May also be involved in cell cycle regulation. (225 aa) |
| | iplA | Inositol 1,4,5-trisphosphate receptor-like protein A; May be a receptor for inositol 1,4,5 trisphosphate which governs calcium fluxes from the endoplasmic reticulum stores into the cytosol. May be involved in autophagic cell death. (3177 aa) |
| | carD | Cyclic AMP receptor 4; Receptor for cAMP. Regulates axial patterning and cellular differentiation during late development. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (443 aa) |
| | ripA | Ras-interacting protein RIP3; Component of a Ras-regulated pathway involved in integrating chemotaxis and signal relay pathways that are essential for aggregation. (838 aa) |
| | rapA | Ras-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells. (186 aa) |
| | DDB0187387 | Uncharacterized protein. (358 aa) |
| | cdh1 | Anaphase-promoting complex subunit cdh1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the WD repeat CDC20/Fizzy family. (754 aa) |
| | gflB | Ras guanine nucleotide exchange factor glfB; GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways. Acts also as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways. (1601 aa) |
| | DDB_G0286627 | Probable serine/threonine-protein kinase DDB_G0286627; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. (671 aa) |
| | CycK | Uncharacterized protein; Belongs to the cyclin family. (405 aa) |
| | cdc20 | Anaphase-promoting complex subunit cdc20; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the WD repeat CDC20/Fizzy family. (499 aa) |
| | Rplp1B | Uncharacterized protein; Belongs to the eukaryotic ribosomal protein P1/P2 family. (100 aa) |
| | cnrN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN; Protein phosphatase that negatively regulates PI3K-dependent pathways. Regulates cAMP signal transduction to control territory size. During development, a lawn of Dictyostelium cells breaks up into territories where cells aggregate in dendritic streams to form groups of 20'000 cells. (639 aa) |
| | rgaA | Ras GTPase-activating-like protein rgaA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell. Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cyt [...] (822 aa) |
| | DDB0187458 | Uncharacterized protein. (1076 aa) |
| | cks1 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function; Belongs to the CKS family. (82 aa) |
| | atg17 | Probable autophagy-related protein 17; Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity); Belongs to the ATG17 family. (488 aa) |
| | DDB_G0284369 | Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. (274 aa) |
| | gefL | Ras guanine nucleotide exchange factor L; Promotes the exchange of Ras-bound GDP by GTP. (2356 aa) |
| | DDB_G0302588 | RanBP2-type zinc finger. (3566 aa) |
| | DDB_G0284307 | Mo25-like family protein. (363 aa) |
| | DDB_G0295717 | RabGAP/TBC domain-containing protein. (821 aa) |
| | darA | Darlin; Part of a signaling pathway that initiates the aggregation and leads to the formation of aggregation centers or streams. Not essential for cytokinesis, pinocytosis or phagocytosis. Not essential for development, except in starvation-induced aggregation. Belongs to the RAP1GDS1 family. (766 aa) |
| | piaA | Protein pianissimo A; Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Required for chemoattractant receptor and G protein- mediated activation of the 12 transmembrane domain adenylyl cyclase. Functions as a part of protein complex TORC2. TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2, but not TORC1, negatively regulates phagocytosis. This protein and dagA protein CRAC, a cytosolic regulator, are both essential for activation of the enzyme adenylyl cyclase. This protein and CRAC do not function re [...] (1148 aa) |
| | phgA | Drainin; May act as a GTPase-activating protein for Rab family protein(s) (By similarity). Required for osmotic regulation by the contractile vacuole in hypo-osmotic environments. Essential for periodic fusion of the contractile vacuole with the plasma membrane and consequent expulsion of water from the cell body. (438 aa) |
| | calA | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (152 aa) |
| | carA-1 | Cyclic AMP receptor 1; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. (392 aa) |
| | rasG | Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | gpaB | Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family. (357 aa) |
| | rplp1 | 60S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (113 aa) |
| | rasC | Ras-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | gpaD | Guanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-4 plays a role in morphogenesis of the multicellular structure. (345 aa) |
| | gpaH | Guanine nucleotide-binding protein alpha-8 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-8 is a potential analog for the G(s)-like G-proteins which stimulate adenylate cyclase in mammals. (403 aa) |
| | pkaC | cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis. (648 aa) |
| | rab1A | Ras-related protein Rab-1A. (202 aa) |
| | racC | Rho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa) |
| | carC | Cyclic AMP receptor 3; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (490 aa) |
| | dagA | Protein CRAC; Couples activated G protein to adenylyl cyclase signal transduction from surface cAMP receptor. Pianissimo a cytosolic regulator and CRAC, are both essential for activation of the enzyme adenylyl cyclase. Pianissimo and CRAC do not function redundantly. Both proteins are integral components of the adenylyl cyclase activation pathway. (698 aa) |
| | gpbA | Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development. (347 aa) |
| | tgrC1 | Tiger protein C1; tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development. Could function as a non-diffusible cell-cell signaling molecule that is required for multicellular development. Has both cell-autonomous and non-cell-autonomous functions. Terminal node, epistatic both to comC and tgrD1. Activates tgrD1. (889 aa) |
| | erkA | Extracellular signal-regulated kinase 1; Kinase involved in a signal transduction pathway. (529 aa) |
| | pkbA | RAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. (444 aa) |
| | pikA | Phosphatidylinositol 3-kinase 1. (1571 aa) |
| | pikB | Phosphatidylinositol 3-kinase 2. (1857 aa) |
| | acgA | Adenylate cyclase, germination specific; Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain. (858 aa) |
| | mobC | MOB kinase activator-like 1 homolog C; Belongs to the MOB1/phocein family. (216 aa) |
| | gefF | Ras guanine nucleotide exchange factor F; Promotes the exchange of Ras-bound GDP by GTP. (1127 aa) |
| | ZizB | Uncharacterized protein; Belongs to the DOCK family. (2147 aa) |
| | mobB | MOB kinase activator-like 1 homolog B; Belongs to the MOB1/phocein family. (216 aa) |
| | lst8 | Protein LST8 homolog; Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay; Belongs to the WD repeat LST8 family. (304 aa) |
| | PsmE4 | Uncharacterized protein. (1905 aa) |
| | DDB_G0292252 | Putative protein DDB_G0292252. (1256 aa) |
| | DDB0184242 | Uncharacterized protein. (1163 aa) |
| | DDB0184177 | Uncharacterized protein. (437 aa) |
| | racGAP | Uncharacterized protein. (1350 aa) |
| | DDB_G0291510 | GTPase-activating protein DDB_G0291510. (1031 aa) |
| | gefK | Ras guanine nucleotide exchange factor K; Promotes the exchange of Ras-bound GDP by GTP. (1557 aa) |
| | DDB0188980 | Uncharacterized protein. (370 aa) |
| | rblA | Retinoblastoma-like protein A; Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin- modifying enzymes to promoters (By similarity). Plays a dual role, regulating cell-cycle progression and transcriptional events leading to terminal differentiation. In the absence of a G1 phase, functions in late G2 contro [...] (1312 aa) |
| | DDB_G0290025 | DCN1-like protein 1; May contribute to neddylation of cullin components of SCF- type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity). (249 aa) |
| | DDB0188549 | Rab-GAP TBC domain-containing protein. (541 aa) |
| | GefAA | Uncharacterized protein. (1371 aa) |
| | DDB0188326 | Uncharacterized protein. (801 aa) |
| | mnat1 | CDK-activating kinase assembly factor MAT1. (325 aa) |
| | DDB0216036 | Rab-GAP TBC domain-containing protein. (463 aa) |
| | DDB0188123 | Rab-GAP TBC domain-containing protein. (829 aa) |
| | DDB0187927 | Rab-GAP TBC domain-containing protein. (733 aa) |
| | DDB_G0288147 | Probable serine/threonine-protein kinase DDB_G0288147; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1347 aa) |
