STRINGSTRING
gpaD gpaD rab1A rab1A gpbA gpbA cycB cycB gflB gflB gskA gskA pkbA pkbA pikA pikA carD carD pteN pteN CycD CycD SUMO SUMO gbpC gbpC pdeE pdeE gefH gefH DDB0169187 DDB0169187 DDB0168506 DDB0168506 DDB0169197 DDB0169197 acbA acbA DDB_G0267588 DDB_G0267588 DDB0189716 DDB0189716 cycH cycH mpl1 mpl1 glkA glkA raptor raptor zak2 zak2 fray2 fray2 DDB0218006 DDB0218006 DDB0204333 DDB0204333 scaA scaA fray1 fray1 mobA mobA DDB0205676 DDB0205676 lkb1 lkb1 DDB0206540 DDB0206540 DDB0205192 DDB0205192 psrA psrA Prkab Prkab far1 far1 pdkA pdkA DDB0204990 DDB0204990 DDB_G0283417 DDB_G0283417 mob2 mob2 gefA gefA pdkB pdkB DDB0218807 DDB0218807 DDB0186996 DDB0186996 CycK CycK pikB pikB acgA acgA cycA cycA mobC mobC mobB mobB DDB_G0292252 DDB_G0292252 mnat1 mnat1 DDB0188206 DDB0188206 Rplp1B Rplp1B DDB0215898 DDB0215898 cdk5rap1 cdk5rap1 cks1 cks1 atg17 atg17 DDB_G0302588 DDB_G0302588 DDB_G0284307 DDB_G0284307 DDB_G0295785 DDB_G0295785 DDB_G0287745 DDB_G0287745 pkaR pkaR carA-1 carA-1 rasG rasG rplp1 rplp1 rasC rasC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gpaDGuanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-4 plays a role in morphogenesis of the multicellular structure. (345 aa)
rab1ARas-related protein Rab-1A. (202 aa)
gpbAGuanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development. (347 aa)
cycBG2/mitotic-specific cyclin-B; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (436 aa)
gflBRas guanine nucleotide exchange factor glfB; GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways. Acts also as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways. (1601 aa)
gskAGlycogen synthase kinase-3; During cellular differentiation, may mediate an extracellular cyclic AMP stimulated signal transduction pathway that regulates prespore and prestalk B-cell proportions through inhibition of stalk cell formation and induction of prespore cell differentiation. The cAMP receptor carC appears to activate gskA via the tyrosine kinases zakA and zak2, to stimulate prespore differentiation, while carD appears to negatively regulate gskA, to promote prestalk formation. (467 aa)
pkbARAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. (444 aa)
pikAPhosphatidylinositol 3-kinase 1. (1571 aa)
carDCyclic AMP receptor 4; Receptor for cAMP. Regulates axial patterning and cellular differentiation during late development. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (443 aa)
pteN3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa)
CycDUncharacterized protein; Belongs to the cyclin family. (694 aa)
SUMOSmall ubiquitin-like protein. (98 aa)
gbpCCyclic GMP-binding protein C; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2631 aa)
pdeEcAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B; Dual specificity cAMP and cGMP phosphodiesterase with marked preference for cyclic AMP, which is activated by cAMP and cGMP. Likely functions as a cAMP-stimulated cAMP-phosphodiesterase which may play a role in regulating the cAMP relay response. Belongs to the metallo-beta-lactamase superfamily. cNMP phosphodiesterase family. (1096 aa)
gefHRas guanine nucleotide exchange factor H; Promotes the exchange of Ras-bound GDP by GTP. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (604 aa)
DDB0169187Uncharacterized protein. (391 aa)
DDB0168506Uncharacterized protein. (135 aa)
DDB0169197Uncharacterized protein. (798 aa)
acbAAcyl-CoA-binding protein; Binds to acyl-CoA. Processed into the SDF-2 (spore differentiation factor 2) a peptide which triggers sporulation. SDF-2 appears to stimulate prestalk cells to release additional SDF-2 by acting through a signal transduction pathway that also involves dhkA, regA and PKA. Induces encapsulation of prespore cells in a dhkA- dependent manner. GABA induces the release of acbA from prespore cells and induces the exposure of tagC on the surface of prestalk cells where it can convert acbA to SDF-2. Glutamate acts as a competitive inhibitor and is also able to inhibit [...] (84 aa)
DDB_G0267588Probable phosphatidylinositol phosphate kinase DDB_G0267588; May be involved in signaling events that underlie chemotaxis via the chemoattractant-mediated pkgB phosphorylation. (719 aa)
DDB0189716Uncharacterized protein. (250 aa)
cycHPutative cyclin-H; May regulate cdk7 involved in transcription regulation and cell cycle progression; Belongs to the cyclin family. Cyclin C subfamily. (286 aa)
mpl1MAP kinase phosphatase with leucine-rich repeats protein 1; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins (By similarity). Dephosphorylates pNPP, in vitro. Essential for proper regulation of erkB (erk2) and optimal motility during development; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (834 aa)
glkAProbable serine/threonine-protein kinase glkA; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. (473 aa)
raptorProtein raptor homolog. (1509 aa)
zak2Dual specificity protein kinase zak2; Positive regulator of gsk3/gskA activity required for cell pattern formation and a downstream effector of carC. The kinases, gsk3/gskA, zakA and zak2, form part of a signaling pathway that responds to extracellular cyclic AMP. The pathway has a role in transcriptional regulation; required to direct prespore/spore fates during development. Zak2 negatively regulates prestalk differentiation by regulating expression of ecmA. Phosphorylates Y-214 of gsk3/gskA, in vitro; In the C-terminal section; belongs to the protein kinase superfamily. TKL Tyr prote [...] (635 aa)
fray2Serine/threonine-protein kinase fray2; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (1028 aa)
DDB0218006CYCLIN domain-containing protein; Belongs to the cyclin family. (463 aa)
DDB0204333Uncharacterized protein. (304 aa)
scaASca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. (1582 aa)
fray1Serine/threonine-protein kinase fray1; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (574 aa)
mobAMOB kinase activator-like 1 homolog A; Belongs to the MOB1/phocein family. (213 aa)
DDB0205676Uncharacterized protein. (242 aa)
lkb1Serine/threonine-protein kinase stk11 homolog; Serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. (586 aa)
DDB0206540Uncharacterized protein. (303 aa)
DDB0205192CYCLIN domain-containing protein. (333 aa)
psrASerine/threonine-protein phosphatase 2A regulatory subunit psrA; Involved in developmental cell fate decision. Belongs to the phosphatase 2A regulatory subunit B56 family. (628 aa)
PrkabAMPKBI domain-containing protein. (347 aa)
far1Metabotropic glutamate receptor-like protein L; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (708 aa)
pdkAProbable serine/threonine-protein kinase pdkA. (686 aa)
DDB0204990Cnn_1N domain-containing protein. (1381 aa)
DDB_G0283417Probable dual specificity protein phosphatase DDB_G0283417; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (230 aa)
mob2MOB kinase activator-like 2; Belongs to the MOB1/phocein family. (217 aa)
gefARas guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (605 aa)
pdkB3-phosphoinositide-dependent protein kinase B. (908 aa)
DDB0218807Uncharacterized protein. (429 aa)
DDB0186996CYCLIN domain-containing protein. (398 aa)
CycKUncharacterized protein; Belongs to the cyclin family. (405 aa)
pikBPhosphatidylinositol 3-kinase 2. (1857 aa)
acgAAdenylate cyclase, germination specific; Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain. (858 aa)
cycACyclin N-terminal domain-containing protein; Belongs to the cyclin family. (588 aa)
mobCMOB kinase activator-like 1 homolog C; Belongs to the MOB1/phocein family. (216 aa)
mobBMOB kinase activator-like 1 homolog B; Belongs to the MOB1/phocein family. (216 aa)
DDB_G0292252Putative protein DDB_G0292252. (1256 aa)
mnat1CDK-activating kinase assembly factor MAT1. (325 aa)
DDB0188206Uncharacterized protein. (427 aa)
Rplp1BUncharacterized protein; Belongs to the eukaryotic ribosomal protein P1/P2 family. (100 aa)
DDB0215898Uncharacterized protein. (559 aa)
cdk5rap1CDK5RAP1-like protein; Probable regulator of CDK5 activity; Belongs to the methylthiotransferase family. MiaB subfamily. (607 aa)
cks1Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function; Belongs to the CKS family. (82 aa)
atg17Probable autophagy-related protein 17; Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity); Belongs to the ATG17 family. (488 aa)
DDB_G0302588RanBP2-type zinc finger. (3566 aa)
DDB_G0284307Mo25-like family protein. (363 aa)
DDB_G0295785Cyclin-related 2 family protein. (361 aa)
DDB_G0287745DUF733 family protein. (599 aa)
pkaRcAMP-dependent protein kinase regulatory subunit. (327 aa)
carA-1Cyclic AMP receptor 1; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. (392 aa)
rasGRas-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
rplp160S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (113 aa)
rasCRas-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.