STRINGSTRING
zakA zakA DDB0167883 DDB0167883 gefH gefH gbpC gbpC SUMO SUMO carD carD ripA ripA DDB0218733 DDB0218733 DDB0186549 DDB0186549 DDB0186548 DDB0186548 DDB0186107 DDB0186107 pdkB pdkB gefA gefA pprA pprA mob2 mob2 pdkA pdkA far1 far1 Rplp1B Rplp1B mnat1 mnat1 DDB0188326 DDB0188326 DDB_G0292252 DDB_G0292252 mobB mobB mobC mobC acgA acgA pikB pikB pikA pikA pkbA pkbA gpbB gpbB gpbA gpbA rab1A rab1A gpaD gpaD rasC rasC rplp1 rplp1 rapA rapA gpaB gpaB rasG rasG carA-1 carA-1 DDB_G0284307 DDB_G0284307 DDB_G0302588 DDB_G0302588 atg17 atg17 cks1 cks1 DDB0206540 DDB0206540 CycK CycK lkb1 lkb1 gcn1 gcn1 DDB0205691 DDB0205691 mobA mobA fray1 fray1 scaA scaA fray2 fray2 zak2 zak2 DDB0217691 DDB0217691 raptor raptor DDB0201908 DDB0201908 DDB_G0267588 DDB_G0267588
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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zakADual specificity protein kinase zakA; Positive regulator of gsk3/gskA activity required for cell pattern formation and a downstream effector of carC. The kinases, gsk3/gskA, zakA and zak2, form part of a signaling pathway that responds to extracellular cyclic AMP. The pathway has a role in transcriptional regulation; required to direct prespore/spore fates during development. ZakA negatively regulates prestalk differentiation by regulating expression of ecmB. Phosphorylates Y-214 of gsk3/gskA, in vitro; In the C-terminal section; belongs to the protein kinase superfamily. TKL Tyr prote [...] (781 aa)
DDB0167883PHB domain-containing protein. (334 aa)
gefHRas guanine nucleotide exchange factor H; Promotes the exchange of Ras-bound GDP by GTP. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (604 aa)
gbpCCyclic GMP-binding protein C; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2631 aa)
SUMOSmall ubiquitin-like protein. (98 aa)
carDCyclic AMP receptor 4; Receptor for cAMP. Regulates axial patterning and cellular differentiation during late development. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (443 aa)
ripARas-interacting protein RIP3; Component of a Ras-regulated pathway involved in integrating chemotaxis and signal relay pathways that are essential for aggregation. (838 aa)
DDB0218733Ubiquitin-like domain-containing protein. (1374 aa)
DDB0186549WD_REPEATS_REGION domain-containing protein. (399 aa)
DDB0186548WD_REPEATS_REGION domain-containing protein. (382 aa)
DDB0186107PHB domain-containing protein. (386 aa)
pdkB3-phosphoinositide-dependent protein kinase B. (908 aa)
gefARas guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (605 aa)
pprAProtein phosphatase 1 regulatory subunit pprA; Regulatory subunit of protein phosphatase 1; Belongs to the SDS22 family. (336 aa)
mob2MOB kinase activator-like 2; Belongs to the MOB1/phocein family. (217 aa)
pdkAProbable serine/threonine-protein kinase pdkA. (686 aa)
far1Metabotropic glutamate receptor-like protein L; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (708 aa)
Rplp1BUncharacterized protein; Belongs to the eukaryotic ribosomal protein P1/P2 family. (100 aa)
mnat1CDK-activating kinase assembly factor MAT1. (325 aa)
DDB0188326Uncharacterized protein. (801 aa)
DDB_G0292252Putative protein DDB_G0292252. (1256 aa)
mobBMOB kinase activator-like 1 homolog B; Belongs to the MOB1/phocein family. (216 aa)
mobCMOB kinase activator-like 1 homolog C; Belongs to the MOB1/phocein family. (216 aa)
acgAAdenylate cyclase, germination specific; Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain. (858 aa)
pikBPhosphatidylinositol 3-kinase 2. (1857 aa)
pikAPhosphatidylinositol 3-kinase 1. (1571 aa)
pkbARAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. (444 aa)
gpbBGuanine nucleotide-binding protein subunit beta-like protein; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (329 aa)
gpbAGuanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development. (347 aa)
rab1ARas-related protein Rab-1A. (202 aa)
gpaDGuanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-4 plays a role in morphogenesis of the multicellular structure. (345 aa)
rasCRas-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
rplp160S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (113 aa)
rapARas-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells. (186 aa)
gpaBGuanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family. (357 aa)
rasGRas-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
carA-1Cyclic AMP receptor 1; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. (392 aa)
DDB_G0284307Mo25-like family protein. (363 aa)
DDB_G0302588RanBP2-type zinc finger. (3566 aa)
atg17Probable autophagy-related protein 17; Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity); Belongs to the ATG17 family. (488 aa)
cks1Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function; Belongs to the CKS family. (82 aa)
DDB0206540Uncharacterized protein. (303 aa)
CycKUncharacterized protein; Belongs to the cyclin family. (405 aa)
lkb1Serine/threonine-protein kinase stk11 homolog; Serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. (586 aa)
gcn1eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the gcn2 protein kinase activity in response to amino acid starvation. Forms a complex with eif2ak4/gcn2 on translating ribosomes; during this process, gcn1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of eif2ak4/gcn2, and hence stimulating eif2ak4/gcn2 kinase activity. Participates in the repression of global protein synthesis and in gene- specific mRNA translation activation, such as the transcriptional activator atf4, by promoting [...] (2667 aa)
DDB0205691PHB domain-containing protein. (342 aa)
mobAMOB kinase activator-like 1 homolog A; Belongs to the MOB1/phocein family. (213 aa)
fray1Serine/threonine-protein kinase fray1; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (574 aa)
scaASca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. (1582 aa)
fray2Serine/threonine-protein kinase fray2; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (1028 aa)
zak2Dual specificity protein kinase zak2; Positive regulator of gsk3/gskA activity required for cell pattern formation and a downstream effector of carC. The kinases, gsk3/gskA, zakA and zak2, form part of a signaling pathway that responds to extracellular cyclic AMP. The pathway has a role in transcriptional regulation; required to direct prespore/spore fates during development. Zak2 negatively regulates prestalk differentiation by regulating expression of ecmA. Phosphorylates Y-214 of gsk3/gskA, in vitro; In the C-terminal section; belongs to the protein kinase superfamily. TKL Tyr prote [...] (635 aa)
DDB0217691Uncharacterized protein. (290 aa)
raptorProtein raptor homolog. (1509 aa)
DDB0201908PHB domain-containing protein. (383 aa)
DDB_G0267588Probable phosphatidylinositol phosphate kinase DDB_G0267588; May be involved in signaling events that underlie chemotaxis via the chemoattractant-mediated pkgB phosphorylation. (719 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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