STRINGSTRING
DDB0167752 DDB0167752 DDB0167388 DDB0167388 DDB0168617 DDB0168617 pigH pigH Dd5P4 Dd5P4 DDB0190143 DDB0190143 pats1 pats1 DDB0190271 DDB0190271 DDB0190357 DDB0190357 DDB0190609 DDB0190609 DDB0191072 DDB0191072 plbB plbB DDB0216866 DDB0216866 sac1 sac1 dpm2-1 dpm2-1 DDB_G0272638 DDB_G0272638 plbF plbF DDB0217695 DDB0217695 DDB0217768 DDB0217768 plbA plbA DDB_G0277537 DDB_G0277537 plbE plbE DDB0205364 DDB0205364 pigO pigO I6KA I6KA DDB0205695 DDB0205695 PigN PigN PigQ PigQ Dd5P1 Dd5P1 DDB_G0280377 DDB_G0280377 DDB0218240 DDB0218240 DDB0218256 DDB0218256 DDB0215235 DDB0215235 DDB0218291 DDB0218291 impa1 impa1 DDB0205575 DDB0205575 DDB0204242 DDB0204242 DDB0187877 DDB0187877 DDB0187976 DDB0187976 pigm pigm DDB0188326 DDB0188326 PigS PigS DDB_G0290005 DDB_G0290005 DDB0219574 DDB0219574 PikH PikH DDB0219722 DDB0219722 Dd5P3 Dd5P3 DDB0191697 DDB0191697 pigl pigl DDB0191855 DDB0191855 DDB_G0293860 DDB_G0293860 DDB_G0288731 DDB_G0288731 smp3 smp3 pikD pikD pikE pikE pikC pikC pikB pikB pikA pikA pigT pigT pip5k3 pip5k3 DDB_G0282011 DDB_G0282011 PikG PikG DDB0185272 DDB0185272 pigX pigX DDB0218526 DDB0218526 PigA PigA Dd5P2 Dd5P2 DDB0185955 DDB0185955 plbD plbD PigB PigB DDB0186027 DDB0186027 PigF PigF DDB0218645 DDB0218645 plbG plbG PikF PikF DDB_G0267588 DDB_G0267588 dpm3 dpm3 bpnt1 bpnt1 PIPkinA PIPkinA DDB_G0268652 DDB_G0268652 pldG pldG rpkA rpkA DDB0219213 DDB0219213 cnrN cnrN pteN pteN PigK PigK DDB_G0285967 DDB_G0285967 pigw pigw DDB_G0286115 DDB_G0286115 plbC plbC pigC pigC DDB0218818 DDB0218818 dpm1 dpm1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB0167752Uncharacterized protein. (1438 aa)
DDB0167388Uncharacterized protein. (714 aa)
DDB0168617PIG-P domain-containing protein. (602 aa)
pigHUncharacterized protein. (237 aa)
Dd5P4Inositol 5-phosphatase 4. (787 aa)
DDB0190143Uncharacterized protein. (1214 aa)
pats1Probable serine/threonine-protein kinase pats1; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor (By similarity). Essential regulator of cytokinesis involved in the binding to actomyosin cytoskeleton. (3184 aa)
DDB0190271Uncharacterized protein. (1292 aa)
DDB0190357Endo/exonuclease/phosphatase domain-containing protein. (575 aa)
DDB0190609PlsC domain-containing protein. (364 aa)
DDB0191072Uncharacterized protein. (448 aa)
plbBPhospholipase B-like protein B; Probable phospholipase; Belongs to the phospholipase B-like family. (572 aa)
DDB0216866Myotubularin phosphatase domain-containing protein. (1738 aa)
sac1Phosphatidylinositide phosphatase SAC1; Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. (581 aa)
dpm2-1Dolichol phosphate-mannose biosynthesis regulatory protein; Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of dpm1 (By similarity); Belongs to the DPM2 family. (79 aa)
DDB_G0272638Phosphatidylinositol-4-phosphate 5-kinase family protein. (1079 aa)
plbFPhospholipase B-like protein F; Probable phospholipase; Belongs to the phospholipase B-like family. (563 aa)
DDB0217695Uncharacterized protein. (527 aa)
DDB0217768Uncharacterized protein. (1442 aa)
plbAPhospholipase B-like protein A; Phospholipase that removes both fatty-acid chains from phosphatidylcholine and produces the water-soluble glycerophosphorylcholine. In addition to phosphatidylcholine deacylation, it also hydrolyzes phosphatidylinositol and phosphatidylethanolamine. (574 aa)
DDB_G0277537Phosphatidylinositol 4-kinase; Belongs to the PI3/PI4-kinase family. (2460 aa)
plbEPhospholipase B-like protein E; Probable phospholipase; Belongs to the phospholipase B-like family. (554 aa)
DDB0205364Myotubularin phosphatase domain-containing protein. (1002 aa)
pigOPhosphatidylinositol glycan, class O. (1120 aa)
I6KAKinase; Belongs to the inositol phosphokinase (IPK) family. (716 aa)
DDB0205695Metallophos domain-containing protein. (387 aa)
PigNPigN domain-containing protein. (1032 aa)
PigQUncharacterized protein. (992 aa)
Dd5P1Inositol 5-phosphatase. (940 aa)
DDB_G0280377Uncharacterized protein. (784 aa)
DDB0218240GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. (1622 aa)
DDB0218256Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1229 aa)
DDB0215235GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. (626 aa)
DDB0218291Uncharacterized protein. (715 aa)
impa1Inositol monophosphatase; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. Has broad substrate specificity and can use myo-inositol monophosphates, myo- inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo- inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. (272 aa)
DDB0205575SAC domain-containing protein. (1391 aa)
DDB0204242Myotubularin phosphatase domain-containing protein. (1343 aa)
DDB0187877Uncharacterized protein. (281 aa)
DDB0187976PlsC domain-containing protein. (345 aa)
pigmGPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly (By similarity). (442 aa)
DDB0188326Uncharacterized protein. (801 aa)
PigSUncharacterized protein. (407 aa)
DDB_G0290005Myotubularin-related protein DDB_G0290005; Phosphatase that acts on lipids with a phosphoinositol headgroup; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. (1324 aa)
DDB0219574Uncharacterized protein. (1717 aa)
PikHUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1820 aa)
DDB0219722PIPK domain-containing protein. (944 aa)
Dd5P3Inositol 5-phosphatase. (1379 aa)
DDB0191697Uncharacterized protein. (453 aa)
piglProbable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity); Belongs to the PIGL family. (258 aa)
DDB0191855Myotubularin phosphatase domain-containing protein. (1192 aa)
DDB_G0293860Uncharacterized protein DDB_G0293860. (270 aa)
DDB_G0288731GRAM domain-containing protein. (1227 aa)
smp3Mannosyltransferase. (667 aa)
pikDPhosphatidylinositol 4-kinase; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. (1180 aa)
pikEPhosphatidylinositol 3-kinase VPS34-like. (816 aa)
pikCPhosphatidylinositol 3-kinase 3. (1697 aa)
pikBPhosphatidylinositol 3-kinase 2. (1857 aa)
pikAPhosphatidylinositol 3-kinase 1. (1571 aa)
pigTUncharacterized protein. (677 aa)
pip5k31-phosphatidylinositol 3-phosphate 5-kinase; Catalyzes the phosphorylation of phosphatidylinositol 3- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. (2656 aa)
DDB_G0282011GPI transamidase subunit PIG-U family protein. (560 aa)
PikGUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1671 aa)
DDB0185272Uncharacterized protein. (467 aa)
pigXPhosphatidylinositol glycan, class X. (594 aa)
DDB0218526Kinase; Belongs to the inositol phosphokinase (IPK) family. (617 aa)
PigAUncharacterized protein. (523 aa)
Dd5P2Inositol 5-phosphatase. (1800 aa)
DDB0185955Uncharacterized protein. (1272 aa)
plbDPhospholipase B-like protein D; Probable phospholipase; Belongs to the phospholipase B-like family. (569 aa)
PigBMannosyltransferase. (547 aa)
DDB0186027Myotubularin phosphatase domain-containing protein. (1028 aa)
PigFUncharacterized protein. (219 aa)
DDB0218645CDP-diacylglycerol--inositol 3-phosphatidyltransferase. (207 aa)
plbGPhospholipase B-like protein G; Probable phospholipase; Belongs to the phospholipase B-like family. (598 aa)
PikFUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1382 aa)
DDB_G0267588Probable phosphatidylinositol phosphate kinase DDB_G0267588; May be involved in signaling events that underlie chemotaxis via the chemoattractant-mediated pkgB phosphorylation. (719 aa)
dpm3Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit dpm1 to the ER. Belongs to the DPM3 family. (92 aa)
bpnt13'(2'),5'-bisphosphate nucleotidase 1; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. (311 aa)
PIPkinAUncharacterized protein. (1589 aa)
DDB_G02686523'(2'),5'-bisphosphate nucleotidase; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur- activation pathway by converting PAPS to APS. Is also able to hydrolyze inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (By similarity). (332 aa)
pldGPhosphatidylinositol-glycan-specific phospholipase D; Hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. May also cleave GPI anchor intermediates intracellularly; Belongs to the GPLD1 family. (948 aa)
rpkARpkA. (828 aa)
DDB0219213Uncharacterized protein. (752 aa)
cnrNPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN; Protein phosphatase that negatively regulates PI3K-dependent pathways. Regulates cAMP signal transduction to control territory size. During development, a lawn of Dictyostelium cells breaks up into territories where cells aggregate in dendritic streams to form groups of 20'000 cells. (639 aa)
pteN3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa)
PigKUncharacterized protein. (446 aa)
DDB_G0285967LIM-type zinc finger-containing protein. (998 aa)
pigwPhosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. (492 aa)
DDB_G0286115Phosphatidylinositol-4-phosphate 5-kinase family protein. (1271 aa)
plbCPhospholipase B-like protein C; Probable phospholipase; Belongs to the phospholipase B-like family. (565 aa)
pigCPutative phosphatidylinositol N-acetylglucosaminyltransferase subunit C; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. (345 aa)
DDB0218818PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (1167 aa)
dpm1Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. (254 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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