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| | DDB0185814 | Rap-GAP domain-containing protein. (366 aa) |
| | dhkG | Hybrid signal transduction histidine kinase G; Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity). (3432 aa) |
| | cf60 | Counting factor 60; Cell-counting factor that limits the maximum size of the multicellular structure. Does not possess acid phosphatase activity. Cells with decreased levels of this protein form large groups while cells overexpressing this protein form small groups. (416 aa) |
| | gefA | Ras guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (605 aa) |
| | pdkB | 3-phosphoinositide-dependent protein kinase B. (908 aa) |
| | RagC | Uncharacterized protein. (360 aa) |
| | DDB0186216 | Rap-GAP domain-containing protein. (1640 aa) |
| | cdk5 | Cyclin-dependent kinase 5 homolog. (292 aa) |
| | DDB0186279 | Uncharacterized protein. (759 aa) |
| | scrA | Protein SCAR; Involved in regulation of actin and microtubule organization. Regulates phagocytosis and macropinocytosis. Belongs to the SCAR/WAVE family. (443 aa) |
| | DDB0186499 | Uncharacterized protein. (746 aa) |
| | DDB_G0285967 | LIM-type zinc finger-containing protein. (998 aa) |
| | strap | Serine-threonine kinase receptor-associated protein; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex (By similarity); Belongs to the WD repeat STRAP family. (293 aa) |
| | gflB | Ras guanine nucleotide exchange factor glfB; GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways. Acts also as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways. (1601 aa) |
| | DDB_G0286931 | Uncharacterized protein. (5222 aa) |
| | DDB0219217 | Dickkopf_N domain-containing protein. (340 aa) |
| | secG | Ankyrin repeat, PH and SEC7 domain containing protein secG. (986 aa) |
| | DDB_G0287625 | Uncharacterized protein DDB_G0287625. (981 aa) |
| | wdr24 | GATOR complex protein WDR24; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. (1023 aa) |
| | cnrN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN; Protein phosphatase that negatively regulates PI3K-dependent pathways. Regulates cAMP signal transduction to control territory size. During development, a lawn of Dictyostelium cells breaks up into territories where cells aggregate in dendritic streams to form groups of 20'000 cells. (639 aa) |
| | p2xE | P2X receptor E; P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Not essential for osmoregulation. Inward currents evoked by intracellular ATP. ATP analog beta, gamma-imido-ATP is a weak partial agonist of p2xE. Exclusively selective for ATP over other nucleotides. Insensitive to copper and P2 receptor antagonists PPADS and suramin but strongly inhibited by sodium ions. More permeable to ammonium than either sodium or potassium ions and less permeable to choline. Permeabl [...] (388 aa) |
| | dst4 | Serine/threonine-protein kinase dst4. (485 aa) |
| | DDB_G0288147 | Probable serine/threonine-protein kinase DDB_G0288147; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1347 aa) |
| | p2xD | P2X receptor D; P2X receptors are ligand-gated ion channels that play a role in intracellular calcium signaling. ATP does not evoke inward currents in p2xD. Not essential for osmoregulation. (407 aa) |
| | ragA | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the TOR signaling cascade; Belongs to the GTR/RAG GTP-binding protein family. (301 aa) |
| | DDB0216036 | Rab-GAP TBC domain-containing protein. (463 aa) |
| | DDB0188195 | Ras-GAP domain-containing protein. (817 aa) |
| | pyk3 | Dual specificity protein kinase pyk3; Involved in the development. Negatively regulates tyrosine phosphorylation and activation state of dstC/STATc, probably by activating a dstC/STATc phosphatase; Belongs to the protein kinase superfamily. TKL Tyr protein kinase family. (1338 aa) |
| | pde7 | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase 7; Phosphodiesterase with dual cAMP/cGMP specificity. However, displays a preference for cAMP over cGMP. Seems to regulate cAMP/cGMP concentration especially during cell aggregation. (425 aa) |
| | prmt2 | Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in some proteins such as histones. (512 aa) |
| | DDB0188800 | Uncharacterized protein. (316 aa) |
| | DDB0219551 | SEC7 domain-containing protein. (1886 aa) |
| | rblA | Retinoblastoma-like protein A; Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin- modifying enzymes to promoters (By similarity). Plays a dual role, regulating cell-cycle progression and transcriptional events leading to terminal differentiation. In the absence of a G1 phase, functions in late G2 contro [...] (1312 aa) |
| | DDB0219603 | SEC7 domain-containing protein. (1748 aa) |
| | mapbpip | Robl_LC7 domain-containing protein. (123 aa) |
| | PikH | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1820 aa) |
| | warA | Homeobox protein Wariai; Putative transcription factor, that seems to be involved in anterior-posterior patterning of the slug, probably by controlling the proportions of prestalk and prespore cells. (803 aa) |
| | dst3 | Serine/threonine-protein kinase dst3. (562 aa) |
| | psenA | Presenilin-A; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity (By similarity); Belongs to the peptidase A22A family. (622 aa) |
| | dimB | Basic-leucine zipper transcription factor B; Transcriptional regulator involved in DIF-1 signaling. DIF-1 (Differentiation Inducing Factor-1) is a signal molecule involved in the differentiation of pstO (prestalk-O) cells (By similarity). May be a direct activator of ecmA. (602 aa) |
| | DDB_G0291610 | Dickkopf_N domain-containing protein. (213 aa) |
| | DDB_G0291510 | GTPase-activating protein DDB_G0291510. (1031 aa) |
| | DDB_G0291948 | Ragulator complex protein LAMTOR4 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity). (87 aa) |
| | racGAP | Uncharacterized protein. (1350 aa) |
| | DDB0184177 | Uncharacterized protein. (437 aa) |
| | sec13 | Protein SEC13 homolog; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 [...] (301 aa) |
| | DDB_G0292056 | WD repeat-containing protein DDB_G0292056. (1823 aa) |
| | DDB_G0292252 | Putative protein DDB_G0292252. (1256 aa) |
| | psenB | Presenilin-B; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity (By similarity); Belongs to the peptidase A22A family. (473 aa) |
| | lst8 | Protein LST8 homolog; Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay; Belongs to the WD repeat LST8 family. (304 aa) |
| | DDB0219798 | BB_PF domain-containing protein. (269 aa) |
| | DDB_G0295799 | BB_PF domain-containing protein. (250 aa) |
| | DDB_G0294611 | Uncharacterized protein. (611 aa) |
| | dgkA | Diacylglycerol kinase A; Belongs to the eukaryotic diacylglycerol kinase family. (887 aa) |
| | racC | Rho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa) |
| | carC | Cyclic AMP receptor 3; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (490 aa) |
| | dagA | Protein CRAC; Couples activated G protein to adenylyl cyclase signal transduction from surface cAMP receptor. Pianissimo a cytosolic regulator and CRAC, are both essential for activation of the enzyme adenylyl cyclase. Pianissimo and CRAC do not function redundantly. Both proteins are integral components of the adenylyl cyclase activation pathway. (698 aa) |
| | gpbA | Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development. (347 aa) |
| | rab2A | Ras-related protein Rab-2A. (207 aa) |
| | gbfA | G-box-binding factor; cAMP-responsive transcriptional activator regulating late gene expression. Essential component of the developmental switch between early and late development. Binds to a number of CA/GT-rich gene regulatory elements. (708 aa) |
| | tgrC1 | Tiger protein C1; tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development. Could function as a non-diffusible cell-cell signaling molecule that is required for multicellular development. Has both cell-autonomous and non-cell-autonomous functions. Terminal node, epistatic both to comC and tgrD1. Activates tgrD1. (889 aa) |
| | erkA | Extracellular signal-regulated kinase 1; Kinase involved in a signal transduction pathway. (529 aa) |
| | gskA | Glycogen synthase kinase-3; During cellular differentiation, may mediate an extracellular cyclic AMP stimulated signal transduction pathway that regulates prespore and prestalk B-cell proportions through inhibition of stalk cell formation and induction of prespore cell differentiation. The cAMP receptor carC appears to activate gskA via the tyrosine kinases zakA and zak2, to stimulate prespore differentiation, while carD appears to negatively regulate gskA, to promote prestalk formation. (467 aa) |
| | ptpC | Tyrosine-protein phosphatase 3; Seems to dephosphorylate a protein of 130 kDa (p130). (990 aa) |
| | pkbA | RAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. (444 aa) |
| | hspD | Heat shock cognate 90 kDa protein; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity); Belongs to the heat shock protein 90 family. (700 aa) |
| | smlA | Small aggregate formation protein; Knockout of the gene for this protein causes small aggregate formation. May regulate the secretion or processing of a secreted factor that regulates aggregate size. (283 aa) |
| | pikA | Phosphatidylinositol 3-kinase 1. (1571 aa) |
| | pikB | Phosphatidylinositol 3-kinase 2. (1857 aa) |
| | pikC | Phosphatidylinositol 3-kinase 3. (1697 aa) |
| | plc | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (801 aa) |
| | acaA | Adenylate cyclase, aggregation specific; Coordinates cell aggregation by synthesizing the cAMP that influences differentiation and morphogenesis of cells within a developing multicellular structure. (1407 aa) |
| | DDB_G0292160 | Uncharacterized protein DDB_G0292160. (174 aa) |
| | racE | Rho-related protein racE; Specifically required for cytokinesis; Belongs to the small GTPase superfamily. Rho family. (223 aa) |
| | regA | 3',5'-cyclic-nucleotide phosphodiesterase regA; Phosphodiesterase specific for cAMP. Involved in the degradation of intracellular cAMP. Morphological suppressor of tagB. Phosphorelay protein that accepts phosphate from rdeA or supplies phosphate from regA; depending on the relative concentration of the phosphodonor proteins; Belongs to the cyclic nucleotide phosphodiesterase family. (793 aa) |
| | yelA | Yellow mounds protein A; Plays as essential role in regulating terminal differentiation. (909 aa) |
| | dstC | Signal transducer and activator of transcription C; Transcription factor that regulates gene expression during development. May play a role in regulating gene expression in response to osmotic stress. (931 aa) |
| | DDB0192055 | Uncharacterized protein. (1641 aa) |
| | DDB_G0293188 | DUF727 domain-containing protein. (114 aa) |
| | DDB0191741 | Uncharacterized protein. (716 aa) |
| | cycC | Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase CDK8 that phosphoryla [...] (255 aa) |
| | DDB0168842 | Uncharacterized protein. (931 aa) |
| | gefH | Ras guanine nucleotide exchange factor H; Promotes the exchange of Ras-bound GDP by GTP. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (604 aa) |
| | gefB | Ras guanine nucleotide exchange factor B; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Involved in phagocytosis, fluid-phase endocytosis, regulation of macropinocytosis and control of cell movement. (1529 aa) |
| | pdeD | cGMP-dependent 3',5'-cGMP phosphodiesterase A; Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP. Involved in the degradation of intracellular cGMP. (867 aa) |
| | pdeE | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B; Dual specificity cAMP and cGMP phosphodiesterase with marked preference for cyclic AMP, which is activated by cAMP and cGMP. Likely functions as a cAMP-stimulated cAMP-phosphodiesterase which may play a role in regulating the cAMP relay response. Belongs to the metallo-beta-lactamase superfamily. cNMP phosphodiesterase family. (1096 aa) |
| | gbpC | Cyclic GMP-binding protein C; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2631 aa) |
| | gefM | Ras guanine nucleotide exchange factor M; Promotes the exchange of Ras-bound GDP by GTP. (929 aa) |
| | qkgA-1 | Probable serine/threonine-protein kinase qkgA; Involved in growth, and during development, in aggregation. (1553 aa) |
| | Dd-gdcA | Gp64-and disintegrin-like. (377 aa) |
| | alxA | ALG-2 interacting protein X; Unknown. Required for development but not for cell death. (794 aa) |
| | DDB0168530 | Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (560 aa) |
| | pteN | 3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa) |
| | gchA | GTP cyclohydrolase 1. (232 aa) |
| | dhkC | Hybrid signal transduction histidine kinase C; Acts in a signal transduction pathway that regulates the slug versus culmination choice. Believed to be the first component of a phosphorelay that couples the sensing of ammonia to the modulation of PKA activity and hence activates culmination and spore germination. Ammonium transporters amtA and amtC are thought to respectively activate and inhibit dhkC phosphorelay. This protein probably undergoes an ATP-dependent autophosphorylation at conserved His residue in the kinase core, and a phosphoryl group is then transferred to a conserved as [...] (1225 aa) |
| | rdiB | Putative rho GDP-dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. (152 aa) |
| | rdiA | Putative rho GDP-dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (By similarity). Regulates the Rac-dependent signaling pathways controlling cytokinesis, actin reorganization and the contractile vacuole. Required for efficient accumulation of cap at the cell cortex. (197 aa) |
| | cdk8 | Probable cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) [...] (380 aa) |
| | psiA | Protein psiA; Growth factor that can induce isolated amoebae to differentiate into prespore cells; Belongs to the prespore-cell-inducing factor family. (557 aa) |
| | amtA | Ammonium transporter 1; Ammonium transporter that mediates the excretion of ammonium. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development; Belongs to the ammonia transporter channel (TC 1.A.11.2) family. (463 aa) |
| | aif | Apoptosis-inducing factor 1, mitochondrial; Probable NADH oxidoreductase that acts as a caspase- independent mitochondrial effector of apoptotic cell death. Belongs to the FAD-dependent oxidoreductase family. (532 aa) |
| | iplA | Inositol 1,4,5-trisphosphate receptor-like protein A; May be a receptor for inositol 1,4,5 trisphosphate which governs calcium fluxes from the endoplasmic reticulum stores into the cytosol. May be involved in autophagic cell death. (3177 aa) |
| | myoM | Myosin-M heavy chain; Myosins are actin-based motor molecules with ATPase activity. Involved in macropinocytosis and remodeling of actin cytoskeleton. (1737 aa) |
| | culB | Cullin-2; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Appears to ensure that the proper number of prestalk cells differentiate at the appropriate time in development. May govern prestalk cell differentiation. (771 aa) |
| | ppp4c | Serine/threonine-protein phosphatase 4 catalytic subunit; Required for development, chemotaxis and the expression of numerous genes. (305 aa) |
| | ripA | Ras-interacting protein RIP3; Component of a Ras-regulated pathway involved in integrating chemotaxis and signal relay pathways that are essential for aggregation. (838 aa) |
| | DDB0191697 | Uncharacterized protein. (453 aa) |
| | sglA | Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (By similarity). Sphingosine-1-phosphate (S1P) probably acts intracellularly as a second messenger perhaps by promoting cell proliferation; the absence of S1P lyase increases its concentration. This leads to increased lateral pseudopod formation as well as defects in the efficiency of chemotaxis. Overexpression of S1P lyase causes decreased growth rates, entry into stationary phase at lower cell density and increased sensitivity to [...] (528 aa) |
| | DDB0185275 | Rap-GAP domain-containing protein. (1069 aa) |
| | DDB0218425 | Rap-GAP domain-containing protein. (1049 aa) |
| | rdeA | Phosphorelay intermediate protein rdeA; Phosphorelay protein that supplies phosphate to regA or accepts phosphate from regA; depending on the relative concentration of the phosphodonor proteins. In vitro, acts as a substrate for cheA (bacterial kinase). Plays a role in the development. ypd1 (yeast) can complement rdeA defect. (254 aa) |
| | dhkL | Hybrid signal transduction histidine kinase L; Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity). (1709 aa) |
| | shkA | Dual specificity protein kinase shkA; Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level. (527 aa) |
| | gpaI | Guanine nucleotide-binding protein alpha-9 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-9 antagonizes broad chemotactic response. It functions rapidly following receptor stimulation to negatively regulate PI3K/PTEN, adenylyl cyclase, and guanylyl cyclase pathways. (342 aa) |
| | DDB0185528 | GGDEF domain-containing protein. (521 aa) |
| | DDB_G0283567 | Ragulator complex protein LAMTOR5 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity). (89 aa) |
| | yakA | Probable serine/threonine-protein kinase yakA; General sensor of environmental conditions, such as heat stress, effecting changes through pkaC. Essential for survival to nitrosoative and oxidative stresses. Required for cell cycle control, not only at the onset but also during development (aggregation process and postaggregative development). (1458 aa) |
| | phg2 | Serine/threonine-protein kinase phg2; Serine/threonine kinase regulating cell substrate adhesion, phagocytosis, motility, chemotaxis, and actin cytoskeleton organization. It is a downstream component of Rap1-regulated adhesion, and it is a regulator of myosin II phosphorylation. It is also a negative regulator of development initiation. (1387 aa) |
| | gacG | Rho GTPase-activating protein gacG; Rho GTPase-activating protein involved in the signal transduction pathway. (1312 aa) |
| | erkB | Extracellular signal-regulated kinase 2; Implicated in the relay of the cAMP chemotactic signal and cell differentiation. Important for receptor-mediated activation of adenylyl cyclase. (369 aa) |
| | DDB0185787 | Uncharacterized protein. (717 aa) |
| | DDB0205274 | Uncharacterized protein. (1386 aa) |
| | rapgapB | RapA guanosine triphosphatase-activating protein B; Mediates the deactivation of rap1 during multicellular development and is required for normal morphogenesis. Also required for the correct patterning of specific subtypes of prestalk cells. (418 aa) |
| | grlH | Metabotropic glutamate receptor-like protein H; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (764 aa) |
| | PikG | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1671 aa) |
| | gbpD | Cyclic GMP-binding protein D; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Induces the formation of substrate-attached pseudopodia, that leads to increased adhesion and thereby negatively influencing cell speed and polarity. (1312 aa) |
| | DDB0204957 | BB_PF domain-containing protein. (284 aa) |
| | orfSGP | BB_PF domain-containing protein. (284 aa) |
| | DDB0204990 | Cnn_1N domain-containing protein. (1381 aa) |
| | pakG | Serine/threonine-protein kinase pakG. (1179 aa) |
| | pkaC | cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis. (648 aa) |
| | gpaH | Guanine nucleotide-binding protein alpha-8 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-8 is a potential analog for the G(s)-like G-proteins which stimulate adenylate cyclase in mammals. (403 aa) |
| | gpaE | Guanine nucleotide-binding protein alpha-5 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. (347 aa) |
| | gpaD | Guanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-4 plays a role in morphogenesis of the multicellular structure. (345 aa) |
| | rasC | Ras-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | pkgB | Protein kinase 2; Required for morphogenesis during multicellular development. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (479 aa) |
| | mlkA | Myosin light chain kinase A; Phosphorylates a specific serine in the N-terminus of a myosin light chain (By similarity). Phosphorylates regulatory myosin light chain (mlcR) during chemotaxis. (295 aa) |
| | rab8B | Ras-related protein Rab-8B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (203 aa) |
| | rab8A | Ras-related protein Rab-8A; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (208 aa) |
| | rapA | Ras-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells. (186 aa) |
| | splB | Dual specificity protein kinase splB. (1155 aa) |
| | gpaB | Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family. (357 aa) |
| | rasG | Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | carA-1 | Cyclic AMP receptor 1; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. (392 aa) |
| | pdsA | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase A; Phosphodiesterase which displays a preference for cAMP over cGMP. Involved in the degradation of extracellular cAMP. Maintains the responsiveness of cells to the chemoattractant cAMP during the aggregation phase of development. (452 aa) |
| | sslA1 | Suppressor of smlA; Involved in regulation of group size of aggregation streams. (578 aa) |
| | pkaR | cAMP-dependent protein kinase regulatory subunit. (327 aa) |
| | calA | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (152 aa) |
| | piaA | Protein pianissimo A; Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Required for chemoattractant receptor and G protein- mediated activation of the 12 transmembrane domain adenylyl cyclase. Functions as a part of protein complex TORC2. TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2, but not TORC1, negatively regulates phagocytosis. This protein and dagA protein CRAC, a cytosolic regulator, are both essential for activation of the enzyme adenylyl cyclase. This protein and CRAC do not function re [...] (1148 aa) |
| | krsA | Serine/threonine-protein kinase 4 homolog A; Regulates both cAMP signaling during early development and the stress response. Functions as an activator of adenylylcyclase. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (461 aa) |
| | adcB | Arrestin domain-containing protein B; Belongs to the arrestin family. (617 aa) |
| | DDB0169145 | Uncharacterized protein; Belongs to the WD repeat SEC13 family. (467 aa) |
| | p2xA | P2X receptor A; P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Inward currents evoked by intracellular ATP and ATP analogs. Exclusively selective for ATP over other nucleotides. Insensitive to P2 receptor antagonists PPADS, suramin and 2',3'-O-(2,4,6-trinitrophenyl)-ATP but inhibited by nanomolar concentrations of copper and sodium ion. More permeable to ammonium than either sodium or potassium ions and less permeable to choline. It has been reported that p2xA is not es [...] (378 aa) |
| | DDB_G0274833 | Ragulator complex protein LAMTOR3 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids (By similarity); Belongs to the LAMTOR3 family. (132 aa) |
| | dpiA | Protein phosphatase inhibitor 2; Inhibitor of protein-phosphatase 1 (PP1). (261 aa) |
| | dst1 | Serine/threonine-protein kinase dst1. (737 aa) |
| | ctnA | Countin-1; Cell-counting factor that limits the maximum size of the multicellular structure. May down-regulate the expression of gp24, which mediates cell adhesion. (258 aa) |
| | rpkA | RpkA. (828 aa) |
| | DDB0168980 | Saposin B-type domain-containing protein. (564 aa) |
| | DDB0169375 | Uncharacterized protein. (312 aa) |
| | DDB0217806 | Rap-GAP domain-containing protein. (855 aa) |
| | pakB | Serine/threonine-protein kinase pakB; Regulator of the myosin I component of the cytoskeleton: required for regulation of cytokinesis, phagocytosis and pinocytosis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (852 aa) |
| | DDB0217157 | BB_PF domain-containing protein. (235 aa) |
| | DDB0217156 | BB_PF domain-containing protein. (303 aa) |
| | cpnA | Copine-A; Required for cytokinesis, contractile vacuole function and development; Belongs to the copine family. (600 aa) |
| | DDB_G0272512 | Uncharacterized protein DDB_G0272512. (308 aa) |
| | htt | HD protein homolog; May play a role in microtubule-mediated transport or vesicle function; Belongs to the huntingtin family. (3095 aa) |
| | gtaC | GATA zinc finger domain-containing protein 3. (587 aa) |
| | wrnip1 | ATPase WRNIP1; Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity). (876 aa) |
| | zakA | Dual specificity protein kinase zakA; Positive regulator of gsk3/gskA activity required for cell pattern formation and a downstream effector of carC. The kinases, gsk3/gskA, zakA and zak2, form part of a signaling pathway that responds to extracellular cyclic AMP. The pathway has a role in transcriptional regulation; required to direct prespore/spore fates during development. ZakA negatively regulates prestalk differentiation by regulating expression of ecmB. Phosphorylates Y-214 of gsk3/gskA, in vitro; In the C-terminal section; belongs to the protein kinase superfamily. TKL Tyr prote [...] (781 aa) |
| | rapgap1 | RapA guanosine triphosphatase-activating protein 1; Mediates the deactivation of rap1 and plays an important role in spatially and temporally regulating cell adhesion and chemotaxis by controlling attachment disassembly in the leading edge through the regulation of myosin II assembly and disassembly. Overexpression leads to defective chemotaxis. (1055 aa) |
| | phlp1 | Phosducin-like protein 1; Required for normal chemotaxis in response to cAMP and folate. Required for the heterodimerization of the G protein beta and gamma subunits gpbA and gpgA, which is itself thought to be necessary for prenylation of the gamma subunit gpgA and its association with plasma membranes; Belongs to the phosducin family. (316 aa) |
| | alrA | Aldose reductase A; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies (By similarity). Probably affects several metabolic pathways in addition to converting glucose to sorbitol. Affects group size; Belongs to the aldo/keto reductase family. (297 aa) |
| | aprA | Autocrine proliferation repressor protein A; Inhibitor that slows proliferation of secreting cells (also known as chalone). May function by binding to cell surface receptors. Requires cfaD for activity. Overexpression slows proliferation. Belongs to the pqaA family. (494 aa) |
| | vasp | Protein VASP homolog; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as lamellipodial and filopodial dynamics in migrating cells. Plays a crucial role in filopodia formation, cell-substratum adhesion, and proper chemotaxis. Nucleates and bundles actin filaments. When complexed with fotH in filopodial tips, may support formin- mediated filament elongation by bundling nascent actin filaments. Belongs to the Ena/VASP family. (380 aa) |
| | pakC | Serine/threonine-protein kinase pakC; Has role in the regulation of chemotaxis. (477 aa) |
| | DDB0189350 | Uncharacterized protein. (885 aa) |
| | DDB_G0267588 | Probable phosphatidylinositol phosphate kinase DDB_G0267588; May be involved in signaling events that underlie chemotaxis via the chemoattractant-mediated pkgB phosphorylation. (719 aa) |
| | ireA | Probable serine/threonine-protein kinase ireA. (984 aa) |
| | DDB0189490 | RING-type domain-containing protein. (592 aa) |
| | cnbA | Calcineurin subunit B type 1; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Important for stalk formation. (180 aa) |
| | DDB0189538 | Uncharacterized protein. (1426 aa) |
| | PikF | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1382 aa) |
| | tsuA | Probable serine/threonine-protein kinase tsuA; Plays a role in chemotaxis and seems to be involved in polarization. (2247 aa) |
| | krsB | Serine/threonine-protein kinase 4 homolog B; Probable serine/threonine-protein kinase; In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (1105 aa) |
| | DDB0189868 | BB_PF domain-containing protein. (257 aa) |
| | stlA | Probable polyketide synthase 1; Probable polyketide synthase (By similarity). Produces only acylpyrones; in vitro. (3147 aa) |
| | DDB_G0269450 | AKAP7_NLS domain-containing protein. (206 aa) |
| | DDB0190465 | Uncharacterized protein. (925 aa) |
| | pakD | Serine/threonine-protein kinase pakD. (1678 aa) |
| | pakA | Serine/threonine-protein kinase pakA; Regulator of the myosin II component of the cytoskeleton: required for regulation of cytokinesis. Functions during chemotaxis, required for maintaining the direction of cell movement, suppressing lateral pseudopod extension, and proper retraction of the posterior of chemotaxing cells; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (1197 aa) |
| | mpl2 | MAP kinase phosphatase with leucine-rich repeats protein 2; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (695 aa) |
| | mpl1 | MAP kinase phosphatase with leucine-rich repeats protein 1; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins (By similarity). Dephosphorylates pNPP, in vitro. Essential for proper regulation of erkB (erk2) and optimal motility during development; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (834 aa) |
| | DDB0216733 | Uncharacterized protein. (842 aa) |
| | adcC | Arrestin domain-containing protein C; Belongs to the arrestin family. (654 aa) |
| | gtaG | GATA zinc finger domain-containing protein 7. (1006 aa) |
| | DDB_G0271288 | NPR2 family protein. (392 aa) |
| | nfaA | Neurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB. (920 aa) |
| | DDB_G0271806 | PH and Rap-GAP domain-containing protein DDB_G0271806. (1167 aa) |
| | DDB_G0272420 | Uncharacterized protein DDB_G0272420. (360 aa) |
| | DDB_G0272530 | Uncharacterized protein DDB_G0272530. (301 aa) |
| | ifkA | Probable serine/threonine-protein kinase ifkA; Phosphorylates eIF2-alpha, from 1 to 7 hours after the onset of development or during the preaggregation state, resulting in a shift from polysomes to free ribosomes for bulk mRNA. (2258 aa) |
| | icmt-1 | Protein-S-isoprenylcysteine O-methyltransferase; Methylates the C-terminal cysteine residues of small GTPases and the heterotrimeric G protein gamma subunit in response to cAMP. The methylation is required for intercellular signaling and regulation of cAMP waves propagation. It also seems to induce the activity of car1, a G protein-coupled receptor which senses extracellular cAMP during the aggregation phase of development; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (237 aa) |
| | DDB0215270 | BB_PF domain-containing protein. (270 aa) |
| | DDB_G0273199 | Probable rhodanese domain-containing dual specificity protein phosphatase; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (476 aa) |
| | bip1-1 | Luminal-binding protein 1; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER; Belongs to the heat shock protein 70 family. (926 aa) |
| | DDB0168059 | SEC7 domain-containing protein. (2048 aa) |
| | pakH-1 | Serine/threonine-protein kinase pakH; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (513 aa) |
| | cf50-1 | Counting factor 50; Cell-counting factor that limits the maximum size of the multicellular structure during aggregation. Has a very low lysozyme activity. (303 aa) |
| | DDB0203290 | Uncharacterized protein. (337 aa) |
| | DDB0217527 | N-acetyltransferase domain-containing protein. (1767 aa) |
| | gca | Guanylyl cyclase, membrane; Synthesizes cyclic GMP (cGMP) from GTP, after activation by heterotrimeric or monomeric G proteins. Involved in chemotaxis. (1483 aa) |
| | p2xB | P2X receptor B; P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Not essential for osmoregulation. Inward currents are evoked by intracellular ATP and ATP analogs. Insensitive to the P2 receptor antagonists PPADS and suramin, and also copper ions. Inhibited by sodium ions. Permeable to chloride ions. (369 aa) |
| | p2xC | P2X receptor C; P2X receptors are ligand-gated ion channels that play a role in intracellular calcium signaling. ATP does not evoke inward currents in p2xC. Not essential for osmoregulation. (368 aa) |
| | DDB0217695 | Uncharacterized protein. (527 aa) |
| | dio3 | Thyroxine 5'-deiodinase. (257 aa) |
| | med26 | Putative mediator of RNA polymerase II transcription subunit 26; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (2073 aa) |
| | nhe1 | Sodium/hydrogen exchanger 1; Regulation of intracellular pH homeostasis in response to cAMP, which is essential for chemotaxis. Necessary for F-actin localization and the kinetics of actin polymerization during chemotaxis and cell polarity but not for directional sensing. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (674 aa) |
| | Mbtps2 | Peptidase_M50 domain-containing protein. (562 aa) |
| | sgcA | Guanylyl cyclase. (2843 aa) |
| | GxcN | Uncharacterized protein. (1094 aa) |
| | rheb | GTP-binding protein Rheb homolog; Binds GTP and exhibits intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rheb family. (185 aa) |
| | DDB_G0277071 | Probable serine/threonine-protein kinase DDB_G0277071. (2454 aa) |
| | ParG | Uncharacterized protein. (658 aa) |
| | racgef1 | Rac guanyl-nucleotide exchange factor. (1218 aa) |
| | gacII | Rho GTPase-activating protein gacII; Rho GTPase-activating protein involved in the signal transduction pathway. (817 aa) |
| | snfA | 5'-AMP-activated serine/threonine-protein kinase catalytic subunit alpha; Activated enzyme phosphorylates target proteins and initiates downstream signaling pathways that shift metabolism from anabolic to catabolic pathways. Acts as a highly sensitive cellular energy sensor. (727 aa) |
| | mpl3 | MAP kinase phosphatase with leucine-rich repeats protein 3; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (856 aa) |
| | DDB0205477 | Uncharacterized protein. (601 aa) |
| | ngap | Probable Ras GTPase-activating-like protein ngap; May function as a Ras GTPase-activating protein. (877 aa) |
| | scaA | Sca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. (1582 aa) |
| | PlaA | PNPLA domain-containing protein. (386 aa) |
| | rckA | RGS domain-containing serine/threonine-protein kinase A; Serine/threonine kinase involved in negative regulation of chemotaxis. (1125 aa) |
| | adprt1A | Poly [ADP-ribose] polymerase. (938 aa) |
| | dimA | Basic-leucine zipper transcription factor A; Transcriptional regulator involved in DIF-1 signaling. DIF-1 (Differentiation Inducing Factor-1) is a signal molecule involved in the differentiation of pstO (prestalk-O) cells. Functions as both an activator of prestalk gene expression and repressor of prespore gene expression. (1230 aa) |
| | DDB_G0279099 | DEP domain-containing protein DDB_G0279099; In the N-terminal section; belongs to the IML1 family. (2242 aa) |
| | DDB0205671 | Uncharacterized protein. (919 aa) |
| | gacN | Rho GTPase-activating protein gacN; Rho GTPase-activating protein involved in the signal transduction pathway. (611 aa) |
| | DDB_G0279427 | Sestrin homolog; May function as a negative feedback regulator of TOR function; Belongs to the sestrin family. (601 aa) |
| | yju2 | Splicing factor YJU2; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. (324 aa) |
| | pldB | Phospholipase D B; Plays a role in cell growth. Hydrolyzes membrane phospholipids, such as PtdCho (phosphatidylcholine), producing the free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own). Involved in the inhibition of actin-based motility and endocytosis. Its inhibition causes complete collapse of F-actin organization. Plays an important role in cell migration by localizing along the anterior cell membrane. Overexpression leads to the inability to aggregate even at higher cell density. Also known as a negative regulator of quorum sensing. (1216 aa) |
| | DDB0205957 | Uncharacterized protein. (378 aa) |
| | DDB0205998 | BB_PF domain-containing protein. (251 aa) |
| | STK19 | Serine/threonine-protein kinase 19 homolog; Serine/threonine-protein kinase. (391 aa) |
| | DDB_0206311 | Protein SEY1 homolog; Probable GTP-binding protein that may be involved in cell development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily. (894 aa) |
| | DDB0206467 | Uncharacterized protein. (298 aa) |
| | hbx9 | Homeobox protein 9; Putative transcription factor. (639 aa) |
| | DDB0218242 | Rap-GAP domain-containing protein. (2935 aa) |
| | DDB_G0280947 | UPF0171 family protein. (718 aa) |
| | DDB_G0280955 | RabGAP/TBC domain-containing protein. (733 aa) |
| | DDB0204021 | UDENN FLCN/SMCR8-type domain-containing protein. (656 aa) |
| | far1 | Metabotropic glutamate receptor-like protein L; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (708 aa) |
| | pdkA | Probable serine/threonine-protein kinase pdkA. (686 aa) |
| | cfaD | Counting factor associated protein D; Inhibitor that slows proliferation of secreting cells (also known as chalone). Requires aprA for activity. (531 aa) |
| | DDB_G0281809 | Rap-GAP domain-containing protein DDB_G0281809. (1619 aa) |
| | DDB_G0281715 | BB_PF domain-containing protein. (80 aa) |
| | DDB0204628 | BB_PF domain-containing protein. (84 aa) |
| | DDB0205121 | Uncharacterized protein. (464 aa) |
