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| | dtfA | Defective in tip formation protein A; Required for correct organization of the actin cytoskeleton and cytokinesis. Also required for apical sorting of prestalk cells, a prerequisite for formation of the tip at the mound stage and subsequent formation of the fruiting body. May be required for cell adhesion. (1402 aa) |
| | calA | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (152 aa) |
| | rasD | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (187 aa) |
| | act1 | Major actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction. (376 aa) |
| | mhcA | Myosin-2 heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2116 aa) |
| | mlcE | Myosin, essential light chain. (150 aa) |
| | talA | Talin-A; Actin-binding protein that may be involved in the control of cell motility and chemotaxis. (1279 aa) |
| | mlcR | Myosin regulatory light chain. (161 aa) |
| | rasG | Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | rapA | Ras-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells. (186 aa) |
| | cryS | Crystal protein; Belongs to the type-B carboxylesterase/lipase family. (550 aa) |
| | mlkA | Myosin light chain kinase A; Phosphorylates a specific serine in the N-terminus of a myosin light chain (By similarity). Phosphorylates regulatory myosin light chain (mlcR) during chemotaxis. (295 aa) |
| | chcA | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. (1694 aa) |
| | proA | Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. (126 aa) |
| | proB | Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. (124 aa) |
| | corA | Coronin-A; Required for normal motility. Participates in cytokinesis. (445 aa) |
| | rasB | Ras-like protein rasB; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (197 aa) |
| | cdk1 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (296 aa) |
| | rac1A | Rho-related protein rac1A; Overexpression promotes the formation of filopodia and membrane ruffles; Belongs to the small GTPase superfamily. Rho family. (194 aa) |
| | rac1B | Rho-related protein rac1B; Overexpression promotes the formation of filopodia and membrane ruffles. (194 aa) |
| | rac1C | Rho-related protein rac1C; Overexpression promotes the formation of filopodia and membrane ruffles. (193 aa) |
| | racB | Rho-related protein racB; Belongs to the small GTPase superfamily. Rho family. (195 aa) |
| | racC | Rho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa) |
| | racD | Rho-related protein racD; Belongs to the small GTPase superfamily. Rho family. (254 aa) |
| | cycB | G2/mitotic-specific cyclin-B; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (436 aa) |
| | erkA | Extracellular signal-regulated kinase 1; Kinase involved in a signal transduction pathway. (529 aa) |
| | mhkA | Myosin heavy chain kinase A; Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament. Requires autophosphorylation for activity. (1146 aa) |
| | gskA | Glycogen synthase kinase-3; During cellular differentiation, may mediate an extracellular cyclic AMP stimulated signal transduction pathway that regulates prespore and prestalk B-cell proportions through inhibition of stalk cell formation and induction of prespore cell differentiation. The cAMP receptor carC appears to activate gskA via the tyrosine kinases zakA and zak2, to stimulate prespore differentiation, while carD appears to negatively regulate gskA, to promote prestalk formation. (467 aa) |
| | fttB | 14-3-3-like protein; Belongs to the 14-3-3 family. (252 aa) |
| | pkbA | RAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. (444 aa) |
| | cap | Adenylyl cyclase-associated protein; May have a regulatory bifunctional role. Binds G-actin and PIP2. Involved in microfilament reorganization near the plasma membrane in a PIP2-regulated manner. (464 aa) |
| | cdk7 | Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation. (360 aa) |
| | aip1 | Actin-interacting protein 1; Implicated in both actin filament depolymerization and polymerization. May enhance chemotaxis by promoting cofilin-dependent actin assembly at cell leading edges. (597 aa) |
| | cdcD | Cell division cycle protein 48; Belongs to the AAA ATPase family. (793 aa) |
| | mhkB | Myosin heavy chain kinase B; Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. (732 aa) |
| | anapc6 | Anaphase-promoting complex subunit 6; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC6/CDC16 family. (865 aa) |
| | racQ | Rho GTPase. (185 aa) |
| | mtaA | Centrosomal protein 224; Involved in regulation of microtubule dynamics. Regulates the interaction of microtubules tips with the centrosome and cell cortex. (2013 aa) |
| | racE | Rho-related protein racE; Specifically required for cytokinesis; Belongs to the small GTPase superfamily. Rho family. (223 aa) |
| | DDB0219915 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1403 aa) |
| | ppkA | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Produces polyP in a broad range of chain lengths (50-300 Pi residues). Involved in development (growth and fruiting body formation), sporulation, phagocytosis, cell division and the late stages of cytokinesis. (1053 aa) |
| | cdc26 | Anaphase-promoting complex subunit cdc26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the CDC26 family. (69 aa) |
| | ZizB | Uncharacterized protein; Belongs to the DOCK family. (2147 aa) |
| | anapc7 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC7 family. (580 aa) |
| | bub3 | Mitotic checkpoint protein bub3; Involved in cell cycle checkpoint enforcement; Belongs to the WD repeat BUB3 family. (331 aa) |
| | DDB0184202 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (878 aa) |
| | epnA | Epsin; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). (686 aa) |
| | cln3 | Battenin. (421 aa) |
| | DDB0189211 | Uncharacterized protein. (382 aa) |
| | act10 | Actin-10; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction (By similarity); Belongs to the actin family. (376 aa) |
| | ctxA | Cortexillin-1; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1; Belongs to the cortexillin family. (444 aa) |
| | DDB0188417 | Mis18 domain-containing protein. (532 aa) |
| | racM | Rho-related protein racM. (189 aa) |
| | ube2s | Ubiquitin-conjugating enzyme E2 S; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. (215 aa) |
| | cenA | Centrin-A; Plays a fundamental role in microtubule-organizing center structure and function. (151 aa) |
| | kif10 | Kinesin-related protein 10; Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity). Cooperates with kif8 and dynein to organize interphase microtubules; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1238 aa) |
| | kif12 | Kinesin-related protein 12; Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity). Required for cytokinesis. May be involved in a vesicle-mediated transport of myosin II, the Aurora kinase (aurK) and other proteins along mitotic extracellular microtubules toward the center of the cell and the cleavage furrow in order to ensure cell division coupled to mitosis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1499 aa) |
| | kif13 | Kinesin-related protein 13; Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity). Cooperates with dynein to control the spindle elongation rate, but is dispensable for mitosis. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily. (1265 aa) |
| | vwkA | Alpha-protein kinase vwkA; Displays a modest preference for threonine over serine residues. Does not phosphorylate myosin II, however can phosphorylate MBP, in vitro. May be involved in the regulation of myosin II function during cytokinesis. Overexpression leads to impaired cell proliferation in suspension culture and fails to develop beyond the mound stage. Both overexpression and absence of the gene can result in defects in cytokinesis and alterations in myosin II abundance and assembly. (625 aa) |
| | pakC | Serine/threonine-protein kinase pakC; Has role in the regulation of chemotaxis. (477 aa) |
| | icpA | Inner centromere protein A; Chromosomal passenger protein that seems to be required for chromosome segregation and the onset of cytokinesis during mitosis. Plays a key role in the abscission of daughter cells at the end of cytokinesis and in the establishment or maintenance of a bipolar spindle. (1320 aa) |
| | abiA | Abl interactor homolog; Involved in regulation of actin and microtubule organization. Required for proper cytokinesis; Belongs to the ABI family. (332 aa) |
| | dlpA | Dynamin-like protein A; Involved in cytokinesis. May hydrolyze GTP. (880 aa) |
| | anapc10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC10 family. (188 aa) |
| | bub2 | Putative mitotic check point protein BUB2; Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis; Belongs to the BUB2 family. (366 aa) |
| | pats1 | Probable serine/threonine-protein kinase pats1; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor (By similarity). Essential regulator of cytokinesis involved in the binding to actomyosin cytoskeleton. (3184 aa) |
| | lvsA | BEACH domain-containing protein lvsA; Involved in myosin-independent cytokinesis and early steps of phagocytosis. Also involved in contractile vacuole-mediated osmoregulation. (3619 aa) |
| | GxcT | Uncharacterized protein. (1574 aa) |
| | pakA | Serine/threonine-protein kinase pakA; Regulator of the myosin II component of the cytoskeleton: required for regulation of cytokinesis. Functions during chemotaxis, required for maintaining the direction of cell movement, suppressing lateral pseudopod extension, and proper retraction of the posterior of chemotaxing cells; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (1197 aa) |
| | mcmbp | Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and may act by promoting the disassembly of the MCM complex from chromatin (By similarity). (719 aa) |
| | DDB0190842 | Uncharacterized protein. (889 aa) |
| | psmC1 | 26S proteasome regulatory subunit 4 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Plays an important role in regulating both growth and multicellular development. (439 aa) |
| | DDB0191071 | Uncharacterized protein. (992 aa) |
| | dlpC | Dynamin-like protein C; Involved in cytokinesis. May hydrolyze GTP. (904 aa) |
| | sun1 | Sun domain-containing protein 1; May have an important role in defining the spacing of the nuclear envelope lumen. Essential for centrosome attachment to the nucleus, maintenance of correct ploidy, proper mitosis, association of the centromere cluster with the centrosome and the maintenance of genome stability. Requires direct chromatin binding for inner nuclear membrane targeting. (905 aa) |
| | mad2l1-1 | Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex until all chromosomes are aligned at the metaphase plate (By similarity). Belongs to the MAD2 family. (203 aa) |
| | pds5 | Sister chromatid cohesion protein PDS5 homolog; May regulate sister chromatid cohesion during mitosis and couple it to DNA replication; Belongs to the PDS5 family. (1450 aa) |
| | smc3 | Structural maintenance of chromosomes protein 3; Central component of cohesin, a complex which is required for the cohesion of sister chromatids after DNA replication. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. Involved in chromosome cohesion during the cell cycle and in DNA repair it also regulates DNA replication. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis and in chromosomes movem [...] (1437 aa) |
| | anapc2 | Anaphase-promoting complex subunit 2; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the cullin family. (907 aa) |
| | DDB_G0276689 | Protein DDB_G0276689. (2772 aa) |
| | ctxB | Cortexillin-2; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1 (By similarity); Belongs to the cortexillin family. (441 aa) |
| | dynC | Putative dynactin 22 kDa subunit. (237 aa) |
| | fszA | Mitochondrial division protein fszA; Probably involved in mitochondrion division process. When overexpressed, induces mitochondrial tubule formation. Binds to and hydrolyzes GTP (By similarity); Belongs to the FtsZ family. (517 aa) |
| | racN | Rho-related protein racN. (219 aa) |
| | DDB_G0278049 | Uncharacterized protein. (73 aa) |
| | DDB_G0278327 | TPR_REGION domain-containing protein. (558 aa) |
| | DDB0205498 | Senescence domain-containing protein. (635 aa) |
| | DDB0206195 | TPR_REGION domain-containing protein. (229 aa) |
| | ap1b1 | AP-1 complex subunit beta; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Also involved in early steps of phagocytosis and macropinocytosis. (942 aa) |
| | cenB | Centrin-B; Plays a fundamental role in microtubule-organizing center structure and function. (150 aa) |
| | brk1 | Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family. (68 aa) |
| | DDB0205723 | Cnd3 domain-containing protein. (1303 aa) |
| | DDB0205827 | Uncharacterized protein. (232 aa) |
| | DDB0205843 | Uncharacterized protein. (469 aa) |
| | DDB0205958 | Uncharacterized protein. (1333 aa) |
| | anapc5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC5 family. (1017 aa) |
| | DDB0206468 | Uncharacterized protein. (771 aa) |
| | rps6 | 40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA; Belongs to the eukaryotic ribosomal protein eS6 family. (236 aa) |
| | dwwA | WW domain-containing protein A; Involved in regulation of actin cytoskeleton organization and cytokinesis. (568 aa) |
| | gmfA | ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. GMF subfamily. (138 aa) |
| | mad2l2 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes; Belongs to the MAD2 family. (332 aa) |
| | sodC | Extracellular superoxide dismutase [Cu-Zn] 3; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxyde radicals into hydrogen peroxyde and oxygen. (407 aa) |
| | phg2 | Serine/threonine-protein kinase phg2; Serine/threonine kinase regulating cell substrate adhesion, phagocytosis, motility, chemotaxis, and actin cytoskeleton organization. It is a downstream component of Rap1-regulated adhesion, and it is a regulator of myosin II phosphorylation. It is also a negative regulator of development initiation. (1387 aa) |
| | cdc25 | M-phase inducer phosphatase; Tyrosine protein phosphatase which may function as a dosage- dependent inducer in mitotic control; Belongs to the MPI phosphatase family. (1053 aa) |
| | lig3 | DNA ligase 3; The alpha isoform interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. The beta isoform does not interact with XRCC1 and may be specifically involved in the completion of homologous recombination events that occur during meiotic prophase; Belongs to the ATP-dependent DNA ligase family. (1175 aa) |
| | Ndc80 | Uncharacterized protein. (855 aa) |
| | erkB | Extracellular signal-regulated kinase 2; Implicated in the relay of the cAMP chemotactic signal and cell differentiation. Important for receptor-mediated activation of adenylyl cyclase. (369 aa) |
| | Spc25 | Uncharacterized protein. (324 aa) |
| | DDB0185814 | Rap-GAP domain-containing protein. (366 aa) |
| | DDB0218571 | Uncharacterized protein. (315 aa) |
| | smc2 | Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity); Belongs to the SMC family. SMC2 subfamily. (1184 aa) |
| | ndrC | Probable serine/threonine-protein kinase ndrC; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1335 aa) |
| | kif4 | Kinesin-related protein 4; Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity). Cooperates with dynein in organizing spindle assembly during cell division. (1922 aa) |
| | anapc4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC4 family. (837 aa) |
| | scrA | Protein SCAR; Involved in regulation of actin and microtubule organization. Regulates phagocytosis and macropinocytosis. Belongs to the SCAR/WAVE family. (443 aa) |
| | anapc1 | Anaphase-promoting complex subunit 1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC1 family. (2269 aa) |
| | hus1 | Checkpoint protein hus1 homolog; Essential in controlling the S-M checkpoint that couples mitosis to the completion of DNA replication. It is also required for the response to DNA damage (By similarity); Belongs to the HUS1 family. (271 aa) |
| | ino1 | Inositol-3-phosphate synthase; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). (511 aa) |
| | cdc20 | Anaphase-promoting complex subunit cdc20; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the WD repeat CDC20/Fizzy family. (499 aa) |
| | sun2 | SUN domain-containing protein 2. (1278 aa) |
| | dlpB | Dynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP. (808 aa) |
| | ctnnA | Probable vinculin; Involved in cell adhesion. Thought to play an important role in cytokinesis B, probably by providing substrate adhesion and traction forces. Required to organize and polarize the tip epithelium during cytokinesis. Required for the normal distribution of myosin in the tip epithelium. Involved in the localization of ctxA, ctxB, dcsA, exoc6 and rgaA. Thought to form a complex with ctxA, ctxB, and rgaA which regulates myosin accumulation to the apical plasma membrane. Belongs to the vinculin/alpha-catenin family. (842 aa) |
| | nudc | Nuclear movement protein nudC; Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase (By similarity). Belongs to the nudC family. (171 aa) |
| | smc4 | Structural maintenance of chromosomes protein 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity); Belongs to the SMC family. SMC4 subfamily. (1415 aa) |
| | anapc11 | Anaphase-promoting complex subunit 11; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the RING-box family. (87 aa) |
| | cdh1 | Anaphase-promoting complex subunit cdh1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the WD repeat CDC20/Fizzy family. (754 aa) |
| | rgaA | Ras GTPase-activating-like protein rgaA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell. Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cyt [...] (822 aa) |
| | Mad1 | Uncharacterized protein. (819 aa) |
| | anapc3 | Anaphase-promoting complex subunit 3; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC3/CDC27 family. (970 aa) |
| | cks1 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function; Belongs to the CKS family. (82 aa) |
| | DDB_G0274805 | SH3 domain-containing protein. (357 aa) |
| | gapA | Ras GTPase-activating-like protein gapA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA in the absence of rgaA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of the dividing cell. (860 aa) |
| | arfA | ADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family. (182 aa) |
| | clua | Clustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. (1320 aa) |
| | svkA | Serine/threonine-protein kinase svkA; Involved in regulation of actin cytoskeleton organization during cell motility; F-actin fragmenting and capping protein allowing dynamic rearrangements of the actin cytoskeleton. Also part of a regulatory pathway from the centrosome to the midzone, thus regulating the completion of cell division; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (478 aa) |
| | phdA | PH domain-containing protein. (284 aa) |
| | piaA | Protein pianissimo A; Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Required for chemoattractant receptor and G protein- mediated activation of the 12 transmembrane domain adenylyl cyclase. Functions as a part of protein complex TORC2. TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2, but not TORC1, negatively regulates phagocytosis. This protein and dagA protein CRAC, a cytosolic regulator, are both essential for activation of the enzyme adenylyl cyclase. This protein and CRAC do not function re [...] (1148 aa) |
| | racF1 | Rho-related protein racF1; Might act in concert and/or share functions with other members of the RHO family in the regulation of a subset of cytoskeletal rearrangements that are required for these processes. (193 aa) |
| | lmpA | Lysosome membrane protein 2-A; May act as a lysosomal receptor (By similarity). May be involved in macropinocytosis and fluid phase exocytosis. Binds to the anionic phospholipid phosphoinositol 4,5-bisphosphate, but not to phosphatidylcholine and only weakly to phosphatidylserine. Belongs to the CD36 family. (779 aa) |
| | dct | Dynacortin. (354 aa) |
| | fszB | Mitochondrial division protein fszB; Probably involved in mitochondrion division process. Binds to and hydrolyzes GTP (By similarity); Belongs to the FtsZ family. (366 aa) |
| | racF2 | Rho-related protein racF2. (193 aa) |
| | racG | Rho-related protein racG. (201 aa) |
| | racH | Rho-related protein racH. (200 aa) |
| | racJ | Rho-related protein racJ. (205 aa) |
| | racL | Rho-related protein racL. (196 aa) |
| | rdiA | Putative rho GDP-dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (By similarity). Regulates the Rac-dependent signaling pathways controlling cytokinesis, actin reorganization and the contractile vacuole. Required for efficient accumulation of cap at the cell cortex. (197 aa) |
| | dymA | Dynamin-A; Function in membrane trafficking processes along the endo- lysosomal pathway. (853 aa) |
| | eb1 | Microtubule-associated protein RP/EB family member 1; Involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes; Belongs to the MAPRE family. (506 aa) |
| | pteN | 3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa) |
| | sepA | Serine/threonine-protein kinase sepA; Serine/threonine-protein kinase involved in the spatial and temporal control system organizing cortical activities in mitotic and postmitotic cells. (1167 aa) |
| | mhkC | Myosin heavy chain kinase C; Phosphorylates threonine at 'Thr-1823', 'Thr-1833' and 'Thr- 2029' in the C-terminal tail region of myosin II heavy chain (mhcA) (By similarity). This phosphorylation is critical in actin-activated ATPase activity of the myosin and regulating the assembly and disassembly of myosin II filament. In vitro, catalytic domain phosphorylates mhcA, myelin basic protein, myosin regulatory light chain, casein and caldesmon. Drives the disassembly of myosin II filaments for efficient cytokinesis and recycling of myosin II that occurs during late cytokinesis. Can be ac [...] (780 aa) |
| | clc | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (194 aa) |
| | paxB | Paxillin-B; Required for cell-substrate adhesion, cell sorting, slug migration, and cell differentiation. May function upstream of limB. (569 aa) |
| | sadA | Substrate-adhesion molecule; Involved in substrate adhesion, myosin-independent cytokinesis, organization of actin cytoskeleton, and phagocytosis. (952 aa) |
| | lis1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the coupling of the nucleus and centrosome and dynein/dynactin-mediated interactions of microtubule tips with the cell cortex; Belongs to the WD repeat LIS1/nudF family. (419 aa) |
| | hbx4 | Homeobox protein 4; Putative transcription factor. (740 aa) |
| | DDB0167485 | Cnd3 domain-containing protein. (1326 aa) |
| | anapc8 | Anaphase-promoting complex subunit 8; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the APC8/CDC23 family. (592 aa) |
| | spkA-1 | Stress-activated protein kinase alpha; May be involved in cortical F-actin organization and resistance to osmotic stress. Activated upon cell detachment, in vitro. (638 aa) |
| | DDB0167169 | Uncharacterized protein. (799 aa) |
| | napA | Nck-associated protein 1 homolog; Involved in regulation of actin and microtubule organization. Involved in cell adhesion. (1160 aa) |
| | pakB | Serine/threonine-protein kinase pakB; Regulator of the myosin I component of the cytoskeleton: required for regulation of cytokinesis, phagocytosis and pinocytosis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (852 aa) |
| | lig1 | DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. (1192 aa) |
| | cpnA | Copine-A; Required for cytokinesis, contractile vacuole function and development; Belongs to the copine family. (600 aa) |
| | htt | HD protein homolog; May play a role in microtubule-mediated transport or vesicle function; Belongs to the huntingtin family. (3095 aa) |
| | EnlA | Fimbrin. (1503 aa) |
| | cdc123 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle; Belongs to the CDC123 family. (384 aa) |
| | pirA | Protein pirA; Involved in regulation of actin and microtubule organization. (1336 aa) |
| | kif8 | Kinesin-related protein 8; Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity). Cooperates with kif10 and dynein to organize interphase microtubules. (1873 aa) |
