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| | DDB0218242 | Rap-GAP domain-containing protein. (2935 aa) |
| | psrA | Serine/threonine-protein phosphatase 2A regulatory subunit psrA; Involved in developmental cell fate decision. Belongs to the phosphatase 2A regulatory subunit B56 family. (628 aa) |
| | tbc1d5A | TBC1 domain family member 5 homolog A; May act as a GTPase-activating protein for Rab family protein(s). (1173 aa) |
| | DDB0205958 | Uncharacterized protein. (1333 aa) |
| | GflD | Ras-GEF domain-containing protein. (1765 aa) |
| | DDB0205813 | Rab-GAP TBC domain-containing protein. (1229 aa) |
| | gacP | Rho GTPase-activating protein gacP; Rho GTPase-activating protein involved in the signal transduction pathway. (576 aa) |
| | GefBB | Uncharacterized protein. (2050 aa) |
| | ngap | Probable Ras GTPase-activating-like protein ngap; May function as a Ras GTPase-activating protein. (877 aa) |
| | DDB_G0278267 | Uncharacterized protein. (876 aa) |
| | DDB0204481 | Uncharacterized protein. (933 aa) |
| | racgef1 | Rac guanyl-nucleotide exchange factor. (1218 aa) |
| | DDB_G0277967 | RabGAP/TBC domain-containing protein. (1047 aa) |
| | ctxB | Cortexillin-2; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1 (By similarity); Belongs to the cortexillin family. (441 aa) |
| | AF310892_3 | Rab-GAP TBC domain-containing protein. (511 aa) |
| | DDB0217791 | Uncharacterized protein. (843 aa) |
| | gefY | Ras guanine nucleotide exchange factor Y; Promotes the exchange of Ras-bound GDP by GTP. (1508 aa) |
| | DDB0202463 | Uncharacterized protein. (1385 aa) |
| | DDB0202560 | Rab-GAP TBC domain-containing protein. (702 aa) |
| | DDB_G0275421 | Uncharacterized protein. (1223 aa) |
| | gacI | Rho GTPase-activating protein gacI; Rho GTPase-activating protein involved in the signal transduction pathway. (799 aa) |
| | ZizC | Uncharacterized protein; Belongs to the DOCK family. (2621 aa) |
| | DDB_G0274699 | WAP domain-containing protein. (145 aa) |
| | adrm1-1 | Proteasomal ubiquitin receptor ADRM1 homolog; Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme uchl5 at the 26S proteasome and promotes its activity (By similarity). Plays a role in the transition from growth to differentiation. (287 aa) |
| | DDB_G0271806 | PH and Rap-GAP domain-containing protein DDB_G0271806. (1167 aa) |
| | nfaA | Neurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB. (920 aa) |
| | glkA | Probable serine/threonine-protein kinase glkA; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. (473 aa) |
| | DDB0190820 | Uncharacterized protein. (130 aa) |
| | DDB0190714 | Rab-GAP TBC domain-containing protein. (544 aa) |
| | DDB0190683 | Uncharacterized protein. (2044 aa) |
| | pakD | Serine/threonine-protein kinase pakD. (1678 aa) |
| | DDB_G0269462 | Ubiquitin domain-containing protein. (2337 aa) |
| | DDB0216649 | Rab-GAP TBC domain-containing protein. (831 aa) |
| | ZizD | Uncharacterized protein; Belongs to the DOCK family. (2162 aa) |
| | bub2 | Putative mitotic check point protein BUB2; Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis; Belongs to the BUB2 family. (366 aa) |
| | DDB0216614 | Rab-GAP TBC domain-containing protein. (604 aa) |
| | gefV | Ras guanine nucleotide exchange factor V; Promotes the exchange of Ras-bound GDP by GTP. (1982 aa) |
| | DDB0189736 | Uncharacterized protein. (617 aa) |
| | tbck | TBC domain-containing protein kinase-like protein. (1033 aa) |
| | gefW | Ras guanine nucleotide exchange factor W; Promotes the exchange of Ras-bound GDP by GTP. (1172 aa) |
| | cpiC | Cystatin-A3; Intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (94 aa) |
| | aprA | Autocrine proliferation repressor protein A; Inhibitor that slows proliferation of secreting cells (also known as chalone). May function by binding to cell surface receptors. Requires cfaD for activity. Overexpression slows proliferation. Belongs to the pqaA family. (494 aa) |
| | cpiB | Cystatin-A2; Intracellular thiol proteinase inhibitor. Inhibits cathepsin B, but not papain. (95 aa) |
| | cpiA | Cystatin-A1; Intracellular thiol proteinase inhibitor. Inhibits papain, but not cathepsin B. (94 aa) |
| | rapgap1 | RapA guanosine triphosphatase-activating protein 1; Mediates the deactivation of rap1 and plays an important role in spatially and temporally regulating cell adhesion and chemotaxis by controlling attachment disassembly in the leading edge through the regulation of myosin II assembly and disassembly. Overexpression leads to defective chemotaxis. (1055 aa) |
| | DDB0216915 | Uncharacterized protein. (1241 aa) |
| | cnrF | RabGAP/TBC domain-containing protein. (986 aa) |
| | htt | HD protein homolog; May play a role in microtubule-mediated transport or vesicle function; Belongs to the huntingtin family. (3095 aa) |
| | DG1112 | Developmental gene product DG1112. (1057 aa) |
| | DDB0217806 | Rap-GAP domain-containing protein. (855 aa) |
| | GacS | Rho-GAP domain-containing protein. (1026 aa) |
| | gefQ | Ras guanine nucleotide exchange factor Q; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis. (1298 aa) |
| | gacFF | Rho GTPase-activating protein gacFF; Rho GTPase-activating protein involved in the signal transduction pathway. (885 aa) |
| | ZizA | Uncharacterized protein; Belongs to the DOCK family. (2284 aa) |
| | gacH | Rho GTPase-activating protein gacH; Rho GTPase-activating protein involved in the signal transduction pathway. (566 aa) |
| | ctnA | Countin-1; Cell-counting factor that limits the maximum size of the multicellular structure. May down-regulate the expression of gp24, which mediates cell adhesion. (258 aa) |
| | dpiA | Protein phosphatase inhibitor 2; Inhibitor of protein-phosphatase 1 (PP1). (261 aa) |
| | DDB0169348 | Ras-GAP domain-containing protein. (703 aa) |
| | p2xA | P2X receptor A; P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Inward currents evoked by intracellular ATP and ATP analogs. Exclusively selective for ATP over other nucleotides. Insensitive to P2 receptor antagonists PPADS, suramin and 2',3'-O-(2,4,6-trinitrophenyl)-ATP but inhibited by nanomolar concentrations of copper and sodium ion. More permeable to ammonium than either sodium or potassium ions and less permeable to choline. It has been reported that p2xA is not es [...] (378 aa) |
| | Dd5P4 | Inositol 5-phosphatase 4. (787 aa) |
| | gefO | Ras guanine nucleotide exchange factor O; Promotes the exchange of Ras-bound GDP by GTP. (944 aa) |
| | gefN | Ras guanine nucleotide exchange factor N; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May play a role in chemotaxis. (1138 aa) |
| | gefJ | Ras guanine nucleotide exchange factor J; Promotes the exchange of Ras-bound GDP by GTP. (812 aa) |
| | gefI | Ras guanine nucleotide exchange factor I; Promotes the exchange of Ras-bound GDP by GTP. (824 aa) |
| | gefH | Ras guanine nucleotide exchange factor H; Promotes the exchange of Ras-bound GDP by GTP. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (604 aa) |
| | gefE | Ras guanine nucleotide exchange factor E; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis. (1037 aa) |
| | gefD | Ras guanine nucleotide exchange factor D; Promotes the exchange of Ras-bound GDP by GTP. (668 aa) |
| | gefC | Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP. (1457 aa) |
| | gefB | Ras guanine nucleotide exchange factor B; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Involved in phagocytosis, fluid-phase endocytosis, regulation of macropinocytosis and control of cell movement. (1529 aa) |
| | pdeD | cGMP-dependent 3',5'-cGMP phosphodiesterase A; Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP. Involved in the degradation of intracellular cGMP. (867 aa) |
| | gefR | Ras guanine nucleotide exchange factor R; Promotes the exchange of Ras-bound GDP by GTP. May also play a role in the activation of rasG. (1721 aa) |
| | gacJJ | Rho GTPase-activating protein gacJJ; Rho GTPase-activating protein involved in the signal transduction pathway. (873 aa) |
| | DDB0188980 | Uncharacterized protein. (370 aa) |
| | DDB0188549 | Rab-GAP TBC domain-containing protein. (541 aa) |
| | GefAA | Uncharacterized protein. (1371 aa) |
| | ctxA | Cortexillin-1; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1; Belongs to the cortexillin family. (444 aa) |
| | rmp | RNA polymerase II subunit 5-mediating protein homolog. (489 aa) |
| | DDB0188195 | Ras-GAP domain-containing protein. (817 aa) |
| | DDB0216036 | Rab-GAP TBC domain-containing protein. (463 aa) |
| | DDB0188123 | Rab-GAP TBC domain-containing protein. (829 aa) |
| | DDB0187927 | Rab-GAP TBC domain-containing protein. (733 aa) |
| | DDB_G0288147 | Probable serine/threonine-protein kinase DDB_G0288147; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1347 aa) |
| | DDB0219267 | A2M domain-containing protein. (2286 aa) |
| | rgaA | Ras GTPase-activating-like protein rgaA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell. Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cyt [...] (822 aa) |
| | DDB0187458 | Uncharacterized protein. (1076 aa) |
| | gflB | Ras guanine nucleotide exchange factor glfB; GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways. Acts also as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways. (1601 aa) |
| | tiprl | TIP41-like protein; Belongs to the TIP41 family. (274 aa) |
| | DDB0186709 | Uncharacterized protein. (235 aa) |
| | scrA | Protein SCAR; Involved in regulation of actin and microtubule organization. Regulates phagocytosis and macropinocytosis. Belongs to the SCAR/WAVE family. (443 aa) |
| | gacT | Rho GTPase-activating protein gacT; Rho GTPase-activating protein involved in the signal transduction pathway. (1009 aa) |
| | DDB0186309 | Rab-GAP TBC domain-containing protein. (290 aa) |
| | DDB0186216 | Rap-GAP domain-containing protein. (1640 aa) |
| | ndrC | Probable serine/threonine-protein kinase ndrC; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1335 aa) |
| | csnk2b | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (268 aa) |
| | gacC | Rho GTPase-activating protein gacC; Rho GTPase-activating protein involved in the signal transduction pathway. (399 aa) |
| | gefA | Ras guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (605 aa) |
| | DDB0185880 | Ras-GAP domain-containing protein. (1056 aa) |
| | DDB0185814 | Rap-GAP domain-containing protein. (366 aa) |
| | erkB | Extracellular signal-regulated kinase 2; Implicated in the relay of the cAMP chemotactic signal and cell differentiation. Important for receptor-mediated activation of adenylyl cyclase. (369 aa) |
| | DDB_G0283567 | Ragulator complex protein LAMTOR5 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity). (89 aa) |
| | DDB0185432 | Rab-GAP TBC domain-containing protein. (1455 aa) |
| | DDB0218425 | Rap-GAP domain-containing protein. (1049 aa) |
| | DDB0204021 | UDENN FLCN/SMCR8-type domain-containing protein. (656 aa) |
| | DDB_G0280955 | RabGAP/TBC domain-containing protein. (733 aa) |
| | rapgapB | RapA guanosine triphosphatase-activating protein B; Mediates the deactivation of rap1 during multicellular development and is required for normal morphogenesis. Also required for the correct patterning of specific subtypes of prestalk cells. (418 aa) |
| | DDB0205121 | Uncharacterized protein. (464 aa) |
| | tbc1d5B | TBC1 domain family member 5 homolog B; May act as a GTPase-activating protein for Rab family protein(s). (1016 aa) |
| | DDB0204612 | Uncharacterized protein. (281 aa) |
| | gefP | Ras guanine nucleotide exchange factor P; Promotes the exchange of Ras-bound GDP by GTP. (1502 aa) |
| | dhkA | Hybrid signal transduction histidine kinase A; Acts as a receptor histidine kinase for the cytokinin SDF-2 in a signal transduction pathway that regulates prestalk gene expression and controls terminal differentiation of prespore cells. Binding of SDF-2 to this protein inhibits phosphorelay and induces rapid sporulation. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. (2150 aa) |
| | DDB_G0281137 | RabGAP/TBC domain-containing protein. (597 aa) |
| | DDB0203971 | RAB3GAP2_N domain-containing protein. (634 aa) |
| | gefM | Ras guanine nucleotide exchange factor M; Promotes the exchange of Ras-bound GDP by GTP. (929 aa) |
| | carD | Cyclic AMP receptor 4; Receptor for cAMP. Regulates axial patterning and cellular differentiation during late development. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (443 aa) |
| | dct | Dynacortin. (354 aa) |
| | racG | Rho-related protein racG. (201 aa) |
| | psmE3 | Proteasome activator 28; Subunit of the 11S REG (also called PA28) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates preferentially the trypsin-like catalytic subunit of the proteasome. May also be involved in cell cycle regulation. (225 aa) |
| | gefG | Ras guanine nucleotide exchange factor G; Promotes the exchange of Ras-bound GDP by GTP. (1556 aa) |
| | gefS | Ras guanine nucleotide exchange factor S; Promotes the exchange of Ras-bound GDP by GTP. (1043 aa) |
| | DDB0167574 | Ras-GAP domain-containing protein. (1728 aa) |
| | gefL | Ras guanine nucleotide exchange factor L; Promotes the exchange of Ras-bound GDP by GTP. (2356 aa) |
| | DDB_G0295717 | RabGAP/TBC domain-containing protein. (821 aa) |
| | gapA | Ras GTPase-activating-like protein gapA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA in the absence of rgaA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of the dividing cell. (860 aa) |
| | darA | Darlin; Part of a signaling pathway that initiates the aggregation and leads to the formation of aggregation centers or streams. Not essential for cytokinesis, pinocytosis or phagocytosis. Not essential for development, except in starvation-induced aggregation. Belongs to the RAP1GDS1 family. (766 aa) |
| | phgA | Drainin; May act as a GTPase-activating protein for Rab family protein(s) (By similarity). Required for osmotic regulation by the contractile vacuole in hypo-osmotic environments. Essential for periodic fusion of the contractile vacuole with the plasma membrane and consequent expulsion of water from the cell body. (438 aa) |
| | calA | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (152 aa) |
| | carA-1 | Cyclic AMP receptor 1; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. (392 aa) |
| | rasG | Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | gpaB | Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family. (357 aa) |
| | gpaA | Guanine nucleotide-binding protein alpha-1 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (356 aa) |
| | rapA | Ras-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells. (186 aa) |
| | pkaC | cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis. (648 aa) |
| | carC | Cyclic AMP receptor 3; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (490 aa) |
| | gpbA | Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development. (347 aa) |
| | gskA | Glycogen synthase kinase-3; During cellular differentiation, may mediate an extracellular cyclic AMP stimulated signal transduction pathway that regulates prespore and prestalk B-cell proportions through inhibition of stalk cell formation and induction of prespore cell differentiation. The cAMP receptor carC appears to activate gskA via the tyrosine kinases zakA and zak2, to stimulate prespore differentiation, while carD appears to negatively regulate gskA, to promote prestalk formation. (467 aa) |
| | smlA | Small aggregate formation protein; Knockout of the gene for this protein causes small aggregate formation. May regulate the secretion or processing of a secreted factor that regulates aggregate size. (283 aa) |
| | gacE | Rho GTPase-activating protein gacE; Rho GTPase-activating protein involved in the signal transduction pathway. (1132 aa) |
| | cpras2 | Circularly permutated Ras protein 2. (3933 aa) |
| | gefF | Ras guanine nucleotide exchange factor F; Promotes the exchange of Ras-bound GDP by GTP. (1127 aa) |
| | ZizB | Uncharacterized protein; Belongs to the DOCK family. (2147 aa) |
| | DDB0191741 | Uncharacterized protein. (716 aa) |
| | PsmE4 | Uncharacterized protein. (1905 aa) |
| | DDB0184242 | Uncharacterized protein. (1163 aa) |
| | DDB0184177 | Uncharacterized protein. (437 aa) |
| | racGAP | Uncharacterized protein. (1350 aa) |
| | gacEE | Rho GTPase-activating protein gacEE; Rho GTPase-activating protein involved in the signal transduction pathway. (570 aa) |
| | DDB_G0291510 | GTPase-activating protein DDB_G0291510. (1031 aa) |
| | DDB0219647 | Uncharacterized protein. (1918 aa) |
| | gefK | Ras guanine nucleotide exchange factor K; Promotes the exchange of Ras-bound GDP by GTP. (1557 aa) |
| | DDB0185275 | Rap-GAP domain-containing protein. (1069 aa) |
| | DDB0185273 | Ras-GAP domain-containing protein. (608 aa) |
| | DDB0218424 | Rab-GAP TBC domain-containing protein. (400 aa) |
| | gbpD | Cyclic GMP-binding protein D; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Induces the formation of substrate-attached pseudopodia, that leads to increased adhesion and thereby negatively influencing cell speed and polarity. (1312 aa) |
| | PsmF1 | Uncharacterized protein. (326 aa) |
| | GxcF | DH domain-containing protein. (932 aa) |
| | grlH | Metabotropic glutamate receptor-like protein H; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (764 aa) |
| | gacQ | Rho GTPase-activating protein gacQ; Rho GTPase-activating protein involved in the signal transduction pathway. (531 aa) |
| | DDB0204167 | Uncharacterized protein. (787 aa) |
